Nature Communications - 2 September 2015

Advertisement Fluorescent Protein Plasmids & Resources Addgene's nonprofit resources gives you access to thousands of published fluorescent protein plasmids created by the world's leading research labs. Find resources and browse FRET, Optogenetics, Subcellular Localization, in vivo Imaging, and Empty Backbone plasmids by color or expression species.  >Browse Fluorescent Plasmids and Resources     Weekly Content Alert Nature Communications is now fully open access. Read more. 02 September 2015  Featured image: Born et al. demonstrate an optical switch with light nanojets and nanoparticles, with switching energy and time on the femto scale. Latest content: Articles Corrigenda Erratum Journal homepage Recommend to library Web feed   Advertisement Blood Cancer Journal is an online-only, open access journal publishing high quality research on hematologic malignancies and related disorders. The journal has an Impact Factor of 3.467. In support of the Blood Cancer Awareness month, explore the latest research articles or sign up to free e-alerts to receive content straight to your inbox.       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Multi-jet propulsion organized by clonal development in a colonial siphonophore OPEN John H. Costello, Sean P. Colin, Brad J. Gemmell, John O. Dabiri and Kelly R. Sutherland Physonect siphonophores are highly mobile jellyfish with complex colonial organization. Here, Costello et al. show that division of labour among developmental stages controls the direction and propulsion of the colony, with older individuals providing thrust and younger individuals providing torque. 01 September 2015 | doi: 10.1038/ncomms9158 Biological Sciences  Oceanography  Zoology  Irreversibly increased nitrogen fixation in Trichodesmium experimentally adapted to elevated carbon dioxide OPEN David A. Hutchins, Nathan G. Walworth, Eric A. Webb, Mak A. Saito, Dawn Moran, Matthew R. McIlvin, Jasmine Gale and Fei-Xue Fu The long-term response of marine cyanobacteria to increased anthropogenic CO2 are not known. Here, Hutchins et al. show that Trichodesmium exposed to long-term selection at elevated CO2 display irreversible increases in nitrogen fixation and growth rates, even after returning to present day conditions. 01 September 2015 | doi: 10.1038/ncomms9155 Biological Sciences  Climate science  Ecology  Evolution  Settling time of a vibrational wavepacket in ionization OPEN Yasuo Nabekawa, Yusuke Furukawa, Tomoya Okino, A. Amani Eilanlou, Eiji J. Takahashi, Kaoru Yamanouchi and Katsumi Midorikawa Instantaneous generation of a vibrational wavepacket in a molecular ion is usually assumed in an ionization process. Here, by means of frequency-resolved optical gating, the authors observe a non-trivial phase modulation in a H2+ molecule, which is interpreted as a ∼1-fs settling time. 01 September 2015 | doi: 10.1038/ncomms9197 Physical Sciences  Atomic and molecular physics  Observation of intervalley quantum interference in epitaxial monolayer tungsten diselenide OPEN Hongjun Liu, Jinglei Chen, Hongyi Yu, Fang Yang, Lu Jiao, Gui-Bin Liu, Wingking Ho, Chunlei Gao, Jinfeng Jia, Wang Yao and Maohai Xie Monolayers of transition metal dichalcogenides have many of the properties required for applications in spintronics and valleytronics. Here, the authors experimentally observe intervalley quantum interference involving conduction band Q-valleys in tungsten diselenide. 