Tuesday, October 25, 2011

Nature Communications - 25 October 2011

 
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25 October 2011
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Ohki et al. study the structure-function relationships of epidermal patterning factors.
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Dermatogenetics
February 9-12, 2012 • Miami, FL, USA
The conference will cover: genetic variation, gene expression and cellular mechanisms in this shared area of exceptional interest to basic researchers, biopharma and translational medicine.
For more information and to register visit: http://www.nature.com/natureconferences/dg2012
 
  Latest Articles View all Articles  
 
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity OPEN
Nicolas Léveillé, Ran Elkon, Veronica Davalos, Vijayalaxmi Manoharan, Dave Hollingworth, Joachim Oude Vrielink, Carlos le Sage, Carlos A. Melo, Hugo M. Horlings, Jelle Wesseling, Jernej Ule, Manel Esteller, Andres Ramos and Reuven Agami
MicroRNAs bind to the 3′-untranslated region of genes to regulate expression. In this study, an RNA-binding protein, RMB38, is shown to selectively regulate the access of some microRNAs to their targets, and control the expression of some p53 target genes.
25 Oct | Nat Commun 2:513 doi:10.1038/ncomms1519 (2011)
Biological sciences Cancer 
Genetics 
Abstract | Full Text | PDF (2,557 kB) |
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The NMR structure of stomagen reveals the basis of stomatal density regulation by plant peptide hormones
Shinya Ohki, Makoto Takeuchi and Masashi Mori
Stomagen is a positive regulator of stomatal development in plants, whereas epidermal patterning factors 1 and 2 are negative regulators. Ohki et al. present the NMR structure of stomagen and show that the stomagen loop domain is sufficient to positively regulate stomatal development.
25 Oct | Nat Commun 2:512 doi:10.1038/ncomms1520 (2011)
Biological sciences Molecular biology 
Plant sciences 
Abstract | Full Text | PDF (725 kB) |
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Redox-responsive self-healing materials formed from host–guest polymers OPEN
Masaki Nakahata, Yoshinori Takashima, Hiroyasu Yamaguchi and Akira Harada
Stimulus-responsive hydrogels have previously been developed that display heat-, light-, pH- or redox-induced sol–gel transitions. Nakahata et al. develop a self-healing supramolecular hydrogel based on host–guest polymers in which redox potential can induce a reversible sol–gel phase transition.
25 Oct | Nat Commun 2:511 doi:10.1038/ncomms1521 (2011)
Chemical sciences Materials science 
Abstract | Full Text | PDF (712 kB) |
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Synapse microarray identification of small molecules that enhance synaptogenesis
Peng Shi, Mark A. Scott, Balaram Ghosh, Dongpeng Wan, Zachary Wissner-Gross, Ralph Mazitschek, Stephen J. Haggarty and Mehmet Fatih Yanik
Large scale synapse assays can facilitate identification of drug leads. Shi et al. develop a 'synapse microarray' technology that enables sensitive, high-throughput, quantitative screening of synaptogenic events, and use it to identify novel histone deacetylase inhibitors that enhance synaptogenesis.
25 Oct | Nat Commun 2:510 doi:10.1038/ncomms1518 (2011)
Biological sciences Bioengineering 
Chemical biology Neuroscience
Abstract | Full Text | PDF (1,251 kB) |
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Theoretical models of nonlinear effects in two-component cooperative supramolecular copolymerizations OPEN
Albert J. Markvoort, Huub M.M. ten Eikelder, Peter A.J. Hilbers, Tom F.A. de Greef and E.W. Meijer
In multi-component mixtures of self-assembling molecules, small differences in association energy between components can be amplified by nonlinear effects. This theoretical investigation of self-assembling systems rationalizes chiral amplification in cooperative supramolecular copolymerizations.
25 Oct | Nat Commun 2:509 doi:10.1038/ncomms1517 (2011)
Chemical sciences Organic chemistry 
Physical chemistry 
Abstract | Full Text | PDF (1,496 kB) |
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