Nature Communications - 20 May 2015

Weekly Content Alert Nature Communications is now fully open access. Read more. 20 May 2015  Featured image: Buehler et al. fabricate synthetic spider webs and show the mechanical response of the webs under multiple loading conditions. Latest content: Articles Corrigenda Advertisement   MCP Call for Papers Molecular & Cellular Proteomics invites submissions for a special issue on chromatin biology and epigenetics. Deadline: July 1, 2015. The ASBMB journal, Molecular & Cellular Proteomics, showcases contributions that describe the structural and functional properties of proteins and their expression, particularly with respect to developmental time courses. Journal homepage Recommend to library Web feed   Advertisement Epigenome Roadmap Nature Publishing Group presents an online portal - the Epigenome Roadmap - which collects key research papers from The NIH Roadmap Epigenomics Program, complemented by thematical 'threads' to help the readers mine the wealth of available information. Access the Epigenome Roadmap for FREE at:  nature.com/epigenomeroadmap Produced with exclusive support from  Illumina     Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Large-scale recent expansion of European patrilineages shown by population resequencing OPEN Chiara Batini, Pille Hallast, Daniel Zadik, Pierpaolo Maisano Delser, Andrea Benazzo, Silvia Ghirotto, Eduardo Arroyo-Pardo, Gianpiero L. Cavalleri, Peter de Knijff, Berit Myhre Dupuy, Heidi A. Eriksen, Turi E. King, Adolfo López de Munain, Ana M. López-Parra, Aphrodite Loutradis, Jelena Milasin, Andrea Novelletto, Horolma Pamjav, Antti Sajantila, Aslıhan Tolun et al. The origins and antiquity of the people of Europe has been much debated. Here, the authors sequence 3.7 Mb of the Y chromosome in over 300 Europeans and Middle Easterners and show a recent, continent-wide and male-specific expansion dating back to the Bronze Age. 19 May 2015 | doi: 10.1038/ncomms8152 Biological Sciences  Evolution  Genetics  Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin OPEN Gurpreet S. Baht, David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei and Benjamin A. Alman The reparative capacity of tissues decreases with age. Here, Baht et al. perform parabiosis experiments and provide evidence for the existence of a soluble factor produced by young, but not old, haematopoietic cells that is capable of improving fracture repair in old mice. 19 May 2015 | doi: 10.1038/ncomms8131 Biological Sciences  Medical research  High Molybdenum availability for evolution in a Mesoproterozoic lacustrine environment John Parnell, Samuel Spinks, Steven Andrews, Wanethon Thayalan and Stephen Bowden Complex life forms began to emerge during the Precambrian. Here, the authors tie this evolution to an increase in trace metal availability, namely the Mo content of lacustrine shales, suggesting that life evolved in terrestrial and marginal marine environments rather than the Mo-limited deep ocean. 19 May 2015 | doi: 10.1038/ncomms7996 Earth Sciences  Geology and geophysics  Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE OPEN Scott Ayton, Noel G. Faux, Ashley I. Bush, Alzheimer's Disease Neuroimaging Initiative, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack Jr., William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marc Raichle et al. Brain-iron elevation is implicated in Alzheimer’s disease (AD), but the impact of the metal on disease outcomes has not been analysed in a longitudinal study. Here, the authors examine the association between the levels of ferritin, an iron storage protein, in the cerebrospinal fluid (CSF) of AD patients and show that CSF ferritin levels predict AD outcomes. 19 May 2015 | doi: 10.1038/ncomms7760 Biological Sciences  Medical research  Neuroscience  Targeted DNA degradation using a CRISPR device stably carried in the host genome OPEN Brian J. Caliando and Christopher A. Voigt The ability to contain and destroy synthetically engineered microorganisms is an important consideration with environmental, industrial and intellectual property implications. Here Caliando et al. design and demonstrate a stably integrated CRISPR-based system for targeted DNA destruction. 