Scientific Reports Biology Table of Contents e-alert: April 2013

02 April 2013      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports                 Scientific Reports is accepting submissions from all scientific fields. Submit your manuscript now.                 Biological Sciences               Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus ▶     Maki Kiso, Ryo Takano, Saori Sakabe et al.     Influenza A(H1N1)pdm virus caused the first human pandemic of the 21st century. Although various probiotic Lactobacillus species have been shown to have anti-microbial effects …             CD8+ T cell activation by murine erythroblasts infected with malaria parasites ▶     Takashi Imai, Hidekazu Ishida, Kazutomo Suzue et al.     Recent studies show that some human malaria parasite species Plasmodium falciparum and P. vivax parasitize erythroblasts; however, the biological and clinical significance of this …             Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes ▶     Guodong Liu, Lei Zhang, Yuqi Qin et al.     Long-term strain improvements through repeated mutagenesis and screening have generated a hyper-producer of cellulases and hemicellulases from Penicillium decumbens 114 which was …             Establishment of a versatile cell line for juvenile hormone signaling analysis in Tribolium castaneum ▶     Takumi Kayukawa, Ken Tateishi, Tetsuro Shinoda     The red flour beetle, Tribolium castaneum, has been widely used as a laboratory model for analyzing gene function. In this study, we established a novel cell line (Tc81) from T. …             FBAR Syndapin 1 recognizes and stabilizes highly curved tubular membranes in a concentration dependent manner ▶     Pradeep Ramesh, Younes F. Baroji, S. Nader S. Reihani et al.     Syndapin 1 FBAR, a member of the Bin-amphiphysin-Rvs (BAR) domain protein family, is known to induce membrane curvature and is an essential component in biological processes like …             Spontaneous synchronized tapping to an auditory rhythm in a chimpanzee ▶     Yuko Hattori, Masaki Tomonaga, Tetsuro Matsuzawa     Humans actively use behavioral synchrony such as dancing and singing when they intend to make affiliative relationships. Such advanced synchronous movement occurs even …             Rapid Facial Mimicry In Geladas ▶     Giada Mancini, Pier Francesco Ferrari, Elisabetta Palagi     Rapid facial mimicry (RFM) is an automatic response, in which individuals mimic others' expressions. RFM, only demonstrated in humans and apes, is grounded in the automatic …             1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice ▶     You-Gui Li, Dong-Feng Ji, Shi Zhong et al.     We investigated the role of 1-deoxynojirimycin (DNJ) on glucose absorption and metabolism in normal and diabetic mice. Oral and intravenous glucose tolerance tests and labeled 13C6…             Inorganic coatings for optimized non-viral transfection of stem cells ▶     Siyoung Choi, Xiaohua Yu, Leenaporn Jongpaiboonkit et al.     “Biomimetic” approaches for heterogeneous growth of inorganic coatings have become particularly widespread in biomedical applications, where calcium phosphate (CaP) mineral …             Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum ▶     Kazuo Imaizumi, Jonathan Y. Shih, Hamilton E. Farris     Studies of patterned spontaneous activity can elucidate how the organization of neural circuits emerges. Using in vivo two-photon Ca2 imaging, we studied spatio-temporal patterns …             Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding ▶     Yan Wu, Guangrong Qin, Feng Gao et al.     The recently discovered 150-cavity (formed by loop residues 147–152, N2 numbering) adjacent to the enzymatic active site of group 1 influenza A neuraminidase (NA) has introduced a …             TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1 ▶     Ju Hyun Shin, Sang-Hyun Min, Seong-Jin Kim et al.     There is growing interest in identifying regulators of autophagy. The molecular mechanism underlying transforming growth factor-β activated kinase 1 (TAK1)-induced autophagy is …             Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis ▶     Marta P. Pereira Morais, Dominic Marshall, Stephen E. Flower et al.     Glycated proteins are important biomarkers for age-related disorders, however their analysis is challenging because of the complexity of the protein-carbohydrate adducts. Here we …             UV-radiation Induced Disruption of Dry-Cavities in Human γD-crystallin Results in Decreased Stability and Faster Unfolding ▶     Zhen Xia, Zaixing Yang, Tien Huynh et al.     