Nature Reviews Immunology Contents August 2015 Volume 15 Number 9 pp 525-594

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TABLE OF CONTENTS
September 2015 Volume 15 Number 9
Impact Factor 34.985 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Immunopathology of multiple sclerosis Calliope A. Dendrou, Lars Fugger & Manuel A. Friese
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RESEARCH HIGHLIGHTS Top Cell death: Tumour suppressor p53 helps phagocytes clean up p525 | doi:10.1038/nri3900 Tumour suppressor p53 promotes immune tolerance by clearing apoptotic cells and upregulating immune checkpoint molecules. PDF Inflammation: NETting a one-two punch p526 | doi:10.1038/nri3898 Neutrophil extracellular traps (NETs) prime macrophages for interleukin-1β production in atherosclerosis. PDF Innate immunity: Memory NK cells identified in primates p526 | doi:10.1038/nri3903 The first demonstration of memory NK cells in a primate species that mount a durable antigen-specific response over a period of several years. PDF Mucosal immunology: Living in harmony p527 | doi:10.1038/nri3907 The mucosal immune system supports intestinal commensalism in multiple ways. PDF JOURNAL CLUB Bacteria, inflammation and cancer p528 | doi:10.1038/nri3899 Jeffrey Pollard describes a 2003 study by Enzler et al. that identified the immune response against bacteria as preventing chronic inflammation-associated tumour development. PDF Tumour immunology: Malaria alters B cell lymphomagenesis p528 | doi:10.1038/nri3906 Malaria infection modifies endemic Burkitt lymphomas by inducing a prolonged expansion of germinal centre B cell numbers. PDF Immunology JOBS of the week Scientist / Sr. Scientist Immunology Valera Postdoc Scientist Immunology Universitätsklinikum Heidelberg Senior Scientist – Center for Immuno-Oncology Dana-Farber Cancer Institute (DFCI) Tenure-Track Assistant Professor Faculty Position Duke University Medical Center Professor in Haematopathology Combined with a Post as Specialist Physician Uppsala University Hospital More Science jobs from Immunology EVENT IMMUNOLOGY 2016™ - AAI Annual Meeting 13.05.16 Seattle, USA More science events from
REVIEWS		Top
Translating nucleic acid-sensing pathways into therapies Tobias Junt & Winfried Barchet p529 | doi:10.1038/nri3875 Nucleic acid-sensing receptors are crucial for initiating protective immune responses against viruses, but aberrant activation of these receptors can also drive pathological inflammation. In this Review, the authors discuss the new agonists and antagonists that are being developed to target these receptors in the clinic. Abstract | Full Text | PDF
Immunopathology of multiple sclerosis Calliope A. Dendrou, Lars Fugger & Manuel A. Friese p545 | doi:10.1038/nri3871 This Review provides an insightful discussion on the current concepts in multiple sclerosis research, including genetic predisposition and environmental triggers, and explores the evolving link between inflammation and neurodegeneration. The authors highlight the clinical challenges and key questions that remain to be addressed. Abstract | Full Text | PDF | Supplementary information
The cytoskeleton in cell-autonomous immunity: structural determinants of host defence Serge Mostowy & Avinash R. Shenoy p559 | doi:10.1038/nri3877 The cytoskeleton is important for both cell structure and cell function. In this Review, the authors summarize the emerging roles of cytoskeletal components in sensing and eliminating bacterial pathogens from host cells. Abstract | Full Text | PDF | Supplementary information
Synchronizing transcriptional control of T cell metabolism and function Kevin Man & Axel Kallies p574 | doi:10.1038/nri3874 T cell differentiation and metabolism are intimately linked. This article describes how T cell receptor-induced transcription factors cooperate with canonical nutrient-sensing pathways to integrate antigen-specific and metabolic signals and appropriately modulate adaptive immune responses. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape Deborah R. Winter, Steffen Jung & Ido Amit p585 | doi:10.1038/nri3884 The enormous potential offered by chromatin profiling to reveal the past, present and future activity of a cell, as well as its ability to respond to the tissue environment, warrants the widespread use of this technique in immunological research. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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