Wednesday, October 16, 2019

Table of Contents Alert: The EMBO Journal, Vol. 38, No. 20, 15 October 2019

The Non-coding Genome
Cover Image The EMBO Journal
Volume 38, Issue 20

15 October 2019


News & Views

p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill
James J Manfredi

EMBO J (2019) 38: e103322 | First Published: 25 September 2019

A new genetic mouse model disentangles p53's roles in cancer progression versus apoptosis.

E2F transcription regulation: an orphan cyclin enters the stage
Heike Ilona Rösner, Claus Storgaard Sørensen

EMBO J (2019) 38: e103421 | First Published: 30 September 2019

Several recent studies suggests that the unusual cyclin F may play very similar cell‐cycle regulatory roles as its closest relatives, merely mediated through a very different mechanism.

Review

Open Access
Tissue rheology in embryonic organization
Nicoletta I Petridou, Carl‐Philipp Heisenberg

EMBO J (2019) 38: e102497 | First Published: 12 September 2019

This review discusses the current insights into how tissue material properties and phase transitions within the tissue regulate development.

Articles

Open Access
VAP‐SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function
Feline W Lindhout, Yujie Cao, Josta T Kevenaar, Anna Bodzęta, Riccardo Stucchi, Maria M Boumpoutsari, Eugene A Katrukha, Maarten Altelaar, Harold D MacGillavry, Casper C Hoogenraad

EMBO J (2019) 38: e101345 | First Published: 23 August 2019

The ER membrane receptors VAPA/VAPB modulate ER integrity and remodeling through interactions with Secernin‐1, thereby regulating calcium homeostasis and synaptic vesicle cycling.

Open Access
Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses
Oleg Timofeev, Boris Klimovich, Jean Schneikert, Michael Wanzel, Evangelos Pavlakis, Julia Noll, Samet Mutlu, Sabrina Elmshäuser, Andrea Nist, Marco Mernberger, Boris Lamp, Ulrich Wenig, Alexander Brobeil, Stefan Gattenlöhner, Kernt Köhler, Thorsten Stiewe

EMBO J (2019) 38: e102096 | First Published: 04 September 2019

Genetic in vivo analyses reveal non‐transcriptional apoptotic p53 roles in development and cancer.

Open Access
Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression
Ruixue Yuan, Qingwu Liu, Hendrika A Segeren, Laurensia Yuniati, Daniele Guardavaccaro, Robert J Lebbink, Bart Westendorp, Alain de Bruin

EMBO J (2019) 38: e101430 | First Published: 02 September 2019

In addition to APC/C‐mediated proteolysis of atypical repressive E2Fs during G1, later downregulation via an SCF ubiquitin ligase is important for repair gene expression and G2/M transition.

Open Access
E2F1 proteolysis via SCF‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition
Kamila Burdova, Hongbin Yang, Roberta Faedda, Samuel Hume, Jagat Chauhan, Daniel Ebner, Benedikt M Kessler, Iolanda Vendrell, David H Drewry, Carrow I Wells, Stephanie B Hatch, Grigory L Dianov, Francesca M Buffa, Vincenzo D'Angiolella

EMBO J (2019) 38: e101443 | First Published: 19 August 2019

A kinase inhibitor screen reveals that Chk1‐dependent checkpoint responses are required to prevent catastrophic replication stress caused by unrestricted E2F1 activity in cells lacking Cyclin F.

Open Access
Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles
Simone Lipinski, Steffen Pfeuffer, Philipp Arnold, Christian Treitz, Konrad Aden, Henriette Ebsen, Maren Falk‐Paulsen, Nicolas Gisch, Antonella Fazio, Jan Kuiper, Anne Luzius, Susanne Billmann‐Born, Stefan Schreiber, Gabriel Nuñez, Hans‐Dietmar Beer, Till Strowig, Mohamed Lamkanfi, Andreas Tholey, Philip Rosenstiel

EMBO J (2019) 38: e101266 | First Published: 23 September 2019

The thiol‐specific peroxidase Prdx4 directly regulates caspase‐1 activity in a redox‐sensitive manner to control IL‐1β maturation.

FOXA2 controls the cis‐regulatory networks of pancreatic cancer cells in a differentiation grade‐specific manner
Marta Milan, Chiara Balestrieri, Gabriele Alfarano, Sara Polletti, Elena Prosperini, Paola Spaggiari, Alessandro Zerbi, Giuseppe R Diaferia, Gioacchino Natoli

EMBO J (2019) 38: e102161 | First Published: 17 September 2019

Interaction with specific transcription factors drives distinct occupancy of FOXA2 at gene sets expressed in well‐ versus poorly‐differentiated pancreatic ductal adenocarcinoma cells.

The Sir4 H‐BRCT domain interacts with phospho‐proteins to sequester and repress yeast heterochromatin
Ishan Deshpande, Jeremy J Keusch, Kiran Challa, Vytautas Iesmantavicius, Susan M Gasser, Heinz Gut

EMBO J (2019) 38: e101744 | First Published: 12 September 2019

A phospho‐peptide consensus sequence within a non‐canonical BRCA1 C‐terminal domain of the transcriptional silencer Sir4 is required for its binding to phosphorylated partners, including the E3 ligase Tom1 as a newly identified interactor.

Editorial Note

Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos
Irina Stancheva, Carmel Hensey, Richard R Meehan

EMBO J (2019) 38: e103221 | First Published: 15 October 2019

This article is a correction.

Retraction

Retraction: Regulation of MBD1‐mediated transcriptional repression by SUMO and PIAS proteins
Matthew J Lyst, Xinsheng Nan, Irina Stancheva

EMBO J (2019) 38: e103220 | First Published: 15 October 2019

This article is a retraction.

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