Age-onset cataracts are believed to be expedited by the accumulation of UV-damaged human γD-crystallins in the eye lens. Here we show with molecular dynamics simulations that the …             Imaging the action of antimicrobial peptides on living bacterial cells ▶     Michelle L. Gee, Matthew Burton, Alistair Grevis-James et al.     Antimicrobial peptides hold promise as broad-spectrum alternatives to conventional antibiotics. The mechanism of action of this class of peptide is a topical area of research …             12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma ▶     Ulaganathan Mabalirajan, Rakhshinda Rehman, Tanveer Ahmad et al.     The mechanisms underlying asthmatic airway epithelial injury are not clear. 12/15-lipoxygenase (an ortholog of human 15-LOX-1), which is induced by IL-13, is associated with …             Drug addiction is associated with leukocyte telomere length ▶     Zhaoyang Yang, Junyi Ye, Candong Li et al.     Telomeres are protective chromosomal structures that play a key role in preserving genomic stability. Telomere length is known to be associated with ageing and age-related …             A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media ▶     Kazuhiro Aoki, Koichi Takahashi, Kazunari Kaizu et al.     Cytoplasm contains a large number of macromolecules at extremely high densities. How this striking nature of intracellular milieu called macromolecular crowding affects …             Extracorporeal Delivery of rAAV with Metabolic Exchange and Oxygenation ▶     Scott Bieber, Jeffrey B. Halldorson, Eric Finn et al.     Over the past decade much progress has been made towards the treatment of disease with recombinant adeno-associated viral vectors, ranging from cancer to muscular dystrophies, and …             Adaptive role switching promotes fairness in networked ultimatum game ▶     Te Wu, Feng Fu, Yanling Zhang et al.     In recent years, mechanisms favoring fair split in the ultimatum game have attracted growing interests because of its practical implications for international bargains. In this …             Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder ▶     Zhongchun Liu, Wanhong Liu, Lihua Yao et al.     Major depressive disorder (MDD) is a long-term, recurrent condition that often takes a chronic course. It seems imperative that research should be focused on gaining a better …             Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients ▶     Rui Li, Tao Ma, Jin Gu et al.     Cold Syndrome and Hot Syndrome are thousand-year-old key therapeutic concepts in traditional Chinese medicine (TCM), which depict the loss of body homeostasis. However, the …             CORRIGENDUM: Positive and negative selection, self-nonself discrimination and the roles of costimulation and anergy ▶     P. Mostardinha, F. Vistulo de Abreu                 Homologous recombination-mediated gene targeting in the liverwort Marchantia polymorpha L. ▶     Kimitsune Ishizaki, Yasuyo Johzuka-Hisatomi, Sakiko Ishida et al.     The liverwort Marchantia polymorpha is an emerging model organism on account of its ideal characteristics for molecular genetics in addition to occupying a crucial position in the …             Novel Nanosomes for Gene Delivery to Plasmodium falciparum-infected Red Blood Cells ▶     Anusha M. Gopalakrishnan, Anup K. Kundu, Tarun K. Mandal et al.     Malaria threatens millions of people annually and is a burden to human health and economic development. Unfortunately in terms of disease control, no effective vaccines are …             A library of programmable DNAzymes that operate in a cellular environment ▶     Maya Kahan-Hanum, Yehonatan Douek, Rivka Adar et al.     DNAzymes were used as inhibitory agents in a variety of experimental disease settings, such as cancer, viral infections and even HIV. Drugs that become active only upon the …             Controlling Circadian Rhythms by Dark-Pulse Perturbations in Arabidopsis thaliana ▶     Hirokazu Fukuda, Haruhiko Murase, Isao T. Tokuda     Plant circadian systems are composed of a large number of self-sustained cellular circadian oscillators. Although the light-dark signal in the natural environment is known to be …             Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing ▶     Wei Ma, Li-Xia Qin, Feng-Tao Liu et al.     