Laboratory Investigation - Table of Contents alert Volume 95 Issue 5

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TABLE OF CONTENTS Volume 95, Issue 5 (May 2015) In this issue Inside the USCAP Journals Research Articles Technical Report Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2015 95: 454-455; 10.1038/labinvest.2015.56 Full Text Research Articles Top ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy This study investigates the role of vascular endothelial growth factor (VEGF) signaling in compensatory lung growth. The authors found that compensatory lung growth is suppressed by a VEGF neutralizing antibody and in VEGF receptor-1 tyrosine kinase-deficient mice (TK-/- mice). The mobilization of progenitor cells expressing VEGFR1+ cells from bone marrow and the recruitment of these cells to lung tissue are also suppressed in TK-/- mice. Overall, these results suggest that VEGF signaling contributes to compensatory lung growth by mobilizing VEGFR1+ cells. Yoshio Matsui, Hideki Amano, Yoshiya Ito, Koji Eshima, Hideaki Tamaki, Fumihiro Ogawa, Akira Iyoda, Masafumi Shibuya, Yuji Kumagai, Yukitoshi Satoh and Masataka Majima 2015 95: 456-468; advance online publication, February 2, 2015; 10.1038/labinvest.2014.159 Abstract | Full Text Involvement of urokinase in cigarette smoke extract-induced epithelial–mesenchymal transition in human small airway epithelial cells This study suggests that patients with chronic obstructive pulmonary disease (COPD) have increased urokinase-type plasminogen activator (uPA) expression in small airway epithelia. Biomarkers of epithelial-mesenchymal transition (EMT) are observed in the small airway epithelial from patients with COPD. In vitro, increased uPA expression leads to EMT. These results suggest that uPA could participate in the process of EMT associated with COPD small airway remodeling. Qin Wang, Yunshan Wang, Yi Zhang, Yuke Zhang and Wei Xiao 2015 95: 469-479; advance online publication, February 23, 2015; 10.1038/labinvest.2015.33 Abstract | Full Text ORAL AND GASTROINTESTINAL SYSTEMS Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice Mice with chemically induced colitis reminiscent of inflammatory bowel disease (IBD) that are subsequently treated with recombinant human MFG-E8 show decreased colitis severity, accompanied by decreases in numbers of neutrophils, the amounts of proinflammatory cytokines and chemokines, and the numbers of apoptotic cells in the animals' colons. MFG-E8 therefore has potential as a new drug for IBD. Yinzhong Zhang, Max Brenner, Weng-Lang Yang and Ping Wang 2015 95: 480-490; advance online publication, March 9, 2015; 10.1038/labinvest.2015.32 Abstract | Full Text GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways Increased numbers of infiltrating tumor-associated macrophages (TAMs) are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma (ESCC). The authors found that growth differentiation factor 15 (GDF15), a member of the transforming growth factor-β superfamily, is secreted by both TAMs and cancer cells in the tumor microenvironment and is associated with aberrant growth and a poor prognosis in human ESCC. Naoki Urakawa, Soken Utsunomiya, Mari Nishio, Manabu Shigeoka, Nobuhisa Takase, Noriaki Arai, Yoshihiro Kakeji, Yu-ichiro Koma and Hiroshi Yokozaki 2015 95: 491-503; advance online publication, March 2, 2015; 10.1038/labinvest.2015.36 Abstract | Full Text HEPATIC AND PANCREATIC SYSTEMS Galactose protects hepatocytes against TNF-α-induced apoptosis by promoting activation of the NF-κB signaling pathway in acute liver failure Various mono- and disaccharides can protect hepatocytes from acute liver injury through distinct mechanisms. Here, the authors demonstrate that galactose prevents tumor necrosis factor-a-induced liver injury through activation of the nuclear factor-κB signaling pathway. These findings may lead to a promising clinical approach to treat acute liver failure. Yanmin Liu, Liuluan Zhu, Shuntao Liang, Shanshan Yao, Rui Li, Sanhai Liu, Yaluan Ma, Xiaobing Zhou, Jinliang