Scientific Reports Biology Table of Contents e-alert: 28 April 2015

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28 April 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         1st Nature Immunology - Cellular & Molecular Immunology Joint Conference: Inflammation, Stress and Immune Homeostasis June 17-19, 2015 | The Swan Lake Hotel, Hefei, China  Register Now!           Biological Sciences               Fluorescence-Activated Cell Sorting Analysis of Heterotypic Cell-in-Cell Structures ▶     Meifang He, Hongyan Huang, Manna Wang et al.     Cell-in-cell structures (CICs), characterized by the presence of one or more viable cells inside another one, were recently found important player in development, immune …             Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications ▶     Daniel M. Czajkowsky, Jan Terje Andersen, Anja Fuchs et al.     The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated …             Nucleotide Sequence-Homology-Independent Breakdown of Transgenic Resistance by More Virulent Virus Strains and a Potential Solution ▶     Yi-Jung Kung, Bang-Jau You, Joseph A. J. Raja et al.     Controlling plant viruses by genetic engineering, including the globally important Papaya ringspot virus (PRSV), mainly involves coat protein (CP) gene mediated resistance via …             FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis ▶     Liang Sun, Caiyou Hu, Chenguang Zheng et al.     Forkhead box class O (FOXO) transcription factors play a crucial role in longevity across species. Several polymorphisms in FOXO3 were previously reported to be associated with …             Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) ▶     M. Fernanda Lima-Costa, Laura C. Rodrigues, Maurício L. Barreto et al.     Brazil never had segregation laws defining membership of an ethnoracial group. Thus, the composition of the Brazilian population is mixed, and its ethnoracial classification is …             Chemical proteomic identification of T-plastin as a novel host cell response factor in HCV infection ▶     Young-Hwa Yoo, JiHyeon Yun, Chang No Yoon et al.     Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease that currently affects at least 170 million people worldwide. Although significant efforts have …             From 2D to 3D: novel nanostructured scaffolds to investigate signalling in reconstructed neuronal networks ▶     Susanna Bosi, Rossana Rauti, Jummi Laishram et al.     To recreate in vitro 3D neuronal circuits will ultimately increase the relevance of results from cultured to whole-brain networks and will promote enabling technologies for …             A sensitive label–free amperometric immunosensor for alpha-fetoprotein based on gold nanorods with different aspect ratio ▶     Chunyang Zhou, Dali Liu, Lin Xu et al.     A simple and accurate label–free amperometric immunosensor for α–fetoprotein (AFP) detection is developed based on gold nanorods (GNRs) with different aspect ratio and compared …             Neuroreceptor Activation by Vibration-Assisted Tunneling ▶     Ross D. Hoehn, David Nichols, Hartmut Neven et al.     G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction …             Extremely High Brightness from Polymer-Encapsulated Quantum Dots for Two-photon Cellular and Deep-tissue Imaging ▶     Yanyan Fan, Helin Liu, Rongcheng Han et al.     Materials possessing high two photon absorption (TPA) are highly desirable for a range of fields, such as three-dimensional data storage, TP microscopy (TPM) and photodynamic …             Synergistic Protection of N-Acetylcysteine and Ascorbic Acid 2-Phosphate on Human Mesenchymal Stem cells Against Mitoptosis, Necroptosis and Apoptosis ▶     Chia-Jung Li, Li-Yi Sun, Cheng-Yoong Pang     Human mesenchymal stem cells (hMSCs) contribute to ischemic tissue repair, regeneration, and possess ability to self-renew. However, poor viability of transplanted hMSCs within …             Loss of PTPRM Associates with the Pathogenic Development of Colorectal Adenoma-Carcinoma Sequence ▶     Putty-Reddy Sudhir, Shiu-Ting Lin, Chien Chia-Wen et al.     Identification and functional analysis of genes from genetically altered chromosomal regions would suggest new molecular targets for cancer diagnosis and treatment. Here we …             Ddx1 knockout results in transgenerational wild-type lethality in mice ▶     Matthew R. Hildebrandt, Devon R. Germain, Elizabeth A. Monckton et al.     DEAD box 1 (DDX1) is a member of the DEAD box family of RNA helicases which are involved in all aspects of RNA metabolism. DDX1 has been implicated in a variety of biological …             MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function ▶     Fang Ni, Chuang Guo, Rui Sun et al.     