01 September 2015 | doi: 10.1038/ncomms9180 Physical Sciences  Condensed matter  Materials science  Electrocatalytic reduction of carbon dioxide to carbon monoxide and methane at an immobilized cobalt protoporphyrin OPEN Jing Shen, Ruud Kortlever, Recep Kas, Yuvraj Y. Birdja, Oscar Diaz-Morales, Youngkook Kwon, Isis Ledezma-Yanez, Klaas Jan P. Schouten, Guido Mul and Marc T. M. Koper The conversion of carbon dioxide to useful products is a major challenge in energy research. Here, the authors report a cobalt protoporphyrin immobilized on graphite that is capable of the selective and efficient electrochemical reduction of carbon dioxide, primarily to carbon monoxide, in acidic media. 01 September 2015 | doi: 10.1038/ncomms9177 Chemical Sciences  Catalysis  Materials science  Physical chemistry  Direct terrestrial test of Lorentz symmetry in electrodynamics to 10−18 OPEN Moritz Nagel, Stephen R. Parker, Evgeny V. Kovalchuk, Paul L. Stanwix, John G. Hartnett, Eugene N. Ivanov, Achim Peters and Michael E. Tobar Lorentz invariance, tested more than a century ago by Michelson and Morley, is a foundational property of modern physics within the standard model and general relativity. Here, the authors report the most precise terrestrial test to date, bounding the lack of violations of Lorentz symmetry in photons to 10–18. 01 September 2015 | doi: 10.1038/ncomms9174 Physical Sciences  Applied physics  Theoretical physics  Nanoscale size effects in crystallization of metallic glass nanorods OPEN Sungwoo Sohn, Yeonwoong Jung, Yujun Xie, Chinedum Osuji, Jan Schroers and Judy J. Cha It is crucial to avoid crystallization in metallic glasses, which show appealing mechanical properties associated with their amorphous structures. Sohn et al. identify unusual nucleation kinetics in metallic glass nanorods, which exhibits a crystallization temperature minimum at a certain diameter. 01 September 2015 | doi: 10.1038/ncomms9157 Physical Sciences  Applied physics  Materials science  Nanotechnology  Predator strike shapes antipredator phenotype through new genetic interactions in water striders OPEN David Armisén, Peter Nagui Refki, Antonin Jean Johan Crumière, Séverine Viala, William Toubiana and Abderrahman Khila Understanding the mechanism underlying the evolution of ecologically relevant traits is challenging. Here the authors show that changes in the Hox protein Ultrabithorax and its target gene gilt contribute to the evolution of long-mid-legs in water striders, a critical trait to escape predators. 01 September 2015 | doi: 10.1038/ncomms9153 Biological Sciences  Evolution  Genetics  Zoology  YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer Gamze Kuser-Abali, Ahmet Alptekin, Michael Lewis, Isla P. Garraway and Bekir Cinar Prostate cancer is regulated by androgen receptor signalling; however, progressive disease can also be androgen-independent, thus hindering antiandrogen therapy. Here, interaction of the Hippo pathway protein, YAP1, with the androgen receptor is shown to confer castration-resistant prostate cancer. 01 September 2015 | doi: 10.1038/ncomms9126 Biological Sciences  Cancer  Cell biology  Medical research  Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters OPEN Wenjun Jiang, Xuejin Zhao, Tslil Gabrieli, Chunbo Lou, Yuval Ebenstein and Ting F. Zhu Genomic engineering often requires the cloning of long DNA segments that contain large gene clusters. Here, the authors describe an RNA-guided Cas9 nuclease assisted in vitro technique that allows the targeted cloning of near-arbitrary, long bacterial genomic sequences of up to 100 kb in a single step. 01 September 2015 | doi: 10.1038/ncomms9101 Biological Sciences  Biotechnology  Molecular biology  Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans OPEN Louise E. Docherty, Faisal I. Rezwan, Rebecca L. Poole, Claire L. S. Turner, Emma Kivuva, Eamonn R. Maher, Sarah F. Smithson, Julian P. Hamilton-Shield, Michal Patalan, Maria Gizewska, Jaroslaw Peregud-Pogorzelski, Jasmin Beygo, Karin Buiting, Bernhard Horsthemke, Lukas Soellner, Matthias Begemann, Thomas Eggermann, Emma Baple, Sahar Mansour, I. Karen Temple et al. Genomic imprinting disturbance can give rise to complex congenital disorders affecting growth, metabolism and behaviour. Here the authors report mutations in NLRP5, which suggests a connection between imprinting, maternal reproductive fitness and zygotic development. 