 | The EMBO Journal Volume 38, Issue 15 01 August 2019 |
News & Views
EGAD! There is an ERAD doppelganger in the Golgi
e102679 | First Published: 22 July 2019
Identification of an ERAD‐like mechanism in Golgi and endosomes shows that membrane protein degradation in the late secretory pathway is not exclusively facilitated by ESCRT‐dependent lysosomal targeting.
Going for the Golgi: small PDI protein helps ATF6 perform better under stress
e102743 | First Published: 22 July 2019
A new study shows that a small redox‐active protein in the endoplasmic reticulum has a big role to play in the response to unfolded protein stress.
Review
Open Access Xenograft and organoid model systems in cancer research
e101654 | First Published: 08 July 2019
This review discusses recent advances in the use of patient‐derived tumour xenografts and patient‐derived tumour organoid models in fundamental and translational cancer research.
Articles
Open Access Microtubule number and length determine cellular shape and function in Plasmodium
e100984 | First Published: 24 May 2019
A combination of gene deletion, gene replacement and mathematical modeling analyses reveals the organismal consequences of altering the number and length of microtubules.
Open Access Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism
e101433 | First Published: 27 May 2019
A novel mechanism for ubiquitin‐dependent extraction from post‐ER compartments regulates proteostasis of yeast membrane protein in addition to ERAD and ESCRT pathways.
Open Access ERp18 regulates activation of ATF6α during unfolded protein response
e100990 | First Published: 17 June 2019
ER‐resident oxidoreductase ERp18 controls ATF6α trafficking to the Golgi complex and serves unique functions in the induction of stress response.
Open Access MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites
e100999 | First Published: 13 June 2019
Chronic ER stress decreases MITOL‐mediated ubiquitylation of unfolded protein response sensor IRE1α to direct cell fate and survival.
Open Access Redox signals at the ER–mitochondria interface control melanoma progression
e100871 | First Published: 15 July 2019
Melanoma growth is maintained by ER‐mitochondria communication and a TMX1/3‐ROS‐NFAT1 signaling axis.
Proteomic identification of a marker signature for MAPKi resistance in melanoma
e95874 | First Published: 26 June 2019
Comparative proteome and transcriptome profiling of primary skin cancers identifies biomarkers associated with therapy resistance and relapse.
Open Access Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin
e101341 | First Published: 04 July 2019
Nucleoli and PML bodies act as dynamic overflow compartments recruiting quality control factors and storing DRiPs for later clearance, failure of which threatens cell survival.
Open Access GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone
e101964 | First Published: 28 June 2019
The detoxification enzyme GSTZ1‐1 acts as tumor suppressor in liver cancer controlling anti‐apoptotic IGF1R signalling.
Open Access F‐actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes
e101183 | First Published: 27 June 2019
Dendritic organelle trafficking is controlled by opposing functions of kinesin and myosin motors, the former driving cargo along microtubules and the latter organizing actin meshes that halt organelle transport.
Open Access Identification of a basal system for unwinding a bacterial chromosome origin
e101649 | First Published: 27 June 2019
Systematic in vivo dissection of sequence elements essential for DnaA‐dependent strand separation in Bacillus subtilis provides a framework for understanding bacterial replication origin architecture and diversity.
Open Access Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids
e100986 | First Published: 21 June 2019
Association of DDX5 with XRN2 nuclease controlled by the methyltransferase PRMT5 is important for removing R‐loops at transcriptional termination regions.
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