Nature Reviews Immunology Contents November 2011 Volume 11 Number 11 pp 713-798

Advertisement
Cell Cycle Analysis: A streamlined approach. New BD FACSuite™ software on the BD FACSVerse™ flow cytometry system provides predefined research assays matched with reagent kits, making it easy to achieve reproducible, consistent results. Download a free application note on cell cycle analysis and see the exciting innovations behind the new BD FACSVerse. bdbiosciences.com/go/verse
TABLE OF CONTENTS
November 2011 Volume 11 Number 11		Advertisement
Impact Factor 35.196 * Subscribe to Nature Reviews Immunology Recommend to your library	In this issue Research Highlights Focus on: Monocytes and macrophages Also this month  Featured article: Protective and pathogenic functions of macrophage subsets Peter J. Murray & Thomas A. Wynn	Th1, Th2, Treg or Th17?Cytokine expression patterns revealed by Quantibody and RayBio Th1/Th2/Th17 Antibody Arrays can help you identify T helper profiles quickly and easily. 1-day processing time. No specialized equipment needed.
Advertisement
Nature Immunology presents a webcast on Current Controversies: Human Immunology Please join our discussion on how to better understand the human immune system, followed by a live question and answer session. October 26th 2011 • 12 noon Eastern / 9 a.m. Pacific/ 5 p.m. GMT / 6 p.m. CET Register for FREE: www.nature.com/webcasts/human_immunology Sponsored by:
In this issue p713 | doi:10.1038/nri3102 Full Text
Editorial: Nobel Prize to immunology p714 | doi:10.1038/nri3103 Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Immunotherapy: Stopping monocytes in their tracks p715 | doi:10.1038/nri3096 Therapeutic targeting of inflammatory monocyte migration attenuates disease severity. PDF T cell memory: The stem of T cell memory p716 | doi:10.1038/nri3098 Identification of human T memory stem cells with increased therapeutic potential. PDF B cell signalling: Right place, right time p716 | doi:10.1038/nri3100 BCR endocytosis compartmentalizes kinase phosphorylation and downstream signalling. PDF T cell memory: Exhausted T cells miss out on methylation p718 | doi:10.1038/nri3093 The inhibitory signal to T cells through PD1 is sustained during chronic viral infection by epigenetic mechanisms. PDF Tumour immunology: IFNs boost cancer killers p718 | doi:10.1038/nri3094 Type I IFN targets CD8α+ DCs for the initiation of antitumour immunity. PDF Immune tolerance: Suicide is painless p719 | doi:10.1038/nri3092 Self-reactive T cells invade and are degraded in hepatocytes, preventing autoimmune disease. PDF T cells: Lymphoid stroma says NO to activated T cells p720 | doi:10.1038/nri3090 Activated T cells induce the production of immunosuppressive nitric oxide by stromal cells. PDF Neuroimmunology: Nervous ChAT p720 | doi:10.1038/nri3091 Acetylcholine-producing T cells convey neural signals to dampen inflammation. PDF Mucosal immunology: Colonic creatures are TReg teachers p721 | doi:10.1038/nri3099 Most regulatory T cells in the colon are specific for commensal bacteria. PDF IN BRIEF Macrophages: Arteriogenic macrophages protect against ischaemia | Monocytes: How a high-fat diet results in monocytosis | Technique: Recapitulating human TB in vitro | T cells: Natural TH17 cell development in the thymus | Cytokines: IL-1 family member dampens intestinal inflammation | Innate immunity: The function of innate lymphoid cells in the lung PDF Immunology JOBS of the week Head of School, Agriculture, Food and Wine The University of Adelaide Adelaide, AU International PhD program: From Biology to Medicine Max Planck Institute of Biochemistry and Max Planck Institute of Neurobiology Munich, DE Assistant Professor or Post Doc in Epigenetics Linkoping University Hospital Linkoping, SE Assistant Professor or Post Doc in Epigenetics Linkoping University Hospital Linkoping, SE Postdoctoral Fellow - Differentiation of Embryonic Stem Cells Mount Sinai School of Medicine (Baron Lab) New York, US More Science jobs from Immunology EVENT Vaccines for Chronic Diseases Symposium 07.-09.02.12 TX, US More science events from
Focus on: Monocytes and macrophages REVIEWS Top Protective and pathogenic functions of macrophage subsets Peter J. Murray & Thomas A. Wynn p723 | doi:10.1038/nri3073 Macrophages exhibit remarkable plasticity and adopt pro- or anti-inflammatory phenotypes in response to environmental signals. This Review article by Murray and Wynn discusses the different macrophage subsets and their contribution to tissue homeostasis and disease pathogenesis. Abstract | Full Text | PDF Macrophage-mediated inflammation in metabolic disease Ajay Chawla, Khoa D. Nguyen & Y. P. Sharon Goh p738 | doi:10.1038/nri3071 Inflammation in adipose tissue is known to mediate insulin resistance in obesity, and macrophages are thought to have a central role in mediating this inflammatory response. But adipose tissue macrophages are not all bad: alternative activation of these cells promotes insulin sensitivity. Abstract | Full Text | PDF Transcriptional regulation of macrophage polarization: enabling diversity with identity Toby Lawrence & Gioacchino Natoli p750 | doi:10.1038/nri3088 This Review describes the key transcription factors that enable the polarization of macrophages in response to the microenvironment in the context of a regulatory landscape that determines macrophage identity. Abstract | Full Text | PDF Monocyte recruitment during infection and inflammation Chao Shi & Eric G. Pamer p762 | doi:10.1038/nri3070 Monocytes serve as precursors for various tissue macrophage and dendritic cell populations and contribute to both protective and pathological immune responses. Here, the authors describe the mechanisms that are involved in mobilizing monocytes to distinct tissue sites, both during steady-state conditions and in response to infection. Abstract | Full Text | PDF Microglial cell origin and phenotypes in health and disease Kaoru Saijo & Christopher K. Glass p775 | doi:10.1038/nri3086 Microglia are brain-resident macrophages with a distinct origin. This Review discusses the development and function of these cells, and describes the association between the different microglial cell phenotypes and disease. Abstract | Full Text | PDF Studying the mononuclear phagocyte system in the molecular age Andrew Chow, Brian D. Brown & Miriam Merad p788 | doi:10.1038/nri3087 Immunologists are making good progress in unravelling the intricacies of the mononuclear phagocyte system, and this is largely due to recent technological advances. This article describes the current tools that exist for studying the origins and functions of mononuclear phagocytes and discusses the future technologies that will enable further progress in the field. Abstract | Full Text | PDF
Advertisement
Exclusive discounts are now available online Nature Lab Offers provides researchers like you with exclusive discounts on products used in your lab. Browse through US Offers or Global Offers on antibodies, cell culture, PCR, software, pipettors, reagents, and more! US Offers Global Offers
Advertisement
NATURE REVIEWS IMMUNOLOGY TURNS 10 Nature Reviews Immunology celebrates 10 years of outstanding Reviews with a special anniversary issue in October, featuring a Viewpoint by our most highly cited authors. In addition, we bring you an immunology-themed crossword puzzle in the October anniversary issue. CLICK HERE or the online version. The answers will be published in the November issue. Good luck!
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2010 Journal Citation Report (Thomson Reuters, 2011)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.