Nature Reviews Cancer contents September 2015 Volume 15 Number 9 pp511-572

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TABLE OF CONTENTS
September 2015 Volume 15 Number 9
Impact Factor 37.912 *	In this issue Research Highlights Reviews Perspectives Also this month Featured article: Cancer origins  Featured article: The dynamic control of signal transduction networks in cancer cells Walter Kolch, Melinda Halasz, Marina Granovskaya & Boris N. Kholodenko
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Primers in your inbox Nature Reviews Disease Primers launched in April 2015 and publishes Primers — introductory review articles that provide overviews of diseases and disorders. Primer articles describe all aspects of a condition: epidemiology; disease mechanisms; diagnosis, screening and prevention; management; and quality of life.  Stay updated on the latest Primers published.
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An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation. Now open for submissions: http://bit.ly/1xXPzzM
RESEARCH HIGHLIGHTS Top Oesophageal cancer: Model refinement p511 | doi:10.1038/nrc4002 Two papers published in Nature Genetics have reported whole-genome and whole-exome sequencing of paired Barrett oesophagus and oesophageal adenocarcinoma (EAC) samples, providing some insights into the development of EAC from its precursor lesion. PDF Autophagy: Exploring the anticancer effects of autophagy inhibition p512 | doi:10.1038/nrc4003 Levy et al. show that autophagy is abnormally active during colorectal cancer development and is required for cancer cell metabolism. PDF Epigenetics: Chromatin reorganization on a 'mega' scale p512 | doi:10.1038/nrc4004 Alekseyenko, Walsh et al. have discovered that NUT fusion proteins, which underlie the development of the aggressive squamous cell cancer NUT midline carcinoma, localize to very large hyperacetylated domains within chromatin, which they term 'megadomains', leading to aberrant transcriptional programmes that promote tumorigenesis. PDF Autophagy: Surviving stress in pancreatic cancer p513 | doi:10.1038/nrc4005 Perera et al. investigated the high levels of autophagy in pancreatic ductal adenocarcinoma (PDAC). PDF Immunotherapy: Engineering a sTrategy for multiple myeloma p514 | doi:10.1038/nrc4006 A paper published in Nature Medicine reports on the results of treating patients with multiple myeloma with engineered T cells that recognise the cancer—testis antigen NY-ESO-1. PDF IN BRIEF Imaging: Polyps in technicolour | Tumour immunology: TReg cells, more than a suppression problem | Genetics: The evil twin | Therapy: Reinventing the wheel PDF Cancer JOBS of the week Computational Cancer Genomics and Evolution Postdoc Stanford BRCA Collaborative Tenure-track Faculty Positions in Cancer and Immunology University of Ottawa PhD in Cancer Research University of Würzburg Postdoctoral Position in Cancer Biology Northwestern University Synthetic Biology and Cancer Biology Postdoctoral Positions Beth Israel Deaconess Med Ctr / Harvard Medical School More Science jobs from Cancer EVENT 16th Biennial Meeting of the International Gynecologic Cancer Society 31.10.16 Lisbon, Portugal More science events from
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Wiley's Oncology portfolio of journals had a successful year for the 2014 Impact Factors. Highlights include - an increase for the American Cancer Society® Family of Journals, in addition to a rising Impact Factor on the Union for International Cancer Control (UICC)'s International Journal of Cancer, and finally Wiley's thriving Open Access title Cancer Medicine received its first ever Impact Factor. We invite Nature readers to view our highlights in Oncology, and to freely access the complimentary Top Cited article for each of our journals. Click now!
REVIEWS		Top
The dynamic control of signal transduction networks in cancer cells Walter Kolch, Melinda Halasz, Marina Granovskaya & Boris N. Kholodenko p515 | doi:10.1038/nrc3983 Cancer cells exhibit huge phenotypic plasticity, which can lead to adaptations to the tumour microenvironment and therapy. Much of this plasticity seems to be encoded in signal transduction networks, such that alterations in signalling dynamics can affect many cancer-associated phenotypes and therapeutic response. Abstract | Full Text | PDF
Deoxyribonucleotide metabolism, mutagenesis and cancer Christopher K. Mathews p528 | doi:10.1038/nrc3981 This Review discusses nucleotide metabolism and how fluctuations in deoxyribonucleoside triphosphate (dNTP) pools affect genomic instability. Drugs that target this system have been in use for many years and some of these are discussed, as well as newer approaches to manipulating deoxyribonucleotide metabolism for cancer treatment. Abstract | Full Text | PDF
Glycosylation in cancer: mechanisms and clinical implications Salome S. Pinho & Celso A. Reis p540 | doi:10.1038/nrc3982 This Review discusses the importance of glycobiology in cancer research, given its role in cancer development and progression, and provides an overview of possible targets for diagnostic application and therapeutic strategies. Abstract | Full Text | PDF
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Join us this September for the Naturejobs Career Expo London 2015!  This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries. The event is free and offers you a chance to get your CV checked, meet and network with employers and leading scientific institutions and attend useful workshops.  Register and find out more.
PERSPECTIVES		Top
OPINION Article series: Cancer origins Imaging innate immune responses at tumour initiation: new insights from fish and flies Yi Feng & Paul Martin p556 | doi:10.1038/nrc3979 This Opinion describes the early interactions between immune cells and pre-neoplastic cells observed in translucent zebrafish and Drosophila melanogaster models, and speculates on their potential implications in human cancer. Abstract | Full Text | PDF | Supplementary information
OPINION Sympathetic nervous system regulation of the tumour microenvironment Steven W. Cole et al. p563 | doi:10.1038/nrc3978 Activation of the peripheral nervous system can promote metastasis of primary tumours. This Opinion article discusses the molecular mechanisms through which physiological stress can have an effect on cancer, and how pharmacological antagonism of β-adrenergic signalling might represent a therapeutic opportunity to target cancer progression. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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