Nature Reviews Neuroscience contents February 2015 Volume 16 Number 2 pp 63-120

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TABLE OF CONTENTS
February 2015 Volume 16 Number 2
Impact Factor 31.376 *	In this issue Research Highlights Progress Reviews Also this month  Featured article: Spatial cognition in bats and rats: from sensory acquisition to multiscale maps and navigation Maya Geva-Sagiv, Liora Las, Yossi Yovel & Nachum Ulanovsky
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RESEARCH HIGHLIGHTS Top Pain: Converging on LTP p63 | doi:10.1038/nrn3913 Chronic pain and anxiety may be mechanistically linked by a presynaptic form of long-term potentiation that occurs at synapses in the anterior cingluate cortex. PDF Neurophysiology: Under pressure p64 | doi:10.1038/nrn3897 Obesity arising from a poor diet often leads to hypertension, and a new study shows that apdipose-derived leptin, acting on neurons in the dorsomedial hypothalams is necessary and sufficient to induce hypertension. PDF Attention: Tuning sensory selection p64 | doi:10.1038/nrn3899 The neuregulin 1 receptor ERBB4 tunes synapse strength in the thalamic reticular nucleus as part of a circuit that regulates selective attention. PDF Neurodegenerative disease: Restoring balance in Huntington disease p66 | doi:10.1038/nrn3906 A new study shows that boosting mTORC1 activity in the striatum can ameliorate disease phenotypes in a mouse model of Huntington disease. PDF Behavioural neuroscience: Swarming away from smells p66 | doi:10.1038/nrn3907 A new study shows that Drosophila melanogaster exhibits collective odour-avoidance behaviour that is dependent on mechanosensory interactions between individual flies. PDF Neurodegenerative disease: Factoring in astrocytes p67 | doi:10.1038/nrn3908 Activation of nuclear factor-κB in astrocytes leads to the release of complement factor 3, which impairs neuronal function, and this mechanism may contribute to Alzheimer disease. PDF Prefrontal cortex: Dopamine double rules p68 | doi:10.1038/nrn3895 Dopamine receptor subtypes 1 and 2 in the prefrontal cortex contribute to rule-based executive function via differential but complementary effects. PDF IN BRIEF Sensory systems: Channelling touch | Neural coding: Time for a song | Cortical Plasticity: Critical depolarization | Navigation: The third dimension | Gene expression: Different ways to splice the cake | Motor systems: Switching sides | Sensory systems: TLC for touch neurons | Neuronal circuits: Waves of perception PDF Neuroscience JOBS of the week Postdoc University of Toledo Health Science Campus Neurobiologist and Cell Biologist Rutgers University - New Brunswick Postdoctoral Associate Univeristy of Minnesota Research Technician University of California - Irvine Principal Investigator &Postdoctoral Associate Positions Institutes of Brain Science, Fudan University, Shanghai, China More Science jobs from Neuroscience EVENT Francis Crick Symposium: Advances in Neuroscience 29.06.15 Suzhou, China More science events from
PROGRESS		Top
Opioid and chemokine receptor crosstalk: a promising target for pain therapy? Stéphane Mélik Parsadaniantz, Cyril Rivat, William Rosténe & Annabelle Réaux-Le Goazigo p69 | doi:10.1038/nrn3858 Chemokine receptors and opioid receptors in nociceptive pathways interact in ways that can alter opioid function. In this Progress article, Réaux-Le Goazigo and colleagues discuss how crosstalk between chemokine and opioid receptors offers a new framework for the development of novel analgesic therapies to alleviate pain. Abstract | Full Text | PDF
REVIEWS		Top
Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits Nadia L. Cerminara, Eric J. Lang, Roy V. Sillitoe & Richard Apps p79 | doi:10.1038/nrn3886 The cerebellar cortex drives smooth goal-directed movement as well as a range of other functions. Apps and colleagues describe studies that have revealed variations in the cytoarchitecture, molecular composition, physiological properties and vulnerability to cell death of different cerebellar cortical regions, and discuss the idea that these underlie different forms of information processing. Abstract | Full Text | PDF | Supplementary information
Spatial cognition in bats and rats: from sensory acquisition to multiscale maps and navigation Maya Geva-Sagiv, Liora Las, Yossi Yovel & Nachum Ulanovsky p94 | doi:10.1038/nrn3888 Although we understand much about mechanisms of spatial navigation in the mammalian brain in the context of laboratory investigations, our knowledge of the neural bases of 'real-world' navigation is more limited. Ulanovsky and colleagues here describe how we can approach this problem through experimental research and theoretical models of large-scale navigation in bats and rats. Abstract | Full Text | PDF
Spreading of pathology in neurodegenerative diseases: a focus on human studies Johannes Brettschneider, Kelly Del Tredici, Virginia M.-Y. Lee & John Q. Trojanowski p109 | doi:10.1038/nrn3887 Various neurodegenerative diseases are characterized by aggregates of pathological proteins, and increasing evidence suggests these disease-associated proteins may 'spread' via neuronal connections. Trojanowski and colleagues describe the molecular mechanisms of such spreading, and present the findings from neuropathological and imaging studies in humans that support this process. Abstract | Full Text | PDF
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