Quantum dots (QDs) have attracted increasing interest in bioimaging and sensing. Here, we report a biosensor of complex I using ubiquinone-terminated disulphides with different …             Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer ▶     Fumio Ishizaki, Tsutomu Nishiyama, Takashi Kawasaki et al.     Intratumoral synthesis of dihydrotestosterone (DHT) from precursors cannot completely explain the castration resistance of prostate cancer. We showed that DHT was intratumorally …             CORRIGENDUM: Centenarians, but not octogenarians, up-regulate the expression of microRNAs ▶     Eva Serna, Juan Gambini, Consuelo Borras et al.                 CORRIGENDUM: Cell sorting in a Petri dish controlled by computer vision ▶     Z. Környei, S. Beke, T. Mihálffy et al.                 The odor of Osmanthus fragrans attenuates food intake ▶     Takashi Yamamoto, Tadashi Inui, Tadataka Tsuji     Odors have been shown to exert an influence on various physiological and behavioral activities. However, little is known whether or not odor stimulation directly affects the …             Exploring structure-function relationships between TRP and Kv channels ▶     Jeet Kalia, Kenton J. Swartz     The molecular mechanisms underlying the activation of Transient Receptor Potential (TRP) ion channels are poorly understood when compared to those of the voltage-activated …             DNA barcoding reveals the coral “laboratory-rat”, Stylophora pistillata encompasses multiple identities ▶     Shashank Keshavmurthy, Sung-Yin Yang, Ada Alamaru et al.     Stylophora pistillata is a widely used coral “lab-rat” species with highly variable morphology and a broad biogeographic range (Red Sea to western central Pacific). Here we show, …             Evolution of collective action in adaptive social structures ▶     João A. Moreira, Jorge M. Pacheco, Francisco C. Santos     Many problems in nature can be conveniently framed as a problem of evolution of collective cooperative behaviour, often modelled resorting to the tools of evolutionary game theory …             Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices ▶     A. Zebda, S. Cosnier, J.-P. Alcaraz et al.     We describe the first implanted glucose biofuel cell (GBFC) that is capable of generating sufficient power from a mammal's body fluids to act as the sole power source for …             Aedes Taeniorhynchus Vectorial Capacity Informs A Pre-Emptive Assessment Of West Nile Virus Establishment In Galápagos ▶     Gillian Eastwood, Simon J. Goodman, Andrew A. Cunningham et al.     Increased connectivity with the mainland has led to the arrival of many invasive species to the Galápagos Islands, including novel pathogens, threatening the archipelago's unique …             Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’ ▶     Felix F. Schumacher, Vishal A. Sanchania, Berend Tolner et al.     A major obstacle to the efficient production of antibody conjugates for therapy and diagnosis is the non-ideal performance of commonly used chemical methods for the attachment of …             Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression ▶     Julia Ledderose, Sandra Dieter, Martin K. Schwarz     γ-protocadherins (γ-pcdhs) are transmembrane receptor proteins ubiquitously expressed in the postnatal and adult mouse brain. γ-pcdhs are required for normal neuronal development …             Humans use Compression Heuristics to Improve the Recall of Social Networks ▶     Matthew E. Brashears     The ability of primates, including humans, to maintain large social networks appears to depend on the ratio of the neocortex to the rest of the brain. However, observed human …             Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice ▶     Rachel A. Bergstrom, Jee Hyun Choi, Armando Manduca et al.     Visual scoring of murine EEG signals is time-consuming and subject to low inter-observer reproducibility. The Racine scale for behavioral seizure severity does not provide …             Using False Discovery Rates to Benchmark SNP-callers in next-generation sequencing projects ▶     Rhys A. Farrer, Daniel A. Henk, Dan MacLean et al.     Sequence alignments form the basis for many comparative and population genomic studies. Alignment tools provide a range of accuracies dependent on the divergence between the …             Hot bodies protect amphibians against chytrid infection in nature ▶     Jodi J. L. Rowley, Ross A. Alford     Environmental context strongly affects many host-pathogen interactions, but the underlying causes of these effects at the individual level are usually poorly understood. The …             Lighting Up Ultraviolet Fluorescence From Chicken Albumen Through Plasmon Resonance Energy Transfer of Gold Nanoparticles ▶     I. -Tsung Chen, Po-Hsiang Chang, Yun-Chorng Chang et al.     