Nature Reviews Genetics Contents September 2015 Volume 16 Number 9 pp 497-559

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TABLE OF CONTENTS
September 2015 Volume 16 Number 9
Impact Factor 39.794 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Genomes by design Adrian D. Haimovich, Paul Muir & Farren J. Isaacs
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Nature Insight: Origin and evolution of vertebrates Vertebrates have many special features - from large brains to unique tissues. But how they evolved from invertebrates is obscure. This Insight looks at the many theories to explain vertebrate origins, the fossil evidence, a new perspective on the origin of the head and a uniquely vertebrate feature called the neural crest. Access the Insight online
RESEARCH HIGHLIGHTS Top Transcription: Stress unleashes the DoGs p497 | doi:10.1038/nrg3994 PDF Systems biology: MoA on DeMAND p498 | doi:10.1038/nrg3996 PDF Epigenetics: Chromatin reorganization on a 'mega' scale p498 | doi:10.1038/nrg4000 PDF Microbial genetics: C. parvum gets the CRISPR upgrade p500 | doi:10.1038/nrg3993 PDF Synthetic biology: UBER — a portable system for cross-species genetic engineering p500 | doi:10.1038/nrg3995 PDF IN BRIEF Functional genomics: Large-scale mouse phenotyping | Pathogen genetics: Sequencing of clinical bacterial isolates | Population genetics: One founding population, or two? PDF Genetics JOBS of the week Computational Cancer Genomics and Evolution Postdoc Stanford BRCA Collaborative MED BIO Fellow in Biostatistics / Statistical Genomics Imperial College London Postdoctoral Fellowships in Computational and Functional Genomics Washington University School of Medicine Postdoctoral Position in Genomics and Molecular Biology at UCLA UCLA Postdoctoral Training Fellow in Cancer Genomics and Bioinformatics Institute of Cancer Research (ICR) More Science jobs from Genetics EVENT Heart Failure: Genetics, Genomics and Epigenetics 03.04.15 Snowbird, USA More science events from
REVIEWS		Top
Genomes by design Adrian D. Haimovich, Paul Muir & Farren J. Isaacs p501 | doi:10.1038/nrg3956 Genome engineering can be used to introduce targeted genetic changes to design and reprogramme organisms, to introduce new functionalities and to discover causal associations in evolving phenotypes. In this Review, the rationale, techniques and applications in genome engineering are described, outlining key advances, technological goals and challenges, as genome engineering approaches move towards massively parallel platforms. Abstract | Full Text | PDF
Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning Pavel V. Baranov, John F. Atkins & Martina M. Yordanova p517 | doi:10.1038/nrg3963 There is accumulating evidence that the genetic code is not fixed but instead varies across organisms and that decoding is influenced by genomic and physiological contexts. This Review describes the various types of non-standard decoding, including altered codon meanings and ribosomal frameshifting, and highlights their pervasiveness, classification and biological implications. Abstract | Full Text | PDF
The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease James B. Stewart & Patrick F. Chinnery p530 | doi:10.1038/nrg3966 Mitochondrial DNA (mtDNA) mutations have been associated with numerous human diseases, from severe inherited disorders to common late-onset diseases. In this Review, the authors consider the origins of these mtDNA mutations in a single cell, their spread across populations and their contributions to disease risk. Abstract | Full Text | PDF
Knocking down disease: a progress report on siRNA therapeutics Anders Wittrup & Judy Lieberman p543 | doi:10.1038/nrg3978 Small interfering RNA (siRNA)-based drugs offer a promising approach to block the synthesis of disease-causing proteins, although their delivery has posed challenges. The authors review recent advances in siRNA therapeutics, including progress in overcoming delivery challenges, and clinical trials showing efficient and durable gene knockdown in the liver. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY Return of genetic testing results in the era of whole-genome sequencing Bartha Maria Knoppers, Ma'n H. Zawati & Karine Sénécal p553 | doi:10.1038/nrg3960 The authors provide a comprehensive survey of international legislation and policies guiding the return of whole-genome-sequencing-based genetic testing results to patients or study participants, within the context of both clinical and research settings. Abstract | Full Text | PDF
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EPIGENOME ROADMAP  Nature Publishing Group presents an online portal -the Epigenome Roadmap - which collects key research papers from The NIH Roadmap Epigenomics Program, complemented by thematical 'threads' to help the readers mine the wealth of available information. Produced with exclusive support from Illumina
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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