EMBO Reports - Table of Contents alert Volume 14 Issue 2, pp 103-212

TABLE OF CONTENTS February 2013 | Volume 14, Issue 2 Upfront Science & Society Reviews Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Systems biology technologies series  This series, published in the open access journal Molecular Systems Biology, features Reviews on the technological platforms and methodologies that are driving systems and synthetic biology forward to reach new frontiers in biology. Access the Free series today    Upfront Top Editorial Circles in the desert Science often takes a meandering path, and sometimes seems to be going in circles. Howy ponders some unresolved issues regarding the replication of extrachromosomal elements. Howy Jacobs EMBO reports (2013), 14, 103; 10.1038/embor.2012.210 Full text | PDF Published online: 01 February 2013 Subject Categories: Philosophy & History of Science Opinion Data-driven hypotheses Omics technologies and the large data sets they produce do not undermine hypothesis-driven research. Rather, they help scientists formulate better and more relevant hypotheses to be put to the test. Paul van Helden EMBO reports (2013), 14, 104; 10.1038/embor.2012.207 Full text | PDF Published online: 21 December 2012 Subject Categories: Technology, Development & Applications Hot off the Press Newborn neuroblasts feel the field in the adult brain A paper in this issue of EMBO reports shows that endogenous electric currents exist in the adult mouse brain and that they may guide neuroblast migration. These findings and their implications are discussed here. Sisi Chen and David V Schaffer EMBO reports (2013), 14, 105 - 106; 10.1038/embor.2012.223 Full text | PDF Published online: 18 January 2013 Subject Categories: Neuroscience Death takes a holiday—non-apoptotic role for caspases in cell migration and invasion Many types of cancer exhibit significantly elevated caspase activity and this is positively correlated with tumour aggression. In this issue of EMBO Reports, Cagan and colleagues reveal a non-apoptotic role for active caspase in cell migration in Drosophila. Marta Portela and Helena E Richardson EMBO reports (2013), 14, 107 - 108; 10.1038/embor.2012.224 Full text | PDF Published online: 15 January 2013 Subject Categories: Differentiation & Death Meeting Point Understanding chromatin and chromosomes: from static views to dynamic thinking The ‘Reconstituting Chromatin: From Self-assembly to Self-organization’ Conference brought together biologists, chemists and physicists to discuss topics ranging from new insights gained from the static views provided by crystal structures to analyses of chromatin dynamics inside living cells. Christian H Haering and Ana Losada EMBO reports (2013), 14, 109 - 111; 10.1038/embor.2012.221 Full text | PDF Published online: 15 January 2013 Subject Categories: Chromatin & Transcription Correspondence A service, rather than a threat, to the credibility of science Bart Penders and Joanna Goven EMBO reports (2013), 14, 112; 10.1038/embor.2012.206 Full text | PDF Published online: 21 December 2012 Subject Categories: Philosophy & History of Science | Genetically Modified Organisms ‘Regular science’ is inherently political Edward S Dove and Vural Özdemir EMBO reports (2013), 14, 113; 10.1038/embor.2012.205 Full text | PDF Published online: 21 December 2012 Subject Categories: Philosophy & History of Science | Genetically Modified Organisms Commentary to ‘The postmodern assault on science’ by Marcel Kuntz Jean-Paul Herman EMBO reports (2013), 14, 113 - 114; 10.1038/embor.2012.209 Full text | PDF Published online: 21 December 2012 Subject Categories: Philosophy & History of Science | Genetically Modified Organisms Why the postmodern attitude towards science should be denounced Marcel Kuntz EMBO reports (2013), 14, 114 - 116; 10.1038/embor.2012.214 Full text | PDF Published online: 11 January 2013 Subject Categories: Philosophy & History of Science | Genetically Modified Organisms Science & Society Top Evolution and control of H5N1 The evolutionary dynamics of the H5N1 virus present a challenge for conventional control measures. Efforts must consider the regional aspects of endemic H5N1. Yohei Watanabe, Madiha S Ibrahim and Kazuyoshi Ikuta EMBO reports (2013), 14, 117 - 122; 10.1038/embor.2012.212 Full text | PDF Published online: 11 January 2013 Subject Categories: Health & Disease | Societal Issues & Politics Navigating the enhancement landscape Research into the efficacy and safety of cognitive enhancers for recreational or lifestyle use has not been done. Should society pay for studies that might improve the lives of already healthy people? Cynthia Forlini, Wayne Hall, Bruce Maxwell, Simon M Outram, Peter B Reiner, Dimitris Repantis, Maartje Schermer and Eric Racine EMBO reports (2013), 14, 123 - 128; 10.1038/embor.2012.225 Full text | PDF Published online: 15 January 2013 Subject Categories: Health & Disease | Science Policy & Funding The health risks of ART Assisted reproductive technologies enable subfertile couples to have children. But there are health risks attached for both mothers and children that need to be properly understood and managed. Daria Grafodatskaya, Cheryl Cytrynbaum and Rosanna Weksberg EMBO reports (2013), 14, 129 - 135; 10.1038/embor.2012.222 Full text | PDF Published online: 22 January 2013 Subject Categories: Health & Disease | Technology, Development & Applications Educating the brain Insights from neuroscience can help us understand what goes on in the brain when we learn. Such insights might have an impact on educational practice in schools and help design programmes for those with learning impairments. Katrin Weigmann EMBO reports (2013), 14, 136 - 139; 10.1038/embor.2012.213 Full text | PDF Published online: 11 January 2013 Subject Categories: Technology, Development & Applications Research funding is not enough Universities compete for research