EMBO reports Table of Contents for September 2015; Vol. 16, No. 9

September 2015 | Volume 16, Number 9 Submit Table of Contents Opinion News & Views Science & Society Reviews Articles Volume 16, Number 9 Opinion Lip sync conferences The trend for scientific meetings to feature ageing stars who repeat their old hits, or up‐and‐comers too afraid to present their latest data, is a hindrance to communication. What could be done to restore meetings as venues to discuss new science? Frank Gannon Published online 21.07.2015 News & Views LEGOs® and legacies of centrioles and centrosomes Centrioles and centrosomes are now amenable to molecular analysis to understand their role in cell division and in organising the cell cytoskeleton. This article discusses recent insights into their assembly, function and transgenerational inheritance. Gerald Schatten and Calvin Simerly Published online 06.08.2015 Science & Society Responsibility and intellectual property in synthetic biology: A proposal for using Responsible Research and Innovation as a basic framework for intellectual property decisions in synthetic biology IP schemes could play an important role in fostering Responsible Research and Innovation in synthetic biology to find solutions for societal problems. The iGEM could become a proving ground to test how IP and open source can influence research. Harald König, Pedro Dorado‐Morales, and Manuel Porcar Published online 12.08.2015 Optimising environmental risk assessments: Accounting for ecosystem services helps to translate broad policy protection goals into specific operational ones for environmental risk assessments Environmental risk assessments cannot cover all conceivable risks. It is therefore necessary to translate broader policies such as sustainable development into specific protection goals with the overall aim of protecting biodiversity and maintaining ecosystem services. Yann Devos, Jörg Romeis, Robert Luttik, Angelo Maggiore, Joe N Perry, Reinhilde Schoonjans, Franz Streissl, José V Tarazona, and Theo CM Brock Published online 11.08.2015 Everything flows: A process perspective on life Studying the dynamics of networks rather than the individual components is essential for our understanding of complex regulatory phenomena. Only by adopting process philosophy as the appropriate conceptual framework can the true potential of systems biology be realized. Johannes Jaeger and Nick Monk Published online 14.08.2015 Better tools, new problems: New technologies help to advance research in the life sciences, but the quantities of data generated are proving hard to manage and interpret Sequencing and microscopy have improved significantly in recent years to allow biologists to discern the increasingly fine molecular details of life. The main bottleneck to progress, however, is making sense of the large amounts of data these instruments generate. Philip Hunter Published online 06.08.2015 Reviews Expanding the ubiquitin code through post‐translational modification This Review analyzes how phosphorylation, acetylation and deamidation of ubiquitin can regulate its functions, focusing on the role of ubiquitin phosphorylation in the control of selective autophagy pathways. Lina Herhaus and Ivan Dikic Published online 12.08.2015 Harnessing the apoptotic programs in cancer stem‐like cells Cancer stem‐like cells are less sensitive to apoptotic signals and more resistant to therapy. This review discusses the regulation of apoptosis in CSCs, focusing on the therapeutical modulation of pro‐ and anti‐apoptotic pathways to induce CSC death. Ying‐Hua Wang and David T Scadden Published online 07.08.2015 Ins and outs of GPCR signaling in primary cilia GPCRs are involved in multiple signaling pathways in primary cilia. This article describes how GPCRs traffic into and out of the cilium and how they control ciliary and cellular functions. GPCR‐targeted drug strategies for the treatment of ciliopathies are also discussed. Kenneth Bødtker Schou, Lotte Bang Pedersen, and Søren Tvorup Christensen Published online 21.08.2015 Articles (Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation In this study, two newly generated antibodies are used to detect endogenous phospho‐ubiquitin in cells and human brain samples. pS65‐Ub is shown to be reversible, respond to mitochondrial stress and accumulate during aging and in Parkinson's disease. Fabienne C Fiesel, Maya Ando, Roman Hudec, Anneliese R Hill, Monica Castanedes‐Casey, Thomas R Caulfield, Elisabeth L Moussaud‐Lamodière, Jeannette N Stankowski, Peter O Bauer, Oswaldo Lorenzo‐Betancor, Isidre Ferrer, José M Arbelo, Joanna Siuda, Li Chen, Valina L Dawson, Ted M Dawson, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, and Wolfdieter Springer Published online 10.07.2015 Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome‐wide turnover This study explores the functional consequences of ubiquitin phosphorylation at Ser65. This modification is found to be induced by oxidative stress and have profound effects on ubiquitin chain disassembly, linkage, and substrate targeting. Danielle L Swaney, Ricard A Rodríguez‐Mias, and Judit Villén Published online 03.07.2015 Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis This study shows that BNip3 loss and the ensuing defects in mitophagy lead to ROS production, Hif transcriptional responses and mammary tumor progression. BNIP3 deletion is a prognostic marker of metastatic potential in triple negative breast cancer. Aparajita H Chourasia, Kristin Tracy, Casey Frankenberger, Michelle L Boland, Marina N Sharifi, Lauren E Drake, Joseph R Sachleben, John M Asara, Jason W Locasale, Gregory S Karczmar, and Kay F Macleod Published online 31.07.2015 Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3 FOXO3 regulates oxidative stress in LT‐HSCs, which are highly sensitive to increased reactive oxygen species. However, while the impaired function of Foxo3−/− LT‐HSCs is associated with defective mitochondrial metabolism, it is not mediated by oxidative stress or mTOR signaling. Pauline Rimmelé, Raymond Liang, Carolina L Bigarella, Fatih Kocabas, Jingjing Xie, Madhavika N Serasinghe, Jerry Chipuk, Hesham Sadek, Cheng Cheng Zhang, and Saghi Ghaffari Published online 24.07.2015 Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells Sox2 and POU‐TF subclasses have distinct interactions that distinguish pluripotent ESC from multipotent NSC. The different combinations of TFs and DNA binding motifs in ESC and NSC might explain why Oct4 alone can convert NSC to pluripotency. Tapan Kumar Mistri, Arun George Devasia, Lee Thean Chu, Wei Ping Ng, Florian Halbritter, Douglas Colby, Ben Martynoga, Simon R Tomlinson, Ian Chambers, Paul Robson, and Thorsten Wohland Published online 11.08.2015 BRHIS1 suppresses rice innate immunity through binding to monoubiquitinated H2A and H2B variants The plant chromatin remodeler BRHIS1 represses the poised promoters of disease defense genes by binding monoubiquitinated histone variants. Repression is counteracted by BRHIS1 down‐regulation upon infection. Xiaoyu Li, Yanxiang Jiang, Zhicheng Ji, Yaoguang Liu, and Qunyu Zhang Published online 22.07.2015 TRAIL+ monocytes and monocyte‐related cells cause lung damage and thereby increase susceptibility to influenza–Streptococcus pneumoniae coinfection This study shows that inflammatory monocyte‐induced lung damage during influenza infection increases susceptibility to subsequent S. pneumoniae coinfection, whereas TNF‐α and neutrophils help control bacterial growth. Gregory T Ellis, Sophia Davidson, Stefania Crotta, Nora Branzk, Venizelos Papayannopoulos, and Andreas Wack Published online 11.08.2015 DGCR8 is essential for tumor progression following PTEN loss in the prostate This study uncovers an essential role for the microRNA biogenesis factor DGCR8 in prostate tumor progression following PTEN loss. The simultaneous deletion of Dgcr8 and Pten allows early progression to hyperplasia but not later progression to dysplasia. Cassandra D Belair, Alireza Paikari, Felix Moltzahn, Archana Shenoy, Christina Yau, Marc Dall'Era, Jeff Simko, Christopher Benz, and Robert Blelloch Published online 23.07.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.