Nature Reviews Immunology Contents August 2015 Volume 15 Number 8 pp 465-523

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TABLE OF CONTENTS
August 2015 Volume 15 Number 8
Impact Factor 33.836 *	In this issue Research Highlights Reviews Also this month  Featured article: Molecular and cellular insights into T cell exhaustion E. John Wherry & Makoto Kurachi
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RESEARCH HIGHLIGHTS Top Tumour immunology: Stressed DCs can't handle T cells p465 | doi:10.1038/nri3885 Endoplasmic reticulum stress in tumour-associated dendritic cells impairs their ability to activate an antitumour T cell response. PDF Asthma and allergy: An IFNγ bias in severe asthma p466 | doi:10.1038/nri3891 An interferon-γ-mediated immune response is dominant in severe asthma. PDF T cells: A killer cytokine p466 | doi:10.1038/nri3895 Interleukin-26 mediates direct antimicrobial and immunostimulatory activities of T helper 17 cells. PDF T cell differentiation: NLRP3 goes beyond the inflammasome p467 | doi:10.1038/nri3886 NLRP3 functions independently of the inflammasome as a transcriptional regulator of T helper 2 cell differentiation. PDF Autoimmunity: Benefits of exhaustion p468 | doi:10.1038/nri3890 CD8+ T cell exhaustion is associated with a good outcome in autoimmune and inflammatory diseases. PDF Mucosal immunology: Microbiota-induced T cells block allergic inflammation p468 | doi:10.1038/nri3894 The intestinal microbiota restrains type 2 immune responses by inducing the development of RORγ-expressing T cells. PDF Neuroimmunology: A painful difference between the sexes p469 | doi:10.1038/nri3892 Male and female mice process mechanical pain using distinct neuroimmune mechanisms. PDF JOURNAL CLUB Dcs tailor T cells to the tissue p469 | doi:10.1038/nri3893 Allan Mowat describes a 2005 study that identified the ability of CD103+ dendritic cells to imprint T cells with gut-homing specificity. PDF Immunology JOBS of the week Department of Immunology Tenure Stream Position Assistant Professor University of Toronto Post-doc in neuro-immune interaction KU Leuven Postdoctoral Fellow University of Connecticut Chair in Immunity and Infection Instituto de Medicina Molecular (iMM Lisboa) Post-doctoral Researcher The Research Institute at Nationwide Children Hospital More Science jobs from Immunology EVENT Workshop: Immunomodulation of Stem Cells 2015 11.12.15 London, UK More science events from
REVIEWS		Top
The multifaceted biology of plasmacytoid dendritic cells Melissa Swiecki & Marco Colonna p471 | doi:10.1038/nri3865 This Review details our current understanding of the biology of plasmacytoid dendritic cells (pDCs). The authors describe the mechanisms controlling the development and functions of pDCs and discuss their roles in infection, inflammatory disease and cancer. Abstract | Full Text | PDF
Molecular and cellular insights into T cell exhaustion E. John Wherry & Makoto Kurachi p486 | doi:10.1038/nri3862 Exhausted T cells display a phenotype characterized by progressive loss of function, and they can develop following exposure to persistent antigen and/or inflammatory signals during chronic viral infections or cancer. The authors describe the molecular mechanisms of T cell exhaustion and how the exhausted phenotype is different from other dysfunctional states of T cells. Abstract | Full Text | PDF
Iron homeostasis in host defence and inflammation Tomas Ganz & Elizabeta Nemeth p500 | doi:10.1038/nri3863 Mammalian hosts have evolved a range of mechanisms that limit the ability of microorganisms to obtain iron and therefore to survive. Here, the authors describe the role of iron in infection and how iron homeostasis is altered as a consequence of nutritional immunity. Abstract | Full Text | PDF
Eicosanoid storm in infection and inflammation Edward A. Dennis & Paul C. Norris p511 | doi:10.1038/nri3859 Eicosanoids are bioactive signalling lipids that regulate numerous homeostatic and inflammatory processes. Here, the authors review our current understanding of cellular eicosanoid metabolism and the physiological functions of pro-inflammatory and pro-resolving eicosanoids in infection and inflammation. Abstract | Full Text | PDF | Supplementary information
Erratum: A brain drain Yvonne Bordon p523 | doi:10.1038/nri3888 Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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