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|  | | 09 April 2013 | | | Featured image: | |  | | | Calcareous nannofossils found in North Sea chalk by Mutterlose et al. suggest warm high-latitude conditions in the Early Cretaceous. | | | | | | |
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Ludwig Institute for Cancer Research, Nature Genetics, and Nature Reviews Cancer present: Nuclear Reprogramming and the Cancer Genome
St. Catherine's College, University of Oxford, Oxford, UK
September 25-27, 2013
Click here for more information or to register for this conference. | | | | | | | Latest Articles | View all Articles | | | | | Design principle for increasing charge mobility of π-conjugated polymers using regularly localized molecular orbitals OPEN | | | Jun Terao, Akihisa Wadahama, Akitoshi Matono, Tomofumi Tada, Satoshi Watanabe, Shu Seki, Tetsuaki Fujihara and Yasushi Tsuji | | | Polymers are good potential processable materials for electronic components; however, their charge mobilities are quite low. Here, the authors show that wrapping polymers with macrocycles and localization of π-orbitals realizes an ideal orbital alignment for charge hopping with subsequently increased mobility. | | | 09 Apr | Nat Commun 4:1691 doi:10.1038/ncomms2707 (2013) | | | Chemical sciences Materials science | | | Organic chemistry Physical chemistry | | Abstract | Full Text | PDF (1,133 kB) |
Supplementary Information |
| Diamond-integrated optomechanical circuits | | | Patrik Rath, Svetlana Khasminskaya, Christoph Nebel, Christoph Wild and Wolfram H.P. Pernice | | | Diamond is of interest for optical and electronic applications owing to its unique mechanical and optical properties. Here, Rath et al. demonstrate the use of small nanometre-sized beams etched from diamond thin films for integrated photonic circuits. | | | 09 Apr | Nat Commun 4:1690 doi:10.1038/ncomms2710 (2013) | | | Physical sciences Materials science | | | Nanotechnology Optical physics | | | Abstract | Full Text | PDF (1,642 kB) |
| Symmetry protected Josephson supercurrents in three-dimensional topological insulators | | | Sungjae Cho, Brian Dellabetta, Alina Yang, John Schneeloch, Zhijun Xu, Tonica Valla, Genda Gu, Matthew J. Gilbert and Nadya Mason | | | When a topological insulator is coupled with a superconductor, supercurrents arise that—if fully understood—may allow the detection of long-sought Majorana fermions. Here the nature of these supercurrents is further elucidated as they are characterized as non-symmetric and carried by surface states. | | | 09 Apr | Nat Commun 4:1689 doi:10.1038/ncomms2701 (2013) | | | Physical sciences Condensed matter | | Abstract | Full Text | PDF (1,109 kB) |
Supplementary Information |
| Shaping colloids for self-assembly | | | Stefano Sacanna, Mark Korpics, Kelvin Rodriguez, Laura Colón-Meléndez, Seung-Hyun Kim, David J. Pine and Gi-Ra Yi | | | Creating new materials requires novel approaches to design and synthesize small building particles. Sacanna et al. develop a versatile synthetic strategy to design and mass-produce colloidal building blocks starting from two different colloids that leads to selectively functionalized surface areas. | | | 09 Apr | Nat Commun 4:1688 doi:10.1038/ncomms2694 (2013) | | | Physical sciences Condensed matter | | | Materials science Nanotechnology | | Abstract | Full Text | PDF (1,281 kB) |
Supplementary Information |
| Graphene-modified LiFePO4 cathode for lithium ion battery beyond theoretical capacity | | | By Lung-Hao Hu, Feng-Yu Wu, Cheng-Te Lin, Andrei N. Khlobystov and Lain-Jong Li | | | The specific capacity of an important commercial cathode material, lithium iron phosphate, is much lower than its theoretical value. Hu et al. report that incorporation of electrochemically exfoliated graphene layers in a carbon coating improves capacity beyond that predicted by theory. | | | 09 Apr | Nat Commun 4:1687 doi:10.1038/ncomms2705 (2013) | | | Chemical sciences Materials science | | | Nanotechnology Physical chemistry | | Abstract | Full Text | PDF (906 kB) |
Supplementary Information |
