 | The EMBO Journal Volume 38, Issue 20 15 October 2019 |
News & Views
p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill
EMBO J (2019) 38: e103322 | First Published: 25 September 2019
A new genetic mouse model disentangles p53's roles in cancer progression versus apoptosis.
E2F transcription regulation: an orphan cyclin enters the stage
EMBO J (2019) 38: e103421 | First Published: 30 September 2019
Several recent studies suggests that the unusual cyclin F may play very similar cell‐cycle regulatory roles as its closest relatives, merely mediated through a very different mechanism.
Review
Open Access Tissue rheology in embryonic organization
EMBO J (2019) 38: e102497 | First Published: 12 September 2019
This review discusses the current insights into how tissue material properties and phase transitions within the tissue regulate development.
Articles
Open Access VAP‐SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function
EMBO J (2019) 38: e101345 | First Published: 23 August 2019
The ER membrane receptors VAPA/VAPB modulate ER integrity and remodeling through interactions with Secernin‐1, thereby regulating calcium homeostasis and synaptic vesicle cycling.
Open Access Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses
EMBO J (2019) 38: e102096 | First Published: 04 September 2019
Genetic in vivo analyses reveal non‐transcriptional apoptotic p53 roles in development and cancer.
Open Access Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression
EMBO J (2019) 38: e101430 | First Published: 02 September 2019
In addition to APC/C‐mediated proteolysis of atypical repressive E2Fs during G1, later downregulation via an SCF ubiquitin ligase is important for repair gene expression and G2/M transition.
Open Access E2F1 proteolysis via SCF‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition
EMBO J (2019) 38: e101443 | First Published: 19 August 2019
A kinase inhibitor screen reveals that Chk1‐dependent checkpoint responses are required to prevent catastrophic replication stress caused by unrestricted E2F1 activity in cells lacking Cyclin F.
Open Access Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles
EMBO J (2019) 38: e101266 | First Published: 23 September 2019
The thiol‐specific peroxidase Prdx4 directly regulates caspase‐1 activity in a redox‐sensitive manner to control IL‐1β maturation.
FOXA2 controls the cis‐regulatory networks of pancreatic cancer cells in a differentiation grade‐specific manner
EMBO J (2019) 38: e102161 | First Published: 17 September 2019
Interaction with specific transcription factors drives distinct occupancy of FOXA2 at gene sets expressed in well‐ versus poorly‐differentiated pancreatic ductal adenocarcinoma cells.
The Sir4 H‐BRCT domain interacts with phospho‐proteins to sequester and repress yeast heterochromatin
EMBO J (2019) 38: e101744 | First Published: 12 September 2019
A phospho‐peptide consensus sequence within a non‐canonical BRCA1 C‐terminal domain of the transcriptional silencer Sir4 is required for its binding to phosphorylated partners, including the E3 ligase Tom1 as a newly identified interactor.
Editorial Note
Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos
EMBO J (2019) 38: e103221 | First Published: 15 October 2019
This article is a correction.
Retraction
Retraction: Regulation of MBD1‐mediated transcriptional repression by SUMO and PIAS proteins
EMBO J (2019) 38: e103220 | First Published: 15 October 2019
This article is a retraction.
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