Nature Reviews Neuroscience contents June 2015 Volume 16 Number 6 pp 313-372

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TABLE OF CONTENTS
June 2015 Volume 16 Number 6
Impact Factor 31.376 *	In this issue Research Highlights Reviews Also this month Featured article: Stress  Featured article: Neuronal circuits for fear and anxiety Philip Tovote, Jonathan Paul Fadok & Andreas Lüthi
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RESEARCH HIGHLIGHTS Top Computational neuroscience: Population coupling p313 | doi:10.1038/nrn3965 How the firing of neurons in a population generates cortical representations has not been fully elucidated, but a new study shows that population activity can be understood in terms of the degree of coupling of the spiking of a single neuron to the spiking of the overall population. PDF Myelination: An active process p314 | doi:10.1038/nrn3964 Two studies use zebrafish models to investigate the mechanisms through which neuronal activity influences myelination. PDF Gene expression: Converging pathways p314 | doi:10.1038/nrn3968 Reelin induces transcriptional changes in neurons by increasing the formation of an intracellular fragment of its target receptor that interacts with specific enhancer regions in the nucleus. PDF Behavioural neuroscience: Picking up the pups p315 | doi:10.1038/nrn3967 Oxytocin tunes the responses of neurons in the left auditory cortex to pup calls and may thus promote pup retrieval by virgin female mice. PDF Neural circuits: Pain or pleasure? p316 | doi:10.1038/nrn3975 A study uses optogenetics to dissect the circuits involved in associating environmental stimuli with positive or negative outcomes. PDF IN BRIEF Glia: Diffusible danger | Neurodegeneration: Neurodegeneration takes its TOLL | Cognitive neuroscience: Gridlock | Glia: The devil in the detail PDF Neuroscience JOBS of the week Postdoctoral fellow (m / f) in Neuroscience Klinikum der Universität München Postdoctoral Fellow / Research Associate in Stroke Research Weill Cornell Medical School Postdoctoral Research Associate University of Colorado Boulder Research Associate University College London (UCL) Tenure Track Faculty Positions Albert Einstein College of Medicine of Yeshiva University (AECOM) More Science jobs from Neuroscience EVENT Champalimaud Neuroscience Symposium – Perspectives on Social Behaviour 16.09.15 Lisbon, Portugal More science events from
REVIEWS		Top
Neuronal circuits for fear and anxiety Philip Tovote, Jonathan Paul Fadok & Andreas Lüthi p317 | doi:10.1038/nrn3945 Recent methodological progress has greatly facilitated the determination of the connectivity and functional characterization of complex neural circuits. In this Review, Tovote, Fadok and Lüthi examine studies that have adopted circuit-based approaches to gain insight into how the brain governs fear and anxiety. Abstract | Full Text | PDF
Article series: Stress Epigenetic and transgenerational reprogramming of brain development Tracy L. Bale p332 | doi:10.1038/nrn3818 Exposure to environmental insults such as maternal stress during prenatal and postnatal development or paternal stress experience can have long-term effects on offspring brain function and behaviour. In this Review, Bale describes the mechanisms through which diverse insults reprogramme the epigenome and can even lead to transmission of the phenotype to subsequent generations. Abstract | Full Text | PDF
Compromised autophagy and neurodegenerative diseases Fiona M. Menzies, Angeleen Fleming & David C. Rubinsztein p345 | doi:10.1038/nrn3961 Dysfunction of autophagy — an intracellular degradation pathway for cytosolic material — has been implicated in the pathogenesis of various neurodegenerative diseases. Rubinsztein and colleagues review recent progress in this area, focusing on macroautophagy, and discuss how this process may be manipulated to protect against neurodegeneration. Abstract | Full Text | PDF
Immune attack: the role of inflammation in Alzheimer disease Frank L. Heppner, Richard M. Ransohoff & Burkhard Becher p358 | doi:10.1038/nrn3880 It is now emerging that the neuroinflammation that is associated with Alzheimer disease may have a key role in driving this disease. In this Review, Heppner, Ransohoff and Becher examine the contribution of the immune system to the pathogenesis of this disorder. Abstract | Full Text | PDF
Erratum: Astrocyte barriers to neurotoxic inflammation Michael V. Sofroniew p372 | doi:10.1038/nrn3966 Full Text | PDF
Corrigendum: Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy Ivan Soltesz, Bradley E. Alger, Masanobu Kano, Sang-Hun Lee, David M. Lovinger, Takako Ohno-Shosaku & Masahiko Watanabe p372 | doi:10.1038/nrn3974 Full Text | PDF
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