Natural killer (NK) cells are critical effectors in the immune response against malignancy and infection, and microRNAs (miRNAs) play important roles in NK cell biology. Here we …             Droplet-interface-bilayer assays in microfluidic passive networks ▶     Bárbara Schlicht, Michele Zagnoni     Basic biophysical studies and pharmacological processes can be investigated by mimicking the intracellular and extracellular environments across an artificial cell membrane …             An Ordovician variation on Burgess Shale-type biotas ▶     Joseph P. Botting, Lucy A. Muir, Naomi Jordan et al.     The Cambrian Burgess Shale-type biotas form a globally consistent ecosystem, usually dominated by arthropods. Elements of these communities continued into the Early Ordovician at …             A modelling methodology to assess the effect of insect pest control on agro-ecosystems ▶     Nian-Feng Wan, Xiang-Yun Ji, Jie-Xian Jiang et al.     The extensive use of chemical pesticides for pest management in agricultural systems can entail risks to the complex ecosystems consisting of economic, ecological and social …             Association of CD8+ T lymphocyte repertoire spreading with the severity of DRESS syndrome ▶     Jun Niu, Qingzhu Jia, Qingshan Ni et al.     T-cell receptor (TCR)-mediated cross-recognition is a major mechanism in the pathogenesis of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. However, the …             Mechanistic Insights into Elastin Degradation by Pseudolysin, the Major Virulence Factor of the Opportunistic Pathogen Pseudomonas aeruginosa ▶     Jie Yang, Hui-Lin Zhao, Li-Yuan Ran et al.     Pseudolysin is the most abundant protease secreted by Pseudomonas aeruginosa and is the major extracellular virulence factor of this opportunistic human pathogen. Pseudolysin …             Deciphering the Venomic Transcriptome of Killer-Wasp Vespa velutina ▶     Zhirui Liu, Shuanggang Chen, You Zhou et al.     Wasp stings have been arising to be a severe public health problem in China in recent years. However, molecular information about lethal or toxic factors in wasp venom is …             Antibacterial activity of silver-killed bacteria: the "zombies" effect ▶     Racheli Ben-Knaz Wakshlak, Rami Pedahzur, David Avnir     We report a previously unrecognized mechanism for the prolonged action of biocidal agents, which we denote as the zombies effect: biocidally-killed bacteria are capable of killing …             Illusory ownership of an invisible body reduces autonomic and subjective social anxiety responses ▶     Arvid Guterstam, Zakaryah Abdulkarim, H. Henrik Ehrsson     What is it like to be invisible? This question has long fascinated man and has been the central theme of many classic literary works. Recent advances in materials science suggest …             Oxygen-induced cell migration and on-line monitoring biomarkers modulation of cervical cancers on a microfluidic system ▶     Xuexia Lin, Qiushui Chen, Wu Liu et al.     In this work, we report an integrated microfluidic device for cell co-culture under different concentrations of oxygen, in which the secreted protein VEGF165 was on-line …             Development of a 3D printer using scanning projection stereolithography ▶     Michael P. Lee, Geoffrey J. T. Cooper, Trevor Hinkley et al.     We have developed a system for the rapid fabrication of low cost 3D devices and systems in the laboratory with micro-scale features yet cm-scale objects. Our system is inspired by …             Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis ▶     Fuqiang Chen, Qingshu Li, Yang Yu et al.     A dose-response meta-analysis was conducted to assess the association of vitamin C, D, E with risk of bladder cancer. Pertinent studies were identified in PubMed and Embase. The …             Red Queen dynamics in multi-host and multi-parasite interaction system ▶     Jomar F. Rabajante, Jerrold M. Tubay, Takashi Uehara et al.     In host-parasite systems, dominant host types are expected to be eventually replaced by other hosts due to the elevated potency of their specific parasites. This leads to changes …             Variations in the non-coding transcriptome as a driver of inter-strain divergence and physiological adaptation in bacteria ▶     Matthias Kopf, Stephan Klähn, Ingeborg Scholz et al.     In all studied organisms, a substantial portion of the transcriptome consists of non-coding RNAs that frequently execute regulatory functions. Here, we have compared the primary …             Prognostic value of serum cytokeratin 19 fragments (Cyfra 21-1) in patients with non-small cell lung cancer ▶     Youtao Xu, Lei Xu, Mantang Qiu et al.     The role of serum CYFRA 21-1 level in patients with non-small cell lung cancer (NSCLC) remains to be defined. To re-evaluate the impact of serum CYFRA 21-1 in NSCLC survival, we …             Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation ▶     Yejing Weng, Zhigang Sui, Hao Jiang et al.     Due to the important roles of N-glycoproteins in various biological processes, the global N-glycoproteome analysis has been paid much attention. However, by current strategies for …             Hypothermic temperature effects on organ survival and restoration ▶     Jun Ishikawa, Masamitsu Oshima, Fumitaka Iwasaki et al.     