Cell Death and Disease - Table of Contents alert Volume 6, October 2015

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TABLE OF CONTENTS Volume 6, October 2015 In this issue Editorial News and Commentaries Review Original Articles Correspondence Sign up for e-alerts Web feed Advertisement Web Focus on p53 p53 is the most frequently mutated gene in any type of human cancer and its importance is reflected by its large presence in our journals. This Web Focus highlights some of the latest research and thinking on p53 from the world's most recognized experts. It is subdivided according to the distinct pathways investigated and we hope it will be of interest to our readers. Look out for some new podcasts too! Access the Web Focus here   Editorial Top Succinate dehydrogenase/complex II activity obligatorily links mitochondrial reserve respiratory capacity to cell survival in cardiac myocytes R Dhingra and L A Kirshenbaum Cell Death Dis 2015 6: e1956; 10.1038/cddis.2015.310 Full Text News and Commentaries Top Heme-albumin: an honorary enzyme P Ascenzi, A di Masi, G Fanali and M Fasano Cell Death Dis 2015 6: e1895; 10.1038/cddis.2015.287 Full Text Adding another piece to the retinoblastoma puzzle M K E Blixt, S Shirazi Fard, C All-Ericsson and F Hallböök Cell Death Dis 2015 6: e1957; 10.1038/cddis.2015.317 Full Text Nrf2: new insight in cell apoptosis M Bonay and T B Deramaudt Cell Death Dis 2015 6: e1897; 10.1038/cddis.2015.256 Full Text Heart disease: recruitment of MEF2 activity by β−blockers wards off cardiomyocyte death S Hashemi, S Wales, T Miyake and J C McDermott Cell Death Dis 2015 6: e1916; 10.1038/cddis.2015.293 Full Text Considering autophagy, β-Catenin and E-Cadherin as innovative therapy aspects in AML K Kühn and W Römer Cell Death Dis 2015 6: e1950; 10.1038/cddis.2015.314 Abstract | Full Text Stressing out the Hippo/YAP signaling pathway: toward a new role in Schwann cells S Melfi, A Colciago, G Giannotti, V Bonalume, L Caffino, F Fumagalli and V Magnaghi Cell Death Dis 2015 6: e1915; 10.1038/cddis.2015.291 Full Text Bcl-2 proteins, cell migration and embryonic development: lessons from zebrafish J Prudent, N Popgeorgiev, B Bonneau and G Gillet Cell Death Dis 2015 6: e1910; 10.1038/cddis.2015.286 Full Text Autophagy dysregulation by mutant fused in sarcoma—implications for amyotrophic lateral sclerosis K Y Soo and J D Atkin Cell Death Dis 2015 6: e1945; 10.1038/cddis.2015.311 Full Text Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death H Sugimoto, M Nakamura, H Yoda, K Hiraoka, K Shinohara, M Sang, K Fujiwara, O Shimozato, H Nagase and T Ozaki Cell Death Dis 2015 6: e1914; 10.1038/cddis.2015.242 Full Text TSPO as a target for treatments of diseases, including neuropathological disorders L Veenman, A Vainshtein and M Gavish Cell Death Dis 2015 6: e1911; 10.1038/cddis.2015.294 Full Text Review Top In vitro differentiation of germ cells from stem cells: a comparison between primordial germ cells and in vitro derived primordial germ cell-like cells W Ge, C Chen, M De Felici and W Shen Cell Death Dis 2015 6: e1906; 10.1038/cddis.2015.265 Abstract | Full Text Original Articles Top Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates E-J Bae, N Y Yang, C Lee, S Kim, H-J Lee and S-J Lee Cell Death Dis 2015 6: e1901; 10.1038/cddis.2015.283 Abstract | Full Text Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR T Bertrand, F Lesept, A Chevilley, S Lenoir, M Aimable, A Briens, Y Hommet, I Bardou, J Parcq and D Vivien Cell Death Dis 2015 6: e1924; 10.1038/cddis.2015.296 Abstract | Full Text Evaluation of low doses BPA-induced perturbation of glycemia by toxicogenomics points to a primary role of pancreatic islets and to the mechanism of toxicity E Carchia, I Porreca, P J Almeida, F D'Angelo, D Cuomo, M Ceccarelli, M De Felice, M Mallardo and C Ambrosino Cell Death Dis 2015 6: e1959; 10.1038/cddis.2015.319 Abstract | Full Text miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors F M Cruz, M Tomé, J A Bernal and A Bernad Cell Death Dis 2015 6: e1953; 10.1038/cddis.2015.255 Abstract | Full Text Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5 A Fassl, K E Tagscherer, J Richter, J De-Castro Arce, C Savini, F Rösl and W Roth Cell Death Dis 2015 6: e1921; 10.1038/cddis.2015.261 Abstract | Full Text RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging P N Fernández Larrosa, M Ruíz Grecco, D Mengual Gómez, C V Alvarado, L C Panelo, M F Rubio, D F Alonso, D E Gómez and M A Costas Cell Death Dis 2015 6: e1902; 10.1038/cddis.2015.218 Abstract | Full Text Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation V Forschbach, M Goppelt-Struebe, K Kunzelmann, R Schreiber, R Piedagnel, A Kraus, K-U Eckardt and B Buchholz Cell Death Dis 2015 6: e1899; 10.1038/cddis.2015.273 Abstract | Full Text IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs L Guo, C-H Chen, L-L Zhang, X-J Cao, Q-L Ma, P Deng, G Zhu, C-Y Gao, B-H Li, Y Pi, Y Liu, Z-C Hu, L Zhang, Z-P Yu, Z Zhou and J-C Li Cell Death Dis 2015 6: e1949; 10.1038/cddis.2015.212 Abstract | Full Text Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner W Guo, Y Zhang, Z Ling, X Liu, X Zhao, Z Yuan, C Nie and Y Wei Cell Death Dis 2015 6: e1919; 10.1038/cddis.2015.276 Abstract | Full Text Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma Y Ha, H Liu, Z Xu, H Yokota, S P Narayanan, T Lemtalsi, S B Smith, R W Caldwell, R B Caldwell and W Zhang Cell Death Dis 2015 6: e1900; 10.1038/cddis.2015.281 Abstract | Full Text Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome E Hedström, C Pederiva, J Farnebo, B Nodin, K Jirström, D J Brennan and M Farnebo Cell Death Dis 2015 6: e1892; 10.1038/cddis.2015.250 Abstract | Full Text IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype S M Kessler, S Laggai, A Barghash, C S Schultheiss, E Lederer, M Artl, V Helms, J Haybaeck and A K Kiemer Cell Death Dis 2015 6: e1894; 10.1038/cddis.2015.241 Abstract | Full Text p53 regulates the mevalonate pathway in human glioblastoma multiforme C Laezza, A D'Alessandro, L Di Croce, P Picardi, E Ciaglia, S Pisanti, A M Malfitano, M Comegna, R Faraonio, P Gazzerro and M Bifulco Cell Death Dis 2015 6: e1909; 10.1038/cddis.2015.279 Abstract | Full Text Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression Z-H Liu, J-L Hu, J-Z Liang, A-J Zhou, M-Z Li, S-M Yan, X Zhang, S Gao, L Chen, Q Zhong and M-S Zeng Cell Death Dis 2015 6: e1920; 10.1038/cddis.2015.258 Abstract | Full Text A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans B A Martinez, H Kim, A Ray, G A Caldwell and K A Caldwell Cell Death Dis 2015 6: e1908; 10.1038/cddis.2015.270 Abstract | Full Text A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells W Mughal, L Nguyen, S Pustylnik, S C da Silva Rosa, S Piotrowski, D