Au nanoparticles (AuNPs), which easily aggregate in organic thin film, are observed to well-disperse in chicken albumen thin films. The incorporated AuNPs is distributed uniformly …             ERRATUM: A Broadly Cross-Reactive Monoclonal Antibody Against an Epitope on the N-terminus of Meningococcal fHbp ▶     David M. Vu, Rolando Pajon, Donald C. Reason et al.                 Nutrient supply from fishes facilitates macroalgae and suppresses corals in a Caribbean coral reef ecosystem ▶     Deron E. Burkepile, Jacob E. Allgeier, Andrew A. Shantz et al.     On coral reefs, fishes can facilitate coral growth via nutrient excretion; however, as coral abundance declines, these nutrients may help facilitate increases in macroalgae. By …             Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier ▶     Eduard Urich, Christoph Patsch, Stefan Aigner et al.     The blood brain barrier (BBB) has evolved unique characteristics such as dense coverage of the endothelial cells by pericytes and interactions with astrocytes through perivascular …             Effects of Gravitational Mechanical Unloading in Endothelial Cells: Association between Caveolins, Inflammation and Adhesion Molecules ▶     S. Marlene Grenon, Marion Jeanne, Jesus Aguado-Zuniga et al.     Mechanical forces including gravity affect endothelial cell (ECs) function, and have been implicated in vascular disease as well as physiologic changes associated with low gravity …             ERRATUM: DNA Nanostructure-based Interfacial engineering for PCR-free ultrasensitive electrochemical analysis of microRNA ▶     Yanli Wen, Hao Pei, Ye Shen et al.                 How Natural Selection Can Create Both Self- and Other-Regarding Preferences, and Networked Minds ▶     Thomas Grund, Christian Waloszek, Dirk Helbing     Biological competition is widely believed to result in the evolution of selfish preferences. The related concept of the ‘homo economicus’ is at the core of mainstream economics. …             Interregional neural synchrony has similar dynamics during spontaneous and stimulus-driven states ▶     Avniel Singh Ghuman, Rebecca N. van den Honert, Alex Martin     Assessing the correspondence between spontaneous and stimulus-driven neural activity can reveal intrinsic properties of the brain. Recent studies have demonstrated that many …             Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging ▶     Chunxia Qin, Kai Cheng, Kai Chen et al.     Development of reporter genes for multimodality molecular imaging is highly important. In contrast to the conventional strategies which have focused on fusing several reporter …             How human location-specific contact patterns impact spatial transmission between populations? ▶     Lin Wang, Zhen Wang, Yan Zhang et al.     The structured-population model has been widely used to study the spatial transmission of epidemics in human society. Many seminal works have demonstrated the impact of human …             Synthesis and characterization of a new class of anti-angiogenic agents based on ruthenium clusters ▶     Alexey A. Nazarov, Mathurin Baquié, Patrycja Nowak-Sliwinska et al.     New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic …             Gliotoxicity of the cyanotoxin, β-methyl-amino-L-alanine (BMAA) ▶     Alexander S. Chiu, Michelle M. Gehringer, Nady Braidy et al.     The amino acid variant β-methyl-amino-L-alanine (BMAA) has long been associated with the increased incidence and progression of the amyotrophic lateral sclerosis/Parkinsonism …             Profiling core-periphery network structure by random walkers ▶     Fabio Della Rossa, Fabio Dercole, Carlo Piccardi     Disclosing the main features of the structure of a network is crucial to understand a number of static and dynamic properties, such as robustness to failures, spreading dynamics, …             Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2 ▶     Jifeng Zhang, Yuan Zhang, Tingwan Sun et al.     The molecular mechanism to regulate energy balance is not completely understood. Here we observed that Egr-1 expression in white adipose tissue (WAT) was highly correlated with …             Feeding requirements of white sharks may be higher than originally thought ▶     J. M. Semmens, N. L. Payne, C. Huveneers et al.     