TABLE OF CONTENTS
| | April 2013 | Volume 14, Issue 4 |  | | |  |  Upfront
 Science & Society
 Reviews
 Scientific Reports
Also new
 AOP
| | | |  | | Advertisement | | | | | | | Upfront | Top | | | | Editorial | |  | | The long and winding helix Molecular biology celebrates its diamond jubilee this month, the 60th anniversary of the publication of Watson and Crick's seminal paper on the structure of DNA. It's an appropriate moment to ask how far the subject has come, and where we are headed. Howy Jacobs EMBO reports (2013), 14, 293; 10.1038/embor.2013.31 Full text | PDF Published online: 02 April 2013 Subject Categories: Philosophy & History of Science | | | | Opinion | | | | Biopedagogy The world is changing fast and teachers are struggling to familiarize children and young people with the norms and values of society. Biopedagogy—the biology behind pedagogy approaches—might provide some insights and guidance. Ladislav Kováč EMBO reports (2013), 14, 294; 10.1038/embor.2013.18 Full text | PDF Published online: 05 March 2013 Subject Categories: Societal Issues & Politics | | | | Hot off the Press | | | | A RING finger to wed TCF and β-catenin In this issue of EMBO reports, Waterman and colleagues identify RNF14 as a new enhancer of the Wnt-dependent transcriptional outputs that acts at the level of the TCF/LEF–β-catenin complex. Claudio Cantù, Tomas Valenta and Konrad Basler EMBO reports (2013), 14, 295 - 296; 10.1038/embor.2013.21 Full text | PDF Published online: 12 March 2013 Subject Categories: Chromatin & Transcription | Signal Transduction | | | | Telomere stability—Wnt it or lose it Gilson and colleagues show in this issue of EMBO reports that β-catenin directly controls TRF2 expression and that this is critical for telomere protection in cancer cells. These findings and their implications are discussed here. Kerstin Bauer, Si Tao and K Lenhard Rudolph EMBO reports (2013), 14, 297 - 298; 10.1038/embor.2013.28 Full text | PDF Published online: 19 March 2013 Subject Categories: Genome Stability & Dynamics | Chromatin & Transcription | | | | Meeting Point | | | | Hijacking nature—new approaches to unravel enzyme mechanisms and engineer improved biocatalysts The second EMBO conference on 'Catalytic Mechanisms by Biological Systems' took place in October 2012 and covered technologies to improve our mechanistic understanding of enzymes, as well as the design of robust biocatalysts. Ivan Campeotto and Carlos G Acevedo-Rocha EMBO reports (2013), 14, 299 - 301; 10.1038/embor.2013.26 Full text | PDF Published online: 12 March 2013 Subject Categories: Molecular Evolution | Proteins | Structural Biology | | | | Biggest challenges in bioinformatics The third Heidelberg Unseminars in Bioinformatics (HUB) was held in October at Heidelberg University in Germany. HUB brought together around 40 bioinformaticians from academia and industry to discuss the ‘Biggest Challenges in Bioinformatics’ in a ‘World Café’ style event. Jonathan C Fuller, Pierre Khoueiry, Holger Dinkel, Kristoffer Forslund, Alexandros Stamatakis, Joseph Barry, Aidan Budd, Theodoros G Soldatos, Katja Linssen, Abdul Mateen Rajput and HUB Participants: EMBO reports (2013), 14, 302 - 304; 10.1038/embor.2013.34 Full text | PDF Published online: 15 March 2013 Subject Categories: Genomic & Computational Biology | | Science & Society | Top | | | | Spinning plates and juggling balls A PhD thesis is a project with an established goal and a deadline. As such, the tools, strategies and insight of professional project management can be used effectively to improve both research success and personal well-being. Richard Alun Williams EMBO reports (2013), 14, 305 - 309; 10.1038/embor.2013.17 Full text | PDF Published online: 05 March 2013 Subject Categories: Scientific Training & Careers | | | | Rethinking the life sciences The life sciences are at loggerheads with society and neither much trusts the other. To unleash the full potential of molecular life science, a new contract with society and more organized ways of doing research are needed. Tsjalling Swierstra, Niki Vermeulen, Johan Braeckman and Roel van Driel EMBO reports (2013), 14, 310 - 314; 10.1038/embor.2013.30 Full text | PDF Published online: 19 March 2013 Subject Categories: Science Policy & Funding | Societal Issues & Politics | | | | Brain drain, brain gain or brain sharing? Scientific migration has long been seen in terms of brain drain and brain gain. Recent studies show that the reality is more complex and that even exporters of skilled scientists gain in the long term. Philip Hunter EMBO reports (2013), 14, 315 - 318; 10.1038/embor.2013.33 Full text | PDF Published online: 15 March 2013 Subject Categories: Scientific Training & Careers | | Reviews | Top | | | | The dynamics of gut-associated microbial communities during inflammation Intestinal inflammation is associated with alterations of the microbiota and outgrowth of potentially harmful bacterial species. How these changes in microbial community structure occur is discussed here, highlighting the role of electron acceptors in feeding facultative anaerobic bacteria. Sebastian E Winter, Christopher A Lopez and Andreas J Bäumler EMBO reports (2013), 14, 319 - 327; 10.1038/embor.2013.27 Abstract | Full text | PDF Published online: 12 March 