Wednesday, October 2, 2019

Table of Contents Alert: The EMBO Journal, Vol. 38, No. 19, 01 October 2019

Cancer - metabolism, microenvironment and models (2019)
Cover Image The EMBO Journal
Volume 38, Issue 19

01 October 2019


Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?
Jason C Mills, Ben Z Stanger, Maike Sander

EMBO J (2019) 38: e103148 | First Published: 02 September 2019

This commentary outlines challenges with current definitions of cell identity changes, as discussed in a workshop during the recent Keystone Symposium on cellular plasticity, and recommends best practices to developing an accurate and acceptable terminology.

News & Views

Lymph vessels find a hairy niche
Chen Y Kam, Valentina Greco

EMBO J (2019) 38: e103219 | First Published: 17 September 2019

New work reveals a role for lymphatic vessels in control of hair follicle development and cycling in the skin epithelium.

Transcriptional repressors as guardians of tissue macrophage identity
Francesco Gualdrini, Gioacchino Natoli

EMBO J (2019) 38: e103271 | First Published: 17 September 2019

A new study reports involvement of two BHLHE family proteins in the regulation of tissue macrophage development and function.


Open Access
Allosteric gate modulation confers K+ coupling in glutamate transporters
Daniel Kortzak, Claudia Alleva, Ingo Weyand, David Ewers, Meike I Zimmermann, Arne Franzen, Jan‐Philipp Machtens, Christoph Fahlke

EMBO J (2019) 38: e101468 | First Published: 10 September 2019

Structure‐function analyses identify potassium coupling to be strictly required in mammalian glutamate transporters but to be dispensable for their archeal counterparts.

Open Access
Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo
Daniel Peña‐Jimenez, Silvia Fontenete, Diego Megias, Coral Fustero‐Torre, Osvaldo Graña‐Castro, Donatello Castellana, Robert Loewe, Mirna Perez‐Moreno

EMBO J (2019) 38: e101688 | First Published: 02 September 2019

Lymph vessels and the hair follicles are structurally and functionally associated during skin growth and maintenance.

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity
René Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia A‐Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J Rossner, Michael H Sieweke, Melanie Greter, Robert Månsson, Meinrad Busslinger, Taras Kreslavsky

EMBO J (2019) 38: e101233 | First Published: 15 August 2019

Two newly identified transcription factors safeguard identity and self‐renewal of tissue‐specific macrophages in lung alveoli via repression of "lineage‐inappropriate" genes.

The TRAPP complex mediates secretion arrest induced by stress granule assembly
Francesca Zappa, Cathal Wilson, Giuseppe Di Tullio, Michele Santoro, Piero Pucci, Maria Monti, Davide D'Amico, Sandra Pisonero‐Vaquero, Rossella De Cegli, Alessia Romano, Moin A Saleem, Elena Polishchuk, Mario Failli, Laura Giaquinto, Maria Antonietta De Matteis

EMBO J (2019) 38: e101704 | First Published: 20 August 2019

TRAPP‐dependent stress granule recruitment of COPII vesicle coats to halt secretion and limit energy consumption is involved in cellular adapation to acute stress.

ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization
Fei Li, Zhong Deng, Ling Zhang, Caizhi Wu, Ying Jin, Inah Hwang, Olga Vladimirova, Libo Xu, Lynnie Yang, Bin Lu, Javaraju Dheekollu, Jian‐Yi Li, Hua Feng, Jian Hu, Christopher R Vakoc, Haoqiang Ying, Jihye Paik, Paul M Lieberman, Hongwu Zheng

EMBO J (2019) 38: e96659 | First Published: 27 August 2019

Telomere maintenance by ALT emerges as an adaptive response to progressive telomere decompaction in the absence of the H3.3 chaperone ATRX/DAXX, rather than being immediately de‐repressed upon ATRX depletion.

Metabolism‐induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells
Gregory J Thomson, Claire Hernon, Nicanor Austriaco, Rebecca S Shapiro, Peter Belenky, Richard J Bennett

EMBO J (2019) 38: e101597 | First Published: 26 August 2019

Genome dynamics in the fungal pathogen C. albicans precipitated by ROS‐induced DNA breaks may represent a primordial mechanism for ploidy reduction in eukaryotes.

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