Quantifying the energy requirements of animals in nature is critical for understanding physiological, behavioural, and ecosystem ecology; however, for difficult-to-study species …             Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice ▶     Nobuhisa Iwata, Misaki Sekiguchi, Yoshino Hattori et al.     Accumulation of amyloid-β peptide (Aβ) in the brain is closely associated with cognitive decline in Alzheimer's disease (AD). Stereotaxic infusion of neprilysin-encoding viral …             Frequency representation within the human brain: Stability versus plasticity ▶     Hubert H. Lim, Minoo Lenarz, Gert Joseph et al.     A topographical representation for frequency has been identified throughout the auditory brain in animals but with limited evidence in humans. Using a midbrain implant, we …             Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation ▶     Guofeng Guan, Lidan Wu, Ali Asgar Bhagat et al.     The paper reports a new method for three-dimensional observation of the location of focused particle streams along both the depth and width of the channel cross-section in spiral …             Carbon Nanoparticle-based Fluorescent Bioimaging Probes ▶     Susanta Kumar Bhunia, Arindam Saha, Amit Ranjan Maity et al.     Fluorescent nanoparticle-based imaging probes have advanced current labelling technology and are expected to generate new medical diagnostic tools based on their superior …             Deriving dopaminergic neurons for clinical use. A practical approach ▶     Rodolfo Gonzalez, Ibon Garitaonandia, Tatiana Abramihina et al.     New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was …             Ultrasonography of wallaby prenatal development shows that the climb to the pouch begins in utero ▶     Barbara Drews, Kathleen Roellig, Brandon R. Menzies et al.     Marsupials have a functional placenta for a shorter period of time compared to that of eutherian species, and their altricial young reach the teats without any help from the …             High dose folic acid supplementation of rats alters synaptic transmission and seizure susceptibility in offspring ▶     Fernando Girotto, Lucas Scott, Yosef Avchalumov et al.     Maternal folic acid supplementation is essential to reduce the risk of neural tube defects. We hypothesize that high levels of folic acid throughout gestation may produce neural …             Selective modulation of cell response on engineered fractal silicon substrates ▶     Francesco Gentile, Rebecca Medda, Ling Cheng et al.     A plethora of work has been dedicated to the analysis of cell behavior on substrates with ordered topographical features. However, the natural cell microenvironment is …             A novel human endogenous retroviral protein inhibits cell-cell fusion ▶     Jun Sugimoto, Makiko Sugimoto, Helene Bernstein et al.     While common in viral infections and neoplasia, spontaneous cell-cell fusion, or syncytialization, is quite restricted in healthy tissues. Such fusion is essential to human …             Red coral extinction risk enhanced by ocean acidification ▶     Carlo Cerrano, Ulisse Cardini, Silvia Bianchelli et al.     The red coral Corallium rubrum is a habitat-forming species with a prominent and structural role in mesophotic habitats, which sustains biodiversity hotspots. This precious coral …             Protein structure alignment beyond spatial proximity ▶     Sheng Wang, Jianzhu Ma, Jian Peng et al.     Protein structure alignment is a fundamental problem in computational structure biology. Many programs have been developed for automatic protein structure alignment, but most of …             Discovery of some 400 million year-old sensory structures in the compound eyes of trilobites ▶     Brigitte Schoenemann, Euan N. K. Clarkson     Fossilised arthropod compound eyes have frequently been described. Among the oldest known are those from the lower Cambrian of the Chengjiang Lagerstätte (China, c 525 Ma). All …             Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides ▶     Fang Zhu, Hemant Gujar, Jennifer R. Gordon et al.     Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex …             Equilibrium-fluctuation-analysis of single liposome binding events reveals how cholesterol and Ca2+ modulate glycosphingolipid trans-interactions ▶     Angelika Kunze, Marta Bally, Fredrik Höök et al.     