Tuesday, May 5, 2015

Scientific Reports Biology Table of Contents e-alert: 5 May 2015

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  05 May 2015   
 
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Biological Sciences
 
 
 
 
 
 
 

Meta-Analysis of the Relationship between XRCC1-Arg399Gln and Arg280His Polymorphisms and the Risk of Prostate Cancer

 
 

Jie Yan, Xiantao Wang, Hui Tao et al.

 
 

Prostate cancer is one of the most common noncutaneous malignancies in Western countries. Because there has been a debate regarding the relationship between the XRCC1-Arg399Gln …

 
 
 
 
 
 

TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway

 
 

Hong-Pei Yu, Jia-Ming Xie, Bin Li et al.

 
 

Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. However, it remains …

 
 
 
 
 
 

The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe

 
 

Shinsuke Takata, Tomomi Masuda, Shinsuke Nakamura et al.

 
 

Hypoxic stress is a risk factor of ocular neovascularization. Hypoxia visualization may provide clues regarding the underlying cause of angiogenesis. Recently, we developed a …

 
 
 
 
 
 

Auto-inhibitory Mechanism of the Human Mitochondrial RNase P Protein Complex

 
 

Fengzhi Li, Xiaofen Liu, Weihong Zhou et al.

 
 

It is known that tRNAs play an essential role in genetic information transfer from DNA to protein. The maturation of tRNA precursors is performed by the endoribonuclease RNase P, …

 
 
 
 
 
 

SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton

 
 

Tadamoto Isogai, Rob van der Kammen, Metello Innocenti

 
 

Formin proteins are key regulators of the cytoskeleton involved in developmental and homeostatic programs, and human disease. For these reasons, small molecules interfering with …

 
 
 
 
 
 

Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations

 
 

Chao Zhang, Jing Li, Lei Tian et al.

 
 

Zinc transporters play important roles in all eukaryotes by maintaining the rational zinc concentration in cells. However, the diversity of zinc transporter genes (ZTGs) remains …

 
 
 
 
 
 

Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines

 
 

Yan-Shen Shan, Hui-Ping Hsu, Ming-Derg Lai et al.

 
 

Gastric cancer metastasis remains a major cause of cancer-related deaths. There is an urgent need to develop new therapeutic approaches targeting metastatic gastric cancer. …

 
 
 
 
 
 

Preclinical Study of Locoregional Therapy of Hepatocellular Carcinoma by Bioelectric Ablation with Microsecond Pulsed Electric Fields (μsPEFs)

 
 

Xinhua Chen, Zhigang Ren, Chengxiang Li et al.

 
 

Unresectable hepatocellular carcinoma (HCC) needs locoregional ablation as a curative or downstage therapy. Microsecond Pulsed Electric Fields (μsPEFs) is an option. A xenograft …

 
 
 
 
 
 

Raman spectroscopic sensing of carbonate intercalation in breast microcalcifications at stereotactic biopsy

 
 

R. Sathyavathi, Anushree Saha, Jaqueline S. Soares et al.

 
 

Microcalcifications are an early mammographic sign of breast cancer and frequent target for stereotactic biopsy. Despite their indisputable value, microcalcifications, …

 
 
 
 
 
 

New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish

 
 

O. P. Chevallier, S. F. Graham, E. Alonso et al.

 
 

Azaspiracid (AZA) poisoning was unknown until 1995 when shellfish harvested in Ireland caused illness manifesting by vomiting and diarrhoea. Further in vivo/vitro studies showed …

 
 
 
 
 
 

Remodeling of RecG Helicase at the DNA Replication Fork by SSB Protein

 
 

Zhiqiang Sun, Hui Yin Tan, Piero R. Bianco et al.

 
 

The RecG DNA helicase a key player in stalled replication fork rescue. The single-stranded DNA binding protein (SSB) participates in this process, but its role in the interaction …

 
 
 
 
 
 

Disruption of the rice nitrate transporter OsNPF2.2 hinders root-to-shoot nitrate transport and vascular development

 
 

Yuge Li, Jie Ouyang, Ya-Yun Wang et al.

