Nature Reviews Drug Discovery contents May 2015 Volume 14 Number 5 pp 295-365

If you are unable to see the message below, click here to view.

Advertisement
NEW WHITE PAPER: Xenograft Host Selection - Important Factors for Experimental Success  Genetically engineered mouse models are an integral part of understanding tumor biology, validating in vitro findings, and mimicking disease progression. This Paper explores: 5 critical elements to in-vivo study design Spontaneous immune deficient mice utility GEM application in Oncology research Download Now
TABLE OF CONTENTS
May 2015 Volume 14 Number 5		Advertisement
Impact Factor 37.231 *	In this issue Comment News and Analysis Research Highlights Reviews Also this month  Featured article: New treatment options for hearing loss Ulrich Müller & Peter G. Barr-Gillespie	CRISPR sgRNA Library: Download Tech Note Individually cloned, sequenced and cultured. Comprehensive representation of sgRNAs 7 premade libraries or custom options available. Pooled or singularly arrayed options
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities
Comment: From silos to systems: an integrated approach to neuroscience innovation Donald T. Stuss p295 | doi:10.1038/nrd4615 The Ontario Brain Institute manages a network of partnerships among researchers, clinicians, industry representatives and patients to maximize their collective impact on developing better treatment and care for those living with brain disorders. Abstract | Full Text | PDF
NEWS AND ANALYSIS		Top
Drug developers reboot anti-NGF pain programmes Asher Mullard p297 | doi:10.1038/nrd4612 Pfizer, Eli Lilly, Janssen and Regeneron are advancing a promising class of analgesic drugs, hoping to put concerns around autonomic dysfunction and joint destruction behind them. PDF
March of the synthesis machines Katharine Sanderson p299 | doi:10.1038/nrd4613 What impact will advances in automated chemical synthesis have for medicinal chemists? PDF
NEWS IN BRIEF CAR–T cell companies cash in Asher Mullard p301 | doi:10.1038/nrd4634 PDF
DPP4 inhibitors dodge cardiovascular bullet Asher Mullard p301 | doi:10.1038/nrd4635 PDF
Phase II antisense sets Crohn disease precedents Asher Mullard p301 | doi:10.1038/nrd4636 PDF
BIOBUSINESS BRIEFS Regulatory watch: Impact of scientific advice from the European Medicines Agency Matthias P. Hofer, Christina Jakobsson, Nikolaos Zafiropoulos, Spiros Vamvakas, Thorsten Vetter, Jan Regnstrom & Robert J. Hemmings p302 | doi:10.1038/nrd4621 PDF
BIOBUSINESS BRIEFS Patent watch: Have the biosimilar floodgates been opened in the United States? Courtenay C. Brinckerhoff & Kristel Schorr p303 | doi:10.1038/nrd4622 PDF
AN AUDIENCE WITH Dirk Gevers p305 | doi:10.1038/nrd4614 Dirk Gevers, Head of the Janssen Human Microbiome Institute, discusses Janssen's plan to be a first mover in the microbiome space. PDF
FROM THE ANALYST'S COUCH Changes in clinical trial length Lisette Pregelj, Martie-Louise Verreynne & Damian Hine p307 | doi:10.1038/nrd4611 This analysis of changes in the length of clinical trials over time provides evidence of increased efficiency in drug development and investigates the possible contributing factors. PDF
RESEARCH HIGHLIGHTS Top Cancer: Multifunctional nanodevice reverses drug resistance p309 | doi:10.1038/nrd4617 PDF CNS injury: Microtubule stabilizer repairs spinal cord injury p310 | doi:10.1038/nrd4616 PDF Cardiovascular disease: PDE9A inhibition mends broken hearts p310 | doi:10.1038/nrd4618 PDF Anticancer drugs: Advancing precision medicine in silico p311 | doi:10.1038/nrd4619 PDF Cancer immunotherapy: Primed for a response p312 | doi:10.1038/nrd4620 PDF IN BRIEF Metabolic disease: Cough suppressant reverses diabetes | Kidney injury: TRIM family protein protects the kidney | Infectious disease: Disrupting two-pore channels blocks Ebola virus infection | Epilepsy: LDH inhibition suppresses seizures PDF Drug Discovery JOBS of the week Postdoc in albumin-based drug delivery Aarhus University Postdoctoral Scientist Texas Biomedical Research Institute Post-doctoral position in Biomedical Research Case Western Reserve University Research Fellow Mayo Clinic - Rochester Postdoctoral position in biochemistry (membrane transporters) Université catholique de Louvain (UCL) More Science jobs from Drug Discovery EVENT Phenotypic and Biomarker-Based Drug Discovery 27.10.15 New York, USA More science events from
REVIEWS		Top
Targeting the sarcomere to correct muscle function Peter M. Hwang & Brian D. Sykes p313 | doi:10.1038/nrd4554 The balance between muscle contraction and relaxation is disrupted in various human diseases, including heart failure, cardiomyopathies, skeletal myopathies and neuromuscular conditions. Here, Hwang and Sykes discuss therapeutic strategies aimed at modulating the mechanical function of the sarcomere, focusing on agents that affect the function of myosin or the troponin complex. Abstract | Full Text | PDF
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter John L. Wallace & Rui Wang p329 | doi:10.1038/nrd4433 Hydrogen sulfide (H2S) is a ubiquitous gaseous signalling molecule with a plethora of important roles. In this Review, Wallace and Wang describe the pathways for the synthesis and metabolism of H2S and its major mechanisms of action in health and in disease processes, before discussing examples of attempts to exploit the actions of H2S in the design of novel drugs. Abstract | Full Text | PDF
New treatment options for hearing loss Ulrich Muller & Peter G. Barr-Gillespie p346 | doi:10.1038/nrd4533 Hearing loss, which is caused by both genetic and environmental factors, is the most common form of sensory impairment in humans. Current treatment relies on medical devices and there are no drug-based therapies available. Here, Muller and Barr-Gillespie review the various forms of hearing loss, highlight emerging pharmacological targets and discuss the potential of regenerative medicine and gene therapy to restore auditory function. Abstract | Full Text | PDF
Erratum: HDAC inhibitors still need a home run, despite recent approval Malini Guha p365 | doi:10.1038/nrd4632 Full Text | PDF
Erratum: A holistic approach to targeting disease with polymeric nanoparticles Christopher J. Cheng, Gregory T. Tietjen, Jennifer K. Saucier-Sawyer & W. Mark Saltzman p365 | doi:10.1038/nrd4633 Full Text | PDF
Advertisement
The Naturejobs Career Expo is returning to Boston! May 20, 2015 This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries, such as pharmaceutical organisations, digital technology companies, science publishing and more. Register for FREE today!
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2013 Journal Citation Report (Thomson Reuters, 2014)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.