19 May 2015 | doi: 10.1038/ncomms7989 Biological Sciences  Biotechnology  Molecular biology  C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling OPEN Pingping Zhu, Yanying Wang, Ying Du, Lei He, Guanling Huang, Geng Zhang, Xinlong Yan and Zusen Fan Cancer stem cells are a small proportion of tumours that often confer resistance to chemotherapy but how these cells are maintained is unclear. Here, Zhu et al. study hepatocellular carcinoma stem cells and identify C8orf4 as a negative regulator of Notch2, which is required for the self-renewal of the cells. 19 May 2015 | doi: 10.1038/ncomms8122 Biological Sciences  Cancer  Medical research  Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance OPEN Mahima Swamy, Lucie Abeler-Dörner, James Chettle, Tanel Mahlakõiv, Delphine Goubau, Probir Chakravarty, George Ramsay, Caetano Reis e Sousa, Peter Staeheli, Barbara A. Blacklaws, Jonathan L. Heeney and Adrian C. Hayday Intraepithelial lymphocytes in the gut eliminate dysfunctional epithelial cells and promote regrowth of healthy cells. Here the authors show that, in addition, these lymphocytes protect cells against viral infections by rapidly activating interferon-dependent pathways in intestinal epithelial cells. 19 May 2015 | doi: 10.1038/ncomms8090 Biological Sciences  Immunology  Virology  Allele-specific analysis of DNA replication origins in mammalian cells OPEN Boris Bartholdy, Rituparna Mukhopadhyay, Julien Lajugie, Mirit I. Aladjem and Eric E. Bouhassira DNA sequences contribute to the location and timing of replication origin firings. Here by allele-specific analysis, the authors show that replication asynchrony is associated with small cumulative variations in the initiation efficiency of origins, rather than with the activation of dormant origins. 19 May 2015 | doi: 10.1038/ncomms8051 Biological Sciences  Genetics  Molecular biology  Change in ocean subsurface environment to suppress tropical cyclone intensification under global warming OPEN Ping Huang, I. -I Lin, Chia Chou and Rong-Hui Huang Changing atmospheric and oceanic environments under the effects of a warming climate are likely to influence the intensity of tropical cyclones. Here, the authors analyse 22 state-of-the-art climate models and show that future subsurface ocean environments might further suppress cyclone intensification. 18 May 2015 | doi: 10.1038/ncomms8188 Earth Sciences  Atmospheric science  Climate science  Strain induced fragility transition in metallic glass OPEN Hai-Bin Yu, Ranko Richert, Robert Maaß and Konrad Samwer The equivalency of stress and temperature as driving force for the relaxation in metallic glasses is widely accepted. Here, Yu et al. examine this assumption in simulations and find that stress induces a fragile-to-strong transition in addition to accelerated relaxation dynamics as temperature does. 18 May 2015 | doi: 10.1038/ncomms8179 Physical Sciences  Condensed matter  Physical chemistry  Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation OPEN Eun-Jae Lee, Hyejin Lee, Tzyy-Nan Huang, Changuk Chung, Wangyong Shin, Kyungdeok Kim, Jae-Young Koh, Yi-Ping Hsueh and Eunjoon Kim Zinc is a nutritional factor implicated in autism spectrum disorders (ASDs), but evidence for a strong association and linking mechanism is largely lacking. Here, the authors report that trans-synaptic zinc mobilization rapidly rescues social interaction in two independent mouse models of ASD. 18 May 2015 | doi: 10.1038/ncomms8168 Biological Sciences  Medical research  Neuroscience  Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis Jing Xue, Vishal Sharma, Michael H. Hsieh, Ajay Chawla, Ramachandran Murali, Stephen J. Pandol and Aida Habtezion Chronic pancreatitis is an inflammatory disease accompanied by fibrosis. Here the authors show that pancreatic stellate cells produce IL-4 and IL-13 that trigger alternative activation of macrophages, and that genetic or pharmacological inhibition of IL-4/IL-13 signaling ameliorates the disease. 