Carbohydrate−carbohydrate interactions (CCIs) are of central importance for several biological processes. However, the ultra-weak nature of CCIs generates difficulties in studying …             The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry ▶     Donna M. Omiatek, Amanda J. Bressler, Ann-Sofie Cans et al.     Resolution of synaptic vesicle neurotransmitter content has mostly been limited to the study of stimulated release in cultured cell systems, and it has been controversial as to …             Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1 ▶     Teresa Lambe, John B. Carey, Yuanyuan Li et al.     Alternate prime/boost vaccination regimens employing recombinant replication-deficient adenovirus or MVA, expressing Influenza A virus nucleoprotein and matrix protein 1, induced …             CancerDR: Cancer Drug Resistance Database ▶     Rahul Kumar, Kumardeep Chaudhary, Sudheer Gupta et al.     Cancer therapies are limited by the development of drug resistance, and mutations in drug targets is one of the main reasons for developing acquired resistance. The adequate …             Indirect reciprocity is sensitive to costs of information transfer ▶     Shinsuke Suzuki, Hiromichi Kimura     How natural selection can promote cooperative or altruistic behavior is a fundamental question in biological and social sciences. One of the persuasive mechanisms is "indirect …             The Actinobacterial Colonization of Etruscan Paintings ▶     Marta Diaz-Herraiz, Valme Jurado, Soledad Cuezva et al.     The paintings from Tomba della Scimmia, in Tuscany, are representative of the heavy bacterial colonization experienced in most Etruscan necropolises. The tomb remained open until …             Monitoring dynamics of human adenovirus disassembly induced by mechanical fatigue ▶     A. Ortega-Esteban, A. J. Pérez-Berná, R. Menéndez-Conejero et al.     The standard pathway for virus infection of eukaryotic cells requires disassembly of the viral shell to facilitate release of the viral genome into the host cell. Here we use …             ERRATUM: A high-throughput behavioral paradigm for Drosophila olfaction - The Flywalk ▶     Kathrin Steck, Daniel Veit, Ronald Grandy et al.                 Generation of eX vivo-vascularized Muscle Engineered Tissue (X-MET) ▶     Silvia Carosio, Laura Barberi, Emanuele Rizzuto et al.     The object of this study was to develop an in vitro bioengineered three-dimensional vascularized skeletal muscle tissue, named eX-vivo Muscle Engineered Tissue (X-MET). This new …             Loss of the six3/6 controlling pathways might have resulted in pinhole-eye evolution in Nautilus ▶     Atsushi Ogura, Masa-aki Yoshida, Takeya Moritaki et al.     Coleoid cephalopods have an elaborate camera eye whereas nautiloids have primitive pinhole eye without lens and cornea. The Nautilus pinhole eye provides a unique example to …             Effects of cold stress and heat stress on coral fluorescence in reef-building corals ▶     Melissa S. Roth, Dimitri D. Deheyn     Widespread temperature stress has caused catastrophic coral bleaching events that have been devastating for coral reefs. Here, we evaluate whether coral fluorescence could be …             Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis ▶     A. Butykai, A. Orbán, V. Kocsis et al.     The need to develop new methods for the high-sensitivity diagnosis of malaria has initiated a global activity in medical and interdisciplinary sciences. Most of the diverse …             Soil-type influences human selenium status and underlies widespread selenium deficiency risks in Malawi ▶     Rachel Hurst, Edwin W. P. Siyame, Scott D. Young et al.     Selenium (Se) is an essential human micronutrient with critical roles in immune functioning and antioxidant defence. Estimates of dietary Se intakes and status are scarce for …             Detection and Quantification of Methylation in DNA using Solid-State Nanopores ▶     Jiwook Shim, Gwendolyn I. Humphreys, Bala Murali Venkatesan et al.     Epigenetic modifications in eukaryotic genomes occur primarily in the form of 5-methylcytosine (5 mC). These modifications are heavily involved in transcriptional repression, gene …             Gene network requirements for regulation of metabolic gene expression to a desired state ▶     Jan Berkhout, Bas Teusink, Frank J. Bruggeman     Gene circuits that control metabolism should restore metabolic functions upon environmental changes. Whether gene networks are capable of steering metabolism to optimal states is …             Highlighted Ca2+ imaging with a genetically encoded ‘caged’ indicator ▶     Tomoki Matsuda, Kazuki Horikawa, Kenta Saito et al.     