EMBO reports Table of Contents for March 2015; Vol. 16, No. 3

March 2015 | Volume 16, Number 3 Submit Table of Contents Opinion Correspondence Science & Society Review Scientific Reports Volume 16, Number 3 Opinion Changing the future, not the past: a translational paradigm shift in treating anxiety Understanding how long‐term memories are enshrined at the molecular level has led to new drug targets for treating anxiety disorders. But drugs do not provide lasting effects and we need to find ways to better couple them with therapy to help patients cope with traumatic experiences. Jürgen Margraf and Armin Zlomuzica Published online 06.02.2015 Correspondence A comment on “Scientometrics in a changing research landscape” A comment on “Scientometrics in a changing research landscape”. Stephen T Holgate Published online 20.01.2015 Response to Stephen Holgate Response to Stephen Holgate. Lutz Bornmann and Loet Leydesdorff Published online 20.01.2015 Science & Society Censoring government scientists and the role of consensus in science advice: A structured process for scientific advice in governments and peer‐review in academia should shape science communication strategies Scientific findings and discussions should be public and transparent, and scientists should be free to express their opinions. But when scientists act as government advisors, is some censorship necessary and prudent? Derrick Tupper de Kerckhove, Michael David Rennie, and Roland Cormier Published online 28.01.2015 Crowdfunding 2.0: the next‐generation philanthropy: A new approach for philanthropists and citizens to co‐fund disruptive innovation in global health Visionary ideas and innovation are needed to tackle a variety of global health problems. A structured combination of crowdfunding and angel investors could support research currently considered too uncertain for funding by national systems. Vural Özdemir, Jack Faris, and Sanjeeva Srivastava Published online 05.02.2015 Science for food: Molecular biology contributes to the production and preparation of food As developing countries aspire to meat‐rich “Western” diets, and as the climate changes, the world faces increasing difficulties for agriculture. Molecular biology uses tissue culture and genetic engineering to provide solutions, but what do chefs, epicures and the public make of these inventive tools? Howard Wolinsky and Kristofor Husted Published online 17.02.2015 The second coming of epigenetic drugs: A more strategic and broader research framework could boost the development of new drugs to modify epigenetic factors and gene expression Drugs that modify or shut down the expression of disease‐related genes through epigenetic tinkering hold great promise, but are few and far between. To better understand and exploit the mechanisms of epigenetic gene regulation, research and drug discovery in this area is becoming more strategic and more organized. Philip Hunter Published online 06.02.2015 Review Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure The term ‘oncogene addiction’ refers to the fact that cancer cells depend on relatively few oncogenes to sustain a malignant phenotype. This review summarizes our current understanding of this process and how it can be exploited in cancer therapy. Raymond Pagliarini, Wenlin Shao, and William R Sellers Published online 13.02.2015 Scientific Reports Starvation‐induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome–lysosome fusion Sbf/MTMR13 and Rab21 promote endosomal sorting of VAMP8 required for autophagosome–lysosome fusion. Starvation induces Sbf/MTMR13 GEF and Rab21 activity, the binding to VAMP8 and VAMP8 trafficking to endolysosomes where it mediates autophagosome fusion. Steve Jean, Sarah Cox, Sonya Nassari, and Amy A Kiger Published online 03.02.2015 Plasticity of PI4KIIIα interactions at the plasma membrane TMEM150A, a homologue of yeast Sfk1, interacts with the PIPI4KIIIα–EFR3 complex at the plasma membrane and positively regulates PI(4,5)P2 synthesis. It affects the composition of the PI4KIIIα complex, revealing a plasticity of the molecular interactions that control PI4KIIIα localization and function. Jeeyun Chung, Fubito Nakatsu, Jeremy M Baskin, and Pietro De Camilli Published online 21.01.2015 Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism Glycosphingolipid expression is altered during EMT. Here, the transcription factor Zeb1 is found to directly control glycosphingolipid expression with functional consequences for alleviating intercellular adhesion during EMT. Daniel Mathow, Federica Chessa, Mariona Rabionet, Sylvia Kaden, Richard Jennemann, Roger Sandhoff, Hermann‐Josef Gröne, and Alexander Feuerborn Published online 02.02.2015 Genome‐wide screen identifies a novel p97/CDC‐48‐dependent pathway regulating ER‐stress‐induced gene transcription During ER stress, p97/CDC‐48 mediates reptin degradation thereby enabling both ATF6 activation and XBP1 mRNA splicing. This work uncovers another layer in the regulation of canonical ER stress signaling. Esther Marza, Saïd Taouji, Kim Barroso, Anne‐Aurélie Raymond, Léo Guignard, Marc Bonneu, Néstor Pallares‐Lupon, Jean‐William Dupuy, Martin E Fernandez‐Zapico, Jean Rosenbaum, Francesca Palladino, Denis Dupuy, and Eric Chevet Published online 04.02.2015 IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans Reducing intracellular IP3 signaling enhances RNAi sensitivity in C. elegans through a function of IP3 in the intestine. This suggests that an animal's physiology or environment may influence its RNAi responses. Anikó I Nagy, Rafael P Vázquez‐Manrique, Marie Lopez, Christo P Christov, María Dolores Sequedo, Mareike Herzog, Anna E Herlihy, Maxime Bodak, Roxani Gatsi, and Howard A Baylis Published online 21.01.2015 Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection The checkpoint protein Rad9 inhibits the Sgs1/Dna2 long‐range resection machinery and thereby increases the requirement for MRX‐Sae2 activities in DSB resection. Diego Bonetti, Matteo Villa, Elisa Gobbini, Corinne Cassani, Giulia Tedeschi, and Maria Pia Longhese Published online 30.01.2015 Cabut/dTIEG associates with the transcription factor Yorkie for growth control The transcription factor Cbt associates with Yki, a key effector of growth control in the Hippo pathway. Up‐regulation of Cbt promotes cell proliferation, while down‐regulation suppresses Yki‐dependent overgrowth in Drosophila. Marina Ruiz‐Romero, Enrique Blanco, Nuria Paricio, Florenci Serras, and Montserrat Corominas Published online 08.01.2015 Epigenetic predisposition to reprogramming fates in somatic cells The potential of Mouse Embryonic Fibroblasts (MEFs) to generate iPSCs is determined before OKSM induction and symmetrically maintained over the short term. Epigenetic perturbations of MEFs can alter their future response to reprogramming. Maayan Pour, Inbar Pilzer, Roni Rosner, Zachary D Smith, Alexander Meissner, and Iftach Nachman Published online 18.01.2015 Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, the genomes of which they protect from the expression of transposable elements. The enzymes also associate with the germ granule Tudor protein. Ming Gao, Travis C Thomson, T Michael Creed, Shikui Tu, Sudan N Loganathan, Christina A Jackson, Patrick McCluskey, Yanyan Lin, Scott E Collier, Zhiping Weng, Paul Lasko, Melanie D Ohi, and Alexey L Arkov Published online 18.01.2015 Single muscle fiber proteomics reveals unexpected mitochondrial specialization Here, single multinucleated muscle fibers are analyzed by high sensitivity proteomics for the first time. This reveals an unexpected diversity and specialization in metabolic properties of individual fiber types, in particular in mitochondrial function. Marta Murgia, Nagarjuna Nagaraj, Atul S Deshmukh, Marlis Zeiler, Pasqua Cancellara, Irene Moretti, Carlo Reggiani, Stefano Schiaffino, and Matthias Mann Published online 02.02.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.