Nature Reviews Neuroscience contents February 2013 Volume 14 Number 2 pp 77-152

TABLE OF CONTENTS
February 2013 Volume 14 Number 2
Impact Factor 30.455 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Histone acetylation: molecular mnemonics on the chromatin Johannes Gräff & Li-Huei Tsai
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RESEARCH HIGHLIGHTS Top Neurogenetics: Trauma and stress, from child to adult p77 | doi:10.1038/nrn3425 Childhood trauma can predispose people with certain genotypes to disorders such as post-traumatic stress disorder in adulthood. Now, Klengel et al. show that a particular polymorphism in a gene involved in glucocorticoid regulation can interact with childhood trauma, leading to lasting epigenetic changes in the stress response system. PDF Cell fate: Priming asymmetry p78 | doi:10.1038/nrn3426 microRNA priming enables asymmetric gene expression patterns in ASE gustatory neurons in Caenorhabditis elegans. PDF Spinal cord: Speeding up locomotion p78 | doi:10.1038/nrn3435 The recruitment of V2a interneurons to increase swimming speed in zebrafish is incremental and is determined by the combined effect of their excitatory synaptic currents and input resistance. PDF Neurodevelopmental disorders: Overproducing autism p79 | doi:10.1038/nrn3440 In mice, increased eukaryotic translation initiation factor 4E-dependent translation causes an autism-like condition. PDF Synaptic plasticity: A twist in the LTP tail p80 | doi:10.1038/nrn3428 Long-term potentiation does not require the GluA1 C-tail but instead relies on the availability of an extrasynaptic pool of glutamate receptors. PDF Metabolism: The power of translation p80 | doi:10.1038/nrn3429 Cytoplasmic polyadenylation element binding protein 1, which promotes mRNA translation, is an important regulator of neuronal mitochondrial ATP generation. PDF IN BRIEF Sensory systems: Discriminating taste from waste | Stem cells: Sending cells back in time | Neurodegenerative disorders: Parkinson's disease reveals hidden depths | Motor systems: From dream to reality for 'bionic' limbs? | Sensory processing: Itch-specific neurons | Neurodevelopment: A refining role for NMDARs | Sensory processing: Follow the smell | Cognitive neuroscience: Categorical continuity PDF Neuroscience JOBS of the week Post-Doctoral Position in Neuroscience, Thomas Jefferson University Thomas Jefferson University Neuroscience Postdoctoral Fellowship National Institutes of Health (NIH) Postdoctoral Positions in Visual Neuroscience NERF (Neuro-Electronics Research Flanders, Imec) Neuroscience PhD University of Edinburgh Tenure Track Faculty Position Georgia State University More Science jobs from Neuroscience EVENT Summer Program in Neuroscience, Ethics & Survival 06.22.13 Woods Hole, US More science events from
REVIEWS		Top
The impact of microsaccades on vision: towards a unified theory of saccadic function Susana Martinez-Conde, Jorge Otero-Millan & Stephen L. Macknik p83 | doi:10.1038/nrn3405 Microsaccades are small, rapid eye movements that occur when we are attempting to fix our gaze on one spot. Martinez-Conde et al. review the physiology and functions of microsaccades and conclude that they form part of a continuum with larger saccades. Abstract | Full Text | PDF
Histone acetylation: molecular mnemonics on the chromatin Johannes Gräff & Li-Huei Tsai p97 | doi:10.1038/nrn3427 Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms such as histone acetylation. Gräff and Tsai review the roles of histone acetylation in memory and consider whether histone deacetylase inhibitors might have promise as therapeutic interventions against cognitive frailty. Abstract | Full Text | PDF
Human brain evolution: transcripts, metabolites and their regulators Mehmet Somel, Xiling Liu & Philipp Khaitovich p112 | doi:10.1038/nrn3372 The emergence of human cognition during evolution did not just involve mutations in brain-related genes. In this Review, Khaitovich and colleagues consider the contribution of human-specific changes in metabolism and gene expression, and their underlying mechanisms, to the human cognitive phenotype. Abstract | Full Text | PDF
Animal models of traumatic brain injury Ye Xiong, Asim Mahmood & Michael Chopp p128 | doi:10.1038/nrn3407 Traumatic brain injury (TBI) is a leading cause of mortality and morbidity in humans, but the therapeutic options for TBI are limited. Xiong et al. critically review animal models of TBI and discuss how studies involving such models could be improved to develop more-effective TBI treatments. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION The nature of feelings: evolutionary and neurobiological origins Antonio Damasio & Gil B. Carvalho p143 | doi:10.1038/nrn3403 Homeostatic maintenance of the state of the body within an optimal range is essential for survival. Damasio and Carvalho discuss how feelings derived from body states enhance the effectiveness of the corrective response and suggest a cellular mechanism for how feelings might be generated. Abstract | Full Text | PDF
Erratum: Normalization as a canonical neural computation Matteo Carandini & David J. Heeger p152 | doi:10.1038/nrn3424 Full Text | PDF
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