Scientific Reports Biology Table of Contents e-alert: February 2013

01 February 2013      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports             We've got something to share with you  Access the latest scientific news and research when and where you want it. Download the latest issues to browse at your convenience, zoom in on figures and images, save your searches and synchronize your bookmarks across devices.  Tap in to find out more                Biological Sciences               Professional athletes have extraordinary skills for rapidly learning complex and neutral dynamic visual scenes ▶     Jocelyn Faubert     Evidence suggests that an athlete's sports-related perceptual-cognitive expertise is a crucial element of top-level competitive sports. When directly assessing whether such …             Epidemic potential of an emerging vector borne disease in a marginal environment: Schmallenberg in Scotland ▶     Paul R. Bessell, Kate R. Searle, Harriet K. Auty et al.     During 2011 Schmallenberg virus (SBV) presented as a novel disease of cattle and sheep that had apparently spread through northern Europe over a relatively short period of time, …             Optimized Surface Markers for the Prospective Isolation of High-Quality hiPSCs using Flow Cytometry Selection ▶     Ramzey Abujarour, Bahram Valamehr, Megan Robinson et al.     hiPSC derivation and selection remains inefficient; with selection of high quality clones dependent on extensive characterization which is not amenable to high-throughput (HTP) …             Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells ▶     Yen-Hsing Li, Hsu-Yu Chen, Ya-Wen Li et al.     Myogenic progenitor cell (MPC) is responsible for postembryonic muscle growth and regeneration. Progranulin (PGRN) is a pluripotent growth factor that is correlated with …             Cholinergic modulation of response gain in the rat primary visual cortex ▶     Shogo Soma, Satoshi Shimegi, Naofumi Suematsu et al.     Acetylcholine (ACh) is known to modulate neuronal activity in the rodent primary visual cortex (V1). Although cholinergic modulation has been extensively examined in vitro, far …             Specificity and Heterogeneity of Terahertz Radiation Effect on Gene Expression in Mouse Mesenchymal Stem Cells ▶     Boian S. Alexandrov, M. Lisa Phipps, Ludmil B. Alexandrov et al.     We report that terahertz (THz) irradiation of mouse mesenchymal stem cells (mMSCs) with a single-frequency (SF) 2.52 THz laser or pulsed broadband (centered at 10 THz) source …             Integrating muscle cell biochemistry and whole-body physiology in humans:31P-MRS data from the InSight trial ▶     Lindsay M. Edwards, Graham J. Kemp, Renee M. Dwyer et al.     We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing …             Interdependent network reciprocity in evolutionary games ▶     Zhen Wang, Attila Szolnoki, Matjaž Perc     Besides the structure of interactions within networks, also the interactions between networks are of the outmost importance. We therefore study the outcome of the public goods …             Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules ▶     Jianping Liu, Yanmei Liu, Honggang Wang et al.     Recent evidence suggests that experimental induction of hepatocytes into pancreatic cells provides new cell transplantation therapy prospects for type 1 diabetes mellitus. …             A simple medium enables bovine embryos to be held for seven days at 4°C ▶     Atsushi Ideta, Yoshito Aoyagi, Kanami Tsuchiya et al.     Cryopreservation methods using liquid nitrogen (LN2) for gametes and embryos are prevalent in mammalian artificial reproduction. However, the pregnancy rate from frozen embryos …             Time perception of visual motion is tuned by the motor representation of human actions ▶     Gioele Gavazzi, Ambra Bisio, Thierry Pozzo     Several studies have shown that the observation of a rapidly moving stimulus dilates our perception of time. However, this effect appears to be at odds with the fact that our …             The α-helical regions of KERP1 are important in Entamoeba histolytica adherence to human cells ▶     Doranda Perdomo, Bruno Baron, Arturo Rojo-Domínguez et al.     The lysine and glutamic acid rich protein KERP1 is a unique surface adhesion factor associated with virulence in the human pathogen Entamoeba histolytica. Both the function and …             Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase ▶     Catherine Trepanier, Gang Lei, Yu-Feng Xie et al.     Group II metabotropic glutamate receptors (mGluR2/3) have emerged as important targets for the treatment of schizophrenia. Since hypofunction of N-methyl-D-aspartate receptors …             Drug Design for Neuropathic Pain Regulation from Traditional Chinese Medicine ▶     Weng Ieong Tou, Su-Sen Chang, Cheng-Chun Lee et al.     