Nature Reviews Genetics Contents January 2015 Volume 16 Number 1 pp 1-66

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TABLE OF CONTENTS
January 2015 Volume 16 Number 1
Impact Factor 39.794 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Non-coding RNA Single-cell omics Disease mechanisms  Featured article: Spatially resolved transcriptomics and beyond Nicola Crosetto, Magda Bienko & Alexander van Oudenaarden
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Nature Outlook Haemophilia Hopes are rising rapidly for people with the bleeding disorder haemophilia. The advent of longer-lasting blood-clotting factors is making treatment less onerous, and — on the horizon — gene therapy offers a potential cure.  Access the Outlook free online for six months.   Produced with support from: Baxter Healthcare Corporation
RESEARCH HIGHLIGHTS Top Genomics: The best-laid plans of mice and men p1 | doi:10.1038/nrg3873 PDF Metagenomics: Shaping the gut microbiome p2 | doi:10.1038/nrg3869 PDF Phylogenomics: Building the insect tree-of-life p2 | doi:10.1038/nrg3870 PDF Epigenetics: Histones pass the message on p3 | doi:10.1038/nrg3876 PDF Stem cells: A case of mistaken identity p4 | doi:10.1038/nrg3872 PDF Molecular evolution: Decoupled transcription factor output? p4 | doi:10.1038/nrg3874 PDF Cancer genetics: Leveraging functional data for driver genes p4 | doi:10.1038/nrg3875 PDF IN BRIEF RNA: New CLIP pipeline improves interactome discovery | Epigenetics: Dad's diet controls offspring phenotype | Disease genetics: Therapeutic targeting of a long non-coding RNA | Microbial genetics: Horizontal gene transfer of antibacterial genes | Technology: DNase Hi-C — pitch-perfect chromatin mapping? | Development: Cell fate decisions in mammalian embryogenesis PDF Genetics JOBS of the week Postdoctoral Fellow in Statistical and Computational Genomics University of Chicago Postdoctoral fellow in computational biology and cancer genomics Albert Einstein College of Medicine of Yeshiva University (AECOM) Postdoctoral Fellow in Cancer Genomics Dana-Farber Cancer Institute and Harvard School of Public Health PhD Studentship The University of Sheffield Director Max Planck Institute for Plant Breeding Research More Science jobs from Genetics EVENT Malaria Experimental Genetics 15.03.15 Bangkok, Thailand More science events from
REVIEWS		Top
Article series: Non-coding RNA The RNA World: molecular cooperation at the origins of life Paul G. Higgs & Niles Lehman p7 | doi:10.1038/nrg3841 The RNA World concept is the idea that billions of years ago — before current life based on DNA, RNA and proteins — the primary living substance was RNA or something chemically similar. This Review highlights the challenges and solutions of this point of view, particularly for the synthesis and replication of RNA, and how various types of molecular cooperation probably had important roles. Abstract | Full Text | PDF
Article series: Single-cell omics Single-cell and multivariate approaches in genetic perturbation screens Prisca Liberali, Berend Snijder & Lucas Pelkmans p18 | doi:10.1038/nrg3768 Large-scale genetic perturbation screens have been central to many biological discoveries. This Review outlines the recent advances in the quantification of various perturbations across large numbers of single cells simultaneously and describes the use of genetic perturbation screens to infer functional interactions between genes and phenotypes. Abstract | Full Text | PDF | Supplementary information
Relatedness in the post-genomic era: is it still useful? Doug Speed & David J. Balding p33 | doi:10.1038/nrg3821 Relatedness has traditionally been defined using pedigree-based measures, but these have serious deficiencies. With genome-wide data, SNP-based measures can now be used to directly measure genome similarity, a more useful concept than relatedness. This Review outlines ways to evaluate measures of genome similarity. Abstract | Full Text | PDF | Supplementary information
Article series: Disease mechanisms Cystic fibrosis genetics: from molecular understanding to clinical application Garry R. Cutting p45 | doi:10.1038/nrg3849 Mendelian conditions, which are caused by dysfunction of a single gene, illustrate how the availability of the human genome sequence and tools for interrogating individual genomes can provide insights into disease. In this Review, cystic fibrosis is presented as an example of how genetics can continuously inform clinical research and practice. Abstract | Full Text | PDF
PERSPECTIVES		Top
INNOVATION Article series: Single-cell omics Spatially resolved transcriptomics and beyond Nicola Crosetto, Magda Bienko & Alexander van Oudenaarden p57 | doi:10.1038/nrg3832 Preserving spatial information in gene expression analyses is key for interpreting the single-cell tissue context (and even subcellular environments) of RNAs to achieve a more complete understanding of the underlying physiology. This Innovation article describes the emerging technologies of and biological insights from spatially resolved transcriptomics technologies, and how they set the stage for comprehensive investigations using complementary omic approaches. Abstract | Full Text | PDF
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Nature Reviews Genetics New Article Series: Single-Cell Omics This series is dedicated to high-throughput analyses of the genomes, transcriptomes and proteomes of single cells, and how these approaches are providing novel insights into diverse processes such as development, gene-expression dynamics, tissue heterogeneity and disease pathogenesis.
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