Nature Cell Biology contents: May 2015 Volume 17 Number 5, pp 533-706

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TABLE OF CONTENTS May 2015 Volume 17, Issue 5 Review News and Views Articles Letters Corrigendum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement MSC Scientific Editing gives your research article a high-quality scientific edit that can help you make an impact on your intended audience. Nature-standard editing - English language edit included - Specialist editors in your subject area. Find out more today.    Review Top E-cadherin junctions as active mechanical integrators in tissue dynamics   pp533 - 539 Thomas Lecuit and Alpha S. Yap doi:10.1038/ncb3136 Yap and Lecuit review the interplay of E-cadherin-mediated adhesion and actomyosin-based contractility, and discuss the functional effects of their crosstalk at the cellular and tissue level. News and Views Top A modular tethering complex for endosomal recycling   pp540 - 541 Yann Desfougères, Massimo D'Agostino and Andreas Mayer doi:10.1038/ncb3154 How proteins migrate through the interconnected organelles of the endolysosomal system is poorly understood. A piece of the puzzle has been added with the identification of a complex of tethering factors that functions in the recycling of proteins towards the cell surface. See also: Article by Schindler et al. Linking primary and metastatic tumour re-initiation   pp542 - 543 Barzin Y. Nabet and Andy J. Minn doi:10.1038/ncb3173 Whether the cancer cells responsible for the growth of primary tumours are also able to re-initiate tumour growth after seeding to distant organs is unclear. The characterization of breast cancer cells with both of these attributes now identifies the functional and molecular determinants necessary to mediate primary tumour formation and re-initiation at the secondary site. See also: Article by Ross et al. Cell Biology JOBS of the week ERC-funded Postdoctoral Researcher in Molecular Cell Biology Max Planck Institute of Molecular Physiology PhD fellowship with focus on bioimaging and cell biology University of Copenhagen PhD position in Molecular Biology - Mathematical modelling of single-cell responses Institute of Molecular Biology (IMB) Mainz Postdoctoral Fellow: Breast Cancer / Stem Cell Biology University of Cincinnati College of Medicine Department of Cancer Biology Postdoc position on Stem Cell Biology Sloan-Kettering Institute, Cornell Univ. More Science jobs from Cell Biology EVENT Lab Techniques in Mammalian Cell Biology 06.07.15 London, UK More science events from Advertisement Introducing the SureBeads™ Magnetic Beads System  Faster, more reliable immunoprecipitation at a price you can afford. Priced similarly to leading agarose beads, the SureBeads System lets you eliminate centrifugation steps, shorten time to results, and reduce overall cost by decreasing the amount of antibody required for successful IP. See data comparing SureBeads Magnetic Beads with agarose beads comparison data.   Articles Top The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine   pp545 - 557 Jean-Pierre Etchegaray, Lukas Chavez, Yun Huang, Kenneth N. Ross, Jiho Choi et al. doi:10.1038/ncb3147 Mostoslavsky and colleagues reveal that in embryonic stem cells (ESC) the deacetylase SIRT6 regulates pluripotency genes, which in turn controls ESC differentiation though the activity of Tet enzymes. Independent and coordinate trafficking of single Drosophila germ plasm mRNAs   pp558 - 568 Shawn C. Little, Kristina S. Sinsimer, Jack J. Lee, Eric F. Wieschaus and Elizabeth R. Gavis doi:10.1038/ncb3143 Gavis and colleagues characterize RNP trafficking and assembly using quantitative single-molecule imaging and find mRNAs destined for the germ cells are assembled differently from oskar, the germline determinant mRNA. Anisotropic stress orients remodelling of mammalian limb bud ectoderm   pp569 - 579 Kimberly Lau, Hirotaka Tao, Haijiao Liu, Jun Wen, Kendra Sturgeon et al. doi:10.1038/ncb3156 Hopyan and colleagues show that tension in the mesoderm and ectoderm leads to formation of a stress pattern that drives the rearrangements of ectodermal cells during limb bud morphogenesis in mouse embryos. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages   pp580 - 591 Andrea Ditadi, Christopher M. Sturgeon, Joanna Tober, Geneve Awong, Marion Kennedy et al. doi:10.1038/ncb3161 Keller and colleagues show that haemogenic and vascular endothelium represent distinct lineages and that haemogenic endothelium gives rise to multipotent haematopoietic progenitors through a NOTCH-dependent endothelial-to-haematopoietic transition. Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity   pp592 - 604 Chen Luxenburg, Evan Heller, H. Amalia Pasolli, Sophia Chai, Maria Nikolova et al. doi:10.1038/ncb3146 Fuchs and colleagues report a role for the F-actin binding protein Wdr1 in the establishment of planar polarity in the mouse embryonic epidermis by mediating tension. Quantitative analysis of cytoskeletal reorganization during epithelial tissue sealing by large-volume electron tomography   pp605 - 614 Mikhail Eltsov, Nadia Dubé, Zhou Yu, Laurynas Pasakarnis, Uta Haselmann-Weiss et al. doi:10.1038/ncb3159 Using large-volume correlative electron tomography, Brunner and colleagues show that microtubules provide forces for the sealing of the epidermis during dorsal closure in Drosophila. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors   pp615 - 626 Inês Cebola, Santiago A. Rodríguez-Seguí, Candy H-H. Cho, José Bessa, Meritxell Rovira et al. doi:10.1038/ncb3160 By deciphering the transcriptional network of human embryonic pancreatic progenitors, Ferrer and colleagues identify the Hippo-responsive transcription factor TEAD1 as a regulator of the pancreatic progenitor enhancer programme. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation &nnbsp; pp627 - 638 Gabriele D’Uva, Alla Aharonov, Mattia Lauriola, David Kain, Yfat Yahalom-Ronen et al. doi:10.1038/ncb3149 Tzahor and colleagues show that ErbB2 signalling is required for cardiomyocyte proliferation in fetal and postnatal mouse hearts, and that its activation in adult hearts promotes cardiomyocyte proliferation and regeneration following myocardial ischaemic injury. EARP is a multisubunit tethering complex involved in endocytic recycling   pp639 - 650 Christina Schindler, Yu Chen, Jing Pu, Xiaoli Guo and Juan S. Bonifacino doi:10.1038/ncb3129 Bonifacino and colleagues identify a four-protein complex, called the endosome-associated recycling protein (EARP) complex, that associates with Rab4-positive endosomes and promotes recycling-endosome tethering and fusion. See also: News and Views by Desfougeres et al. Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer   pp651 - 664 Jason B. Ross, Doowon Huh, Lisa B. Noble and Sohail F. Tavazoie doi:10.1038/ncb3148 Using in vivo tumour-cell selection approaches Tavazoie and colleagues identify LAMA4 among the factors that enhance tumour-forming capacity and metastatic efficiency to promote primary and metastatic tumour re-initiation. See also: News and Views by Nabet & Minn The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development   pp665 - 677 Xunlei Kang, Zhigang Lu, Changhao Cui, Mi Deng, Yuqi Fan et al. doi:10.1038/ncb3158 Zhang and colleagues show that the ITIM-containing receptor LAIR1 supports self-renewal and survival of acute myeloid leukaemia stem cells through a signalling pathway that includes the SHP-1 phosphatase, CAMK1 kinase and CREB transcription factor. Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway   pp678 - 688 Spencer C. Wei, Laurent Fattet, Jeff H. Tsai, Yurong Guo, Vincent H. Pai et al. doi:10.1038/ncb3157 Yang and colleagues report that increased extracellular matrix stiffness promotes nuclear localization of Twist1 to drive epithelial–mesenchymal transition, cancer cell invasion and metastasis. Letters Top ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation   pp689 - 696 Felipe K. Teixeira, Carlos G. Sanchez, Thomas R. Hurd, Jessica R. K. Seifert, Benjamin Czech et al. doi:10.1038/ncb3165 Lehmann and colleagues describe a role for the ATP synthase in Drosophila germline stem cell differentiation that is independent of ATP synthesis, and involves the maturation of mitochondrial cristae. Kinetochore components are required for central spindle assembly   pp697 - 705 Gilliane Maton, Frances Edwards, Benjamin Lacroix, Marine Stefanutti, Kimberley Laband et al. doi:10.1038/ncb3150 Using C. elegans zygotes, Dumont and colleagues find that kinetochore proteins, including KNL-1, participate in assembly of central spindle microtubules for cytokinesis. Corrigendum Top Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation   p706 Valentina Cianfanelli, Claudia Fuoco, Mar Lorente, Maria Salazar, Fabio Quondamatteo et al. doi:10.1038/ncb3171 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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