Genetically encoded fluorescent indicators for bioimaging are powerful tools for visualizing biological phenomena in specified cell types or cellular compartments. However, …             The ignored diversity: complex bacterial communities in intensive care units revealed by 16S pyrosequencing ▶     Lisa Oberauner, Christin Zachow, Stefan Lackner et al.     Indoor microbial communities play an important role in everyday human health, especially in the intensive care units (ICUs) of hospitals. We used amplicon pyrosequencing to study …             Laser Engineered Graphene Paper for Mass Spectrometry Imaging ▶     Kun Qian, Liang Zhou, Jian Liu et al.     A pulsed laser engineering approach is developed to prepare novel functional graphene paper with graphitic nanospheres homogeneously decorated on the surface and the superior …             Reduced acoustic and electric integration in concurrent-vowel recognition ▶     Hsin-I Yang, Fan-Gang Zeng     The present study used concurrent-vowel recognition to measure integration efficiency of combined acoustic and electric stimulation in eight actual cochlear-implant subjects who …             iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis ▶     Tetsutaro Kito, Rei Shibata, Masakazu Ishii et al.     Angiogenic cell therapy represents a novel strategy for ischemic diseases, but some patients show poor responses. We investigated the therapeutic potential of an induced …             Effects of constant immigration on the dynamics and persistence of stable and unstable Drosophila populations ▶     Snigdhadip Dey, Amitabh Joshi     Constant immigration can stabilize population size fluctuations but its effects on extinction remain unexplored. We show that constant immigration significantly reduced extinction …             Hierarchical molecular tagging to resolve long continuous sequences by massively parallel sequencing ▶     Sverker Lundin, Joel Gruselius, Björn Nystedt et al.     Here we demonstrate the use of short-read massive sequencing systems to in effect achieve longer read lengths through hierarchical molecular tagging. We show how indexed and …             Spatial and functional organization of mitochondrial protein network ▶     Jae-Seong Yang, Jinho Kim, Solip Park et al.     Characterizing the spatial organization of the human mitochondrial proteome will enhance our understanding of mitochondrial functions at the molecular level and provide key …             ErbB2 Dephosphorylation and Anti-Proliferative Effects of Neuregulin-1 in ErbB2-Overexpressing Cells; Re-evaluation of Their Low-Affinity Interaction ▶     Ran Wang, Yuriko Iwakura, Kazuaki Araki et al.     Neuregulin-1 binds to ErbB3 and ErbB4 and regulates cancer proliferation and differentiation. Neuregulin-1 had been suggested to also react with ErbB2, but this argument becomes …             SOXC transcription factors in mantle cell lymphoma: the role of promoter methylation in SOX11 expression ▶     Agata Magdalena Wasik, Martin Lord, Xiao Wang et al.     The related transcription factors SOX11, SOX4 and SOX12 (classified as the SOXC family) compete for the same target genes. SOX11 is expressed in most mantle cell lymphomas (MCL) …             Intraovarian transplantation of primordial follicles fails to rescue chemotherapy injured ovaries ▶     Mi-Ryung Park, Yun-Jung Choi, Deug-Nam Kwon et al.     Busulfan and cyclophosphamide (B/C)-treated mice exhibited a marked increase in apoptosis and a concomitant decrease in the ovarian weight. Histological and RT-PCR analysis …             Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease ▶     Carmen Noelker, Lydie Morel, Thomas Lescot et al.     In mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression of a variety of immune-response genes, including inflammatory cytokines. It is …             Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells ▶     Akira Nishiyama, Alexei A. Sharov, Yulan Piao et al.     Networks of transcription factors (TFs) are thought to determine and maintain the identity of cells. Here we systematically repressed each of 100 TFs with shRNA and carried out …             Structural Basis for the Interaction of Unstructured Neuron Specific Substrates Neuromodulin and Neurogranin with Calmodulin ▶     Veerendra Kumar, Vishnu Priyanka Reddy Chichili, Ling Zhong et al.     