01 September 2015 | doi: 10.1038/ncomms9086 Biological Sciences  Genetics  High-resolution analysis of the human T-cell receptor repertoire OPEN Eliana Ruggiero, Jan P. Nicolay, Raffaele Fronza, Anne Arens, Anna Paruzynski, Ali Nowrouzi, Gökçe Ürenden, Christina Lulay, Sven Schneider, Sergij Goerdt, Hanno Glimm, Peter H. Krammer, Manfred Schmidt and Christof von Kalle Immune system diversity is generated by V(D)J recombination, leading to clonal T-cell lineages. Here the authors investigate the events leading to T-cell diversity through the use of a modified PCR technique combined with deep sequencing. 01 September 2015 | doi: 10.1038/ncomms9081 Biological Sciences  Genetics  Immunology  Towards outperforming conventional sensor arrays with fabricated individual photonic vapour sensors inspired by Morpho butterflies OPEN Radislav A. Potyrailo, Ravi K. Bonam, John G. Hartley, Timothy A. Starkey, Peter Vukusic, Milana Vasudev, Timothy Bunning, Rajesh R. Naik, Zhexiong Tang, Manuel A. Palacios, Michael Larsen, Laurie A. Le Tarte, James C. Grande, Sheng Zhong and Tao Deng Individual vapour sensors often suffer from poor selectivity, which hinders their broad applicability. Here, Potyrailo et al. fabricate individual sensors inspired by the Morpho butterfly capable of selectively detecting vapours in mixtures and with a variable moisture background. 01 September 2015 | doi: 10.1038/ncomms8959 Physical Sciences  Materials science  Nanotechnology  The phase diagram of high-pressure superionic ice OPEN Jiming Sun, Bryan K. Clark, Salvatore Torquato and Roberto Car At high pressure, water forms superionic ice with an oxygen lattice and melted liquid hydrogens, which could exist on ice-rich planets. Here, Sun et al. predict a new phase of superionic ice where the hydrogens preferentially diffuse in two-dimensions within oxygen superlattice with the P21/c symmetry. 28 August 2015 | doi: 10.1038/ncomms9156 Physical Sciences  Condensed matter  Materials science  Towards nanoprinting with metals on graphene OPEN G. Melinte, S. Moldovan, C. Hirlimann, X. Liu, S. Bégin-Colin, D. Bégin, F. Banhart, C. Pham-Huu and O. Ersen The precise delivery of materials onto graphene is important for nano-processing but little is known about the mechanisms of such processes. Here, the authors use a range of microscopic techniques for the real-time observation of nanoparticle transfer from the inner channel of a carbon nanotube onto graphene. 28 August 2015 | doi: 10.1038/ncomms9071 Chemical Sciences  Materials science  Nanotechnology  Reversible adapting layer produces robust single-crystal electrocatalyst for oxygen evolution OPEN Ching-Wei Tung, Ying-Ya Hsu, Yen-Ping Shen, Yixin Zheng, Ting-Shan Chan, Hwo-Shuenn Sheu, Yuan-Chung Cheng and Hao Ming Chen There is extensive research into water-oxidation electrocatalysts which exhibit long-term stability. Here, the authors report a single-crystal cobalt oxide electrocatalyst displaying high activity and stability, and develop an in situ X-ray diffraction method to probe the structure–activity relationship. 28 August 2015 | doi: 10.1038/ncomms9106 Chemical Sciences  Catalysis  Materials science  Physical chemistry  Integration of photonic nanojets and semiconductor nanoparticles for enhanced all-optical switching OPEN Brandon Born, Jeffrey D. A. Krupa, Simon Geoffroy-Gagnon and Jonathan F. Holzman The terabit-per-second rates of optical fibres exceed the capability of electronics, but all-optical switches are needed to alleviate the bottleneck in these networks. Here, Born et al. describe such a switch using dielectric spheres, yielding femtojoule switching energy and femtosecond switching times. 