FAAH-like anandamide transporter (FLAT) regulates anandamide transport for hydrolysis and may be an attractive drug target for pain regulation. We aimed to discover potential FLAT …             Plasmodium falciparum sulfadoxine resistance is geographically and genetically clustered within the DR Congo ▶     Steve M. Taylor, Alejandro L. Antonia, Christian M. Parobek et al.     Understanding the spatial clustering of Plasmodium falciparum populations can assist efforts to contain drug-resistant parasites and maintain the efficacy of future drugs. We …             The rich club phenomenon in the classroom ▶     Luis M. Vaquero, Manuel Cebrian     We analyse the evolution of the online interactions held by college students and report on novel relationships between social structure and performance. Our results indicate that …             PAPTi: A Peptide Aptamer Interference Toolkit for Perturbation of Protein-Protein Interaction Networks ▶     Johannes T. -H. Yeh, Richard Binari, Tenzin Gocha et al.     Signaling proteins often form dynamic protein-protein interaction (PPI) complexes to achieve multi-functionality. Methods to abrogate a subset of PPI interfaces without depleting …             A Weber-like law for perceptual learning ▶     Andrew T. Astle, Roger W. Li, Ben S. Webb et al.     What determines how much an organism can learn? One possibility is that the neural factors that limit sensory performance prior to learning, place an upper limit on the amount of …             Quantitative Genetic Background of the Host Influences Gut Microbiomes in Chickens ▶     Lele Zhao, Gang Wang, Paul Siegel et al.     Host genotype and gender are among the factors that influence the composition of gut microbiota. We studied the population structure of gut microbiota in two lines of chickens …             Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma ▶     Tomohiro Yamaki, Yusuke Suenaga, Toshihiko Iuchi et al.     Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become …             Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display ▶     Kristin S. Gunnarsen, Solveig G. Kristinsson, Sune Justesen et al.     We here report a novel phage display selection strategy enabling fast and easy selection of thermostabilized proteins. The approach is illustrated with stabilization of an …             In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters ▶     Jianling Wang, Gen Zhang, Qiwei Li et al.     Fluorescence imaging in vivo allows non-invasive tumor diagnostic thus permitting a direct monitoring of cancer therapies progresses. It is established herein that fluorescent …             A reinvestigation of the reference frame of the tilt-adaptation aftereffect ▶     Sebastiaan Mathôt, Jan Theeuwes     The tilt-adaptation aftereffect (TAE) is the phenomenon that prolonged perception of a tilted ‘adapter’ stimulus affects the perceived tilt of a subsequent ‘tester’ stimulus. …             Efficacy of Post Exposure Administration of Doxycycline in a Murine Model of Inhalational Melioidosis ▶     H. Carl Gelhaus, Michael S. Anderson, David A. Fisher et al.     Burkholderia pseudomallei is the causative agent of melioidosis. Treatment of melioidosis is suboptimal and developing improved melioidosis therapies requires animal models. In …             Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway ▶     Hee Jung Kim, Jae Seok Jeong, So Ri Kim et al.     Lipopolysaccharide (LPS) is involved in a variety of inflammatory disorders. Under stress conditions, endoplasmic reticulum (ER) loses the homeostasis in its functions, which is …             Spontaneous synchronization of arm motion between Japanese macaques ▶     Yasuo Nagasaka, Zenas C. Chao, Naomi Hasegawa et al.     Humans show spontaneous synchronization of movements during social interactions; this coordination has been shown to facilitate smooth communication. Although human studies …             Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing ▶     Kai Li, Wei Qin, Dan Ding et al.     Long-term noninvasive cell tracing by fluorescent probes is of great importance to life science and biomedical engineering. For example, understanding genesis, development, …             Metamorphosis of mesothelial cells with active horizontal motility in tissue culture ▶     Hirotaka Nagai, Shan Hwu Chew, Yasumasa Okazaki et al.     Mesothelial cells, which have diverse roles in physiology and pathology, constitute the mesothelium along with connective tissue and the basement membrane; the mesothelium serves …             Circumnutation on the water surface: female flowers of Vallisneria ▶     Keiko Kosuge, Satoko Iida, Kiyoshi Katou et al.     