Molecular Systems Biology - New articles published 19 March 2013

Latest Articles 19th March 2013   Featured Article Research Articles   Web feeds About Open access Advertisement Evolution of biological networks Evolutionary potential, cross-stress behavior and the genetic basis of acquired stress resistance in Escherichia coli Dragosits, Tagkopoulos and colleagues Mol Syst Biol 9:643 Epigenetic epistatic interactions constrain the evolution of gene expression Park & Lehner Mol Syst Biol 9:645 Competition between species can stabilize public-goods cooperation within a species Celiker & Gore Mol Syst Biol 8:621     Featured Article Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines The stoichiometry of the human nuclear pore complex is revealed by targeted mass spectrometry and super-resolution microscopy. The analysis reveals that the composition of the nuclear pore and other nuclear protein complexes is remodeled as a function of the cell type. Alessandro Ori, Niccolò Banterle, Murat Iskar, Amparo Andrés-Pons, Claudia Escher, Huy Khanh Bui, Lenore Sparks, Victor Solis-Mezarino, Oliver Rinner, Peer Bork, Edward A Lemke & Martin Beck Molecular Systems Biology 9:648; doi:10.1038/msb.2013.4; published 19 March 2013 Full Text | PDF | Supp. Inf. | Review Process Research Articles A fluorescent reporter for mapping cellular protein-protein interactions in time and space A method based on a combination of the Split-Ubiquitin system with two spectrally different fluorescent proteins (SPLIFF) is shown to enable measurement of protein interactions in vivo with high spatial and temporal resolution in yeast. Daniel Moreno, Joachim Neller, Hans A Kestler, Johann Kraus, Alexander Dünkler & Nils Johnsson Molecular Systems Biology 9:647; doi:10.1038/msb.2013.3; published 19 March 2013 Full Text | PDF | Supp. Inf. | Review Process Integration of clinical data with a genome-scale metabolic model of the human adipocyte Combining large-scale immunohistochemical analysis and proteomics data, 7340 gene products are identified in human adipocytes. Based on this data, a genome-scale metabolic model is reconstructed and used to integrate clinical and transcriptome data from lean and obese subjects. Adil Mardinoglu, Rasmus Agren, Caroline Kampf, Anna Asplund, Intawat Nookaew, Peter Jacobson, Andrew J Walley, Philippe Froguel, Lena M Carlsson, Mathias Uhlen & Jens Nielsen Molecular Systems Biology 9:649; doi:10.1038/msb.2013.5; published 19 March 2013 Full Text | PDF | Supp. Inf. | Review Process Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures Temperature compensation of the Arabidopsis circadian clock is shown to be mediated by the interaction of light and temperature at the level of the crytochrome photoreceptors. These findings reveal that light and temperature share common input mechanisms to the circadian network. Peter D Gould, Nicolas Ugarte, Mirela Domijan, Maria Costa, Julia Foreman, Dana MacGregor, Ken Rose, Jayne Griffiths, Andrew J Millar, Bärbel Finkenstädt, Steven Penfield, David A Rand, Karen J Halliday & Anthony J W Hall Molecular Systems Biology 9:650; doi:10.1038/msb.2013.7; published 19 March 2013 Full Text | PDF | Supp. Inf. | Review Process

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