Chapman, M Du, N S Alli, J Grigull, A J Halayko, M Aliani, M K Topham, R M Epand, G M Hatch, T J Pereira, S Kereliuk, J C McDermott, C Rampitsch, V W Dolinsky and J W Gordon Cell Death Dis 2015 6: e1944; 10.1038/cddis.2015.306 Abstract | Full Text Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma L R Palam, J Gore, K E Craven, J L Wilson and M Korc Cell Death Dis 2015 6: e1913; 10.1038/cddis.2015.264 Abstract | Full Text Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines R Polanski, J Vincent, U M Polanska, T Petreus and E K Y Tang Cell Death Dis 2015 6: e1893; 10.1038/cddis.2015.234 Abstract | Full Text P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest A A Shamseddine, C J Clarke, B Carroll, M V Airola, S Mohammed, A Rella, L M Obeid and Y A Hannun Cell Death Dis 2015 6: e1947; 10.1038/cddis.2015.268 Abstract | Full Text NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1 J Shi, G Fung, H Deng, J Zhang, F C Fiesel, W Springer, X Li and H Luo Cell Death Dis 2015 6: e1943; 10.1038/cddis.2015.278 Abstract | Full Text Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer X Sun, P Du, W Yuan, Z Du, M Yu, X Yu and T Hu Cell Death Dis 2015 6: e1907; 10.1038/cddis.2015.269 Abstract | Full Text EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury Y Tsenkina, J Ricard, E Runko, M M Quiala- Acosta, J Mier and D J Liebl Cell Death Dis 2015 6: e1922; 10.1038/cddis.2015.262 Abstract | Full Text RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS Z Wang, Y Zhou, X Hu, W Chen, X Lin, L Sun, X Xu, W Hong and T Wang Cell Death Dis 2015 6: e1923; 10.1038/cddis.2015.266 Abstract | Full Text K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells J R Yaron, S Gangaraju, M Y Rao, X Kong, L Zhang, F Su, Y Tian, H L Glenn and D R Meldrum Cell Death Dis 2015 6: e1954; 10.1038/cddis.2015.277 Abstract | Full Text HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS C Zhang, K Liu, K Yao, K Reddy, Y Zhang, Y Fu, G Yang, T A Zykova, S H Shin, H Li, J Ryu, Y-n Jiang, X Yin, W Ma, A M Bode, Z Dong and Z Dong Cell Death Dis 2015 6: e1912; 10.1038/cddis.2015.227 Abstract | Full Text DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis J Zhou, Z Ning, B Wang, E-J Yun, T Zhang, R-C Pong, L Fazli, M Gleave, J Zeng, J Fan, X Wang, L Li, J-T Hsieh, D He and K Wu Cell Death Dis 2015 6: e1955; 10.1038/cddis.2015.289 Abstract | Full Text A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy M d'Avenia, R Citro, M De Marco, A Veronese, A Rosati, R Visone, S Leptidis, L Philippen, G Vitale, A Cavallo, A Silverio, C Prota, P Gravina, A De Cola, E Carletti, G Coppola, S Gallo, G Provenza, E Bossone, F Piscione, M Hahne, L J De Windt, M C Turco and V De Laurenzi Cell Death Dis 2015 6: e1948; 10.1038/cddis.2015.280 Abstract | Full Text Correspondence Top A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo L Catrysse, M Fukaya, M Sze, K Meyerovich, R Beyaert, A K Cardozo and G van Loo Cell Death Dis 2015 6: e1918; 10.1038/cddis.2015.301 Full Text Intrinsic hypoxia sensitivity of the cytomegalovirus promoter K Wendland, M Thielke, A Meisel and P Mergenthaler Cell Death Dis 2015 6: e1905; 10.1038/cddis.2015.259 Full Text Advertisement Online-only and open access, Cell Death Discovery will publish scientifically sound research at the intersection of cell death and medicine. 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