Table of Contents Alert: The EMBO Journal, Vol. 39, No. 1, 02 January 2020

The EMBO Journal Volume 39, Issue 1 02 January 2020

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Review

Open Access

RNA toxicity in non‐coding repeat expansion disorders

Bart Swinnen, Wim Robberecht, Ludo Van Den Bosch

EMBO J (2020) 39: e101112 | First Published: 13 November 2019

This review comprehensively delineates pathogenic mechanisms underlying various neurodegenerative disorders with special focus on disentangling toxicity associated with RNA species or RAN (repeat‐associated non‐ATG) products.

Articles

Highlight

Paracaspase MALT1 regulates glioma cell survival by controlling endo‐lysosome homeostasis

Kathryn A Jacobs, Gwennan André‐Grégoire, Clément Maghe, An Thys, Ying Li, Elizabeth Harford‐Wright, Kilian Trillet, Tiphaine Douanne, Carolina Alves Nicolau, Jean‐Sébastien Frénel, Nicolas Bidère, Julie Gavard

EMBO J (2020) 39: e102030 | First Published: 27 November 2019

Protease MALT1 impairs lysosome biogenesis and increases mTOR signalling and autophagic flux in glioma stem cells.

Open Access Highlight

Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants

Solomiia Korchynska, Maria Krassnitzer, Katarzyna Malenczyk, Rashmi B Prasad, Evgenii O Tretiakov, Sabah Rehman, Valentina Cinquina, Victoria Gernedl, Matthias Farlik, Julian Petersen, Sophia Hannes, Julia Schachenhofer, Sonali N Reisinger, Alice Zambon, Olof Asplund, Isabella Artner, Erik Keimpema, Gert Lubec, Jan Mulder, Christoph Bock, Daniela D Pollak, Roman A Romanov, Christian Pifl, Leif Groop, Tomas GM Hökfelt, Tibor Harkany

EMBO J (2020) 39: e100882 | First Published: 21 November 2019

Use of drugs like amphetamine affects pancreatic beta‐cell function and insulin production of unborn mouse offspring via deregulation of serotonin‐related gene networks.

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia‐like phenotypes in mice

Ashwaq Hassan Alsabban, Momo Morikawa, Yosuke Tanaka, Yosuke Takei, Nobutaka Hirokawa

EMBO J (2020) 39: e101090 | First Published: 20 November 2019

Simultaneous vesicular transport of NMDAR subunit 2A and the adenomatous polyposis coli (APC) complex in neuronal dendrites depends on Kif3b and is disrupted by schizophrenia‐linked mutations.

Non‐canonical AUX/IAA protein IAA33 competes with canonical AUX/IAA repressor IAA5 to negatively regulate auxin signaling

Bingsheng Lv, Qianqian Yu, Jiajia Liu, Xuejing Wen, Zhenwei Yan, Kongqin Hu, Hanbing Li, Xiangpei Kong, Cuiling Li, Huiyu Tian, Ive De Smet, Xian‐Sheng Zhang, Zhaojun Ding

EMBO J (2020) 39: e101515 | First Published: 16 October 2019

In contrast to other AUX/IAA‐family repressor, IAA33 is stabilised by auxin and competes with canonical IAA5 for binding to downstream auxin response factors ARF10/16.

Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor

Rebecca E Vargas, Vy Thuy Duong, Han Han, Albert Paul Ta, Yuxuan Chen, Shiji Zhao, Bing Yang, Gayoung Seo, Kimberly Chuc, Sunwoo Oh, Amal El Ali, Olga V Razorenova, Junjie Chen, Ray Luo, Xu Li, Wenqi Wang

EMBO J (2020) 39: e102406 | First Published: 29 November 2019

Identification of a conserved WW domain sequence mediating specific interactions among Hippo pathway components uncovers a new regulator of Hippo signaling as potential kidney cancer tumor suppressor.

Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming

Keshi Chen, Qi Long, Guangsuo Xing, Tianyu Wang, Yi Wu, Linpeng Li, Juntao Qi, Yanshuang Zhou, Bochao Ma, Hans R Schöler, Jinfu Nie, Duanqing Pei, Xingguo Liu

EMBO J (2020) 39: e99165 | First Published: 01 October 2019

The pluripotency factor Oct4 decondenses chromatin and cooperates with Klf4 to initiate epithelial gene programs.

Nipped‐A regulates the Drosophila circadian clock via histone deubiquitination

Bei Bu, Lixia Chen, Liubin Zheng, Weiwei He, Luoying Zhang

EMBO J (2020) 39: e101259 | First Published: 19 September 2019

The fly homolog of the schizophrenia‐linked TRRAP gene acts via the deubiquitination module of the SAGA chromatin‐modifying complex to set the pace of the circadian clock.

Open Access

Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

Sinah‐Sophia Weiterer, Johanna Meier‐Soelch, Theodore Georgomanolis, Athanasia Mizi, Anna Beyerlein, Hendrik Weiser, Lilija Brant, Christin Mayr‐Buro, Liane Jurida, Knut Beuerlein, Helmut Müller, Axel Weber, Ulas Tenekeci, Oliver Dittrich‐Breiholz, Marek Bartkuhn, Andrea Nist, Thorsten Stiewe, Wilfred FJ van IJcken, Tabea Riedlinger, M Lienhard Schmitz, Argyris Papantonis, Michael Kracht

EMBO J (2020) 39: e101533 | First Published: 07 November 2019

ATAC‐seq, native 4C‐seq and CRISPR genome editing reveal functional hierarchies and chromatin looping dynamics of cytokine‐inducible "master" enhancers that govern gene regulation during the early proinflammatory response.

Open Access

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

Fatima Dhalla, Jeanette Baran‐Gale, Stefano Maio, Lia Chappell, Georg A Holländer, Chris P Ponting

EMBO J (2020) 39: e101828 | First Published: 28 October 2019

Single‐cell RNA sequencing reveals transcriptional heterogeneity based on both ordered and stochastic elements that enables a dedicated cell population to mirror the body's full self‐antigen complement for development of central T‐cell tolerance.

Micropeptide CIP2A‐BP encoded by LINC00665 inhibits triple‐negative breast cancer progression

Binbin Guo, Siqi Wu, Xun Zhu, Liyuan Zhang, Jieqiong Deng, Fang Li, Yirong Wang, Shenghua Zhang, Rui Wu, Jiachun Lu, Yifeng Zhou

EMBO J (2020) 39: e102190 | First Published: 22 November 2019

Long non‐coding RNA‐translated micropeptide CIP2A‐BP impairs oncogenic CIP2A‐PI3K‐AKT signaling but is controlled by TGF‐β in the malignant state.

RanGTP and importin β regulate meiosis I spindle assembly and function in mouse oocytes

David Drutovic, Xing Duan, Rong Li, Petr Kalab, Petr Solc

EMBO J (2020) 39: e101689 | First Published: 16 October 2019

Live‐cell imaging with fluorescent probes and FRET biosensors clarify previous discrepancies between findings in human and mouse oocytes, supporting conserved roles of Ran GTPase in acentrosomal meiotic spindle formation in mammals.

Corrigendum

The Sir4 H‐BRCT domain interacts with phospho‐proteins to sequester and repress yeast heterochromatin

Ishan Deshpande, Jeremy J Keusch, Kiran Challa, Vytautas Iesmantavicius, Susan M Gasser, Heinz Gut

EMBO J (2020) 39: e103976 | First Published: 02 January 2020

This article is a correction.

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