| Early Cretaceous chalks from the North Sea giving evidence for global change | | | Jörg Mutterlose and Cinzia Bottini | | | Calcareous nannofossils were important marine primary producers in Jurassic and Cretaceous oceans at low latitudes. Here, North Sea sediment records reveal that favourable conditions for nannoconids existed also at high latitudes, and nannoconids faced global decline at the onset of greenhouse conditions. | | | 09 Apr | Nat Commun 4:1686 doi:10.1038/ncomms2698 (2013) | | | Earth sciences Oceanography | | | Palaeontology | | | Abstract | Full Text | PDF (702 kB) |
| Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase OPEN | | | Chengcan Yao, Takako Hirata, Kitipong Soontrapa, Xiaojun Ma, Hiroshi Takemori and Shuh Narumiya | | | Activation of cAMP signalling by prostaglandin E2 (PGE2) has long been thought to suppress Tcell receptor activation and Th1 cell differentiation. Yao et al. reveal that dual stimulation of both cAMP and PI 3-kinase pathways by PGE2 synergistically promotes Th1 differentiation by amplifying IL-12 and IFN-γ signalling. | | | 09 Apr | Nat Commun 4:1685 doi:10.1038/ncomms2684 (2013) | | | Biological sciences Immunology | | Abstract | Full Text | PDF (2,799 kB) |
Supplementary Information |
| Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD OPEN | | | Kensei Komatsu, Ji-Yun Lee, Masanori Miyata, Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Haidong Xu, Chen Yan, Hirofumi Kai and Jian-Dong Li | | | Phosphodiesterase 4 inhibitors are under development as anti-inflammatory drugs, however, their mechanisms of action remain poorly understood. Komatsu et al. show that Rolipram, a specific inhibitor of PDE4, reduces inflammation in a model of middle ear infection by upregulating the deubiquitinase CYLD. | | | 09 Apr | Nat Commun 4:1684 doi:10.1038/ncomms2674 (2013) | | | Biological sciences Immunology | | Abstract | Full Text | PDF (1,720 kB) |
Supplementary Information |
| Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10 | | | Patricia Verheugd, Alexandra H. Forst, Larissa Milke, Nicolas Herzog, Karla L.H. Feijs, Elisabeth Kremmer, Henning Kleine and Bernhard Lüscher | | | Mono-ADP-ribosylation is a recently discovered post-translational modification whose function remains unclear. Verheugd et al. show that the mono-ADP-ribosyltransferase ARTD10 inhibits NF-κB activation by preventing the poly-ubiquitination of NEMO, suggesting a functional link between these two modifications. | | | 09 Apr | Nat Commun 4:1683 doi:10.1038/ncomms2672 (2013) | | | Biological sciences Biochemistry | | | Cell biology | | | Abstract | Full Text | PDF (1,447 kB) |
| A role for Piezo2 in EPAC1-dependent mechanical allodynia OPEN | | | N Eijkelkamp, J.E. Linley, J.M. Torres, L. Bee, A.H. Dickenson, M. Gringhuis, M.S. Minett, G.S. Hong, E. Lee, U. Oh, Y. Ishikawa, F.J. Zwartkuis, J.J. Cox and J.N. Wood | | | Mechanical allodynia describes the process whereby innocuous stimuli is perceived as being noxious and is a common symptom of neuropathic pain. Using mice deficient in the cAMP sensor Epac1, the authors in this study find that Epac1 regulates mechanical allodynia by sensitizing the mechanotransducer Piezo2. | | | 09 Apr | Nat Commun 4:1682 doi:10.1038/ncomms2673 (2013) | | | Biological sciences Neuroscience | | Abstract | Full Text | PDF (1,314 kB) |
Supplementary Information |
| Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK | | | Peter D. Mace, Yann Wallez, Michael F. Egger, Małgorzata K Dobaczewska, Howard Robinson, Elena B. Pasquale and Stefan J. Riedl | | | PEA-15 is a scaffold protein that regulates the localization and phosphorylation of the MAP kinase ERK2. By solving the structure of the PEA-15/ERK2 complex, the authors show that PEA-15 restrains ERK2 in a spring-loaded, activated form. | | | 09 Apr | Nat Commun 4:1681 doi:10.1038/ncomms2687 (2013) | | | Biological sciences Biochemistry | | | Cell biology | | Abstract | Full Text | PDF (1,569 kB) |
Supplementary Information |
| Coherent diffraction imaging of nanoscale strain evolution in a single crystal under high pressure OPEN | | | Wenge Yang, Xiaojing Huang, Ross Harder, Jesse N. Clark, Ian K. Robinson and Ho-kwang Mao | | | Extreme pressure can induce significant changes in a material's mechanical response, but characterizing the evolution of these changes as they take place is challenging. Yang et al. demonstrate the use of coherent X-ray diffraction imaging to follow changes in the three-dimensional shape and strain fields within gold particles under pressure. | | | 09 Apr | Nat Commun 4:1680 doi:10.1038/ncomms2661 (2013) | | | Physical sciences Condensed matter | | | Materials science | | Abstract | Full Text | PDF (676 kB) |