Neuromodulin (Nm) and neurogranin (Ng) are neuron-specific substrates of protein kinase C (PKC). Their interactions with Calmodulin (CaM) are crucial for learning and memory …             Laccase production by Coriolopsis caperata RCK2011: Optimization under solid state fermentation by Taguchi DOE methodology ▶     Preeti Nandal, Sreenivas Rao Ravella, Ramesh Chander Kuhad     Laccase production by Coriolopsis caperata RCK2011 under solid state fermentation was optimized following Taguchi design of experiment. An orthogonal array layout of L18 (21 × 37) …             Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology ▶     Stefania Romeo, Cristina Viaggi, Daniela Di Camillo et al.     This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra. Twenty-one days after birth, …             Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28 ▶     Malin Hernebring, Åsa Fredriksson, Maria Liljevald et al.     In embryonic stem cells, removal of oxidatively damaged proteins is triggered upon the first signs of cell fate specification but the underlying mechanism is not known. Here, we …             High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role ▶     K. L. Barott, Y. Helman, L. Haramaty et al.     Corals are an ecologically and evolutionarily significant group, providing the framework for coral reef biodiversity while representing one of the most basal of metazoan phyla. …             Human cooperation by lethal group competition ▶     Martijn Egas, Ralph Kats, Xander van der Sar et al.     Why humans are prone to cooperate puzzles biologists, psychologists and economists alike. Between-group conflict has been hypothesized to drive within-group cooperation. However, …             When do negative and positive emotions modulate working memory performance? ▶     Mariko Osaka, Ken Yaoi, Takehiro Minamoto et al.     The present study investigated when emotion modulates working memory from the perspective of neural activation. Using fMRI, we measured brain activity during the encoding and …             Hirsutella sinensis mycelium suppresses interleukin-1β and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes ▶     Tsung-Teng Huang, Kowit-Yu Chong, David M. Ojcius et al.     Cordyceps sinensis is a medicinal mushroom used for centuries in Asian countries as a health supplement and tonic. Hirsutella sinensis—the anamorphic, mycelial form of C. sinensis…             Bridging nanocontacts to macroscale gecko adhesion by sliding soft lamellar skin supported setal array ▶     Yu Tian, Jin Wan, Noshir Pesika et al.     The study of the mechanism of the controlled adhesion of geckos, which is important for the design and fabrication of bio-inspired dry and reversible adhesive surfaces, is widely …             Bridging the gap between qualitative and quantitative colocalization results in fluorescence microscopy studies ▶     Vadim Zinchuk, Yong Wu, Olga Grossenbacher-Zinchuk     Quantitative colocalization studies suffer from the lack of unified approach to interpret obtained results. We developed a tool to characterize the results of colocalization …             Insect symbiont facilitates vector acquisition, retention, and transmission of plant virus ▶     Qi Su, Huipeng Pan, Baiming Liu et al.     Tomato yellow leaf curl virus (TYLCV) was first detected in China in 2006, following the introduction of Bemisia tabaci Q into China in 2003. Since then, the incidence of TYLCV in …             RNAi suppressor P19 can be broadly exploited for enhanced adenovirus replication and microRNA knockdown experiments ▶     Christina Rauschhuber, Martin Mueck-Haeusl, Wenli Zhang et al.     RNA interference (RNAi) is a key regulator of various biological systems including viral infection. Within a virus life cycle gene products can be modulated by the RNA …             GBM Volumetry using the 3D Slicer Medical Image Computing Platform ▶     Jan Egger, Tina Kapur, Andriy Fedorov et al.     Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using …             Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction ▶     Marianeve Carotenuto, Emilia Pedone, Donatella Diana et al.     Nm23-H1 is one of the most interesting candidate genes for a relevant role in Neuroblastoma pathogenesis. H-Prune is the most characterized Nm23-H1 binding partner, and its …             ERRATUM: Integrated microfluidic device for single-cell trapping and spectroscopy ▶     C. Liberale, G. Cojoc, F. 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