Nature Reviews Immunology Contents March 2015 Volume 15 Number 3 pp 131-197

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Understanding Immunology Metabolism Seahorse Bioscience presents: Mitochondrial respiratory capacity is a critical regulator of CD8+ T Cell memory development Webinar presented by Erika Pearce, PhD, Washington University School of Medicine, St. Louis, MO Watch this webinar at: http://www.seahorsebio.com/nature
TABLE OF CONTENTS
March 2015 Volume 15 Number 3
Impact Factor 33.836 *	In this issue Research Highlights Focus on: 50 years of B cells Also this month  Featured article: The early history of B cells Max D. Cooper
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RESEARCH HIGHLIGHTS Top B cell memory: A second chance for antibodies p131 | doi:10.1038/nri3829 Class-switched memory B cells form secondary germinal centres during recall responses to further diversify the antibody repertoire. PDF B cells: Whatever will B cell be? p132 | doi:10.1038/nri3821 Individual naive B cells show heterogeneity in their response to antigen-mediated activation. PDF Macrophages: Breaking ranks in the lymph node p132 | doi:10.1038/nri3825 Inflammation disrupts the organization of subcapsular sinus macrophages, impairing the B cell response to secondary infections. PDF B cell memory: Making sense in humans p133 | doi:10.1038/nri3822 Key characteristics of human IgM+ memory B cells have been identified, including a high degree of similarity to IgG+ memory B cells. PDF Regulatory T cells: CK2: keeping TH2 cells in check p134 | doi:10.1038/nri3827 Control of excessive T helper 2 cell-type immune responses is mediated by casein kinase 2 (CK2) in regulatory T cells. PDF Innate immunity: Stressed mitochondria provide protection p134 | doi:10.1038/nri3828 Herpesvirus infection can lead to mitochondrial DNA stress and thereby activate antiviral defences. PDF B cells: Meddling with the mind p135 | doi:10.1038/nri3826 B cell infiltration into stroke lesions may contribute to subsequent dementia development. PDF Immunology JOBS of the week Postdoctoral Scholar Positions in Stem Cell, Cancer Biology, Immunology and Synthetic Biology University of California - Irvine Postdoc in Immunology, Novartis Biomedical Research Novartis Institute for BioMedical Research, Basel Post-Doctoral Fellow in Immunology / Antibody Engineering National University of Singapore (NUS) Postdoctoral Scientist in Molecular and Cellular Immunology of T follicular helper (Tfh) CD4 T cells La Jolla Institute for Molecular Medicine Postdoctoral Fellowship in Human Immunology University of Pennsylvania More Science jobs from Immunology EVENT Nutritional Immunology: Role in Health and Disease 26.07.15 Lisbon, Portugal More science events from
Focus on: 50 years of B cells REVIEWS Top Dynamics of B cells in germinal centres Nilushi S. De Silva & Ulf Klein p137 | doi:10.1038/nri3804 The germinal centre (GC) reaction is a highly complex and regulated process. As described in this Review, recent studies have revealed dynamic cellular states in the GC, the requirements for selection of B cells that express high-affinity antibodies and the recirculation of B cells between zones of the GC. Abstract | Full Text | PDF Memory B cells Tomohiro Kurosaki, Kohei Kometani & Wataru Ise p149 | doi:10.1038/nri3802 New insights into the heterogeneity of memory B cells can aid our mechanistic understanding of the longevity of humoral memory and its rapid and robust responsiveness. Abstract | Full Text | PDF The generation of antibody-secreting plasma cells Stephen L. Nutt, Philip D. Hodgkin, David M. Tarlinton & Lynn M. Corcoran p160 | doi:10.1038/nri3795 The terminal differentiation of antibody-secreting cells is controlled by a network of antagonistic transcription factors and, although it is highly complex, this process can be explained by a simple probabilistic differentiation process. Abstract | Full Text | PDF Germinal centres and B cell lymphomagenesis Katia Basso & Riccardo Dalla-Favera p172 | doi:10.1038/nri3814 In this Review, the authors describe the recent advances in the molecular regulation of germinal centre development that are also important for human B cell lymphomagenesis. They summarize the genetic alterations leading to dysregulated pathways that are important for the germinal centre reaction. Abstract | Full Text | PDF PERSPECTIVES Top TIMELINE A brief history of T cell help to B cells Shane Crotty p185 | doi:10.1038/nri3803 The role of T cell help to B cells was discovered only a few years after the discovery of B cells. In this Timeline article, the author describes the key events that led to the identification of T follicular helper (TFH) cells as the main T helper cell type for B cells. Abstract | Full Text | PDF TIMELINE The early history of B cells Max D. Cooper p191 | doi:10.1038/nri3801 As we celebrate 50 years since his seminal Nature paper describing separate lineages for B cells and T cells in the chicken, Max Cooper looks back at the early discoveries that made this breakthrough possible and describes how the B cell field emerged. Abstract | Full Text | PDF
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Nature Insight Frontiers in biology This year's Frontiers in Biology Insight covers the amygdala and how technology is helping us to understand its complex connectivity, innate lymphoid cells, nutrient-sensing mechanisms in mammals, a form of cell death called necroptosis, and the regulation and function of DNA methylation and its use as a cellular marker.  Access the Insight online.
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