Circumnutation, the helical movement of growing organ tips, is ubiquitous in land plants. The mechanisms underlying circumnutation have been debated since Darwin's time. …             A custom magnetoencephalography device reveals brain connectivity and high reading/decoding ability in children with autism ▶     Mitsuru Kikuchi, Yuko Yoshimura, Kiyomi Shitamichi et al.     A subset of individuals with autism spectrum disorder (ASD) performs more proficiently on certain visual tasks than may be predicted by their general cognitive performances. …             Efficient production of adenovirus vector lacking genes of virus-associated RNAs that disturb cellular RNAi machinery ▶     Aya Maekawa, Zheng Pei, Mariko Suzuki et al.     First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed …             Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset ▶     Carmine Di Rienzo, Emanuela Jacchetti, Francesco Cardarelli et al.     Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 …             Predictions of avian Plasmodium expansion under climate change ▶     Claire Loiseau, Ryan J. Harrigan, Coraline Bichet et al.     Vector-borne diseases are particularly responsive to changing environmental conditions. Diurnal temperature variation has been identified as a particularly important factor for …             Novel TPR-containing subunit of TOM complex functions as cytosolic receptor for Entamoeba mitosomal transport ▶     Takashi Makiuchi, Fumika Mi-ichi, Kumiko Nakada-Tsukui et al.     Under anaerobic environments, the mitochondria have undergone remarkable reduction and transformation into highly reduced structures, referred as mitochondrion-related organelles …             Terrestrial pesticide exposure of amphibians: An underestimated cause of global decline? ▶     Carsten A. Brühl, Thomas Schmidt, Silvia Pieper et al.     Amphibians, a class of animals in global decline, are present in agricultural landscapes characterized by agrochemical inputs. Effects of pesticides on terrestrial life stages of …             The interaction of asbestos and iron in lung tissue revealed by synchrotron-based scanning X-ray microscopy ▶     Lorella Pascolo, Alessandra Gianoncelli, Giulia Schneider et al.     Asbestos is a potent carcinogen associated with malignant mesothelioma and lung cancer but its carcinogenic mechanisms are still poorly understood. Asbestos toxicity is ascribed …             Equilibrious Strand Exchange Promoted by DNA Conformational Switching ▶     Zhiguo Wu, Xiao Xie, Puzhen Li et al.     Most of DNA strand exchange reactions in vitro are based on toehold strategy which is generally nonequilibrium, and intracellular strand exchange mediated by proteins shows little …             Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser ▶     Ryosuke Kawakami, Kazuaki Sawada, Aya Sato et al.     In vivo two-photon microscopy has revealed vital information on neural activity for brain function, even in light of its limitation in imaging events at depths greater than …             Handedness helps homing in swimming and flying animals ▶     Promode R. Bandyopadhyay, Henry A. Leinhos, Aren M. Hellum     Swimming and flying animals rely on their ability to home on mobile targets. In some fish, physiological handedness and homing correlate, and dolphins exhibit handedness in their …             Beating the Heat - Fast Scanning Melts Silk Beta Sheet Crystals ▶     Peggy Cebe, Xiao Hu, David L. Kaplan et al.     Beta-pleated-sheet crystals are among the most stable of protein secondary structures, and are responsible for the remarkable physical properties of many fibrous proteins, such as …             CORRIGENDUM: A novel potent tumour promoter aberrantly overexpressed in most human cancers ▶     Atsushi Takahashi, Hisashi Tokita, Kenzo Takahashi et al.                 Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence ▶     Laura C. Clark, Ryan F. Seipke, Pilar Prieto et al.     Understanding the evolution of virulence is key to appreciating the role specific loci play in pathogenicity. Streptomyces species are generally non-pathogenic soil saprophytes, …             Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus ▶     Louise Kristine Vigsnaes, Pieter van den Abbeele, Karolina Sulek et al.     We compared fecal microbial communities derived either from Ulcerative Colitis (UC) patients in remission (n=4) or in relapse (n=4), or from healthy subjects (n=4). These …             Selection of Nanobodies that Target Human Neonatal Fc Receptor ▶     Jan Terje Andersen, Maria Gonzalez-Pajuelo, Stian Foss et al.     FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, …             S100+ cells: A new neuro-immune cross-talkers in lymph organs ▶     Jinyu Huang, Chunfang Zhu, Peipei Zhang et al.     