Nature Reviews Genetics Contents February 2013 Volume 14 Number 2 pp 77-149

TABLE OF CONTENTS
February 2013 Volume 14 Number 2		Advertisement
Impact Factor 38.075 *	In this issue Research Highlights Progress Reviews Also this month Article Series: Non-coding RNA Study designs  Featured article: RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond Stephane E. Castel & Robert A. Martienssen	The POWER of ChIP-seq using just 10,000 cells Diagenode’s new powerful True MicroChIP and Microplex kits now facilitate robust ChIP-seq from truly small inputs: Revolutionary: Highly efficient ChIP recovery and enrichment from ONLY 10,000 cells Reliable and accurate sequencing library preparation from picogram inputs Learn more.
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RESEARCH HIGHLIGHTS Top Neurogenetics: Trauma and stress, from child to adult p77 | doi:10.1038/nrg3406 PDF Gene expression: Predictions across space and time p78 | doi:10.1038/nrg3411 PDF Chromatin: Evolutionary insights into nucleosomes p78 | doi:10.1038/nrg3412 PDF Development: A new phase for scaling p80 | doi:10.1038/nrg3407 PDF Metagenomics: Personalized gut microbiome variants p80 | doi:10.1038/nrg3408 PDF Technology: A CRISPR genome-editing tool p80 | doi:10.1038/nrg3409 PDF Evolution: Genomic pacemakers or ticking clocks? p81 | doi:10.1038/nrg3410 PDF IN BRIEF Small RNA: Long-lived microRNA complexes | DNA Replication: ChIP–seq for human replication origins | Transcription: A role for DNA topoisomerase in activation | Complex traits: Chromatin marks to aid fine mapping | Gene regulation: Global translational pausing in response to stress | Pathogen genetics: Screening to resolve redundancy | Chromatin: Retrotransposons and heterochromatin spreading | Disease genetics: Defective reading of 5hmC in Rett's syndrome PDF Genetics JOBS of the week Post-Doctoral Fellow, Cancer biology and functional genomics North Carolina Central University Post-doctoral Position in Mouse Cancer Genetics Centre for Biotechnology/Prof. Jukka Westermarck Developmental biology Institute of Molecular Genetics (IMG) Research Associate Cambridge Institute for Medical Research (CIMR) Lecturer / Senior Lecturer in Genetics Massey University New Zealand More Science jobs from Genetics EVENT Malaria Experimental Genetics 03.03.13 Cambridge, UK More science events from
PROGRESS		Top
The evolutionary causes and consequences of sex-biased gene expression John Parsch & Hans Ellegren p83 | doi:10.1038/nrg3376 The authors discuss recent advances — mainly gained through genomic methods such as RNA sequencing — in our understanding of the causes and consequences of differences in gene expression between females and males. Areas of progress include our understanding of the roles of sexual antagonism and dosage compensation. Abstract | Full Text | PDF
REVIEWS		Top
Reuse of public genome-wide gene expression data Johan Rung & Alvis Brazma p89 | doi:10.1038/nrg3394 A wealth of microarray gene expression data and a growing volume of RNA sequencing data are now available in public databases. The authors look at how these data are being used and discuss considerations for how such data should be analysed and deposited and how data reuse could be improved. Abstract | Full Text | PDF | Supplementary information
Article series: Non-coding RNA RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond Stephane E. Castel & Robert A. Martienssen p100 | doi:10.1038/nrg3355 In addition to well-known roles in the cytoplasm, a growing number of functions for small RNAs in the nucleus are being discovered. These include roles in transcriptional repression, epigenetic modifications and genome stability. This Review considers examples from animals, plants and fungi. Abstract | Full Text | PDF
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration Doris Bachtrog p113 | doi:10.1038/nrg3366 The Y chromosomes of many species, including humans, are gene-poor and degenerate. The recent application of genome-wide technologies to evolutionarily old and young Y chromosomes has provided insight into the processes that have shaped them and their future. Abstract | Full Text | PDF
Phenotypic impact of genomic structural variation: insights from and for human disease Joachim Weischenfeldt, Orsolya Symmons, François Spitz & Jan O. Korbel p125 | doi:10.1038/nrg3373 With the increased cataloguing of human structural variants, our understanding of their influence on phenotype is ever improving. Here, the influence of structural variants on phenotypes including disease is discussed, and strategies for further characterization are presented. Abstract | Full Text | PDF | Supplementary information
Article series: Study designs The heritability of human disease: estimation, uses and abuses Albert Tenesa & Chris S. Haley p139 | doi:10.1038/nrg3377 Heritability estimates provide a useful means of understanding the genetic and environmental contributions to phenotypic variance. The authors define heritability, discuss how to estimate and interpret it in the context of disease and examine how biases in heritability estimates arise. Abstract | Full Text | PDF
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