Nature Reviews Cancer contents August 2015 Volume 15 Number 8 pp449-509

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TABLE OF CONTENTS
August 2015 Volume 15 Number 8
Impact Factor 37.912 *	In this issue Comment Research Highlights Reviews Perspectives Also this month Article series: Cancer origins  Featured article: Evolving synergistic combinations of targeted immunotherapies to combat cancer Ignacio Melero, David M. Berman, M. Angela Aznar, Alan J. Korman, José Luis Pérez Gracia & John Haanen
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In this issue p449 | doi:10.1038/nrc3994 Full Text
Comment: Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts Robert M. Hoffman p451 | doi:10.1038/nrc3972 Most patient-derived tumours grown subcutaneously as xenografts do not metastasize, but metastasis can occur if intact tumour tissue is orthotopically implanted. This Comment argues that these orthotopic xenografts therefore better mimic patient tumours. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Diagnosis: Fishing for exosomes p453 | doi:10.1038/nrc3990 A paper in Nature identifies glypican 1 as a marker of circulating exosomes derived from pancreatic ductal adenocarcinoma (and from some breast cancers) that could be an effective biomarker for early diagnosis and treatment monitoring. PDF Colorectal cancer: APC restores order p454 | doi:10.1038/nrc3986 Inducible short hairpin RNA (shRNA)-mediated silencing of adenomatous polyposis coli (Apc) in the intestines of mice has revealed that APC loss is crucial for tumour maintenance even in the presence of other oncogenic mutations, and that re-expression of APC can restore normal crypt homeostasis. PDF Metabolism: Mutant BRAF feels the burn p454 | doi:10.1038/nrc3992 A paper published in Molecular Cell indicates that the production of ketones can promote the BRAFV600E-MEK-ERK oncogenic pathway and identifies a potential Achilles' heel. PDF Metastasis: Pushing through a tough stretch p455 | doi:10.1038/nrc3989 Activation of pannexin 1 channels promotes the survival of disseminated cancer cells in the microvasculature of metastasis target organs. PDF Breast cancer: Untangling the role of progesterone receptors p456 | doi:10.1038/nrc3991 Mohammed et al. have examined the functional interactions between oestrogen receptor-α (ERα) and progesterone receptor (PR) in mouse and human breast tumours. They found that activation of PR changes the pattern of ERα chromatin binding, resulting in the expression of antiproliferative genes. PDF IN BRIEF Epigenetics: Targeting histones in metastatic melanoma | Genetics: The importance of mitochondrial tRNA | Breast cancer: A mouse model for metaplastic breast carcinoma PDF Geoscience JOBS of the week Staff Scientist in Translational Cancer Genomics University of Southern California Postdoctoral Position in Functional Cancer Genomics Institute of Oncology Research Post-doctoral Fellow in Cancer Immunology / Immunotherapy Massachuesetts General Hospital/ Harvard Medical School 10 Postdoctoral Fellowships in Cancer Research Helmholtz Association Postdoctoral Research Fellow in Medicinal Chemistry for Cancer Drug Discovery University of Michigan More Science jobs from Geoscience EVENT The Controlling Cancer Summit 2016 17.05.16 London, UK More science events from
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An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation. Now open for submissions.
REVIEWS		Top
Evolving synergistic combinations of targeted immunotherapies to combat cancer Ignacio Melero et al. p457 | doi:10.1038/nrc3973 Immunotherapy has undoubtedly become an effective treatment for many cancers, but how can we make the most of this approach? In this Review, Melero et al. discuss how immune-targeted therapies can be synergistically combined to provide maximal benefit to patients. Abstract | Full Text | PDF | Supplementary information
Article series: Cancer origins Tumorigenesis: it takes a village Doris P. Tabassum & Kornelia Polyak p473 | doi:10.1038/nrc3971 Although most cancers exhibit some degree of intratumour heterogeneity, we are far from understanding the dynamics that operate among subclonal populations within tumours. This Review discusses the growing evidence that cooperative behaviour of tumour subclones can influence disease progression. Abstract | Full Text | PDF
Adiposity and cancer risk: new mechanistic insights from epidemiology Andrew G. Renehan, Marcel Zwahlen & Matthias Egger p484 | doi:10.1038/nrc3967 Obesity is associated with increased (and occasionally decreased) risk of developing several types of cancer. This Review discusses the epidemiological evidence available for, and the possible mechanisms that might lead to, this altered risk. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Article series: Cancer origins Control of cancer formation by intrinsic genetic noise and microenvironmental cues Amy Brock, Silva Krause & Donald E. Ingber p499 | doi:10.1038/nrc3959 In this Opinion article, Brock et al. analyse how intrinsic variability in gene expression in proliferating cells, as well as microenvironmental signals, can drive cells to transform into a neoplastic state or revert to a normalized state. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Radioimmunotherapy of human tumours Steven M. Larson, Jorge A. Carrasquillo, Nai-Kong V. Cheung & Oliver W. Press p509 | doi:10.1038/nrc3987 Full Text | PDF
Erratum: Forging a signature of in vivo senescence Norman E. Sharpless & Charles J. Sherr p509 | doi:10.1038/nrc3988 Full Text | PDF
Erratum: The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence Holly E. Barker, James T. E. Paget, Aadil A. Khan & Kevin J. Harrington p509 | doi:10.1038/nrc3993 Full Text | PDF
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