Supplementary Information |
| Stepwise self-assembly of C60 mediated by atomic scale moiré magnifiers | | | D.V. Gruznev, A.V. Matetskiy, L.V. Bondarenko, O.A. Utas, A.V. Zotov, A.A. Saranin, J.P. Chou, C.M. Wei, M.Y. Lai and Y.L. Wang | | | A promising route towards molecular devices is the self-assembly of atoms or molecules on a surface. Here, Gruznev et al. show that the synthesis of unique geometries of C60 molecules on gold–indium-covered crystalline silicon is governed by moiré interference. | | | 09 Apr | Nat Commun 4:1679 doi:10.1038/ncomms2706 (2013) | | | Chemical sciences Materials science | | | Physical chemistry | | Abstract | Full Text | PDF (1,013 kB) |
Supplementary Information |
| A light-driven sodium ion pump in marine bacteria | | | Keiichi Inoue, Hikaru Ono, Rei Abe-Yoshizumi, Susumu Yoshizawa, Hiroyasu Ito, Kazuhiro Kogure and Hideki Kandori | | | Light-driven proton-pumping rhodopsins are widely distributed in microorganisms and convert sunlight energy into proton gradients. Inoue et al. report the discovery of a light-driven sodium ion pump from marine bacteria. | | | 09 Apr | Nat Commun 4:1678 doi:10.1038/ncomms2689 (2013) | | | Biological sciences Biophysics | | | Microbiology | | Abstract | Full Text | PDF (1,836 kB) |
Supplementary Information |
| Ancient DNA reveals that bowhead whale lineages survived Late Pleistocene climate change and habitat shifts | | | Andrew D. Foote, Kristin Kaschner, Sebastian E. Schultze, Cristina Garilao, Simon Y.W. Ho, Klaas Post, Thomas F.G. Higham, Catherine Stokowska, Henry van der Es, Clare B. Embling, Kristian Gregersen, Friederike Johansson, Eske Willerslev and M Thomas P. Gilbert | | | The response of marine species to the Pleistocene climate change is largely unknown. Foote et al. find that the bowhead whale tracked shifting habitat at the end of the Pleistocene and increased in effective population size as suitable habitat and population connectivity increased. | | | 09 Apr | Nat Commun 4:1677 doi:10.1038/ncomms2714 (2013) | | | Biological sciences Ecology | | | Evolution | | Abstract | Full Text | PDF (836 kB) |
Supplementary Information |
| A new protein complex promoting the assembly of Rad51 filaments | | | Hiroyuki Sasanuma, Maki S. Tawaramoto, Jessica P. Lao, Harumi Hosaka, Eri Sanda, Mamoru Suzuki, Eiki Yamashita, Neil Hunter, Miki Shinohara, Atsushi Nakagawa and Akira Shinohara | | | RecA/Rad51 proteins catalyse the recognition and exchange between two homologous DNA strands during homologous recombination. Sasanuma et al. now demonstrate that Rad51 association with ssDNA is mediated by a complex consisting of Psy3, Csm2, Shu1 and Shu2 proteins. | | | 09 Apr | Nat Commun 4:1676 doi:10.1038/ncomms2678 (2013) | | | Biological sciences Molecular biology | | Abstract | Full Text | PDF (6,273 kB) |
Supplementary Information |
| Electrically driven polarized single-photon emission from an InGaN quantum dot in a GaN nanowire | | | Saniya Deshpande, Junseok Heo, Ayan Das and Pallab Bhattacharya | | | Devices that emit single photons are of importance to quantum information processing. Here, Bhattacharya et al. realize an electrically driven single-photon source for visible light based on an indium gallium nitride quantum dot placed within a gallium nitride nanowire. | | | 09 Apr | Nat Commun 4:1675 doi:10.1038/ncomms2691 (2013) | | | Physical sciences Nanotechnology | | | Optical physics | | Abstract | Full Text | PDF (1,776 kB) |
Supplementary Information |
| Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81 | | | Stéphanie Charrin, Mathilde Latil, Sabrina Soave, Anna Polesskaya, Fabrice Chrétien, Claude Boucheix and Eric Rubinstein | | | The skeletal muscle has a remarkable capacity to regenerate after injury. Here Charrin et al. reveal that restoration of muscle architecture after injury requires a tight control of muscle cell fusion by the tetraspanin proteins CD9 and CD81 through their interaction with the cell surface protein CD9P-1. | | | 09 Apr | Nat Commun 4:1674 doi:10.1038/ncomms2675 (2013) | | | Biological sciences Cell biology | | | Medical research | | Abstract | Full Text | PDF (4,635 kB) |