Up to now, the ‘hardwired’ neural pathway of the neuro-immune regulation is not fully understood. Here we reported a new neural pathway which links sympathetic nerves with immune …             DMD-based LED-illumination Super-resolution and optical sectioning microscopy ▶     Dan Dan, Ming Lei, Baoli Yao et al.     Super-resolution three-dimensional (3D) optical microscopy has incomparable advantages over other high-resolution microscopic technologies, such as electron microscopy and atomic …             Statistically invalid classification of high throughput gene expression data ▶     Shahar Barbash, Hermona Soreq     Classification analysis based on high throughput data is a common feature in neuroscience and other fields of science, with a rapidly increasing impact on both basic biology and …             A cell-based screening system for influenza A viral RNA transcription/replication inhibitors ▶     Makoto Ozawa, Masayuki Shimojima, Hideo Goto et al.     Although two classes of antivirals, NA inhibitors and M2 ion channel blockers, are licensed for influenza treatment, dual resistant mutants, including highly pathogenic H5N1 …             Heterologous viral expression systems in fosmid vectors increase the functional analysis potential of metagenomic libraries ▶     L. Terrón-González, C. Medina, M. C. Limón-Mortés et al.     The extraordinary potential of metagenomic functional analyses to identify activities of interest present in uncultured microorganisms has been limited by reduced gene expression …             Feedback Mechanism in Depolarization-Induced Sustained Activation of Extracellular Signal-Regulated Kinase in the Hippocampus ▶     Chinmoyee Maharana, Kaushik P. Sharma, Shiv K. Sharma     Phosphorylation plays important roles in several processes including synaptic plasticity and memory. The critical role of extracellular signal-regulated kinase (ERK) in these …             Radial arrangement of Janus-like setae permits friction control in spiders ▶     Jonas O. Wolff, Stanislav N. Gorb     Dynamic attachment is the key to move on steep surfaces, with mechanisms being still not well understood. The hunting spider Cupiennius salei (Arachnida, Ctenidae) possesses hairy …             An Exhaustive Epistatic SNP Association Analysis on Expanded Wellcome Trust Data ▶     Christoph Lippert, Jennifer Listgarten, Robert I. Davidson et al.     We present an approach for genome-wide association analysis with improved power on the Wellcome Trust data consisting of seven common phenotypes and shared controls. We achieved …             Flexible packaging of solid-state integrated circuit chips with elastomeric microfluidics ▶     Bowei Zhang, Quan Dong, Can E. Korman et al.     A flexible technology is proposed to integrate smart electronics and microfluidics all embedded in an elastomer package. The microfluidic channels are used to deliver both liquid …             APG: an Active Protein-Gene Network Model to Quantify Regulatory Signals in Complex Biological Systems ▶     Jiguang Wang, Yidan Sun, Si Zheng et al.     Synergistic interactions among transcription factors (TFs) and their cofactors collectively determine gene expression in complex biological systems. In this work, we develop a …             hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity ▶     Naoyuki Kataoka, Izumi Dobashi, Masatoshi Hagiwara et al.     In higher eukaryotes most genes contain multiple introns. Introns are excised from pre-mRNAs by splicing and eventually degraded in the nucleus. It is likely that rapid intron …             Peptide-Conjugation Induced Conformational Changes in Human IgG1 Observed by Optimized Negative-Staining and Individual-Particle Electron Tomography ▶     Huimin Tong, Lei Zhang, Allan Kaspar et al.     Peptides show much promise as potent and selective drug candidates. Fusing peptides to a scaffold monoclonal antibody produces a conjugated antibody which has the advantages of …             Sedimentation of macroscopic rigid knots and its relation to gel electrophoretic mobility of DNA knots ▶     Cédric Weber, Mathias Carlen, Giovanni Dietler et al.     We address the general question of the extent to which the hydrodynamic behaviour of microscopic freely fluctuating objects can be reproduced by macrosopic rigid objects. In …             The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction ▶     Allison B. Chambliss, Shyam B. Khatau, Nicholas Erdenberger et al.     Cells continuously sense and respond to external mechanical forces through their cytoskeleton. Here we show that only a small subset of actin fibers, those forming the perinuclear …             Cell sorting in a Petri dish controlled by computer vision ▶     Z. Környei, S. Beke, T. Mihálffy et al.     