Nature Reviews Microbiology contents August 2015 Volume 13 Number 8 pp 457-523

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TABLE OF CONTENTS
August 2015 Volume 13 Number 8
Impact Factor 23.574 *	In this issue Research Highlights News and Analysis Progress Reviews Also this month  Featured article: A functional perspective on phenotypic heterogeneity in microorganisms Martin Ackermann
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INNOVATE. COLLABORATE. COMMERCIALIZE. Antimicrobial Resistance Explore all areas of developing AMR antibiotics and how to ensure their sustainability Read more...
RESEARCH HIGHLIGHTS Top Bacterial physiology: Obg controls bacterial persistence p457 | doi:10.1038/nrmicro3526 A new study shows that the GTPase Obg controls bacterial persistence by causing membrane depolarization via a mechanism that involves transcriptional activation of the toxin gene hokB. PDF Viral evolution: Keeping a watchful eye on Ebola p457 | doi:10.1038/nrmicro3528 Three new papers report large-scale genome surveillance studies for two countries affected by the 2014 Ebola virus outbreak, Guinea and Sierra Leone. PDF Malaria: Hitting all stages of the parasite life cycle p458 | doi:10.1038/nrmicro3530 This study describes a novel antimalarial drug that targets Plasmodium falciparum translation elongation factor 2 and therefore acts against all stages of the parasite life cycle. PDF IN BRIEF Microbiome: Modifying the gut to treat liver diseases | Bacterial evolution: Plague starts with Pla | Viral infection: TRIMming immune responses to dengue | Bacterial evolution: An intriguing new bacterial phylum | Structural biology: CRISPR preorders for Cas | Techniques & applications: A first genome assembly for nanopore sequencing PDF Microbiology JOBS of the week Postdoctoral Researcher in Immunology New York University School of Medicine Postdoc Position in Molecular Microbiology University of Copenhagen Postdoctoral Position in Theoretical Immunology Icahn School of Medicine at Mount Sinai Laboratory Research Scientist The Francis Crick Institute Research / Academic Opportunities in Infectious Diseases Imperial College London More Science jobs from Microbiology EVENT Genomics and Clinical Microbiology 17.01.16 Cambridge, UK More science events from
NEWS AND ANALYSIS		Top
Genome watch: The chronicles of virus-host affairs Pinky Langat & Velislava Petrova p460 | doi:10.1038/nrmicro3529 This month's Genome Watch highlights a new large-scale serological platform for the simultaneous detection of multiple human viruses in a single drop of blood. PDF
PROGRESS		Top
Viral apoptotic mimicry Ali Amara & Jason Mercer p461 | doi:10.1038/nrmicro3469 Viral apoptotic mimicry, defined by the exposure of phosphatidylserine on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. In this Progress article, Amara and Mercer discuss how viruses acquire phosphatidylserine and how this mimicry might facilitate cell entry and evasion of the immune response. Abstract | Full Text | PDF
REVIEWS		Top
HIV-1 capsid: the multifaceted key player in HIV-1 infection Edward M. Campbell & Thomas J. Hope p471 | doi:10.1038/nrmicro3503 In this Review, Campbell and Hope describe the interactions between the HIV-1 capsid core and several cellular factors that enable efficient HIV-1 genome replication, timely core disassembly, nuclear import and viral integration into the genome of the target cell. Abstract | Full Text | PDF
HIV-1 assembly, release and maturation Eric O. Freed p484 | doi:10.1038/nrmicro3490 In this article, Eric Freed reviews recent progress in elucidating the steps involved in HIV-1 assembly, release and maturation, highlighting how these events are orchestrated by the viral Gag precursor protein and how this information is being used to develop novel anti-HIV-1 therapeutics. Abstract | Full Text | PDF
A functional perspective on phenotypic heterogeneity in microorganisms Martin Ackermann p497 | doi:10.1038/nrmicro3491 Phenotypic heterogeneity is a ubiquitous feature of microbial communities, even within groups of genetically identical cells. In this Review, Martin Ackermann describes the molecular mechanisms that lead to phenotypic heterogeneity and discusses how heterogeneity can increase survival and productivity of microbial populations. Abstract | Full Text | PDF
Discovery of microbial natural products by activation of silent biosynthetic gene clusters Peter J. Rutledge & Gregory L. Challis p509 | doi:10.1038/nrmicro3496 Microorganisms produce a wealth of structurally diverse specialized metabolites with great potential for use in medicine and agriculture. In this Review, Rutledge and Challis provide an overview of the approaches that are available to identify and activate cryptic microbial biosynthetic gene clusters, which represent an untapped reservoir of useful metabolites. Abstract | Full Text | PDF
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*2014Journal Citation Report (Thomson Reuters, 2015)

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