 | The EMBO Journal Volume 38, Issue 19 01 October 2019 |
Commentary
Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?
EMBO J (2019) 38: e103148 | First Published: 02 September 2019
This commentary outlines challenges with current definitions of cell identity changes, as discussed in a workshop during the recent Keystone Symposium on cellular plasticity, and recommends best practices to developing an accurate and acceptable terminology.
News & Views
Lymph vessels find a hairy niche
EMBO J (2019) 38: e103219 | First Published: 17 September 2019
New work reveals a role for lymphatic vessels in control of hair follicle development and cycling in the skin epithelium.
Transcriptional repressors as guardians of tissue macrophage identity
EMBO J (2019) 38: e103271 | First Published: 17 September 2019
A new study reports involvement of two BHLHE family proteins in the regulation of tissue macrophage development and function.
Articles
Open Access Allosteric gate modulation confers K+ coupling in glutamate transporters
EMBO J (2019) 38: e101468 | First Published: 10 September 2019
Structure‐function analyses identify potassium coupling to be strictly required in mammalian glutamate transporters but to be dispensable for their archeal counterparts.
Open Access Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo
EMBO J (2019) 38: e101688 | First Published: 02 September 2019
Lymph vessels and the hair follicles are structurally and functionally associated during skin growth and maintenance.
Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity
EMBO J (2019) 38: e101233 | First Published: 15 August 2019
Two newly identified transcription factors safeguard identity and self‐renewal of tissue‐specific macrophages in lung alveoli via repression of "lineage‐inappropriate" genes.
The TRAPP complex mediates secretion arrest induced by stress granule assembly
EMBO J (2019) 38: e101704 | First Published: 20 August 2019
TRAPP‐dependent stress granule recruitment of COPII vesicle coats to halt secretion and limit energy consumption is involved in cellular adapation to acute stress.
ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization
EMBO J (2019) 38: e96659 | First Published: 27 August 2019
Telomere maintenance by ALT emerges as an adaptive response to progressive telomere decompaction in the absence of the H3.3 chaperone ATRX/DAXX, rather than being immediately de‐repressed upon ATRX depletion.
Metabolism‐induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells
EMBO J (2019) 38: e101597 | First Published: 26 August 2019
Genome dynamics in the fungal pathogen C. albicans precipitated by ROS‐induced DNA breaks may represent a primordial mechanism for ploidy reduction in eukaryotes.
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