Nature Reviews Molecular Cell Biology contents August 2015 Volume 16 Number 8 pp 451-513

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TABLE OF CONTENTS
August 2015 Volume 16 Number 8
Impact Factor 37.806 *	In this issue Research Highlights Progress Reviews Also this month Article series: Cell death and autophagy Article series: Post-translational modifications  Featured article: Short- and long-term effects of chromosome mis-segregation and aneuploidy Stefano Santaguida & Angelika Amon
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RESEARCH HIGHLIGHTS Top Cell signalling: Limiting the side effects of senescence p451 | doi:10.1038/nrm4030 Inhibition of mTOR by rapamycin attenuates the translation of interleukin-1[alpha], thus reducing the secretion of inflammatory cytokines by senescent cells. PDF Chromatin: Histone influences on chromosomal translocations p452 | doi:10.1038/nrm4028 A new report shows that histone modification patterns influence the occurrence of chromosomal translocations. PDF Cell signalling: One kinase targets many secreted proteins p452 | doi:10.1038/nrm4031 A study now shows that the secretory pathway kinase FAM20C phosphorylates the majority of secreted proteins. PDF DNA damage response: The spliceosome cashes in at the ATM p454 | doi:10.1038/nrm4026 Transcription-blocking DNA lesions displace spliceosomes from chromatin and activate a non-canonical ataxia-telangiectasia mutated signalling pathway that modulates splicing. PDF IN BRIEF Chromosomes: Transgenerational remodelling of sperm DNA | Exosomes: Apoptotic beads on a string | Cytoskeleton: Degrading proteins at the primary cilium | Cytoskeleton: Controlling microtubules with light | Post-translational modifications: Resisting heat stress with SUMO | DNA damage response: 'enABLing' the Microprocessor PDF Molecular Cell Biology JOBS of the week Professor of Lipid and Membrane Biology (211-0377) University of Copenhagen Postdoc Helmholtz Association Senior Scientist University of Helsinki Research Assistant California Institute of Technology Professorship in Molecular Biology of Diabetes Pathogenesis University of Southern Denmark More Science jobs from Molecular Cell Biology EVENT More science events from
PROGRESS		Top
DNA-protein crosslink repair Julian Stingele & Stefan Jentsch p455 | doi:10.1038/nrm4015 Recent findings revealed that DNA-protein crosslinks (DPCs) in yeast and Xenopus laevis are repaired by a dedicated, protease-based DNA-repair pathway. Mutations in the putative human homologue of a DPC protease result in premature ageing and cancer predisposition. Abstract | Full Text | PDF | Supplementary information
REVIEWS		Top
Article series: Cell death and autophagy Autophagy at the crossroads of catabolism and anabolism Jasvinder Kaur & Jayanta Debnath p461 | doi:10.1038/nrm4024 Autophagy serves to degrade proteins during starvation. Recent progress has illuminated how, during starvation and nutrient repletion, autophagy can mobilize diverse cellular energy and nutrient stores, such as lipids, carbohydrates and iron, to salvage key metabolites that sustain and facilitate core anabolic functions. Abstract | Full Text | PDF
Short- and long-term effects of chromosome mis-segregation and aneuploidy Stefano Santaguida & Angelika Amon p473 | doi:10.1038/nrm4025 Aneuploidy, which results from chromosome mis-segregation, is a hallmark of cancer, but it can also inhibit tumorigenesis. Recent studies on the short- and long-term consequences of aneuploidy, which are caused by gene-specific effects and a stereotypic aneuploidy stress response, provide insights into this contradictory role in tumorigenesis. Abstract | Full Text | PDF | Supplementary information
Forcing cells into shape: the mechanics of actomyosin contractility Michael Murrell, Patrick W. Oakes, Martin Lenz & Margaret L. Gardel p486 | doi:10.1038/nrm4012 Actomyosin-mediated contractility generates mechanical stress in animal cells and underlies muscle contraction, cell migration, cell division and tissue morphogenesis. Insight into the mechanics of actomyosin arrays that lack sarcomeric organization has revealed novel modes of force transmission and shown that diverse mechanical behaviours can arise from common molecular components. Abstract | Full Text | PDF
Article series: Post-translational modifications Sound of silence: the properties and functions of repressive Lys methyltransferases Chiara Mozzetta, Ekaterina Boyarchuk, Julien Pontis & Slimane Ait-Si-Ali p499 | doi:10.1038/nrm4029 Repressive histone Lys methyltransferases (KMTs) mediate gene silencing by methylating histone H3 Lys 9 (H3K9), H3K27 and H4K20. Progress has been made in our understanding of the biochemical and functional properties of KMTs, the mechanisms of their recruitment to chromatin and the interplay between them. Abstract | Full Text | PDF | Supplementary information
Corrigendum: In the right place at the right time: visualizing and understanding mRNA localization Adina R. Buxbaum, Gal Haimovich & Robert H. Singer p513 | doi:10.1038/nrm4027 Full Text | PDF
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