Fluorescence-activated cell sorting (FACS) applying flow cytometry to separate cells on a molecular basis is a widespread method. We demonstrate that both fluorescent and …             CORRIGENDUM: When a photograph can be heard: Vision activates the auditory cortex within 110 ms ▶     Alice Mado Proverbio, Guido Edoardo D'Aniello, Roberta Adorni et al.                 Developing neuronal networks: Self-organized criticality predicts the future ▶     Jiangbo Pu, Hui Gong, Xiangning Li et al.     Self-organized criticality emerged in neural activity is one of the key concepts to describe the formation and the function of developing neuronal networks. The relationship …             A sclerite-bearing stem group entoproct from the early Cambrian and its implications ▶     Zhifei Zhang, Lars E. Holmer, Christian B. Skovsted et al.     The Lophotrochozoa includes disparate tentacle-bearing sessile protostome animals, which apparently appeared in the Cambrian explosion, but lack an uncontested fossil record. Here …             CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice ▶     Robin K. Minor, Joseph A. Baur, Ana P. Gomes et al.                 Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module ▶     Tao Wang, Jiahai Zhang, Xuecheng Zhang et al.     Streptococcus pneumoniae is a pathogen causing acute respiratory infection, otitis media and some other severe diseases in human. In this study, the solution structure of a …             An analysis and validation pipeline for large-scale RNAi-based screens ▶     Michael Plank, Guang Hu, A. Sofia Silva et al.     Large-scale RNAi-based screens are a major technology, but require adequate prioritization and validation of candidate genes from the primary screen. In this work, we performed a …             Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis ▶     Zufeng Ding, Shijie Liu, Xianwei Wang et al.     Our studies in HUVECs show that ox-LDL induced autophagy and damaged mtDNA leading to TLR9 expression. LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated …             The Open Gate Structure of the Membrane-Embedded KcsA Potassium Channel Viewed From the Cytoplasmic Side ▶     Ayumi Sumino, Takashi Sumikama, Masayuki Iwamoto et al.     Crystallographic studies of channel proteins have provided insight into the molecular mechanisms of ion channels, even though these structures are obtained in the absence of the …             A serum “sweet-doughnut” protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis ▶     Atsushi Kuno, Yuzuru Ikehara, Yasuhito Tanaka et al.     Although liver fibrosis reflects disease severity in chronic hepatitis patients, there has been no simple and accurate system to evaluate the therapeutic effect based on fibrosis. …             An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate ▶     Tiziana Gigliobianco, Marjorie Gangolf, Bernard Lakaye et al.     In E. coli, thiamine triphosphate (ThTP), a putative signaling molecule, transiently accumulates in response to amino acid starvation. This accumulation requires the presence of …             Emergent dynamics of laboratory insect swarms ▶     Douglas H. Kelley, Nicholas T. Ouellette     Collective animal behaviour occurs at nearly every biological size scale, from single-celled organisms to the largest animals on earth. It has long been known that models with …             Novel Selective and Irreversible Mosquito Acetylcholinesterase Inhibitors for Controlling Malaria and Other Mosquito-Borne Diseases ▶     Dengfeng Dou, Jewn Giew Park, Sandeep Rana et al.     We reported previously that insect acetylcholinesterases (AChEs) could be selectively and irreversibly inhibited by methanethiosulfonates presumably through conjugation to an …             Surprise maximization reveals the community structure of complex networks ▶     Rodrigo Aldecoa, Ignacio Marín     How to determine the community structure of complex networks is an open question. It is critical to establish the best strategies for community detection in networks of unknown …             CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner ▶     Akihiro Yoshida, Noriko Yoneda-Kato, Jun-ya Kato     The fifth component (CSN5) of the mammalian COP9 signalosome complex plays an essential role in cell proliferation and senescence, but its molecular mediator remains to be …             The VMP1-Beclin 1 interaction regulates autophagy induction ▶     Maria I. Molejon, Alejandro Ropolo, Andrea Lo Re et al.     The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases. In the current study, we …             Controlled variations in stimulus similarity during learning determine visual discrimination capacity in freely moving mice ▶     Mario Treviño, Tatiana Oviedo, Patrick Jendritza et al.     