18 May 2015 | doi: 10.1038/ncomms8158 Biological Sciences  Immunology  Medical research  Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages Mingyue Wen, Xianwei Ma, Hong Cheng, Wei Jiang, Xiongfei Xu, Yi Zhang, Yan Zhang, Zhenhong Guo, Yizhi Yu, Hongmei Xu, Cheng Qian, Xuetao Cao and Huazhang An Activation of innate immune responses is subject to versatile regulation. Here the authors show that a conserved LATS family kinase Stk38 limits proinflammatory signalling downstream of TLR9 in macrophages and protects mice from lethal sepsis by MEKK2 ubiquitination and degradation. 18 May 2015 | doi: 10.1038/ncomms8167 Biological Sciences  Immunology  Molecular biology  Rethinking Indian monsoon rainfall prediction in the context of recent global warming OPEN Bin Wang, Baoqiang Xiang, Juan Li, Peter J. Webster, Madhavan N. Rajeevan, Jian Liu and Kyung-Ja Ha Indian summer monsoon rainfall impacts millions of people and accurate forecasts are highly desirable, yet official operational forecasts have failed to predict extreme events in 1994, 2002, 2004 and 2009. Here, the authors use dynamical and physical–empirical models to investigate the reasons for this failure. 18 May 2015 | doi: 10.1038/ncomms8154 Earth Sciences  Atmospheric science  Climate science  PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium OPEN Michela Noseda, Mutsuo Harada, Sara McSweeney, Thomas Leja, Elisa Belian, Daniel J. Stuckey, Marta S. Abreu Paiva, Josef Habib, Iain Macaulay, Adam J. de Smith, Farah al-Beidh, Robert Sampson, R. Thomas Lumbers, Pulivarthi Rao, Sian E. Harding, Alexandra I. F. Blakemore, Sten Eirik Jacobsen, Mauricio Barahona and Michael D. Schneider Adult cardiac progenitor/stem cells (CPSCs) possess valuable potential for heart repair that is limited by the elusiveness of these cells. Here Noseda et al. refine the definition of murine CPSCs producing stem cell antigen 1 (Sca1), mapping the cardiogenic signature and clonogenicity to the subgroup of Sca1+ cells expressing PDGFRα. 18 May 2015 | doi: 10.1038/ncomms7930 Biological Sciences  Developmental biology  Medical research  Rise to modern levels of ocean oxygenation coincided with the Cambrian radiation of animals OPEN Xi Chen, Hong-Fei Ling, Derek Vance, Graham A. Shields-Zhou, Maoyan Zhu, Simon W. Poulton, Lawrence M. Och, Shao-Yong Jiang, Da Li, Lorenzo Cremonese and Corey Archer The Cambrian explosion of biological diversity has been associated with widespread ocean oxygenation, yet early Cambrian ocean redox conditions remain controversial. Here, the authors present a suite of molybdenum isotope data and show that the ocean was oxygenated to modern-like levels by 521 Ma. 18 May 2015 | doi: 10.1038/ncomms8142 Earth Sciences  Biogeochemistry  Palaeontology  STED nanoscopy with fluorescent quantum dots OPEN Janina Hanne, Henning J. Falk, Frederik Görlitz, Patrick Hoyer, Johann Engelhardt, Steffen J. Sahl and Stefan W. Hell STED nanoscopy enables sub-diffraction imaging with a wide range of fluorescent probes. Here, the authors show that a bright and very photostable class of fluorescent quantum dots can be super-resolved with STED as biolabels in cellular contexts. 18 May 2015 | doi: 10.1038/ncomms8127 Physical Sciences  Nanotechnology  Optical physics  Volcano seismicity and ground deformation unveil the gravity-driven magma discharge dynamics of a volcanic eruption Maurizio Ripepe, Dario Delle Donne, Riccardo Genco, Giuseppe Maggio, Marco Pistolesi, Emanuele Marchetti, Giorgio Lacanna, Giacomo Ulivieri and Pasquale Poggi Volcanic eruptions are thought to restore equilibrium when overpressure in the crust is induced by new magma rising from depth. Here, the authors use data from the 2007 Stromboli eruption as well as models to suggest that eruption is instead a consequence of the gravity-driven instability of the volcanic edifice. 18 May 2015 | doi: 10.1038/ncomms7998 Earth Sciences  Geology and geophysics  Crystallization seeds favour crystallization only during initial growth OPEN E. Allahyarov, K. Sandomirski, S.U. Egelhaaf and H. Löwen Crystallization is often heterogeneously seeded, but rarely the seeds are perfectly compatible with the thermodynamically favoured crystal structure. Here, Allahyarov et al. show that the seeds, although initially promoting crystallization, prevent the crystallite’s growth and lead to its detachment. 