28 August 2015 | doi: 10.1038/ncomms9097 Physical Sciences  Nanotechnology  Optical physics  Hybrid glasses from strong and fragile metal-organic framework liquids OPEN Thomas D. Bennett, Jin-Chong Tan, Yuanzheng Yue, Emma Baxter, Caterina Ducati, Nick J. Terrill, Hamish H. -M. Yeung, Zhongfu Zhou, Wenlin Chen, Sebastian Henke, Anthony K. Cheetham and G. Neville Greaves The fine interface between crystallinity and amorphicity in synthetic hybrid materials has to-date been relatively under-explored. Here, the authors probe the relationship between amorphisation and melting behaviour in zeolitic metal-organic frameworks as a route towards functional glasses. 28 August 2015 | doi: 10.1038/ncomms9079 Chemical Sciences  Inorganic chemistry  Materials science  A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis OPEN Joon-Yung Cha, Woe-Yeon Kim, Sun Bin Kang, Jeong Im Kim, Dongwon Baek, In Jung Jung, Mi Ri Kim, Ning Li, Hyun-Jin Kim, Masatoshi Nakajima, Tadao Asami, Jamal S. M. Sabir, Hyeong Cheol Park, Sang Yeol Lee, Hans J. Bohnert, Ray A. Bressan, Jose M. Pardo and Dae-Jin Yun YUC6 is a flavin monooxygenase required for the synthesis of the plant hormone auxin. Cha et al. discover that in Arabidopsis, this enzyme also plays a role in combatting oxidative stress independently of auxin biosynthesis, by acting as a thiol-reductase. 28 August 2015 | doi: 10.1038/ncomms9041 Biological Sciences  Biochemistry  Plant sciences  Measurement of the cleavage energy of graphite OPEN Wen Wang, Shuyang Dai, Xide Li, Jiarui Yang, David J. Srolovitz and Quanshui Zheng Knowing the cleavage energy of graphite layers is important to understand the mechanical properties of graphite, graphene and related compounds. Here, the authors report a high accuracy experimental measurement of the cleavage energy and validation through multiscale modelling. 28 August 2015 | doi: 10.1038/ncomms8853 Physical Sciences  Materials science  Nanotechnology  Cationic mononuclear ruthenium carboxylates as catalyst prototypes for self-induced hydrogenation of carboxylic acids OPEN Masayuki Naruto and Susumu Saito Many structurally diverse carboxylic acids are available from renewable and petrochemical sources. Here, the authors report a method to reduce carboxylic acids to alcohols using hydrogen, with high selectivity, wherein the carboxylates form active and hydrogen-accepting parts of the catalyst system. 28 August 2015 | doi: 10.1038/ncomms9140 Chemical Sciences  Catalysis  Inorganic chemistry  Organic chemistry  Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain OPEN Rebeca Caires, Enoch Luis, Francisco J. Taberner, Gregorio Fernandez-Ballester, Antonio Ferrer-Montiel, Endre A. Balazs, Ana Gomis, Carlos Belmonte and Elvira de la Peña Hyaluronan is a major component of the extracellular matrix, and is used to treat joint pain in osteoarthritis. In this study, Caires et al. show hyaluronan achieves its analgesic effects by targeting TRPV1 and stabilising the channel in its closed state. 27 August 2015 | doi: 10.1038/ncomms9095 Biological Sciences  Cell biology  Neuroscience  Optical control of NMDA receptors with a diffusible photoswitch OPEN Laura Laprell, Emilienne Repak, Vilius Franckevicius, Felix Hartrampf, Jan Terhag, Michael Hollmann, Martin Sumser, Nelson Rebola, David A. DiGregorio and Dirk Trauner N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity, learning and memory. Here the authors describe azobenzene-triazole-glutamate (ATG), a new diffusible photoswitchable agonist that allows precise temporal control over NMDAR activity. 