A three-dimensional multicellular organism maintains the biological functions of life support by using the blood circulation to transport oxygen and nutrients and to regulate body …             Direct ethanol production from starch using a natural isolate, Scheffersomyces shehatae: Toward consolidated bioprocessing ▶     Ayumi Tanimura, Minako Kikukawa, Shino Yamaguchi et al.     Consolidated bioprocessing (CBP), which integrates enzyme production, saccharification and fermentation into a one-step process, is a promising strategy for cost-effective ethanol …             NMR spectroscopy reveals the presence and association of lipids and keratin in adhesive gecko setae ▶     Dharamdeep Jain, Alyssa Y. Stark, Peter H. Niewiarowski et al.     Lipid and protein aggregates are one of the fundamental materials of biological systems. Examples include cell membranes, insect cuticle, vertebrate epidermis, feathers, hair and …             Functional Optical Coherence Tomography Enables In Vivo Physiological Assessment of Retinal Rod and Cone Photoreceptors ▶     Qiuxiang Zhang, Rongwen Lu, Benquan Wang et al.     Transient intrinsic optical signal (IOS) changes have been observed in retinal photoreceptors, suggesting a unique biomarker for eye disease detection. However, clinical …             The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells ▶     Basudev Chowdhury, Andrew McGovern, Yi Cui et al.     The USFDA approved “epigenetic drug”, Decitabine, exerts its effect by hypomethylating DNA, demonstrating the pivotal role aberrant genome-wide DNA methylation patterns play in …             Dynamic Distribution of the Gut Microbiota and the Relationship with Apparent Crude Fiber Digestibility and Growth Stages in Pigs ▶     Qing Niu, Pinghua Li, Shuaishuai Hao et al.     The gut microbiota plays an important role in nutrient digestibility in animals. To examine changes in the pig gut microbiota across growth stages and its effects on nutrient …             Structural basis for cooperative oxygen binding and bracelet-assisted assembly of Lumbricus terrestris hemoglobin ▶     Wei-Ting Chen, Yu-Chuen Chen, Horng-Huei Liou et al.     The iron-containing hemoglobins (Hbs) are essential proteins to serve as oxygen transporters in the blood. Among various kinds of Hbs, the earthworm Hbs are the champions in …             Effects of substrate conductivity on cell morphogenesis and proliferation using tailored, atomic layer deposition-grown ZnO thin films ▶     Won Jin Choi, Jongjin Jung, Sujin Lee et al.     We demonstrate that ZnO films grown by atomic layer deposition (ALD) can be employed as a substrate to explore the effects of electrical conductivity on cell adhesion, …             Yeast nitrogen utilization in the phyllosphere during plant lifespan under regulation of autophagy ▶     Kosuke Shiraishi, Masahide Oku, Kosuke Kawaguchi et al.     Recently, microbe-plant interactions at the above-ground parts have attracted great attention. Here we describe nitrogen metabolism and regulation of autophagy in the …             Segregation of information about emotional arousal and valence in horse whinnies ▶     Elodie F. Briefer, Anne-Laure Maigrot, Roi Mandel et al.     Studying vocal correlates of emotions is important to provide a better understanding of the evolution of emotion expression through cross-species comparisons. Emotions are …             Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin ▶     King Chi Chan, Lai Sheung Chan, Joseph Chok Yan Ip et al.     Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with …             Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells ▶     Simona Daniele, Barbara Costa, Elisa Zappelli et al.     The poor prognosis of Glioblastoma Multiforme (GBM) is due to a high resistance to conventional treatments and to the presence of a subpopulation of glioma stem cells (GSCs). …             Recombinant Mutated Human TNF in Combination with Chemotherapy for Stage IIIB/IV Non-Small Cell Lung Cancer: A Randomized, Phase III Study ▶     Xiaowen Ma, Yang Song, Kuo Zhang et al.     Tumor necrosis factor (TNF), an anti-angiogenic agent in cancer treatment, is limited to isolated limb perfusion due to systemic toxicities. We previously prepared a TNF mutant …             Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat ▶     Hemmings Wu, Hartwin Ghekiere, Dorien Beeckmans et al.     Conventional deep brain stimulation (DBS) applies constant electrical stimulation to specific brain regions to treat neurological disorders. Closed-loop DBS with real-time …                 Introducing HGV Database The HGV Database is a fully searchable online database of genome variations published in peer-reviewed Data Reports in Human Genome Variation   Search and filter by specific disease, gene, region, population. 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