TABLE OF CONTENTS
| | | | Volume 135, Issue 11 (November 2015) | | In this issue Editorial Research Techniques Made Simple Snapshot Dx Quiz Cells to Surgery Quiz Commentaries Perspective Review Article Original Articles Letters to the Editor Corrigenda/Errata Addendum
Also new AOP | | | | | Advertisement | | As of January 2016, the Journal of Investigative Dermatology will be published by Elsevier. To ensure that you stay informed of the latest content published in JID next year, you'll need to sign up to receive Elsevier's New Content Alerts. Starting January 4, go to www.jidonline.org to sign up. | | | | | | Editorial | Top | | The FDA: Doctors, Investigators, and Translational ResearchWilliam H Eaglstein J Invest Dermatol 2015 135: 2555-2556; 10.1038/jid.2015.258 Full Text | PDF | | | | Clinical SnippetsJ Invest Dermatol 2015 135: 2557; 10.1038/jid.2015.340 Full Text | PDF | | | | BJD Editor's ChoiceJ Invest Dermatol 2015 135: 2558; 10.1038/jid.2015.341 Full Text | PDF | | | | Editors' PicksJ Invest Dermatol 2015 135: 2559; 10.1038/jid.2015.342 Full Text | PDF | | Research Techniques Made Simple | Top | | Research Techniques Made Simple: Drug Delivery Techniques, Part 1: Concepts in Transepidermal Penetration and AbsorptionShawn Schmieder, Parth Patel and Karthik Krishnamurthy J Invest Dermatol 2015 135: 1-5; 10.1038/jid.2015.343 Full Text | PDF | | Snapshot Dx Quiz | Top | | November 2015 Snapshot Dx Quiz: Linking Science to Patient CareAdam Wulkan and Mariya Miteva J Invest Dermatol 2015 135: e34; 10.1038/jid.2015.344 Full Text | PDF | | Cells to Surgery Quiz | Top | | Cells to Surgery Quiz: November 2015Stephanie Mlacker, Adam S Aldahan, Vidhi V Shah, Mohammed Alsaidan, Sahal Samarkandy and Keyvan Nouri J Invest Dermatol 2015 135: e19; 10.1038/jid.2015.345 Full Text | PDF | | Commentaries | Top | | Melanoma Incidence and Lethality Is Increased Following Solid Organ TransplantationDavid C Whiteman and Catherine M Olsen J Invest Dermatol 2015 135: 2560-2562; 10.1038/jid.2015.326 Abstract | Full Text | PDF | | | | CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?Taihao Quan, Andrew Johnston, Johann E Gudjonsson and Gary J Fisher J Invest Dermatol 2015 135: 2562-2564; 10.1038/jid.2015.300 Abstract | Full Text | PDF | | | | Down-RANKing the Threat of HSV-1: RANKL Upregulates MHC-Class-I-Restricted Anti-Viral Immunity in Herpes Simplex Virus InfectionKatja Finsterbusch and Vincent Piguet J Invest Dermatol 2015 135: 2565-2567; 10.1038/jid.2015.293 Abstract | Full Text | PDF | | | | Bad Hair Day: Testosterone and WntsAmanda M Nelson and Luis A Garza J Invest Dermatol 2015 135: 2567-2569; 10.1038/jid.2015.304 Abstract | Full Text | PDF | | | | Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen MatrixGeoffrey C Gurtner and Victor W Wong J Invest Dermatol 2015 135: 2569-2571; 10.1038/jid.2015.327 Abstract | Full Text | PDF | | Perspective | Top | | The Janus-Faced Role of Aryl Hydrocarbon Receptor Signaling in the Skin: Consequences for Prevention and Treatment of Skin DisordersThomas Haarmann-Stemmann, Charlotte Esser and Jean Krutmann J Invest Dermatol 2015 135: 2572-2576; advance online publication, August 13, 2015; 10.1038/jid.2015.285 Abstract | Full Text | PDF | | Review Article | Top | | Skin Disease in Laminopathy-Associated Premature AgingTomás McKenna, Agustín Sola Carvajal and Maria Eriksson J Invest Dermatol 2015 135: 2577-2583; advance online publication, July 29, 2015; 10.1038/jid.2015.295 Abstract | Full Text | PDF | | Original Articles | Top | | APPENDAGES | Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell QuiescenceShin-Ichi Osada, Naoko Minematsu, Fumino Oda, Kazunori Akimoto, Seiji Kawana and Shigeo Ohno J Invest Dermatol 2015 135: 2584-2592; advance online publication, April 23, 2015; 10.1038/jid.2015.222 Abstract | Full Text | PDF | | | | Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1Shreya Bhattacharya, Heather Wheeler, Mark Leid, Gitali Ganguli-Indra and Arup K Indra J Invest Dermatol 2015 135: 2593-2602; advance online publication, July 15, 2015; 10.1038/jid.2015.281 Abstract | Full Text | PDF | | | | CELL BIOLOGY | Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin DifferentiationKai-Ming Liu, Yi-Ju Chen, Li-Fen Shen, Amir N S Haddad, I-Wen Song, Li-Ying Chen, Yu-Ju Chen, Jer-Yuarn Wu, Jeffrey J Y Yen and Yuan-Tsong Chen J Invest Dermatol 2015 135: 2603-2610; advance online publication, June 29, 2015; 10.1038/jid.2015.240 Abstract | Full Text | PDF | | | | Photoactivation of ROS Production In Situ Transiently Activates Cell Proliferation in Mouse Skin and in the Hair Follicle Stem Cell Niche Promoting Hair Growth and Wound HealingElisa Carrasco, María I Calvo, Alfonso Blázquez-Castro, Daniela Vecchio, Alicia Zamarrón, Irma Joyce Dias de Almeida, Juan C Stockert, Michael R Hamblin, Ángeles Juarranz and Jesús Espada J Invest Dermatol 2015 135: 2611-2622; advance online publication, July 2, 2015; 10.1038/jid.2015.248 Abstract | Full Text | PDF | | | | CLINICAL RESEARCH | Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive CryolipolysisLilit Garibyan, Laura Cornelissen, William Sipprell, Joachim Pruessner, Sarina Elmariah, Tuan Luo, Ethan A Lerner, Yookyung Jung, Conor Evans, David Zurakowski, Charles B Berde and R Rox Anderson J Invest Dermatol 2015 135: 2623-2631; advance online publication, June 22, 2015; 10.1038/jid.2015.233 Abstract | Full Text | PDF | | | | EPIDEMIOLOGY | Differential Drug Survival of Biologic Therapies for the Treatment of Psoriasis: A Prospective Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR)Richard B Warren, Catherine H Smith, Zenas Z N Yiu, Darren M Ashcroft, Jonathan N W N Barker, A David Burden, Mark Lunt, Kathleen McElhone, Anthony D Ormerod, Caroline M Owen, Nick J Reynolds and Christopher E M Griffiths on behalf of the BADBIR Study Group J Invest Dermatol 2015 135: 2632-2640; advance online publication, June 8, 2015; 10.1038/jid.2015.208 Abstract | Full Text | PDF | | | | Efficacy and Safety of Systemic Long-Term Treatments for Moderate-to-Severe Psoriasis: A Systematic Review and Meta-AnalysisAlexander Nast, Anja Jacobs, Stefanie Rosumeck and Ricardo N Werner J Invest Dermatol 2015 135: 2641-2648; advance online publication, June 5, 2015; 10.1038/jid.2015.206 Abstract | Full Text | PDF | | | | Predicting the Risk of a Second Basal Cell CarcinomaJoris A C Verkouteren, Hilde Smedinga, Ewout W Steyerberg, Albert Hofman and Tamar Nijsten J