27 August 2015 | doi: 10.1038/ncomms9076 Biological Sciences  Chemical biology  Neuroscience  Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A OPEN Pui-Mun Wong, Yan Feng, Junru Wang, Rong Shi and Xuejun Jiang Starvation rapidly triggers autophagy by inactivating mTORC1 signalling, however mTORC1 inhibition does not fully recapitulate this rapid induction. Wong et al. identify a parallel starvation-senstive pathway regulating autophagy, mediated by protein phosphatase 2A-dependent dephosphorylation of ULK1. 27 August 2015 | doi: 10.1038/ncomms9048 Biological Sciences  Cell biology  Efficient expression of full-length antibodies in the cytoplasm of engineered bacteria OPEN Michael-Paul Robinson, Na Ke, Julie Lobstein, Cristen Peterson, Alana Szkodny, Thomas J. Mansell, Corinna Tuckey, Paul D. Riggs, Paul A. Colussi, Christopher J. Noren, Christopher H. Taron, Matthew P. DeLisa and Mehmet Berkmen Current methods for production of monoclonal antibodies often require refolding steps or secretion across biological membranes. Here, Robinson et al. describe engineered E. coli strains for efficient production of functional immunoglobulin G antibodies in the bacterial cytoplasm. 27 August 2015 | doi: 10.1038/ncomms9072 Biological Sciences  Bioengineering  Biotechnology  Microbiology  Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis OPEN Sara M. Nowinski, Ashley Solmonson, Joyce E. Rundhaug, Okkyung Rho, Jiyoon Cho, Cory U. Lago, Christopher L. Riley, Sunhee Lee, Shohei Kohno, Christine K. Dao, Takeshi Nikawa, Shawn B. Bratton, Casey W. Wright, Susan M. Fischer, John DiGiovanni and Edward M. Mills Aerobic glycolysis and diminished oxidative phosphorylation exhibited by tumour cells enables the production of energy necessary to support malignant proliferation. Here the authors show that UCP3 promotes mitochondrial uncoupling and prevents tumorigenesis through a mitochondrially-driven pathway of AKT inhibition. 27 August 2015 | doi: 10.1038/ncomms9137 Biological Sciences  Biochemistry  Cancer  Nonradiating anapole modes in dielectric nanoparticles OPEN Andrey E. Miroshnichenko, Andrey B. Evlyukhin, Ye Feng Yu, Reuben M. Bakker, Arkadi Chipouline, Arseniy I. Kuznetsov, Boris Luk’yanchuk, Boris N. Chichkov and Yuri S. Kivshar The anapole is an intriguing example of a nonradiating source useful in the study of electromagnetic properties in complex phenomena. Here, Miroshnichenko et al. demonstrate that a single dielectric nanoparticle can exhibit a radiationless anapole mode at visible wavelengths. 27 August 2015 | doi: 10.1038/ncomms9069 Physical Sciences  Nanotechnology  Optical physics  Theoretical physics  Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures OPEN Yuki Suzuki, Masayuki Endo and Hiroshi Sugiyama Self-assembly is a useful method to fabricate novel supramolecular architectures. Here, the authors use lipid-bilayer-assisted self-assembly to obtain two-dimensional crystalline DNA origami lattices, imaging dynamic assembly phenomena using high-speed atomic force microscopy. 27 August 2015 | doi: 10.1038/ncomms9052 Physical Sciences  Materials science  Nanotechnology  Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1 OPEN Philipp Schneider, Juan Miguel Bayo-Fina, Rajeev Singh, Pavan Kumar Dhanyamraju, Philipp Holz, Aninja Baier, Volker Fendrich, Annette Ramaswamy, Stefan Baumeister, Elisabeth D. Martinez and Matthias Lauth The regulation of the Hedgehog (Hh) pathway by the kinase DYRK1A is controversial. Here the authors uncover a novel inhibitory activity of DYRK1A that functions to destabilize the Hh downstream transcription factor GLI1 by destabilizing actin and preventing the nuclear accumulation of protective MKL1/JMJD1A complexes. 