Nature Structural & Molecular Biology Contents: 2015 Volume #22 pp 509-585

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TABLE OF CONTENTS July 2015 Volume 22, Issue 7 News and Views Articles Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Presented by Nature Medicine and the Volkswagen Foundation AGING: CELLULAR MECHANISMS AND THERAPEUTIC OPPORTUNITIES, A HERRENHAUSEN SYMPOSIUM September 29-30, 2015 | Hanover, Germany  REGISTER NOW!    News and Views Top Synaptic-vesicle fusion: a need for speed   pp509 - 511 Mary Munson doi:10.1038/nsmb.3056 Two new studies reveal mechanistic insights into how neurons control the assembly of SNARE complexes and the rapid fusion of synaptic vesicles. Structural, biophysical and functional experiments are combined to elucidate the roles of two critical regulators: Munc13 and synaptotagmin. See also: Article by Yang et al. | Article by Brewer et al. Articles Small-RNA asymmetry is directly driven by mammalian Argonautes   pp512 - 521 Hiroshi I Suzuki, Akihiro Katsura, Takahiko Yasuda, Toshihide Ueno, Hiroyuki Mano,Koichi Sugimoto & Kohei Miyazono doi:10.1038/nsmb.3050 Asymmetric selection of single-stranded guide RNAs from double-stranded RNA precursors is determined by Ago2, which detects 5′-nucleotide identity and thermodynamic stability of microRNA duplex ends via its MID domain. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env   pp522 - 531 Young Do Kwon, Marie Pancera, Priyamvada Acharya, Ivelin S Georgiev, Emma T Crooks,Jason Gorman, M Gordon Joyce, Miklos Guttman, Xiaochu Ma, Sandeep Narpala, Cinque Soto, Daniel S Terry, Yongping Yang, Tongqing Zhou, Goran Ahlsen, Robert T Bailer, Michael Chambers, Gwo-Yu Chuang, Nicole A Doria-Rose, Aliaksandr Druz, Mark A Hallen, Adam Harned, Tatsiana Kirys, Mark K Louder, Sijy O'Dell, Gilad Ofek, Keiko Osawa, Madhu Prabhakaran, Mallika Sastry, Guillaume B E Stewart-Jones, Jonathan Stuckey, Paul V Thomas, Tishina Tittley, Constance Williams, Baoshan Zhang, Hong Zhao, Zhou Zhou, Bruce R Donald, Lawrence K Lee, Susan Zolla-Pazner, Ulrich Baxa, Arne Schön, Ernesto Freire, Lawrence Shapiro, Kelly K Lee, James Arthos, James B Munro, Scott C Blanchard, Walther Mothes, James M Binley, Adrian B McDermott, John R Mascola & Peter D Kwong doi:10.1038/nsmb.3051 The structure of the ligand-free HIV-1-Env trimer allows conformational fixation of Env and generation of an antigen that binds CD4 with high affinity and is recognized by broadly neutralizing antibodies but not poorly neutralizing ones. Structural & Molecular Biology JOBS of the week Postdoctoral Position University of California - San Francisco Computational Chemist (m / f) Boehringer Ingelheim Postdoctoral Position University of California - San Francisco Research Fellow (VT) / IMCB (A*STAR) Biomedical Sciences Institutes (BMSI) / A*STAR Faculty Positions at The Wistar Institute The Wistar Institute More Science jobs from Structural & Molecular Biology EVENT 3rd Annual Congress of the European Society for Translational Medicine (EUSTM-2015) 01.09.15 Vienna, Austria More science events from The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope   pp532 - 539 Sarah C Atkinson, Jennifer S Armistead, Derrick K Mathias, Maurice M Sandeu, Dingyin Tao,Nahid Borhani-Dizaji, Brian B Tarimo, Isabelle Morlais, Rhoel R Dinglasan & Natalie A Borg doi:10.1038/nsmb.3048 New X-ray crystal structure and immunoanalyses of alanyl aminopeptidase N (AnAPN1), a gut antigen of the Anopheles mosquito vector of Plasmodium falciparum, reveal how AnAPN1-specific antibodies block transmission of the malarial parasite. The pilus usher controls protein interactions via domain masking and is functional as an oligomer   pp540 - 546 Glenn T Werneburg, Nadine S Henderson, Erica B Portnoy, Samema Sarowar, Scott J Hultgren,Huilin Li & David G Thanassi doi:10.1038/nsmb.3044 Biochemical analyses show that in the Escherichia coli type I pilus the plug domain controls activation of usher by masking the substrate-binding site in the C-terminal domains when usher is in resting state. Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming   pp547 - 554 Xiaoyu Yang, Shen Wang, Yi Sheng, Mingshu Zhang, Wenjuan Zou,Lijie Wu, Lijun Kang, Josep Rizo, Rongguang Zhang, Tao Xu & Cong Ma doi:10.1038/nsmb.3038 Crystallographic and functional studies reveal the arch-shaped architecture of the Munc13 MUN domain and show the molecular basis for Munc13's role in synaptic-vesicle priming by mediating syntaxin-1 opening and SNARE-complex assembly. See also: News and Views by Munson Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution   pp555 - 564 Kyle D Brewer, Taulant Bacaj, Andrea Cavalli, Carlo Camilloni, James D Swarbrick,Jin Liu, Amy Zhou, Peng Zhou, Nicholas Barlow, Junjie Xu, Alpay B Seven, Eric A Prinslow, Rashmi Voleti, Daniel Häussinger, Alexandre M J J Bonvin, Diana R Tomchick, Michele Vendruscolo, Bim Graham, Thomas C Südhof & Josep Rizo doi:10.1038/nsmb.3035 The NMR-derived structural model of the dynamic interaction between synaptotagmin-1 and the SNARE complex contributes to addressing the longstanding problem of how synaptotagmin-1 triggers neurotransmitter release. See also: News and Views by Munson ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism   pp565 - 571 Nathan K Karpowich, Jin Mei Song, Nicolette Cocco and Da-Neng Wang doi:10.1038/nsmb.3040 Bacterial energy-coupling factor (ECF) transporters mediate ATP-dependent uptake of essential environmental micronutrients. Biochemical and fluorescence analyses now show that ATP binding promotes release of a substrate-capturing subunit that dynamically reassociates with the transmembrane module during the transport cycle. Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation   pp572 - 580 Hironori Suzuki, Takeshi Kaizuka, Noboru Mizushima and Nobuo N Noda doi:10.1038/nsmb.3036 The crystal structure of the Atg101-Atg13 complex elucidates the function of Atg101 and sheds light on the molecular mechanisms of autophagy initiation in higher eukaryotes. Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate   pp581 - 585 Hui Wang, Michael G Klein, Hua Zou, Weston Lane, Gyorgy Snell, Rena Levin, Ke Li & Bi-Ching Sang doi:10.1038/nsmb.3049 The crystal structure of human stearoyl-CoA desaturase-1 in complex with its natural substrate provides a close-up view of a key enzymatic step in the synthesis of unsaturated fatty acids. Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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