The mouse is receiving growing interest as a model organism for studying visual perception. However, little is known about how discrimination and learning interact to produce …             Functional multiplex reporter assay using tagged Gaussia luciferase ▶     Sjoerd van Rijn, Jonas Nilsson, David P. Noske et al.     We have developed a multiplex reporter system to monitor multiple biological variables in real-time. The secreted Gaussia luciferase was fused to ten different epitope tags (Gluc…             Long-term change in a meso-predator community in response to prolonged and heterogeneous human impact ▶     Francesco Ferretti, Giacomo C. Osio, Chris J. Jenkins et al.     Sharks and rays' abundance can decline considerably with fishing. Community changes, however, are more complex because of species interactions, and variable vulnerability and …             Viewing men's faces does not lead to accurate predictions of trustworthiness ▶     Charles Efferson, Sonja Vogt     The evolution of cooperation requires some mechanism that reduces the risk of exploitation for cooperative individuals. Recent studies have shown that men with wide faces are …             Cholera in Haiti: Reproductive numbers and vaccination coverage estimates ▶     Zindoga Mukandavire, David L. Smith, J. Glenn Morris Jr     Cholera reappeared in Haiti in October, 2010 after decades of absence. Cases were first detected in Artibonite region and in the ensuing months the disease spread to every …             Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid ▶     Li Liang, Silvia Juarez, Tran Vu Thieu Nga et al.     Current serological diagnostic assays for typhoid fever are based on detecting antibodies against Salmonella LPS or flagellum, resulting in a high false-positive rate. Here we …             Murine Colitis is Mediated by Vimentin ▶     Nirit Mor-Vaknin, Maureen Legendre, Yue Yu et al.     Vimentin, an abundant intermediate filament protein, presumably has an important role in stabilizing intracellular architecture, but its function is otherwise poorly understood. …             Developmental processes in face perception ▶     Christoph D. Dahl, Malte J. Rasch, Masaki Tomonaga et al.     Understanding the developmental origins of face recognition has been the goal of many studies of various approaches. Contributions of experience-expectant mechanisms (early …             Genetic origins of social networks in rhesus macaques ▶     Lauren J. N. Brent, Sarah R. Heilbronner, Julie E. Horvath et al.     Sociality is believed to have evolved as a strategy for animals to cope with their environments. Yet the genetic basis of sociality remains unclear. Here we provide evidence that …             p38 MAPK mediates calcium oxalate crystal-induced tight junction disruption in distal renal tubular epithelial cells ▶     Paleerath Peerapen, Visith Thongboonkerd     We examined whether p38 MAPK plays role in calcium oxalate monohydrate (COM) crystal-induced tight junction disruption. Polarized MDCK cells were pretreated with or without 20 μM …             ERRATUM: Acquired immunity of transgenic torenia plants overexpressing agmatine coumaroyltransferase to pathogens and herbivore pests ▶     Atsushi Muroi, Kenji Matsui, Takeshi Shimoda et al.                 Function of Shaker potassium channels produced by cell-free translation upon injection into Xenopus oocytes ▶     Brian W. Jarecki, Shin-ichi Makino, Emily T. Beebe et al.     Voltage-gated ion channels are a class of membrane proteins that temporally orchestrate the ion flux critical for chemical and electrical signaling in excitable cells. Current …             Competition Drives Clumpy Species Coexistence in Estuarine Phytoplankton ▶     A. M. Segura, C. Kruk, D. Calliari et al.     Understanding the mechanisms that maintain biodiversity is a fundamental problem in ecology. Competition is thought to reduce diversity, but hundreds of microbial aquatic primary …             Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory ▶     Zhenzhong Cui, Ruiben Feng, Stephanie Jacobs et al.     The NR2A:NR2B subunit ratio of the NMDA receptors is widely known to increase in the brain from postnatal development to sexual maturity and to aging, yet its impact on memory …             Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity ▶     Natalia Realini, Carlos Solorzano, Chiara Pagliuca et al.     The expression of acid ceramidase (AC) – a cysteine amidase that hydrolyses the proapoptotic lipid ceramide – is abnormally high in several human tumors, which is suggestive of a …             Blockade of CD47 increases survival of mice exposed to lethal total body irradiation ▶     David R. Soto-Pantoja, Lisa A. Ridnour, David A. Wink et al.     