   | Download the latest Spotlight On… Melanoma report
This quarter’s Spotlight On… report focuses on Melanoma, which is currently experiencing an innovation breakthrough. The Spotlight On... report draws on the expert insight and strategic data from Thomson Reuters Pharma – the world's leading competitive intelligence solution. Download today. |
 - Nanofiber Solutions' scaffold used in artificial trachea
Swedish researchers used a nanofiber scaffold from Nanofiber Solutions to grow a synthetic trachea for transplant. The researchers used the patient's own stem cells to grow the organ in the lab. Nanofiber Solutions was co-founded by an Ohio State University doctoral student who won a business plan competition. MedCityNews.com (11/30)       - Celldex starts late-stage testing of vaccine for brain tumor
Celldex Therapeutics launched an international Phase III study to evaluate vaccine candidate rindopepimut in as many as 440 patients with glioblastoma, an aggressive type of brain cancer. The vaccine, which targets a mutation in the epidermal growth factor receptor gene, holds orphan-drug and fast-track designations in the U.S. Celldex also plans to start a midstage trial of rindopepimut in combination with Avastin, by Roche Holding unit Genentech. Mass High Tech (Boston) (12/1) - Technology shrinks labs to the size of a fingernail
Advances in nanotechnology, biotechnology and micro-electronics are allowing doctors and researchers to perform complex diagnoses using a single drop of blood. For example, a lab-on-a-chip being developed at the London Centre for Nanotechnology requires only a drop of blood to detect HIV. "Potentially you can detect the presence of, for example, cancer or diabetes at a much earlier stage and then treat it more effectively," said Mark Morrison, CEO of the U.K.'s Institute of Nanotechnology. "If you treat the disease earlier on, you have a much greater chance of success." The Guardian (London) (11/28) - Researchers develop iPS cells from Pompe disease cells
Taiwanese researchers have developed induced pluripotent stem cells from the skin cells of patients with Pompe disease. The researchers also tested drugs on the iPS cells and were able to pinpoint marker genes whose expression correlates with the effect of drug treatment. The findings could aid in early diagnosis, drug testing and disease marker identification. Asian Scientist (Singapore) (11/30) - Study: Tumor sequencing may pave way for new biomarker trials
High-speed sequencing of two tumor biopsies' entire genomes, exomes and RNA transcriptomes revealed a mutation in the HRAS gene and a rearrangement of CDKN2C in a melanoma patient, and mutations in the NRAS, TP53, AURKA, FAS and MYH11 genes in a colorectal cancer patient, a study found. The findings suggest that genetic sequencing can help identify patient-specific mutations to enable new biomarker-based treatment trials, researchers reported in Science Translational Medicine. MedPage Today (free registration) (11/30) - DNA sequencing is outpacing storage, communication technology
As DNA sequencing becomes faster and cheaper, scientists are struggling to process, analyze and translate a deluge of data into clinically meaningful information. "We have these giant piles of data and no way to connect them," said biologist H. Steven Wiley of the Pacific Northwest National Laboratory. Researchers are increasingly using cloud computing, and a scientist at Cold Spring Harbor Laboratory is trying to apply techniques used by Google to the management of genomic data. The New York Times (tiered subscription model) (11/30) - Study sheds light on how malaria develops in human blood cells
British and French researchers have discovered the genes in the Plasmodium falciparum parasite that produce kinases, which are enzymes that promote the development of the malaria parasite in human blood cells. The researchers said they are now working to discover drugs that can block the function of the kinases. The study was published in the journal Nature Communications. Google/Agence France-Presse (11/29)  | LET’S GO DESIGN: Episode #6
This time, we go inside the tracks and review the shocks and suspension system. Also, Jeremy hears the expert opinion of a mom on the baby buggy and unveils the chosen cockpit design. Watch the new episode now at LetsGoDesign.tv |
  | Developments in the Use of PAT and Laboratory Automation
Technical breakthroughs for better understanding and characterization of chemical or biochemical processes are key to meet today’s industry challenges. Integration of process analyzers and process automation with multivariate tools for design, data acquisition and analysis is critical. Register for the webinar. |
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| Food & Agriculture |  |  | | - Experts: Pakistan needs biotech to boost agricultural production
Pakistan's agricultural sector needs to adopt biotech crops and promote biotech studies in order to increase the country's food production and meet the needs of a growing population, experts said during a seminar hosted by the Pakistan Biotechnology Information Center in Lahore. The country also needs to raise farmers' awareness about the benefits of biotechnology, biotechnologist Anwar Naseem said. Another official said new laws are needed to protect plant breeders' rights and that bigger investments are needed in agricultural research. The News - International (Pakistan) (12/2) | Industrial & Environmental | | | | - U.S. market may not have room for palm-based biodiesel, official says
Palm-based biodiesel from Indonesia will have a hard time competing in the U.S. market, where supplies of corn oil and waste oils are plentiful, according to Michael Dwyer, director of the Department of Agriculture's global policy analysis unit. "The United States is frankly very competitive for biodiesel, and it's going to be hard to justify for palm oil when it costs over $900 a ton," Dwyer said. A key competitor for palm-based biofuel in the U.S. would be corn oil derived from the production of distillers dried grains, Dwyer added. Reuters (12/1)  | |  | | The Buzz(CORPORATE ANNOUNCEMENTS)
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| News from BIO | | | | - Ship with FedEx
FedEx is now offering member companies discounts of up to 35% off select FedEx services, both U.S. and international services. The BIO program with FedEx is one of the many cost-savings programs offered by BIO through its Business Solutions program. There is no charge for BIO member companies to participate in any of the BIO Business Solutions programs -- it is a benefit of membership. Learn more about the BIO and FedEx program.
| SmartQuote | | | |  | Deliberation is the work of many men. Action, of one alone."
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