Zhang, Hui Zeng and Xianbo Wang 2015 95: 504-514; advance online publication, March 9, 2015; 10.1038/labinvest.2015.34 Abstract | Full Text Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism Acetaminophen (APAP)-induced acute liver injury is attenuated in cytoglobin-null mice compared to that in wild-type mice. This study demonstrates the mechanism for cytoglobin-accelerated APAP-induced hepatotoxicity: it contributes to the cytochrome P450-mediated metabolism of xenobiotics by supplying O2 for enzymatic oxidation. Yuga Teranishi, Tsutomu Matsubara, Kristopher W Krausz, Thi T T Le, Frank J Gonzalez, Katsutoshi Yoshizato, Kazuo Ikeda and Norifumi Kawada 2015 95: 515-524; advance online publication, February 16, 2015; 10.1038/labinvest.2015.29 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS Dipeptidyl peptidase-4 deficiency protects against experimental diabetic nephropathy partly by blocking the advanced glycation end products-receptor axis Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. Linagliptin, an inhibitor of dipeptidyl peptidase-4 (DPP-4), inhibit renal damage in type 1 diabetic rats by suppressing the AGE-RAGE axis. The authors now show that DPP-4 deficiency in streptozotocin-treated rats exerts beneficial actions on type 1 diabetic nephropathy, partly by blocking the AGE-RAGE axis. DPP-4 might therefore be a novel therapeutic target for preventing diabetic nephropathy. Takanori Matsui, Sae Nakashima, Yuri Nishino, Ayako Ojima, Nobutaka Nakamura, Kazunari Arima, Kei Fukami, Seiya Okuda and Sho-ichi Yamagishi 2015 95: 525-533; advance online publication, March 2, 2015; 10.1038/labinvest.2015.35 Abstract | Full Text SV2B is essential for the integrity of the glomerular filtration barrier This study shows that synaptic vesicle protein 2B (SV2B) plays an important role in the maintenance of the filtration barrier of kidney glomerular capillary wall and that the dysfunction of SV2B participates in the development of proteinuria. SV2B and other synaptic vesicle-associated molecules could be a novel therapeutic target for nephrotic syndrome. Yoshiyasu Fukusumi, Ayako Wakamatsu, Natsumi Takashima, Eriko Hasegawa, Naoko Miyauchi, Masayuki Tomita and Hiroshi Kawachi 2015 95: 534-545; advance online publication, March 2, 2015; 10.1038/labinvest.2015.39 Abstract | Full Text MODELS AND TECHNIQUES Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model This paper establishes a novel mouse line carrying defined genomic rearrangements and exhibiting a strong propensity for estrogen-induced bladder outlet obstruction (BOO) that is independent of prostate enlargement. The obstructive symptoms are alleviated by testosterone supplement. This model may serve as a promising tool for deciphering hormonal and genomic mechanisms underscoring the pathogenesis and susceptibility of BOO, a common urological disorder in men. Neville Ngai-Chung Tam, Xiang Zhang, Hong Xiao, Dan Song, Linda Levin, Jarek Meller and Shuk-Mei Ho 2015 95: 546-560; advance online publication, February 23, 2015; 10.1038/labinvest.2015.30 Abstract | Full Text Technical Report Top Critical roles of specimen type and temperature before and during fixation in the detection of phosphoproteins in breast cancer tissues The integrity of phosphoproteins is strongly dependent on tissue handling. Fixation in cold formalin improves the preservation phosphoproteins in breast cancer tissues and their evaluation seems more reliable in core biopsy than in resection specimens. Pre-analytical conditions play a key role to move a step forward in personalized cancer treatments by assessing the activity of deregulated kinases in formalin-fixed, paraffin-embedded tissue specimens. Sibylle Gündisch, Laura Annaratone, Christian Beese, Enken Drecol, Caterina Marchiò, Elena Quaglino, Anna Sapino, Karl-Friedrich Becker and Gianni Bussolati 2015 95: 561-571; advance online publication, March 2, 2015; 10.1038/labinvest.2015.37 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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