 
 

Plants have evolved to express some members of the nitrate transporter 1/peptide transporter family (NPF) to uptake and transport nitrate. However, little is known of the …

 
 
 
 
 
 

Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD

 
 

Isaac K. Sundar, Tanveer Ahmad, Hongwei Yao et al.

 
 

Daily oscillations of pulmonary function depend on the rhythmic activity of the circadian timing system. Environmental tobacco/cigarette smoke (CS) disrupts circadian clock …

 
 
 
 
 
 

Sensorimotor transformation via sparse coding

 
 

Ken Takiyama

 
 

Sensorimotor transformation is indispensable to the accurate motion of the human body in daily life. For instance, when we grasp an object, the distance from our hands to an …

 
 
 
 
 
 

SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors

 
 

Shivani Malik, Lidia Villanova, Shinji Tanaka et al.

 
 

Metastasis is responsible for over 90% of cancer-associated mortality. In epithelial carcinomas, a key process in metastatic progression is the epigenetic reprogramming of an …

 
 
 
 
 
 

Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network

 
 

Hyun-Jun Nam, Inhae Kim, James U. Bowie et al.

 
 

A central question in animal evolution is how multicellular animals evolved from unicellular ancestors. We hypothesize that membrane proteins must be key players in the …

 
 
 
 
 
 

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

 
 

Alejandro Rojas-Fernandez, Lina Herhaus, Thomas Macartney et al.

 
 

CRISPR/Cas9 technologies have been employed for genome editing to achieve gene knockouts and knock-ins in somatic cells. Similarly, certain endogenous genes have been tagged with …

 
 
 
 
 
 

OsTCP19 influences developmental and abiotic stress signaling by modulating ABI4-mediated pathways

 
 

Pradipto Mukhopadhyay, Akhilesh Kumar Tyagi, Akhilesh Kumar Tyagi

 
 

Class-I TCP transcription factors are plant-specific developmental regulators. In this study, the role of one such rice gene, OsTCP19, in water-deficit and salt stress response …

 
 
 
 
 
 

Simultaneous silence organizes structured higher-order interactions in neural populations

 
 

Hideaki Shimazaki, Kolia Sadeghi, Tomoe Ishikawa et al.

 
 

Activity patterns of neural population are constrained by underlying biological mechanisms. These patterns are characterized not only by individual activity rates and pairwise …

 
 
 
 
 
 

Increased signaling entropy in cancer requires the scale-free property of protein interaction networks

 
 

Andrew E. Teschendorff, Christopher R. S. Banerji, Simone Severini et al.

 
 

One of the key characteristics of cancer cells is an increased phenotypic plasticity, driven by underlying genetic and epigenetic perturbations. However, at a systems-level it is …

 
 
 
 
 
 

Discerning mechanistically rewired biological pathways by cumulative interaction heterogeneity statistics

 
 

Travis B. Cotton, Hien H. Nguyen, Joseph I. Said et al.

 
 

Changes in response of a biological pathway could be a consequence of either pathway rewiring, changed input, or a combination of both. Most pathway analysis methods are not …

 
 
 
 
 
 

MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1

 
 

Yancheng Lin, Allan Yi Liu, Chuannan Fan et al.

 
 

MicroRNAs are a class of small noncoding RNAs that regulate gene expression post-transcriptionally either by inhibiting protein translation or by causing the degradation of target …

 
 
 
 
 
 

Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer

 
 

Sabindra K. Samal, Samapika Routray, Ganesh Kumar Veeramachaneni et al.

 
 

DDX3 belongs to DEAD box RNA helicase family and is involved in the progression of several types of cancer. In this work, we employed a High Throughput Virtual screening approach …

 
 
 
 
 
 
 
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