Supplementary Information |
| Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin | | | M.I. Setyawati, C.Y. Tay, S.L. Chia, S.L. Goh, W. Fang, M.J. Neo, H.C. Chong, S.M. Tan, S.C.J. Loo, K.W. Ng, J.P. Xie, C.N. Ong, N.S. Tan and D.T. Leong | | | Nanoparticles can accumulate in tissues but how they interact with cells is poorly understood. Here Setyawati and colleagues report that titanium dioxide nanoparticles disrupt protein complexes of the tight junction protein VE-cadherin on endothelial cells to increase blood vessel permeability. | | | 09 Apr | Nat Commun 4:1673 doi:10.1038/ncomms2655 (2013) | | | Biological sciences Medical research Nanotechnology | | Abstract | Full Text | PDF (2,999 kB) |
Supplementary Information |
| VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation OPEN | | | Makoto Hayashi, Arindam Majumdar, Xiujuan Li, Jeremy Adler, Zuyue Sun, Simona Vertuani, Carina Hellberg, Sofie Mellberg, Sina Koch, Anna Dimberg, Gou Young Koh, Elisabetta Dejana, Heinz-Georg Belting, Markus Affolter, Gavin Thurston, Lars Holmgren, Dietmar Vestweber and Lena Claesson-Welsh | | | Vascular endothelial growth factor is implicated in blood vessel development. In zebrafish, Hayashi et al. find that blood vessel development is dependent on the suppression of vascular endothelial growth factor by the phosphatase VE-PTP, which is recruited by activation of the angiopoietin receptor Tie2. | | | 09 Apr | Nat Commun 4:1672 doi:10.1038/ncomms2683 (2013) | | | Biological sciences Developmental biology | | Abstract | Full Text | PDF (4,568 kB) |
Supplementary Information |
| A strong electro-optically active lead-free ferroelectric integrated on silicon | | | Stefan Abel, Thilo Stöferle, Chiara Marchiori, Christophe Rossel, Marta D. Rossell, Rolf Erni, Daniele Caimi, Marilyne Sousa, Alexei Chelnokov, Bert J. Offrein and Jean Fompeyrine | | | The strong electro-optical response of BaTiO3 could be useful for making high-speed switches for optical telecommunications. Abel et al. demonstrate the ability to maintain this response in BaTiO3 films grown directly onto silicon, extending its potential to the development of silicon photonics. | | | 09 Apr | Nat Commun 4:1671 doi:10.1038/ncomms2695 (2013) | | | Physical sciences Materials science | | | Optical physics | | Abstract | Full Text | PDF (1,020 kB) |
Supplementary Information |
| A violation of the uncertainty principle implies a violation of the second law of thermodynamics | | | Esther Hänggi and Stephanie Wehner | | | The laws of thermodynamics and of quantum mechanics are usually derived within different theoretical frameworks. But, Hänggi and Wehner show they are intimately related, such that a violation of quantum uncertainty would allow a heat cycle with a net work gain, violating the second law of thermodynamics. | | | 09 Apr | Nat Commun 4:1670 doi:10.1038/ncomms2665 (2013) | | | Physical sciences Theoretical physics | | Abstract | Full Text | PDF (220 kB) |
Supplementary Information |
| Soft X-ray spectromicroscopy using ptychography with randomly phased illumination | | | A.M. Maiden, G.R. Morrison, B. Kaulich, A. Gianoncelli and J.M. Rodenburg | | | Ptychographic methods can retrieve the complex sample transmittance from diffraction patterns that may have a large dynamic range. For soft X-ray spectromicroscopy, Maiden et al. use a diffuser to randomize the probe phase, reducing the dynamic range of the diffraction data by an order of magnitude. | | | 09 Apr | Nat Commun 4:1669 doi:10.1038/ncomms2640 (2013) | | | Physical sciences Applied physics | | | Optical physics | | | Abstract | Full Text | PDF (1,519 kB) |
| Seismic detection of increased degassing before Kīlauea's 2008 summit explosion | | | Jessica H. Johnson and Michael P. Poland | | | The onset of the ongoing summit eruption at Kīlauea Volcano was associated with changes in seismic anisotropy and increased gas flux. This study shows that seismic anisotropy variations are also a function of alterations in stress conditions, and provides a new method for tracking gas flux using seismic observations. | | | 09 Apr | Nat Commun 4:1668 doi:10.1038/ncomms2703 (2013) | | | Earth sciences Geology and geophysics | | Abstract | Full Text | PDF (2,545 kB) |