15 May 2015 | doi: 10.1038/ncomms8110 Physical Sciences  Condensed matter  Materials science  Physical chemistry  Atomistic design of microbial opsin-based blue-shifted optogenetics tools OPEN Hideaki E. Kato, Motoshi Kamiya, Seiya Sugo, Jumpei Ito, Reiya Taniguchi, Ayaka Orito, Kunio Hirata, Ayumu Inutsuka, Akihiro Yamanaka, Andrés D. Maturana, Ryuichiro Ishitani, Yuki Sudo, Shigehiko Hayashi and Osamu Nureki Retinal-bound opsins are widely used tools for optical control of neuronal activity in vivo, so called optogenetics. Here, using molecular simulations, biochemistry, electrophysiology and X-ray crystallography, the authors present new molecular design principles for the generation of blue-shifted variants of microbial rhodopsins. 15 May 2015 | doi: 10.1038/ncomms8177 Biological Sciences  Biophysics  Biotechnology  Coherent control of plasma dynamics Z.-H. He, B. Hou, V. Lebailly, J.A. Nees, K. Krushelnick and A.G.R. Thomas Intense laser pulses can induce the propagation of coherent waves through a plasma, which are useful for accelerating electrons. Here, the authors use a genetic algorithm and a deformable mirror to optimize the wavefront and improve electron beam intensity and divergence. 15 May 2015 | doi: 10.1038/ncomms8156 Physical Sciences  Fluids and plasma physics  Optical physics  Clean carbon nanotubes coupled to superconducting impedance-matching circuits V. Ranjan, G. Puebla-Hellmann, M. Jung, T. Hasler, A. Nunnenkamp, M. Muoth, C. Hierold, A. Wallraff and C. Schönenberger Radio-frequency circuits offer fast low-noise detection of signals in carbon nanotubes, but incompatibilities in fabrication degrade the performance of the hybrid device. Here, the authors use a deterministic mechanical transfer to couple pristine nanotubes to a gigahertz superconducting matching circuit. 15 May 2015 | doi: 10.1038/ncomms8165 Physical Sciences  Applied physics  Nanotechnology  Structural optimization of 3D-printed synthetic spider webs for high strength OPEN Zhao Qin, Brett G. Compton, Jennifer A. Lewis and Markus J. Buehler Spider webs have some intriguing mechanical properties, but understanding of the properties is limited to individual silk fibres. Here, the authors create mimics of spider web using 3D techniques, which enables them to acquire knowledge of mechanical strength of the entire synthetic web. 15 May 2015 | doi: 10.1038/ncomms8038 Physical Sciences  Biotechnology  Materials science  Wave energy budget analysis in the Earth’s radiation belts uncovers a missing energy OPEN A.V. Artemyev, O.V. Agapitov, D. Mourenas, V.V. Krasnoselskikh and F.S. Mozer Whistler-mode waves regulate trapped electrons in the magnetosphere, but an accurate determination of their energy budget has remained elusive. This study presents a full analysis of their magnetic and electric field contributions and finds that a large amount of energy is stored in oblique waves. 15 May 2015 | doi: 10.1038/ncomms8143 Physical Sciences  Astronomy  Fluids and plasma physics  Planetary sciences  Wearable red–green–blue quantum dot light-emitting diode array using high-resolution intaglio transfer printing OPEN Moon Kee Choi, Jiwoong Yang, Kwanghun Kang, Dong Chan Kim, Changsoon Choi, Chaneui Park, Seok Joo Kim, Sue In Chae, Tae-Ho Kim, Ji Hoon Kim, Taeghwan Hyeon and Dae-Hyeong Kim Deformable and high-resolution LEDs have attracted great interest for wearable electronics, but full-colour display is still challenging. Using a stamp printing technology, Choi et al. build ultra-thin RGB quantum dot pixel arrays with luminous efficiency of 14,000 cd m−2 operated at low voltage of 7 V. 14 May 2015 | doi: 10.1038/ncomms8149 Physical Sciences  Materials science  Nanotechnology  Long-term decline in grassland productivity driven by increasing dryness OPEN E. N. J. Brookshire and T. Weaver How primary production is influenced by climatic forcing has not been tested in most ecosystems. Here, the authors study a four-decade record of grassland production and find a sustained decline in above-ground net primary production attributable to increased aridity from declining late-summer rainfall. 