Nature Reviews Molecular Cell Biology contents February 2013 Volume 14 Number 2

TABLE OF CONTENTS
February 2013 Volume 14 Number 2
Impact Factor 39.123 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Finding the end: recruitment of telomerase to telomeres Jayakrishnan Nandakumar & Thomas R. Cech
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RESEARCH HIGHLIGHTS Top Membrane dynamics: ER trailblazing by RAB10 p63 | doi:10.1038/nrm3509 A role for RAB10 in guiding ER dynamics. PDF Chromatin: TET2 keeps histones sweet p64 | doi:10.1038/nrm3511 TET2 promotes the modification of histones by O-linked β-D-N-acetylglucosamine. PDF Stem cells: A metabolic switch p64 | doi:10.1038/nrm3515 Quiescent haematopoietic stem cells use glycolysis and switch to aerobic respiration for differentiation. PDF Membrane dynamics: How lysosomes SNARE autophagosomes p65 | doi:10.1038/nrm3506 The SNARE protein STX17 is recruited specifically to completed autophagosomes to mediate fusion with lysosomes. PDF Cell signalling: How monoubiquitylation keeps RAS active p66 | doi:10.1038/nrm3500 Monoubiquitylation at Lys147 keeps RAS active by reducing its sensitivity to GAPs. PDF Organelle dynamics: Bridging the ER and plasma membrane p66 | doi:10.1038/nrm3508 Scs2, Scs22, Ist2, Tcb1, Tcb2 and Tcb3 tether the ER to the plasma membrane in yeast. PDF STRUCTURE WATCH Understanding α-catenin interactions p66 | doi:10.1038/nrm3519 PDF STRUCTURE WATCH Dissecting TFIID assembly p66 | doi:10.1038/nrm3520 PDF Cell cycle: Centralspindlin — the missing link p68 | doi:10.1038/nrm3514 Centralspindlin connects the mitotic spindle to the plasma membrane during cytokinesis. PDF IN BRIEF Cytoskeleton: A new partner for microtubules | Metabolism: Role for mTORC2 in insulin resistance | Cytoskeleton: Nucleating actin PDF Molecular Cell Biology JOBS of the week Immediate Opening on Circulating Tumor Cell (CTC) Biology and Its Clinical Research The Pennsylvania State University Postdoctoral Scientist in Molecular Biology (two posts) University of Oxford Cell Biology and Neurophotonics, Paris, France Universite Paris Descartes Postdoctoral Fellow In Cancer Biology and Stem Cell University of Texas at Houston, Medical School More Science jobs from Molecular Cell Biology EVENT TM's 2nd world molecular & cell biology online conference 05.-08.02.13 Online More science events from
REVIEWS		Top
Finding the end: recruitment of telomerase to telomeres Jayakrishnan Nandakumar & Thomas R. Cech p69 | doi:10.1038/nrm3505 Unicellular eukaryotes and mammalian germ cells and stem cells can maintain their telomere length through the action of telomerase. Insights into the mechanism by which telomerase is recruited to capped telomeres, and the individual contributions of telomere-associated proteins, highlight differences in this process between humans, budding yeast and fission yeast. Abstract | Full Text | PDF
FOXOs: signalling integrators for homeostasis maintenance Astrid Eijkelenboom & Boudewijn M. T. Burgering p83 | doi:10.1038/nrm3507 The class O forkhead box transcription factors (FOXOs) control diverse gene expression programmes and are themselves regulated by several post-translational mechanisms. A common principle of their many roles is the maintenance of tissue homeostasis in response to environmental changes. Abstract | Full Text | PDF
Caveolae as plasma membrane sensors, protectors and organizers Robert G. Parton & Miguel A. del Pozo p98 | doi:10.1038/nrm3512 Caveolae in the plasma membrane mediate signalling control and the response to membrane stress. The roles of caveolins and cavins hold the key to caveola structure and function, and their dysfunction is linked to several human diseases. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION A two-segment model for thin filament architecture in skeletal muscle David S. Gokhin & Velia M. Fowler p113 | doi:10.1038/nrm3510 Myofilament length is a crucial parameter for efficient skeletal muscle contraction. Thin actin filament specification can be explained by a novel 'two-segment' model, whereby the filament consists of two concatenated segments that are of either constant or variable length. This model implicates that actin dynamics are subject to position-specific microregulation. Abstract | Full Text | PDF
ESSAY Beyond a pedagogical tool: 30 years of Molecular Biology of the Cell Norberto Serpente p120 | doi:10.1038/nrm3513 The first edition of the textbook Molecular Biology of the Cell was published in 1983. Its unique features and aim and the way it was written lie at the heart of its success. Abstract | Full Text | PDF
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