Accidental or therapeutic total body exposure to ionizing radiation has profound pathophysiological consequences including acute radiation syndrome. Currently only investigational …             Applying Shannon's information theory to bacterial and phage genomes and metagenomes ▶     Sajia Akhter, Barbara A. Bailey, Peter Salamon et al.     All sequence data contain inherent information that can be measured by Shannon's uncertainty theory. Such measurement is valuable in evaluating large data sets, such as …             Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax ▶     Shuai Ding, Run Ye, Dongmei Zhang et al.     Can we predict the rise and spread of resistance to multi-drug therapy in a more predictable manner? We raise this question after analyzing over 500 Plasmodium vivax isolates …             Aerobic deconstruction of cellulosic biomass by an insect-associated Streptomyces ▶     Taichi E. Takasuka, Adam J. Book, Gina R. Lewin et al.     Streptomyces are best known for producing antimicrobial secondary metabolites, but they are also recognized for their contributions to biomass utilization. Despite their …             Somatization Severity Associated with Postero-Medial Complex Structures ▶     Erwin Lemche, Vincent P. Giampietro, Michael J. Brammer et al.     Somatisation is a frequent problem in various psychiatric disorders, yet the cerebral mechanisms of somatisation remain unexamined. To test if somatisation is susceptible to …             Water pollutant fingerprinting tracks recent industrial transfer from coastal to inland China: A case study ▶     Weiwei Zheng, Xia Wang, Dajun Tian et al.     In recent years, China’s developed regions have transferred industries to undeveloped regions. Large numbers of unlicensed or unregistered enterprises are widespread in these …             Axonal trafficking of an antisense RNA transcribed from a pseudogene is regulated by classical conditioning ▶     Sergei A. Korneev, Ildiko Kemenes, Natalia L. Bettini et al.     Natural antisense transcripts (NATs) are endogenous RNA molecules that are complementary to known RNA transcripts. The functional significance of NATs is poorly understood, but …             Braving the attitude of altitude: Caragana jubata at work in cold desert of Himalaya ▶     Pardeep Kumar Bhardwaj, Ritu Kapoor, Deep Mala et al.     The present work was conducted to understand the basis of adaptation in Caragana jubata in its niche environment at high altitude cold desert of Himalaya. Molecular data showed …             A novel triangle mapping technique to study the h-index based citation distribution ▶     Chun-Ting Zhang     The h-index has received wide attention in recent years. The area under the citation function is divided by the h-index into three parts, representing h-squared, excess and h-tail …             Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents ▶     Chun-Yan Cao, Ying-Ying Shen, Jian-Dong Wang et al.     Herein we developed a new “smart” Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to …                         Scientific Reports is accepting submissions from all scientific fields. Submit your manuscript now.               • Careers & Jobs           naturejobs.com Science jobs of the week       Toxicology and Regulatory Testing Internship     Physicians Committee for Responsible Medicine            Postdoc Research Trainee - Movement Disorders     University of Tennessee Health Science Center            Chief Magazine Editor     Nature Publishing Group (NPG)            PhD student Biomolecular Mass Spectrometry     University of Antwerp            Research Associate     McGill University - Department of Physiology            Research Associate     Cambridge Institute for Medical Research (CIMR)            Research Associate     University of Glasgow            PhD Student     Max-Planck-Institute for Molecular Biomedicine            PhD Scholarships     Nanyang Technological University (NTU)            Postdoctoral Scientist     National Institute for Medical Research          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.           • Scientific Reports events featured events           natureevents featured events         Computational Cell Biology: The Interplay Between Models and Experimentation     19th March Cold Spring Harbor, US         Nature events is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.                 Your email address is in the Scientific Reports: Biology mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th floor | New York | NY 10013-1917 | USA Nature Publishing Group's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Boston - Buenos Aires - Delhi - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Washington DC Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.