Nature Reviews Microbiology contents July 2015 Volume 13 Number 7 pp 397-456

TABLE OF CONTENTS
July 2015 Volume 13 Number 7
Impact Factor 23.317 *	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month Article series: Microbiome  Featured article: HIV-1 and interferons: who's interfering with whom? Tomas Doyle, Caroline Goujon & Michael H. Malim
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RESEARCH HIGHLIGHTS Top Marine microbiology: Deep sequencing of the global oceans p397 | doi:10.1038/nrmicro3509 Five studies report the initial findings of the international Tara Oceans consortium, which describe the microbial composition of the global oceans and the ecological factors that govern community structure in these ecosystems. PDF Bacterial physiology: Linking cell differentiation and growth p398 | doi:10.1038/nrmicro3505 This study identifies cyclic diguanylate (c-di-GMP) as a crucial regulator of both cell morphogenesis and chromosome replication in Caulobacter crescentus. PDF Structural biology: Copying the bunyavirus genome p398 | doi:10.1038/nrmicro3507 The structure of the La Crosse orthobunyavirus L protein suggests a new model for the replication of segmented negative-strand viral genomes. PDF Bacterial pathogenesis: Message in a bottle p400 | doi:10.1038/nrmicro3510 Outer membrane vesicles access intestinal macrophages in a sulfatase-dependent manner where they induce inflammation in susceptible hosts. PDF Marine microbiology: An interkingdom partnership p400 | doi:10.1038/nrmicro3515 A new study reports a highly specific partnership between a marine diatom and a bacterium, which is the result of a mutually beneficial exchange of nutrients and signalling molecules. PDF IN BRIEF Parasite biology: Punching through vacuolar membranes | Antimicrobials: Fine-tuned antifungals | Microbiome: A gut instinct for recovery | Microbiome: Gut bacteria feed a healthy brain | Bacterial physiology: Type IV pili function as mechanosensors | Viral evolution: Global patterns of influenza circulation PDF Microbiology JOBS of the week Professors in synthetic biology at the Department of Fundamental Microbiology The Faculty of Biology and Medicine of the University of Lausanne, Switzerland Assistant or Associate Profess Tenure Track University of California - Davis postdoctoral fellow Medical College of Wisconsin Postdoctoral Position in Biomedical Engineering University of Massachusetts PhD position Microbial Immunology Leibniz Institute for Natural Product Research and Infection Biology More Science jobs from Microbiology EVENT More science events from
NEWS AND ANALYSIS		Top
Genome watch: Adaptation: it's a bug's race Arporn Wangwiwatsin & Anna V. Protasio p401 | doi:10.1038/nrmicro3514 This month's Genome Watch highlights studies that investigate links between Wolbachia genotypes and their phenotypes, and explore how Wolbachia adapts to new host environments. PDF
REVIEWS		Top
HIV-1 and interferons: who's interfering with whom? Tomas Doyle, Caroline Goujon & Michael H. Malim p403 | doi:10.1038/nrmicro3449 In this Review, Malim and colleagues discuss the evidence that type I interferons (IFNs) can control HIV-1 replication in vivo and debate the controversial role of IFNs in promoting the pathological sequelae of chronic HIV-1 infection. Abstract | Full Text | PDF
Bottlenecks in HIV-1 transmission: insights from the study of founder viruses Sarah B. Joseph, Ronald Swanstrom, Angela D. M. Kashuba & Myron S. Cohen p414 | doi:10.1038/nrmicro3471 HIV-1 infection typically results from the transmission of a single viral variant, the transmitted/founder (T/F) virus. In this Review, Joseph and colleagues discuss how studying these T/F viruses contributes to a better understanding of HIV-1 transmission and affects prevention strategies. Abstract | Full Text | PDF
Broad-spectrum antivirals against viral fusion Frederic Vigant, Nuno C. Santos & Benhur Lee p426 | doi:10.1038/nrmicro3475 In this Review, Lee and colleagues describe the mechanism of fusion between virus and host cell membranes that occurs during enveloped virus entry and discuss how broad-spectrum antivirals can target this process to prevent viral infection. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Microbiome Dispersing misconceptions and identifying opportunities for the use of 'omics' in soil microbial ecology James I. Prosser p439 | doi:10.1038/nrmicro3468 In this Opinion article, James Prosser considers the conceptual limitations of metagenomics and metatranscriptomics in contributing to our understanding of soil microbial ecology, and also explores potential opportunities for using these techniques to address specific ecological questions. Abstract | Full Text | PDF
OPINION Bacterial gene import and mesophilic adaptation in archaea Purificación López-García, Yvan Zivanovic, Philippe Deschamps & David Moreira p447 | doi:10.1038/nrmicro3485 In this Opinion article, López-García et al. describe recent archaeal phylogenomic data relating to the massive acquisition of bacterial genes by horizontal gene transfer. They argue that the findings presented suggest that the import of these bacterial genes was crucial for the adaptation of archaea to mesophilic lifestyles. Abstract | Full Text | PDF | Supplementary information
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