Nature Immunology Contents: July 2012 Volume 13 pp 623 - 702

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Request a free sample and get connected to high-sensitivity detection of intracellular and intranuclear proteins with flow cytometry. bdbiosciences.com/go/tfbuffer TABLE OF CONTENTS July 2012 Volume 13, Issue 7 Correspondence Commentary News and Views Research Highlights Perspective Articles Addendum Advertisement Solution savings: Best-in-class bead-based immunoassays With a combined value package you can save 10% on the BD Accuri™ C6 personal flow cytometer, 40% on BD™ CBA reagents for 2 full years, plus $6,500 worth of free software and cytometer options. There's never been a better time to buy the best-in-class solution for bead-based immunoassays.  bdbiosciences.com/go/c6beads Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement ThymUS 2012 International Conference on Lymphopoiesis, T cell differentiation and Immune Reconstitution November 04-09, 2012 Trump International Beach Resort Sunny Isles Beach, FL, USA Keynote Speaker: Dr. Richard Flavell, HHMI/Yale School of Medicine Website I EMAIL   Correspondence Top On the differentiation of mouse IgE+ cells   p623 Juan J Lafaille, Huizhong Xiong and Maria A Curotto de Lafaille doi:10.1038/ni.2313 See also: Correspondence by Talay et al. Reply to "On the differentiation of mouse IgE+ cells"   pp623 - 624 Oezcan Talay, Donghong Yan, Hans D Brightbill, Elizabeth E M Straney, Meijuan Zhou, Ena Ladi, Wyne P Lee, Jackson G Egen, Cary D Austin, Min Xu and Lawren C Wu doi:10.1038/ni.2323 See also: Correspondence by Lafaille et al. Commentary Top The IFReC-SIgN Winter School on Advanced Immunology   pp625 - 627 Peter D Burrows doi:10.1038/ni.2348 News and Views Top TGF-β puts the brakes on homeostatic proliferation   pp628 - 630 Charles D Surh and Jonathan Sprent doi:10.1038/ni.2345 The cellular mechanism by which the cytokine TGF-β maintains the homeostasis of mature T cells and prevents the emergence of severe lethal lymphoproliferative disease has remained obscure. It is now shown that TGF-β restrains the homeostatic T cell proliferation driven by self ligands from erupting into overt autoimmunity. See also: Article by Zhang & Bevan Lymph node choreography: B cells take the lead   pp630 - 632 Jennifer L Cannons, Kristina T Lu and Pamela L Schwartzberg doi:10.1038/ni.2349 The role of T cells in providing help to B cells is well established; however, the converse—that B cells provide signals to help initiate T cell-mediated immunity—is less well appreciated. New data now show B cells modulate the earliest stages of T cell activation in a T helper type 2 response. See also: Article by Leon et al. Born this way? Understanding the immunological basis of effective HIV control   pp632 - 634 Mark B Feinberg and Rafi Ahmed doi:10.1038/ni.2351 'Elite controllers' of human immunodeficiency virus (HIV) maintain a long-term disease-free status after infection with HIV. A comparison of elite controllers and people who progress to disease after infection with HIV now suggests that clonotypic profiles of HIV-specific CD8+ T cells may underlie elite control. See also: Article by Chen et al. IRF3: a molecular switch in pathogen responses   pp634 - 635 Osamu Takeuchi doi:10.1038/ni.2346 Antiviral innate immunity often has deleterious effects on the course of bacterial infection. Activation of the transcription factor IRF3 induced by the recognition of double-stranded RNA by RIG-I-like receptors suppresses the Toll-like receptor-induced expression of interleukins 12 and 23 and antibacterial responses. See also: Article by Negishi et al. Immunology JOBS of the week Post-doctoral Fellow (S Nath) - Genetic epidemiology of Systemic Lupus Erythematosus (SLE) - Arthritis and Clinical Immunology Oklahoma Medical Research Foundation (OMRF) PhD-Studentship, Institute For Immunology Medical School Essen, University of Essen Postdoctoral Fellowships and PhD Studentship Opportunities in Immunology Trinity College Dublin Non-Clinical Senior Lecturer in Immunology Imperial College London Oncology Research Scientist - Immunology & Pharmacology Sanofi More Science jobs from Immunology EVENT Cell Symposia: Human Immunity 19th August - 21st August 2012 Lisbon, Portugal More science events from Research Highlights Top NLRP3 lights a flame in the eyes | A new cellular player in asthma | Reporter effects | Building high affinity | cDC-specific transcription factor | PPAR-γ in fat Treg cells Perspective Top The many lives of IL-9: a question of survival?   