Invest Dermatol 2015 135: 2649-2656; advance online publication, March 3, 2015; 10.1038/jid.2015.244 Abstract | Full Text | PDF | | | | Melanoma Risk and Survival among Organ Transplant RecipientsHilary A Robbins, Christina A Clarke, Sarah T Arron, Zaria Tatalovich, Amy R Kahn, Brenda Y Hernandez, Lisa Paddock, Elizabeth L Yanik, Charles F Lynch, Bertram L Kasiske, Jon Snyder and Eric A Engels J Invest Dermatol 2015 135: 2657-2665; advance online publication, August 13, 2015; 10.1038/jid.2015.312 Abstract | Full Text | PDF | | | | IMMUNOLOGY/INFECTION | CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte ActivationYue Sun, Jie Zhang, Zhou Zhou, Pinru Wu, Rongfen Huo, Beiqing Wang, Zhengyu Shen, Huidan Li, Tianhang Zhai, Baihua Shen, Xiangdong Chen and Ningli Li J Invest Dermatol 2015 135: 2666-2675; advance online publication, June 22, 2015; 10.1038/jid.2015.231 Abstract | Full Text | PDF | | | | Cutaneous RANK–RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell ApoptosisLars Klenner, Wali Hafezi, Björn E Clausen, Eva U Lorentzen, Thomas A Luger, Stefan Beissert, Joachim E Kühn and Karin Loser J Invest Dermatol 2015 135: 2676-2687; advance online publication, June 15, 2015; 10.1038/jid.2015.225 Abstract | Full Text | PDF | | | | Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin DiseaseMinjun Yu, David M Owens, Sankar Ghosh and Donna L Farber J Invest Dermatol 2015 135: 2688-2696; advance online publication, June 22, 2015; 10.1038/jid.2015.232 Abstract | Full Text | PDF | | | | In situ Delivery of Tumor Antigen– and Adjuvant-Loaded Liposomes Boosts Antigen-Specific T-Cell Responses by Human Dermal Dendritic CellsMartine A Boks, Sven C M Bruijns, Martino Ambrosini, Hakan Kalay, Louis van Bloois, Gert Storm, Tanja de Gruijl and Yvette van Kooyk J Invest Dermatol 2015 135: 2697-2704; advance online publication, June 17, 2015; 10.1038/jid.2015.226 Abstract | Full Text | PDF | | | | Aspartame Attenuates 2, 4-Dinitrofluorobenzene-Induced Atopic Dermatitis–Like Clinical Symptoms in NC/Nga MiceGun-Dong Kim, Yong Seek Park, Hyun-Jong Ahn, Jeong-Je Cho and Cheung-Seog Park J Invest Dermatol 2015 135: 2705-2713; advance online publication, June 22, 2015; 10.1038/jid.2015.234 Abstract | Full Text | PDF | | | | IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureusPei-Feng Liu, Jin-Shiung Cheng, Cheng-Len Sy, Wei-Chun Huang, Hsiu-Chen Yang, Richard L Gallo, Chun-Ming Huang and Chih-Wen Shu J Invest Dermatol 2015 135: 2714-2722; advance online publication, July 2, 2015; 10.1038/jid.2015.254 Abstract | Full Text | PDF | | | | Nitric Oxide–Releasing Nanoparticles Prevent Propionibacterium acnes–Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune ResponseMin Qin, Angelo Landriscina, Jamie M Rosen, Gabrielle Wei, Stephanie Kao, William Olcott, George W Agak, Karin B Paz, Josephine Bonventre, Alicea Clendaniel, Stacey Harper, Brandon L Adler, Aimee E Krausz, Joel M Friedman, Joshua D Nosanchuk, Jenny Kim and Adam J Friedman J Invest Dermatol 2015 135: 2723-2731; advance online publication, July 14, 2015; 10.1038/jid.2015.277 Abstract | Full Text | PDF | | | | AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic SkinGeneviève Garcin, Isabelle Guiraud, Matthieu