2013 Subject Categories: Microbiology & Pathogens | Immunology | | | | Programming cancer cells for high expression levels of Mcl1 The pro-survival members of the Bcl2 family have been recognized for their ability to save cancer cells from undergoing apoptosis. This review discusses recent progress in understanding the complex biology of one of those proteins, Mcl1, the multiple mechanisms available for re-programming Mcl1 expression by cancer cells, and how this knowledge can be exploited for therapeutic applications. Franziska Ertel, Mai Nguyen, Anne Roulston and Gordon C Shore EMBO reports (2013), 14, 328 - 336; 10.1038/embor.2013.20 Abstract | Full text | PDF Published online: 12 March 2013 Subject Categories: Differentiation & Death | Molecular Biology of Disease | | | | Breathing-in epigenetic change with vitamin C Vitamin C maintains the activity of iron and α-ketoglutarate-dependent dioxygenases. This review discusses recent insight into the roles of such dioxygenases in reprogramming, epigenetic regulation and stem cell differentiation and points out that dioxygenase function might be influenced by the available levels of vitamin C. Asun Monfort and Anton Wutz EMBO reports (2013), 14, 337 - 346; 10.1038/embor.2013.29 Abstract | Full text | PDF Published online: 15 March 2013 Subject Categories: Chromatin & Transcription | Cellular Metabolism | Differentiation & Death | | Scientific Reports | Top | | | | Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival This report identifies RNF14 as a new binding partner of TCF/LEF transcription factors that positively regulates Wnt signalling in human cancer cells and in an in vivo zebra fish model. Beibei Wu, Sarah Piloto, Weihua Zeng, Nate P Hoverter, Thomas F Schilling and Marian L Waterman EMBO reports (2013), 14, 347 - 355; 10.1038/embor.2013.19 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 March 2013 Subject Categories: Signal Transduction | Chromatin & Transcription | | | | Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway This study indicates that TRF2 is a direct target of Wnt/β-catenin signalling in normal and cancer cells, and shows that β-catenin-controlled TRF2 expression is crucial for telomere protection in cancer cells. Irmina Diala, Nicole Wagner, Frédérique Magdinier, Marina Shkreli, Maria Sirakov, Serge Bauwens, Caroline Schluth-Bolard, Thomas Simonet, Valérie M Renault, Jing Ye, Abdelnnadir Djerbi, Pascal Pineau, Jinkuk Choi, Steven Artandi, Anne Dejean, Michelina Plateroti and Eric Gilson EMBO reports (2013), 14, 356 - 363; 10.1038/embor.2013.16 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 February 2013 Subject Categories: Genome Stability & Dynamics | | | | Beclin-1 is required for chromosome congression and proper outer kinetochore assembly Beclin-1 has a new role independent of the PI3K-III complex and autophagy. Loss of Beclin-1 reduces outer kinetochore proteins and causes severe problems in chromosome congression, and its interaction with Zwint-1 promotes kinetochore–microtubule interactions. Stéphane Frémont, Annabelle Gérard, Marie Galloux, Katy Janvier, Roger E Karess and Clarisse Berlioz-Torrent EMBO reports (2013), 14, 364 - 372; 10.1038/embor.2013.23 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 March 2013 Subject Categories: Cell Cycle | Genome Stability & Dynamics | | | | Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery Ubiquilins are ubiquitin-binding proteins involved in protein degradation and implicated in neurodegenerative disease. Ubqln1 regulates autophagosome maturation, and this study reports that Ubqln4 is essential in this process, as it recruits Ubqln1 to LC3. Dong Yun Lee, David Arnott and Eric J Brown EMBO reports (2013), 14, 373 - 381; 10.1038/embor.2013.22 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 05 March 2013 Subject Categories: Membranes & Transport | Proteins | | | | ORE1 balances leaf senescence against maintenance by antagonizing G2-like-mediated transcription Transcription factor ORE1 is a key regulator of senescence in Arabidopsis thaliana. Here, it is shown to also inhibit the function of Golden2-like transcription factors, which antagonize senescence, revealing a new mechanism of ORE1-mediated senescence control. Mamoona Rauf, Muhammad Arif, Hakan Dortay, Lilian P Matallana-Ramírez, Mark T Waters, Hong Gil Nam, Pyung-Ok Lim, Bernd Mueller-Roeber and Salma Balazadeh EMBO reports (2013), 14, 382 - 388; 10.1038/embor.2013.24 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 05 March 2013 Subject Categories: Cell Cycle | Plant Biology | | | | Physiological release of endogenous tau is stimulated by neuronal activity EMBO Open This report provides evidence that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from cortical neurons via a calcium-dependent mechanism. Dysregulation of this process could lead to the spread of tau pathology in disease. Amy M Pooler, Emma C Phillips, Dawn H W Lau, Wendy Noble and Diane P Hanger EMBO reports (2013), 14, 389 - 394; 10.1038/embor.2013.15 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 February 2013 Subject Categories: Membranes & Transport | Neuroscience | Molecular Biology of Disease | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. 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