27 August 2015 | doi: 10.1038/ncomms9023 Biological Sciences  Cell biology  Efficiently photo-charging lithium-ion battery by perovskite solar cell OPEN Jiantie Xu, Yonghua Chen and Liming Dai Photo-charged battery devices are an attractive technology but suffer from low photo-electric storage conversion efficiency and poor cycling stability. Here, the authors demonstrate the use of perovskite solar cells in conjunction with a lithium ion battery which displays excellent properties. 27 August 2015 | doi: 10.1038/ncomms9103 Chemical Sciences  Materials science  Physical chemistry  PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus OPEN Daqian Xu, Zheng Wang, Yuxue Zhang, Wei Jiang, Yi Pan, Bao-Liang Song and Yan Chen Under conditions of sterol depletion, the Scap/SREBP complex is transported from the endoplasmic reticulum to the Golgi apparatus. Here Xu and Wang et al. show that the Golgi protein PAQR3 interacts with Scap and SREBP in a cholesterol regulated manner to help regulate sterol homeostasis. 27 August 2015 | doi: 10.1038/ncomms9100 Biological Sciences  Cell biology  A stem acrodontan lizard in the Cretaceous of Brazil revises early lizard evolution in Gondwana OPEN Tiago R. Simões, Everton Wilner, Michael W. Caldwell, Luiz C. Weinschütz and Alexander W. A. Kellner Iguanians are a diverse group of lizards. Here, the authors report an acrodontan iguanian from the Late Cretaceous of Brazil, which suggests that this group achieved a global distribution during the Mesozoic but was replaced by non-acrodontans in the Americas. 26 August 2015 | doi: 10.1038/ncomms9149 Biological Sciences  Evolution  Palaeontology  Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1 OPEN Gilles Vanwalleghem, Frédéric Fontaine, Laurence Lecordier, Patricia Tebabi, Kristoffer Klewe, Derek P. Nolan, Yoshiki Yamaryo-Botté, Cyrille Botté, Anneke Kremer, Gabriela Schumann Burkard, Joachim Rassow, Isabel Roditi, David Pérez-Morga and Etienne Pays The human serum protein apolipoprotein L1 (APOL1) is taken up by trypanosomes where it triggers cell death, forming pores in endolysosomal membranes. Vanwalleghem et al. show that APOL1 triggers both lysosomal and mitochondrial membrane permeabilization, and that the latter is responsible for trypanolysis. 26 August 2015 | doi: 10.1038/ncomms9078 Biological Sciences  Cell biology  Microbiology  Chamber identity programs drive early functional partitioning of the heart OPEN Christian Mosimann, Daniela Panáková, Andreas A. Werdich, Gabriel Musso, Alexa Burger, Katy L. Lawson, Logan A. Carr, Kathleen R. Nevis, M. Khaled Sabeh, Yi Zhou, Alan J. Davidson, Anthony DiBiase, Caroline E. Burns, C. Geoffrey Burns, Calum A. MacRae and Leonard I. Zon The heart forms from combining the first with the second heart field, which in mammals creates left and right ventricle. Here transgenic zebrafish and physiology studies reveal that transcription factors controlling septation in mammals already in teleosts guide muscle coupling by controlling the relative contribution of the two fields to the heart. 26 August 2015 | doi: 10.1038/ncomms9146 Biological Sciences  Developmental biology  A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity OPEN Alejandro Conde-Perez, Gwendoline Gros, Christine Longvert, Malin Pedersen, Valérie Petit, Zackie Aktary, Amaya Viros, Franck Gesbert, Véronique Delmas, Florian Rambow, Boris C. Bastian, Andrew D. Campbell, Sophie Colombo, Isabel Puig, Alfonso Bellacosa, Owen Sansom, Richard Marais, Leon C. L. T. Van Kempen and Lionel Larue The mechanism by which PTEN mutation is melanomagenic is complicated by different PTEN functions in different cellular locations. Here, the authors identify an alternative to membrane PI3K–AKT signalling, a caveolin-1-dependent PTEN pathway that induces nuclear localization and activation of β-catenin. 