Lacroix, Clémence Genthon, Stéphanie Rialle, Jean-Marie Joujoux, Laurent Meunier, Thierry Lavabre-Bertrand, Pierre-Emmanuel Stoebner and Lionel Le Gallic J Invest Dermatol 2015 135: 2732-2741; advance online publication, June 15, 2015; 10.1038/jid.2015.282 Abstract | Full Text | PDF | | | | Lymphatic Function Regulates Contact Hypersensitivity Dermatitis in ObesityIra L Savetsky, Nicholas J Albano, Daniel A Cuzzone, Jason C Gardenier, Jeremy S Torrisi, Gabriela D García Nores, Matthew D Nitti, Geoffrey E Hespe, Tyler S Nelson, Raghu P Kataru, J Brandon Dixon and Babak J Mehrara J Invest Dermatol 2015 135: 2742-2752; advance online publication, July 15, 2015; 10.1038/jid.2015.283 Abstract | Full Text | PDF | | | | KERATINOCYTES/EPIDERMIS | The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem CellsJIDOPENKai Kretzschmar, Denny L Cottle, Pawel J Schweiger and Fiona M Watt J Invest Dermatol 2015 135: 2753-2763; advance online publication, June 29, 2015; 10.1038/jid.2015.242 Abstract | Full Text | PDF | | | | Decreased Expression of Caveolin-1 Contributes to the Pathogenesis of Psoriasiform Dermatitis in MiceYukie Yamaguchi, Yuko Watanabe, Tomoya Watanabe, Noriko Komitsu and Michiko Aihara J Invest Dermatol 2015 135: 2764-2774; advance online publication, July 2, 2015; 10.1038/jid.2015.249 Abstract | Full Text | PDF | | | | MELANOCYTES/MELANOMA | Cell Surface CD74–MIF Interactions Drive Melanoma Survival in Response to Interferon-γKeiji Tanese, Yuuri Hashimoto, Zuzana Berkova, Yuling Wang, Felipe Samaniego, Jeffrey E Lee, Suhendan Ekmekcioglu and Elizabeth A Grimm J Invest Dermatol 2015 135: 2775-2784; advance online publication, June 3, 2015; 10.1038/jid.2015.204 Abstract | Full Text | PDF | | | | Impaired gp100-Specific CD8+ T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma ModelJIDOPENDavid G Mairhofer, Daniela Ortner, Christoph H Tripp, Sandra Schaffenrath, Viktor Fleming, Lukas Heger, Kerstin Komenda, Daniela Reider, Diana Dudziak, Suzie Chen, Jürgen C Becker, Vincent Flacher and Patrizia Stoitzner J Invest Dermatol 2015 135: 2785-2793; advance online publication, June 29, 2015; 10.1038/jid.2015.241 Abstract | Full Text | PDF | | | | Sensitization of Melanoma Cells for Death Ligand TRAIL Is Based on Cell Cycle Arrest, ROS Production, and Activation of Proapoptotic Bcl-2 ProteinsSandra-Annika Quast, Katja Steinhorst, Michael Plötz and Jürgen Eberle J Invest Dermatol 2015 135: 2794-2804; advance online publication, July 2, 2015; 10.1038/jid.2015.250 Abstract | Full Text | PDF | | | | CCN2 Expression by Tumor Stroma Is Required for Melanoma MetastasisJames Hutchenreuther, Krista M Vincent, David E Carter, Lynne-Marie Postovit and Andrew Leask J Invest Dermatol 2015 135: 2805-2813; advance online publication, July 13, 2015; 10.1038/jid.2015.279 Abstract | Full Text | PDF | | | | NEUROBIOLOGY | Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch PatientsHideki Mochizuki, Alexandru D P Papoiu, Leigh A Nattkemper, Andrew C Lin, Robert A Kraft, Robert C Coghill and Gil Yosipovitch J Invest Dermatol 2015 135: 2814-2823; advance online publication, June 15, 2015; 10.1038/jid.2015.223 Abstract | Full Text | PDF | | | | PHOTOBIOLOGY | Langerhans Cells