pp637 - 641 Christoph Wilhelm, Jan-Eric Turner, Jacques Van Snick and Brigitta Stockinger doi:10.1038/ni.2303 Advertisement While our name has changed over the years from Cappel to ICN to MP Biomedicals, our commitment to supplying quality secondary antibodies remains unchanged. Choose from secondary antibodies with multiple conjugation forms, over 15 target species, various assay applications and flexible custom manufacturing. Click here for details on free gifts with qualifying purchases.   Articles Top Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization   pp642 - 650 Haixia Xu, Jimmy Zhu, Sinead Smith, Julia Foldi, Baohong Zhao, Allen Y Chung, Hasina Outtz, Jan Kitajewski, Chao Shi, Silvio Weber, Paul Saftig, Yueming Li, Keiko Ozato, Carl P Blobel, Lionel B Ivashkiv and Xiaoyu Hu doi:10.1038/ni.2304 Notch signaling is known to modulate macrophage polarization. Hu and colleagues show that the Notch-RBP-J axis controls the expression of M1 macrophage-specific genes by promoting translation of the transcription factor IRF8. F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation   pp651 - 658 Jing Zhao, Jianxin Wei, Rachel K Mialki, Daniel F Mallampalli, Bill B Chen, Tiffany Coon, Chunbin Zou, Rama K Mallampalli and Yutong Zhao doi:10.1038/ni.2341 Little is known about the regulation of the ST2L receptor for IL-33. Zhao and colleagues identify the F-box protein FBXL19 as being key to the degradation and negative regulation of ST2L. Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses   pp659 - 666 Hideo Negishi, Hideyuki Yanai, Akira Nakajima, Ryuji Koshiba, Koji Atarashi, Atsushi Matsuda, Kosuke Matsuki, Shoji Miki, Takahiro Doi, Alan Aderem, Junko Nishio, Stephen T Smale, Kenya Honda and Tadatsugu Taniguchi doi:10.1038/ni.2307 Whether cross-interference between innate immune receptors affects the outcome of immune responses remains unclear. Taniguchi and colleagues show that RLR activation interferes with activation of the Il12b promoter induced by TLR signaling. See also: News and Views by Takeuchi TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation   pp667 - 673 Nu Zhang and Michael J Bevan doi:10.1038/ni.2319 The pleiotropic cytokine TGF-β is involved in the generation of Treg cells and maintaining tolerance. Zhang and Bevan show that TGF-β acts specifically to block the proliferation of low-affinity T cells independently of effects on the development of Treg cells. See also: News and Views by Surh & Sprent Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC   pp674 - 680 Jianming Xie, Johannes B Huppa, Evan W Newell, Jun Huang, Peter J R Ebert, Qi-Jing Li and Mark M Davis doi:10.1038/ni.2344 Tetramers of peptide and major histocompatibility complex (pMHC) are very useful for the detection of specific T cell antigen receptors; however, they have several drawbacks. Davis and colleagues describe photocrosslinkable pMHC monomers with several important advantages and use these to probe the immunological synapse. Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells   pp681 - 690 Beatriz León, André Ballesteros-Tato, Jeffrey L Browning, Robert Dunn, Troy D Randall and Frances E Lund doi:10.1038/ni.2309 In lymph nodes, cellular positioning can dictate the immune response. Lund and colleagues show that nematode infection triggers interactions between lymphotoxin-producing B cells and CXCR5+ dendritic cells and CD4+ T cells to initiate T helper type 2 responses. See also: News and Views by Cannons et al. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection   pp691 - 700 Huabiao Chen, Zaza M Ndhlovu, Dongfang Liu, Lindsay C Porter, Justin W Fang, Sam Darko, Mark A Brockman, Toshiyuki Miura, Zabrina L Brumme, Arne Schneidewind, Alicja Piechocka-Trocha, Kevin T Cesa, Jennifer Sela, Thai D Cung, Ildiko Toth, Florencia Pereyra, Xu G Yu, Daniel C Douek, Daniel E Kaufmann, Todd M Allen and Bruce D Walker doi:10.1038/ni.2342 The functional basis of elite control of HIV is still unclear. Walker and colleagues show that elite controllers are tolerant of viral escape variants and more rapidly mobilize cytotoxic granules to the immunological synapse. See also: News and Views by Feinberg & Ahmed Addendum Top Defective Dock2 expression in a subset of ASC-deficient mouse lines   pp701 - 702 Sirish K Ippagunta, R K Subbarao Malireddi, Patrick J Shaw, Geoffrey A Neale, Lieselotte Vande Walle, Yoshinori Fukui, Douglas R Green, Mohamed Lamkanfi and Thirumala-Devi Kanneganti doi:10.1038/ni.2095 Top Advertisement Scientific Reports publishes 457 open access papers in its first year Publishing technically sound research articles, Scientific Reports is Nature Publishing Group’s fastest growing journal. Given the speed and visibility offered, no wonder 93% of our authors said that they are “likely” or “very likely” to submit again. Keep your research moving. Submit to Scientific Reports   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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