14 May 2015 | doi: 10.1038/ncomms8148 Biological Sciences  Biogeochemistry  Climate science  Ecology  Exploring the quantum critical behaviour in a driven Tavis–Cummings circuit OPEN M. Feng, Y.P. Zhong, T. Liu, L.L. Yan, W.L. Yang, J. Twamley and H. Wang Quantum phase transitions are a discontinuous change in a property of the ground state or the structure of the excited states as a system parameter traverses a critical point. Here, the authors recreate analogous effects with laboratory-achievable light-matter coupling in an on-chip superconducting circuit 14 May 2015 | doi: 10.1038/ncomms8111 Physical Sciences  Applied physics  Condensed matter  A carbon nanotube wall membrane for water treatment Byeongho Lee, Youngbin Baek, Minwoo Lee, Dae Hong Jeong, Hong H. Lee, Jeyong Yoon and Yong Hyup Kim Carbon nanotubes have been proposed for many forms of water treatment, although ultrafiltration nanotube-based membranes with very high flow rates remain rare. Here, the authors fabricate a membrane delivering water permeability close to 30,000 litres per square meter per hour at 1 bar. 14 May 2015 | doi: 10.1038/ncomms8109 Chemical Sciences  Materials science  Nanotechnology  Muscle stem cells contribute to myofibres in sedentary adult mice Alexandra C. Keefe, Jennifer A. Lawson, Steven D. Flygare, Zachary D. Fox, Mary P. Colasanto, Sam J. Mathew, Mark Yandell and Gabrielle Kardon Skeletal muscle satellite cells are muscle stem cells believed to contribute only to regenerating myofibres. Here Keefe et al. show that in adult sedentary mice satellite cells continue to fuse with uninjured myofibres, but they are not globally required for the maintenance of aging muscles. 14 May 2015 | doi: 10.1038/ncomms8087 Biological Sciences  Medical research  Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing Maayan Salton, Wojciech K. Kasprzak, Ty Voss, Bruce A. Shapiro, Poulikos I. Poulikakos and Tom Misteli BRAF inhibitors have shown encouraging clinical effects in melanoma patients; however, patients rapidly develop resistance via different mechanisms including alternative splicing. Here the authors find a specific mutation affecting BRAF splicing and highlight the therapeutic potential of splicing interference. 14 May 2015 | doi: 10.1038/ncomms8103 Biological Sciences  Cancer  Molecular biology  Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency OPEN Young Eun Kim, Yu-na Kim, Jung A. Kim, Ho Min Kim and Yongwon Jung Supramolecular protein assemblies can provide novel nano-architectures with diverse structures and functions. Here, the authors report a fabrication strategy for a series of monodisperse protein oligomers, which allows valency-controlled display of various functional proteins. 14 May 2015 | doi: 10.1038/ncomms8134 Biological Sciences  Biotechnology  Nanotechnology  Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes OPEN Henry R. Hampton, Jacqueline Bailey, Michio Tomura, Robert Brink and Tatyana Chtanova Both sterile and microbial injuries lead to rapid neutrophil recruitment to the site of inflammation. Here the authors show that only neutrophils responding to microbial ligands leave inflamed skin and migrate to draining lymph nodes where they stimulate lymphocyte proliferation. 14 May 2015 | doi: 10.1038/ncomms8139 Biological Sciences  Immunology  Exotic topological density waves in cold atomic Rydberg-dressed fermions OPEN Xiaopeng Li and S Das Sarma Rydberg atomic gases have proven a fertile playground for exploring exotic phases of condensed matter systems. Here, Li and Das Sarma study Rydberg-dressed atomic fermions in a 3D optical lattice and find a series of mixed topological density wave phases having no analogue in conventional materials. 14 May 2015 | doi: 10.1038/ncomms8137 Physical Sciences  Atomic and molecular physics  Condensed matter  Theoretical physics  Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin Beeke Wienert, Alister P. W. Funnell, Laura J. Norton, Richard C. M. Pearson, Lorna E. Wilkinson-White, Krystal Lester, Jim Vadolas, Matthew H. Porteus, Jacqueline M. Matthews, Kate G. R. Quinlan and Merlin Crossley Adult expression of fetal haemoglobin is beneficial and thus desirable in patients with haemoglobin disorders. Here the authors introduce a naturally occurring mutation in the γ-globin promoter and show that it causes binding of an activator TAL1, chromosome looping and revival of fetal haemoglobin expression in erythroid cells. 