Facilitate UVB-Induced Epidermal CarcinogenesisJulia M Lewis, Christina D Bürgler, Marianna Freudzon, Kseniya Golubets, Juliet F Gibson, Renata B Filler and Michael Girardi J Invest Dermatol 2015 135: 2824-2833; advance online publication, June 8, 2015; 10.1038/jid.2015.207 Abstract | Full Text | PDF | | | | Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human CellsMelisa Guven, Reto Brem, Peter Macpherson, Matthew Peacock and Peter Karran J Invest Dermatol 2015 135: 2834-2841; advance online publication, July 2, 2015; 10.1038/jid.2015.255 Abstract | Full Text | PDF | | | | WOUND HEALING | Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1James A Roper, Rosalind C Williamson, Blandine Bally, Christopher A M Cowell, Rebecca Brooks, Phil Stephens, Andrew J Harrison and Mark D Bass J Invest Dermatol 2015 135: 2842-2851; advance online publication, June 16, 2015; 10.1038/jid.2015.224 Abstract | Full Text | PDF | | | | Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen MatrixHamid Mohammadi, Vanessa I Pinto, Yongqiang Wang, Boris Hinz, Paul A Janmey and Christopher A McCulloch J Invest Dermatol 2015 135: 2852-2861; advance online publication, July 2, 2015; 10.1038/jid.2015.251 Abstract | Full Text | PDF | | | | Interleukin-22 Promotes Wound Repair in Diabetes by Improving Keratinocyte Pro-Healing FunctionsSimona Avitabile, Teresa Odorisio, Stefania Madonna, Stefanie Eyerich, Liliana Guerra, Kilian Eyerich, Giovanna Zambruno, Andrea Cavani and Francesca Cianfarani J Invest Dermatol 2015 135: 2862-2870; advance online publication, July 13, 2015; 10.1038/jid.2015.278 Abstract | Full Text | PDF | | Letters to the Editor | Top | | Skin Cancer Risk Factors and Preventative Behaviors among United States Military Veterans Deployed to Iraq and AfghanistanJennifer G Powers, Neelam A Patel, Edward M Powers, Jonathan E Mayer, George P Stricklin and Alan C Geller J Invest Dermatol 2015 135: 2871-2873; advance online publication, June 25, 2015; 10.1038/jid.2015.238 Full Text | PDF | | | | Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for SclerodermaJIDOPENAnupam Mitra, Jesus I Luna, Alina I Marusina, Alexander Merleev, Smriti Kundu-Raychaudhuri, David Fiorentino, Siba P Raychaudhuri and Emanual Maverakis J Invest Dermatol 2015 135: 2873-2876; advance online publication, July 2, 2015; 10.1038/jid.2015.252 Full Text | PDF | | | | A Deep-Intronic FERMT1 Mutation Causes Kindler Syndrome: An Explanation for Genetically Unsolved CasesNadja Chmel, Sorina Danescu, Amelie Gruler, Dimitra Kiritsi, Leena Bruckner-Tuderman, Alexander Kreuter, Jürgen Kohlhase and Cristina Has J Invest Dermatol 2015 135: 2876-2879; advance online publication, June 17, 2015; 10.1038/jid.2015.227 Full Text | PDF | | | | Expanding the Phenotypic Spectrum of Olmsted SyndromeJIDOPENNeil J Wilson, Christian Cole, Leonard M Milstone, Ana E Kiszewski, C David Hansen, Edel A O'Toole, Mary E Schwartz, W H Irwin McLean and Frances J D Smith J Invest Dermatol 2015 135: 2879-2883; advance online publication, June 12, 2015; 10.1038/jid.2015.217 Full Text | PDF | | | | Receptor Activator of NF-κB Ligand Promotes the Production of CCL17 from RANK+ M2 MacrophagesTaku Fujimura, Yumi Kambayashi, Sadanori Furudate, Masayuki