money but at the risk of neglecting teaching and maintenance of their infrastructure. Philip Hunter EMBO reports (2013), 14, 140 - 142; 10.1038/embor.2012.226 Full text | PDF Published online: 15 January 2013 Subject Categories: Science Policy & Funding Reviews Top Non-autophagic roles of autophagy-related proteins Autophagy is a key cellular process that involves the degradation of a cell's own components through the lysosome machinery. Recent studies suggest that autophagy proteins can also participate in diverse non-autophagy-related cellular processes. This review discusses the growing number of non-autophagy roles of autophagy-related proteins. Suresh Subramani and Vivek Malhotra EMBO reports (2013), 14, 143 - 151; 10.1038/embor.2012.220 Abstract | Full text | PDF Published online: 22 January 2013 Subject Categories: Membranes & Transport | Differentiation & Death | Microbiology & Pathogens The puzzle of TRPV4 channelopathies This review describes the phenotypes of human diseases caused by mutations in the TRPV4 calcium channel and discusses the puzzle of how mutations in the same domain of the channel can lead to diverse diseases with different phenotypes. Bernd Nilius and Thomas Voets EMBO reports (2013), 14, 152 - 163; 10.1038/embor.2012.219 Abstract | Full text | PDF Published online: 11 January 2013 Subject Categories: Molecular Biology of Disease | Membranes & Transport Scientific Reports Top Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking The endocytic adaptor ß-arrestin2 recruits the E3 ubiquitin ligase Nedd4 and arrestin-domain-containing proteins to form a relay team for delivering agonist-stimulated ß2 adrenergic receptors to sorting endosomes. Sang-Oh Han, Reddy P Kommaddi and Sudha K Shenoy EMBO reports (2013), 14, 164 - 171; 10.1038/embor.2012.187 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 December 2012 Subject Categories: Membranes & Transport | Proteins Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion Tumour cells can exhibit high levels of effector caspase activity without undergoing apoptosis. The present study using Drosophila as a model system shows that sub-apoptotic caspase activation leads to MMP expression and cell invasion through the activation of the Jnk signalling pathway. Vivek A Rudrapatna, Erdem Bangi and Ross L Cagan EMBO reports (2013), 14, 172 - 177; 10.1038/embor.2012.217 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 January 2013 Subject Categories: Cell & Tissue Architecture Facilitated aggregation of FG nucleoporins under molecular crowding conditions Intrinsically disordered FG-nucleoporins that form the permeability barrier of the nuclear pore complex aggregate rapidly under molecular crowding conditions and form amyloid fibres that can also interlace into hydrogels at high protein concentrations. Nuclear transport receptors inhibit FG-nucleoporin aggregation. Sigrid Milles, Khanh Huy Bui, Christine Koehler, Mikhail Eltsov, Martin Beck and Edward A Lemke EMBO reports (2013), 14, 178 - 183; 10.1038/embor.2012.204 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 December 2012 Endogenous electric currents might guide rostral migration of neuroblasts This study reports naturally occurring electric currents and electric fields along the rostral migration path in adult mouse brain. The data indicate that electric fields might serve as guidance cues for neuroblast migration. Lin Cao, Dongguang Wei, Brian Reid, Siwei Zhao, Jin Pu, Tingrui Pan, Ebenezer N Yamoah and Min Zhao EMBO reports (2013), 14, 184 - 190; 10.1038/embor.2012.215 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 January 2013 Subject Categories: Neuroscience Chromatin-dependent and -independent regulation of DNA replication origin activation in budding yeast Efficient activation of early DNA replication origins in S phase depends on the binding of Forkhead transcription factors and is independent of the chromatin environment. Marko Lõoke, Kersti Kristjuhan, Signe Värv and Arnold Kristjuhan EMBO reports (2013), 14, 191 - 198; 10.1038/embor.2012.196 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 December 2012 Subject Categories: Chromatin & Transcription | Cell Cycle Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB The crystal structure of the Legionella GTPase-activating-protein LepB in complex with the vesicular trafficking regulator Rab1b and functional assays reveal that LepB acts by a catalytic mechanism that is reminiscent of classical GAPs and distinct from conventional TBC-like RabGAPs. Emerich Mihai Gazdag, Alexandra Streller, Ina Haneburger, Hubert Hilbi, Ingrid R Vetter, Roger S Goody and Aymelt Itzen EMBO reports (2013), 14, 199 - 205; 10.1038/embor.2012.211 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 January 2013 Subject Categories: Microbiology & Pathogens Structure of the Atg12–Atg5 conjugate reveals a platform for stimulating Atg8–PE conjugation This study reports the crystal structure of the autophagy-essential Atg12–Atg5 conjugate revealing the molecular role of Atg12 modification in autophagy. Nobuo N Noda, Yuko Fujioka, Takao Hanada, Yoshinori Ohsumi and Fuyuhiko Inagaki EMBO reports (2013), 14, 206 - 211; 10.1038/embor.2012.208 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 December 2012 Corrections Top Corrigendum Cellular promiscuity: explaining cellular fidelity in vivo against unrestrained pluripotency in vitro Gerald Schatten EMBO reports (2013), 14, 212; 10.1038/embor.2012.216 Full text | PDF Published online: 21 December 2012 Advertisement EMBO - Transparency in Scientific Publishing EMBO reports has a fair and transparent process to rapidly publish your best science. Transparent - No confidential referee remarks - Published referee reports - Detailed decisions - Source Data published alongside figures Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. 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