Nature Reviews Microbiology contents March 2015 Volume 13 Number 3 pp 1-184

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TABLE OF CONTENTS
March 2015 Volume 13 Number 3
Impact Factor 23.317 *	In this issue Research Highlights News and Analysis Correspondence Reviews Also this month Featured article: New technologies: methods and applications Featured article: Vector-borne diseases  Featured article: Rising to the challenge: accelerated pace of discovery transforms marine virology Jennifer R. Brum & Matthew B. Sullivan
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RESEARCH HIGHLIGHTS Top Synthetic biology: GMOs in lockdown p125 | doi:10.1038/nrmicro3443 Two studies describe the design of safer genetically modified organisms that cannot grow in natural ecosystems because they require synthetic amino acids for growth. PDF Antimicrobials: A new drug for resistant bugs p126 | doi:10.1038/nrmicro3429 A study reports the discovery of a new antibiotic with a novel mechanism of action and a low propensity to select for resistance. PDF Parasite biology: PINning down Theileria p126 | doi:10.1038/nrmicro3444 A new study identifies the mechanistic basis for host cell transformation by Theileria spp. parasites. PDF Bacterial genetics: sRNA toolkit for Vibrio p128 | doi:10.1038/nrmicro3434 Bassler and colleagues show that a small regulatory RNA from Vibrio harveyi regulates multiple target mRNAs by distinct mechanisms, which influences quorum sensing dynamics. PDF Parasite biology: An anchor for Plasmodium invasion p128 | doi:10.1038/nrmicro3436 This study identifies CyRPA as the anchor of an essential Plasmodium falciparum invasion complex at the merozoite surface. PDF Bacterial physiology: Putting the 'BREX' on phage replication p129 | doi:10.1038/nrmicro3437 This study identifies bacteriophage exclusion (BREX) as a novel bacterial defence system that protects against lytic and lysogenic phage infection. PDF IN BRIEF Fungal physiology: A phospho-switch for pathogenesis | Bacterial pathogenesis: Crossing the barriers | Symbiosis: Metabolites in differentiation | Microbiome: Secret behind commensal resilience revealed | Bacterial physiology: Riboswitch control is key to ZTP mystery | Microbiome: A dysbiotic enteric virome PDF Microbiology JOBS of the week Postdoctoral Fellow in Molecular Microbiology Imaging Ecole Polytechnique Fédérale de Lausanne (EPFL) PhD Student Position in Microbiology Belgian Nuclear Research Centre Professor- Researcher: Microbiology Institut national de la recherche scientifique (INRS) More Science jobs from Microbiology EVENT EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology 11.10.15 Heidelberg, Germany More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH R-M systems go on the offensive John Lees & Rebecca A. Gladstone p131 | doi:10.1038/nrmicro3435 This month's Genome Watch explores how genetic variation in restriction-modification systems from Streptococcus pneumoniae contributes to the defence against phages and to bacterial virulence. PDF
CORRESPONDENCE		Top
The importance of soil archives for microbial ecology Jan Dolfing & Youzhi Feng p1 | doi:10.1038/nrmicro3382-c1 Full Text | PDF
REVIEWS		Top
Marine microbial community dynamics and their ecological interpretation Jed A. Fuhrman, Jacob A. Cram & David M. Needham p133 | doi:10.1038/nrmicro3417 In this Review, Fuhrman and colleagues summarize our current understanding of marine microbial community dynamics at various scales — from hours to decades — and consider how long-term time series illustrate important ecological concepts such as community resilience and seasonality, as well as interactions among microorganisms in the global oceans. Abstract | Full Text | PDF
Article series: New technologies: methods and applications Rising to the challenge: accelerated pace of discovery transforms marine virology Jennifer R. Brum & Matthew B. Sullivan p147 | doi:10.1038/nrmicro3404 Marine viruses have important roles in modulating the dynamics of microbial life in the global oceans. Brum and Sullivan discuss the recent technological advances that are facilitating an accelerated pace of discovery in marine virology, including metagenomics and several cultivation-dependent and cultivation-independent tools. Abstract | Full Text | PDF
Article series: Vector-borne diseases Post-translational protein modifications in malaria parasites Christian Doerig, Julian C. Rayner, Artur Scherf & Andrew B. Tobin p160 | doi:10.1038/nrmicro3402 Plasmodium falciparum, the malaria parasite, relies on post-translational modifications of proteins to regulate several fundamental aspects of its life cycle and pathogenesis. Here, Doerig and colleagues focus on the roles of protein phosphorylation, acetylation, methylation and lipidation in P. falciparum biology, and they discuss how the enzymes that mediate these modifications can be targeted by novel antimalarial drugs. Abstract | Full Text | PDF | Supplementary information
Pathogen manipulation of B cells: the best defence is a good offence Katharina Nothelfer, Philippe J. Sansonetti & Armelle Phalipon p173 | doi:10.1038/nrmicro3415 B cells are essential components of the immune response against infection. However, several bacteria, viruses and parasites are able to infect B cells and manipulate B cell functions and survival. Here, the authors review how pathogens use B cells as reservoirs, manipulate B cell differentiation and interfere with B cell survival, and they discuss the implications for ongoing immune responses. Abstract | Full Text | PDF
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