26 August 2015 | doi: 10.1038/ncomms9093 Biological Sciences  Cancer  Cell biology  Dual-topology insertion of a dual-topology membrane protein OPEN Nicholas B. Woodall, Ying Yin and James U. Bowie Dual-topology membrane proteins consist of subunits that have identical sequence but reside in the membrane in two inverted orientations. Here, Woodall et al. find that the dual topology of the transporter EmrE is largely achieved by initial insertion in both topologies rather than major rearrangements after insertion. 26 August 2015 | doi: 10.1038/ncomms9099 Biological Sciences  Biophysics  JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis OPEN Hüseyin Tuncay, Benjamin F. Brinkmann, Tim Steinbacher, Annika Schürmann, Volker Gerke, Sandra Iden and Klaus Ebnet Polarized epithelial cells orient their mitotic spindles in the plane of the sheet but the role of cell adhesion molecules in this process is poorly understood. Here Tuncay et al. show that JAM-A regulates spindle orientation by creating a gradient of PtdIns(3,4,5)P3, regulating cortical actin assembly and localizing dynactin to the cell cortex. 26 August 2015 | doi: 10.1038/ncomms9128 Biological Sciences  Cell biology    Nature Communications JOBS of the week Sr Research Asst The University of Texas MD Anderson Cancer Center Tenure-track Assistant Professor Washington University School of Medicine Research Associate Imperial College London Associate Professor Position in Theoretical / Computational Biophysics Università degli Studi di Trento Senior Bioinformatician Guy's and St Thomas' NHS Foundation Trust Professor of Sustainability Science (tenure track) Lappeenranta University of Technology (LUT) Postdoctoral Fellowship Icahn School of Medicine at Mount Sinai Senior Lecturer / Associate Professor in Physical Chemistry Uppsala University Bioinformatician John Innes Centre (JIC) Postdoctoral Research Position Harvard Medical School More Science jobs from Nature Communications EVENT LS2 Annual Meeting 2016 26.02.16 Lausanne, Switzerland More science events from       Latest Corrigenda     Corrigendum: GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters OPEN Sunita A. Ramesh, Stephen D. Tyerman, Bo Xu, Jayakumar Bose, Satwinder Kaur, Vanessa Conn, Patricia Domingos, Sana Ullah, Stefanie Wege, Sergey Shabala, José A. Feijó, Peter R. Ryan and Matthew Gilliham 28 August 2015 | doi: 10.1038/ncomms9293 Biological Sciences  Plant sciences      Corrigendum: Circadian control of bile acid synthesis by a KLF15-Fgf15 axis OPEN Shuxin Han, Rongli Zhang, Rajan Jain, Hong Shi, Lilei Zhang, Guangjin Zhou, Panjamaporn Sangwung, Derin Tugal, G. Brandon Atkins, Domenick A. Prosdocimo, Yuan Lu, Xiaonan Han, Patrick Tso, Xudong Liao, Jonathan A. Epstein and Mukesh K. Jain 27 August 2015 | doi: 10.1038/ncomms9270 Biological Sciences  Medical research      Corrigendum: Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals OPEN Nora Lenkey, Tekla Kirizs, Noemi Holderith, Zoltán Máté, Gábor Szabó, E. Sylvester Vizi, Norbert Hájos and Zoltan Nusser 26 August 2015 | doi: 10.1038/ncomms9226 Biological Sciences  Cell biology  Neuroscience        Latest Erratum     Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin OPEN Gurpreet S. Baht, David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei and Benjamin A. Alman 26 August 2015 | doi: 10.1038/ncomms8761 Biological Sciences  Medical research      Advertisement  A*STAR Research - Highlighting the best of research at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization   Recent Highlights Gel electrophoresis: Snap-and-go band analysis | Plasmonics: Close to the point of more efficient chips | Infectious diseases: The signature of Chikungunya  Download the A*STAR Research app now!   Advertisement Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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