Friday, January 6, 2012

chemistry@nature contents: 06 January 2012

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6 January 2012

Primary Research
Protocols
Blog Entries from The Sceptical Chymist

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  Primary Research

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Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Ryosuke Nakashima et al.
Nature
doi:10.1038/nature10641
Abstract


Intermediates in the transformation of phosphonates to phosphate by bacteria
Siddhesh S. Kamat et al.
Nature
doi:10.1038/nature10622
Abstract


Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis
David A. Nagib & David W. C. MacMillan
Nature
doi:10.1038/nature10647
Abstract


Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor
Solveigh C Koeberle et al.
Nature Chemical Biology
doi:10.1038/nchembio.761
Abstract


Chemical informatics and target identification in a zebrafish phenotypic screen
Christian Laggner et al.
Nature Chemical Biology
doi:Nature Chemical Biology
Abstract


Small-molecule proteostasis regulators for protein conformational diseases
Barbara Calamini et al.
Nature Chemical Biology
doi:10.1038/nchembio.763
Abstract


Natural product-inspired cascade synthesis yields modulators of centrosome integrity
Heiko Duckert et al.
Nature Chemical Biology
doi:10.1038/nchembio.758
Abstract


Primary amines protect against retinal degeneration in mouse models of retinopathies
Akiko Maeda et al.
Nature Chemical Biology
doi:10.1038/nchembio.759
Abstract


A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis
Tom Bretschneider et al.
Nature Chemical Biology
doi:10.1038/nchembio.746
Abstract


How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels
Jana Kusch et al.
Nature Chemical Biology
doi:10.1038/nchembio.747
Abstract


Knot formation in newly translated proteins is spontaneous and accelerated by chaperonins
Anna L Mallam & Sophie E Jackson
Nature Chemical Biology
doi:10.1038/nchembio.742
Abstract


Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
Candice E Paulsen et al.
Nature Chemical Biology
doi:10.1038/nchembio.736
Abstract


Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams
Douglas C. Behenna et al.
Nature Chemistry
doi:10.1038/nchem.1222
Abstract


The promoting effect of adsorbed carbon monoxide on the oxidation of alcohols on a gold catalyst
Paramaconi Rodriguez, Youngkook Kwon & Marc T. M. Koper
Nature Chemistry
doi:10.1038/nchem.1221
Abstract


Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity
Andrew J. Keefe & Shaoyi Jiang
Nature Chemistry
doi:10.1038/nchem.1213
Abstract


Metal-adeninate vertices for the construction of an exceptionally porous metal-organic framework
Jihyun An et al.
Nature Communications
doi:10.1038/ncomms1618
Abstract


Photoswitchable gel assembly based on molecular recognition
Hiroyasu Yamaguchi et al.
Nature Communications
doi:10.1038/ncomms1617
Abstract


Stable prenucleation mineral clusters are liquid-like ionic polymers
Raffaella Demichelis et al.
Nature Communications
doi:10.1038/ncomms1604
Abstract


Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging
Graham T Dempsey, Joshua C Vaughan, Kok Hao Chen, Mark Bates & Xiaowei Zhuang
Nature Methods
doi:10.1038/nmeth.1768
Abstract


Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach
Auyeung, E. et al.
Nature Nanotechnology
doi:10.1038/nnano.2011.222
Abstract


A surface-anchored molecular four-level conductance switch based on single proton transfer
Auwarter, W. et al.
Nature Nanotechnology
doi:10.1038/nnano.2011.211
Abstract


Enhanced and switchable nanoscale thermal conduction due to van der Waals interfaces
Yang, J. et al.
Nature Nanotechnology
doi:10.1038/nnano.2011.216
Abstract


  Protocols

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Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry
William P Heal, Megan H Wright, Emmanuelle Thinon & Edward W Tate
Nature Protocols
doi:10.1038/nprot.2011.425
Abstract


Depletion of hemoglobin and carbonic anhydrase from erythrocyte cytosolic samples by preparative clear native electrophoresis
Gian Maria D'Amici, Sara Rinalducci & Lello Zolla
Nature Protocols
doi:10.1038/nprot.2011.427
Abstract


SILEC: a protocol for generating and using isotopically labeled coenzyme A mass spectrometry standards
Sankha S Basu & Ian A Blair
Nature Protocols
doi:10.1038/nprot.2011.421
Abstract


  Review Articles

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Rethinking amide bond synthesis
Vijaya R. Pattabiraman & Jeffrey W. Bode
Nature
doi:10.1038/nature10702
Abstract


Bacteria and host interactions in the gut epithelial barrier
Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Hitomi Mimuro & Chihiro Sasakawa
Nature Chemical Biology
doi:10.1038/nchembio.741
Abstract


Bugs, drugs and chemical genomics
Terry Roemer, Julian Davies, Guri Giaever & Corey Nislow
Nature Chemical Biology
doi:10.1038/nchembio.744
Abstract


Interfacial inhibitors: targeting macromolecular complexes
Yves Pommier & Christophe Marchand
Nature Reviews Drug Discovery
doi:10.1038/nrd3404
Abstract


Designing antimicrobial peptides: form follows function
Christopher D. Fjell, Jan A. Hiss, Robert E. W. Hancock & Gisbert Schneider
Nature Reviews Drug Discovery
doi:10.1038/nrd3591
Abstract


The pharmacological landscape and therapeutic potential of serine hydrolases
Daniel A. Bachovchin & Benjamin F. Cravatt
Nature Reviews Drug Discovery
doi:10.1038/nrd3620
Abstract


Targeting proteinase-activated receptors: therapeutic potential and challenges
Rithwik Ramachandran, Farshid Noorbakhsh, Kathryn DeFea & Morley D. Hollenberg
Nature Reviews Drug Discovery
doi:10.1038/nrd3615
Abstract

  Blog Entries from The Sceptical Chymist

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A new look
Welcome to the new-look Sceptical Chymist! Of course, if you?re just reading this in your RSS reader, then things will look pretty familiar...
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