Asano, Aya Kakizaki and Setsuya Aiba J Invest Dermatol 2015 135: 2884-2887; advance online publication, June 8, 2015; 10.1038/jid.2015.209 Full Text | PDF | | | | Cathelicidin LL-37 Induces Semaphorin 3A Expression in Human Epidermal Keratinocytes: Implications for Possible Application to PruritusYoshie Umehara, Yayoi Kamata, Mitsutoshi Tominaga, François Niyonsaba, Hideoki Ogawa and Kenji Takamori J Invest Dermatol 2015 135: 2887-2890; advance online publication, June 29, 2015; 10.1038/jid.2015.243 Full Text | PDF | | | | IL-10 signaling in dendritic cells attenuates anti-Leishmania major immunity without affecting protective memory responsesMathilde J H Girard-Madoux, Kordula Kautz-Neu, Beate Lorenz, Julia L Ober-Blöbaum, Esther von Stebut and Björn E Clausen J Invest Dermatol 2015 135: 2890-2894; advance online publication, June 22, 2015; 10.1038/jid.2015.236 Full Text | PDF | | | | Dact1 Regulates the Ability of 3T3-J2 Cells to Support Proliferation of Human Epidermal KeratinocytesDaisuke Suzuki and Makoto Senoo J Invest Dermatol 2015 135: 2894-2897; advance online publication, June 22, 2015; 10.1038/jid.2015.235 Full Text | PDF | | | | Lack of Evidence From a Transgenic Mouse Model that the Activation and Migration of Melanocytes to the Epidermis after Neonatal UVR Enhances Melanoma DevelopmentHerlina Y Handoko, Mathieu P Rodero, H Konrad Muller, Kiarash Khosrotehrani and Graeme J Walker J Invest Dermatol 2015 135: 2897-2900; advance online publication, June 2, 2015; 10.1038/jid.2015.203 Full Text | PDF | | Corrigenda/Errata | Top | | Editors’ PicksJ Invest Dermatol 2015 135: 2901; advance online publication, July 16, 2015; 10.1038/jid.2015.228 Full Text | PDF | | | | Cell Surface CD74–MIF Interactions Drive Melanoma Survival in Response to Interferon-γKeiji Tanese, Yuuri Hashimoto, Zuzana Berkova, Yuling Wang, Felipe Samaniego, Jeffrey E Lee, Suhendan Ekmekcioglu and Elizabeth A Grimm J Invest Dermatol 2015 135: 2901; advance online publication, July 16, 2015; 10.1038/jid.2015.259 Full Text | PDF | | | | Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe PsoriasisJ Invest Dermatol 2015 135: 2901-2902; advance online publication, June 25, 2015; 10.1038/jid.2015.220 Full Text | PDF | | | | Skin Care in Organ Transplant Patients Europe Meeting Report from Annual Meeting, Leiden, The Netherlands, 15–18 May 2014Günther F L Hofbauer, Deniz Seçkin, Petter Gjersvik and Jan Nico Bouwes Bavinck J Invest Dermatol 2015 135: 2902; advance online publication, August 20, 2015; 10.1038/jid.2015.294 Full Text | PDF | | Addendum | Top | | Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt SignalingJeffrey S Pawlikowski, Claire Brock, Sheau-Chiann Chen, Lara Al-Olabi, Colin Nixon, Fiona McGregor, Simon Paine, Estelle Chanudet, Wendy Lambie, William M Holmes, James M Mullin, Ann Richmond, Hong Wu, Karen Blyth, Ayala King, Veronica A Kinsler and Peter D Adams J Invest Dermatol 2015 135: 2902; advance online publication, July 16, 2015; 10.1038/jid.2015.230 Full Text | PDF | | | | Please note that you need to be a subscriber or site-license holder to enjoy full-text access to The Journal of Investigative Dermatology. 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