14 May 2015 | doi: 10.1038/ncomms8085 Biological Sciences  Cell biology  Medical research  Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters OPEN Charles P. Lai, Edward Y. Kim, Christian E. Badr, Ralph Weissleder, Thorsten R. Mempel, Bakhos A. Tannous and Xandra O. Breakefield Extracellular vesicles (EVs) act as a conduit for intercellular communication through the exchange of cellular materials without direct cell-to-cell contacts. Here the authors develop a multiplexed reporter system that allows monitoring of EV exchange, cargo delivery and protein translation between different cell populations. 13 May 2015 | doi: 10.1038/ncomms8029 Biological Sciences  Cell biology  Molecular biology  Directional cell movement through tissues is controlled by exosome secretion OPEN Bong Hwan Sung, Tatiana Ketova, Daisuke Hoshino, Andries Zijlstra and Alissa M. Weaver How cells maintain directional polarity when migrating through a complex environment is not well understood. Here Sung et al. show that autocrine exosome secretion is required for persistent and efficient in vivo cancer cell motility and promotes assembly of adhesion complexes by delivering fibronectin-bound exosomes. 13 May 2015 | doi: 10.1038/ncomms8164 Biological Sciences  Cell biology  Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency OPEN Hongwei Chen, Irène Aksoy, Fabrice Gonnot, Pierre Osteil, Maxime Aubry, Claire Hamela, Cloé Rognard, Arnaud Hochard, Sophie Voisin, Emeline Fontaine, Magali Mure, Marielle Afanassieff, Elouan Cleroux, Sylvain Guibert, Jiaxuan Chen, Céline Vallot, Hervé Acloque, Clémence Genthon, Cécile Donnadieu, John De Vos et al. LIF/STAT3 signalling characterizes naive pluripotency in mouse embryonic stem cells (ESCs), but whether this pathway can sustain a similar state in human cells is not completely understood. Here the authors show that LIF stimulation and enhancement of STAT3 activity allow human ESCs to escape from FGF2 dependency and facilitates their entry into a naive-like state of pluripotency. 13 May 2015 | doi: 10.1038/ncomms8095 Biological Sciences  Cell biology  Developmental biology  Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity J. David Peske, Elizabeth D. Thompson, Lelisa Gemta, Richard A. Baylis, Yang-Xin Fu and Victor H. Engelhard The presence of lymph node-like vasculature in tumours correlates with positive prognosis, but the mechanisms by which it forms and affects tumour growth are unclear. Here the authors show that it is induced by CD8 and NK cells, and supports naive T cells’ differentiation into antitumour effectors. 13 May 2015 | doi: 10.1038/ncomms8114 Biological Sciences  Cancer  Immunology  Contrasting host–pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes OPEN Christopher A. Desjardins, Neil D. Sanscrainte, Jonathan M. Goldberg, David Heiman, Sarah Young, Qiandong Zeng, Hiten D. Madhani, James J. Becnel and Christina A Cuomo Microsporidia are intracellular parasitic fungi that infect diverse animal hosts including humans. Here, Desjardins et al. present genomic and transcriptomic data for two microsporidia that infect disease-transmitting mosquitoes, highlighting differences in potential host interplay mechanisms. 13 May 2015 | doi: 10.1038/ncomms8121 Biological Sciences  Evolution  Genetics  Microbiology  The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells Bing Zhao, Zhen Qi, Yehua Li, Chongkai Wang, Wei Fu and Ye-Guang Chen Colitis is a common human disorder but the clinical interventions are limited as the pathological mechanisms are not very clear. Here the authors find an elevated expression of non-muscle-myosin-II heavy chain Myh9 in a colitis mouse model, and show that Myh9 expression reduction or activity inhibition ameliorates epithelial injuries. 13 May 2015 | doi: 10.1038/ncomms8166 Biological Sciences  Cell biology  Medical research  Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese OPEN Changgui Li, Zhiqiang Li, Shiguo Liu, Can Wang, Lin Han, Lingling Cui, Jingguo Zhou, Hejian Zou, Zhen Liu, Jianhua Chen, Xiaoyu Cheng, Zhaowei Zhou, Chengcheng Ding, Meng Wang, Tong Chen, Ying Cui, Hongmei He, Keke Zhang, Congcong Yin, Yunlong Wang et al. Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al. conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout. 13 May 2015 | doi: 10.1038/ncomms8041 Biological Sciences  Genetics  Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells OPEN Zhongfang Wang, Yanmin Wan, Chenli Qiu, Sergio Quiñones-Parra, Zhaoqin Zhu, Liyen Loh, Di Tian, Yanqin Ren, Yunwen Hu, Xiaoyan Zhang, Paul G. Thomas, Michael Inouye, Peter C. Doherty, Katherine Kedzierska and Jianqing Xu H7N9 avian influenza viruses can cause severe human disease. Here, the authors analyse blood samples from hospitalized H7N9 patients and show that a diversity of immune mechanisms seem to influence disease length and outcome. 13 May 2015 | doi: 10.1038/ncomms7833 Biological Sciences  Immunology  Medical research  Virology  FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization OPEN Tsuyoshi Udagawa, Yusuke Fujioka, Motoki Tanaka, Daiyu Honda, Satoshi Yokoi, Yuichi Riku, Daisuke Ibi, Taku Nagai, Kiyofumi Yamada, Hirohisa Watanabe, Masahisa Katsuno, Toshifumi Inada, Kinji Ohno, Masahiro Sokabe, Haruo Okado, Shinsuke Ishigaki and Gen Sobue FUS is an RNA/DNA-binding protein involved in gene expression regulation and associated with amyotrophic lateral sclerosis and frontotemporal dementia (FTLD) but the disease-causing mechanisms are unclear. Here the authors show that FUS regulates the stability of GluA1 mRNA and dendritic maturation and plays a role in FTLD-associated behaviours. 13 May 2015 | doi: 10.1038/ncomms8098 Biological Sciences  Neuroscience  Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 OPEN Karen F.S. Bell, Bashayer Al-Mubarak, Marc-André Martel, Sean McKay, Nicola Wheelan, Philip Hasel, Nóra M. Márkus, Paul Baxter, Ruth F. Deighton, Andrea Serio, Bilada Bilican, Sudhir Chowdhry, Paul J. Meakin, Michael L.J. Ashford, David J.A. Wyllie, Robert H. Scannevin, Siddharthan Chandran, John D. Hayes and Giles E. Hardingham Neurons in the brain are more susceptible to oxidative stress than astroglial cells but the molecular basis and biological reasons for this are poorly understood. Here the authors show that developing cortical neurons have reduced levels of the antioxidant transcription factor Nrf2 due to epigenetic silencing and that this is necessary for proper neuronal development. 13 May 2015 | doi: 10.1038/ncomms8066 Biological Sciences  Developmental biology  Neuroscience    Nature communications JOBS of the week Postdoctoral Fellow Thomas Jefferson University (TJU) Vandervell Postdoctoral Fellowship University of Exeter Research Assistant / Associate x 2 (Fixed Term) University of Cambridge Postdoctoral Associates MIT Postdoctoral Researcher NUI Galway Research Assistant / Associate University of Glasgow Post-Doctoral Research Associate Texas Tech University Health Sciences Center Group Leader Positions Medical Research Council Postdoc Position Hannover Medical School (MHH) Postdoctoral Fellow University of Arkansas for Medical Sciences More Science jobs from Nature communications EVENT The 15th International Conference on Progress in Vaccination Against Cancer (PIVAC-15) 06.10.15 Tübingen, Germany More science events from       Latest Corrigenda     Corrigendum: Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster Adam J. Dobson, John M. Chaston, Peter D. Newell, Leanne Donahue, Sara L. Hermann, David R. Sannino, Stephanie Westmiller, Adam C.-N. Wong, Andrew G. Clark, Brian P. Lazzaro and Angela E. Douglas 15 May 2015 | doi: 10.1038/ncomms8296 Biological Sciences  Genetics  Microbiology      Corrigendum: MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs Prabhakar Tiwari, Garima Arora, Mamta Singh, Saqib Kidwai, Om Prakash Narayan and Ramandeep Singh 15 May 2015 | doi: 10.1038/ncomms8273 Biological Sciences  Microbiology  Molecular biology      Corrigendum: Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence I. Gonzalez-Valdes, I. Hidalgo, A. Bujarrabal, E. Lara-Pezzi, L. Padron-Barthe, P. Garcia-Pavia, Pablo Gómez-del Arco, J.M. Redondo, J.M. Ruiz-Cabello, L.J. Jimenez-Borreguero, J.A. Enriquez, J.L. de la Pompa, A. Hidalgo and S. Gonzalez 14 May 2015 | doi: 10.1038/ncomms8242 Biological Sciences  Medical research      Advertisement Nature Nanotechnology Focus on Spin-transfer-torque memory  Access the Focus for FREE  Produced with exclusive support from Spin Transfer Technologies     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.