Supplementary Information |
| Reactivity mapping with electrochemical gradients for monitoring reactivity at surfaces in space and time OPEN | | | Sven O. Krabbenborg, Carlo Nicosia, Pengkun Chen and Jurriaan Huskens | | | Liquid chemical reactions on surfaces are important, but conventional characterization techniques for solutions cannot be directly applied. This study shows a high-throughput method to control and monitor chemical reactivity on surfaces via an electrochemically produced pH gradient in solutions. | | | 09 Apr | Nat Commun 4:1667 doi:10.1038/ncomms2688 (2013) | | | Chemical sciences Physical chemistry | | Abstract | Full Text | PDF (733 kB) |
Supplementary Information |
| Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus | | | Daisuke Ono, Sato Honma and Ken-ichi Honma | | | The genes encoding cryptochromes are implicated in regulating circadian rhythms in mammals. Ono and colleagues monitor circadian rhythms in cultured suprachiasmatic nucleus tissue from transgenic mice lacking cryptochromes, and find that circadian rhythms are present in neonates but not mature animals. | | | 09 Apr | Nat Commun 4:1666 doi:10.1038/ncomms2670 (2013) | | | Biological sciences Neuroscience | | Abstract | Full Text | PDF (2,233 kB) |
Supplementary Information |
| Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex | | | Bridget E. LaMonica, Jan H. Lui, David V. Hansen and Arnold R. Kriegstein | | | Human neocortex expansion is partly due to neuronal production by outer radial glial cells. In the developing human cortex, LaMonica et al. find that horizontal divisions of ventricular radial glial cells produce outer radial glial cells displaying cell-intrinsic regulation of mitosis and spindle orientation. | | | 09 Apr | Nat Commun 4:1665 doi:10.1038/ncomms2647 (2013) | | | Biological sciences Developmental biology | | | Neuroscience | | Abstract | Full Text | PDF (1,738 kB) |
Supplementary Information |
| Ocean lead at the termination of the Younger Dryas cold spell OPEN | | | Christof Pearce, Marit-Solveig Seidenkrantz, Antoon Kuijpers, Guillaume Massé, Njáll F. Reynisson and Søren M. Kristiansen | | | The abrupt ending of the Younger Dryas cooling episode marked the onset of the present interglacial and was the most prominent climate change in the Earth's recent history. This study shows evidence for a sequence of events with a leading role of the ocean at the transition into the present day warm Holocene epoch. | | | 09 Apr | Nat Commun 4:1664 doi:10.1038/ncomms2686 (2013) | | | Earth sciences Climate science | | | Oceanography | | | Abstract | Full Text | PDF (542 kB) |
| Metallized DNA nanolithography for encoding and transferring spatial information for graphene patterning | | | Zhong Jin, Wei Sun, Yonggang Ke, Chih-Jen Shih, Geraldine L.C. Paulus, Qing Hua Wang, Bin Mu, Peng Yin and Michael S. Strano | | | The structuring of graphene is important towards its use in electronic applications. Here Strano et al. develop a fast and efficient lithography process enabling the transfer of shape information from self-assembled DNA templates to custom graphene patterns at a resolution of about 10 nm. | | | 09 Apr | Nat Commun 4:1663 doi:10.1038/ncomms2690 (2013) | | | Chemical sciences Materials science | | | Nanotechnology Physical chemistry | | Abstract | Full Text | PDF (2,203 kB) |
Supplementary Information |
| FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4 | | | Kuppusamy Balamurugan, Shikha Sharan, Kimberly D. Klarmann, Youhong Zhang, Vincenzo Coppola, Glenn H. Summers, Thierry Roger, Deborah K. Morrison, Jonathan R. Keller and Esta Sterneck | | | The innate immune sensor Toll-like receptor 4 controls inflammatory gene expression. Here the authors identify a network of positive and negative feedback loops involving the transcription factor C/EBPδ and ubiquitin ligase substrate adaptor FBXW7α that regulate TLR4 levels and inflammatory signalling. | | | 09 Apr | Nat Commun 4:1662 doi:10.1038/ncomms2677 (2013) | | | Biological sciences Immunology | | Abstract | Full Text | PDF (861 kB) |
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