Friday, August 2, 2019

Table of Contents Alert: The EMBO Journal, Vol. 38, No. 15, 01 August 2019

Creating is Understanding: Synthetic Biology Masters Complexity
Cover Image The EMBO Journal
Volume 38, Issue 15

01 August 2019

News & Views

EGAD! There is an ERAD doppelganger in the Golgi
Daniel Fonseca, Pedro Carvalho

e102679 | First Published: 22 July 2019

Identification of an ERAD‐like mechanism in Golgi and endosomes shows that membrane protein degradation in the late secretory pathway is not exclusively facilitated by ESCRT‐dependent lysosomal targeting.

Going for the Golgi: small PDI protein helps ATF6 perform better under stress
Deborah Fass

e102743 | First Published: 22 July 2019

A new study shows that a small redox‐active protein in the endoplasmic reticulum has a big role to play in the response to unfolded protein stress.


Open Access
Xenograft and organoid model systems in cancer research
Margit Bleijs, Marc van de Wetering, Hans Clevers, Jarno Drost

e101654 | First Published: 08 July 2019

This review discusses recent advances in the use of patient‐derived tumour xenografts and patient‐derived tumour organoid models in fundamental and translational cancer research.


Open Access
Microtubule number and length determine cellular shape and function in Plasmodium
Benjamin Spreng, Hannah Fleckenstein, Patrick Kübler, Claudia Di Biagio, Madlen Benz, Pintu Patra, Ulrich S Schwarz, Marek Cyrklaff, Friedrich Frischknecht

e100984 | First Published: 24 May 2019

A combination of gene deletion, gene replacement and mathematical modeling analyses reveals the organismal consequences of altering the number and length of microtubules.

Open Access
Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism
Oliver Schmidt, Yannick Weyer, Verena Baumann, Michael A Widerin, Sebastian Eising, Mihaela Angelova, Alexander Schleiffer, Leopold Kremser, Herbert Lindner, Matthias Peter, Florian Fröhlich, David Teis

e101433 | First Published: 27 May 2019

A novel mechanism for ubiquitin‐dependent extraction from post‐ER compartments regulates proteostasis of yeast membrane protein in addition to ERAD and ESCRT pathways.

Open Access
ERp18 regulates activation of ATF6α during unfolded protein response
Ojore BV Oka, Marcel van Lith, Jana Rudolf, Wanida Tungkum, Marie Anne Pringle, Neil J Bulleid

e100990 | First Published: 17 June 2019

ER‐resident oxidoreductase ERp18 controls ATF6α trafficking to the Golgi complex and serves unique functions in the induction of stress response.

Open Access
MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites
Keisuke Takeda, Shun Nagashima, Isshin Shiiba, Aoi Uda, Takeshi Tokuyama, Naoki Ito, Toshifumi Fukuda, Nobuko Matsushita, Satoshi Ishido, Takao Iwawaki, Takashi Uehara, Ryoko Inatome, Shigeru Yanagi

e100999 | First Published: 13 June 2019

Chronic ER stress decreases MITOL‐mediated ubiquitylation of unfolded protein response sensor IRE1α to direct cell fate and survival.

Open Access
Redox signals at the ER–mitochondria interface control melanoma progression
Xin Zhang, Christine S Gibhardt, Thorsten Will, Hedwig Stanisz, Christina Körbel, Miso Mitkovski, Ioana Stejerean, Sabrina Cappello, David Pacheu‐Grau, Jan Dudek, Nasser Tahbaz, Lucas Mina, Thomas Simmen, Matthias W Laschke, Michael D Menger, Michael P Schön, Volkhard Helms, Barbara A Niemeyer, Peter Rehling, Adina Vultur, Ivan Bogeski

e100871 | First Published: 15 July 2019

Melanoma growth is maintained by ER‐mitochondria communication and a TMX1/3‐ROS‐NFAT1 signaling axis.

Proteomic identification of a marker signature for MAPKi resistance in melanoma
Verena Paulitschke, Ossia Eichhoff, Christopher Gerner, Philipp Paulitschke, Andrea Bileck, Thomas Mohr, Phil F Cheng, Alexander Leitner, Emmanuella Guenova, Ieva Saulite, Sandra N Freiberger, Anja Irmisch, Bernhard Knapp, Nina Zila, Theodora‐Pagona Chatziisaak, Jürgen Stephan, Joanna Mangana, Rainer Kunstfeld, Hubert Pehamberger, Ruedi Aebersold, Reinhard Dummer, Mitchell P Levesque

e95874 | First Published: 26 June 2019

Comparative proteome and transcriptome profiling of primary skin cancers identifies biomarkers associated with therapy resistance and relapse.

Open Access
Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin
Laura Mediani, Jordina Guillén‐Boixet, Jonathan Vinet, Titus M Franzmann, Ilaria Bigi, Daniel Mateju, Arianna D Carrà, Federica F Morelli, Tatiana Tiago, Ina Poser, Simon Alberti, Serena Carra

e101341 | First Published: 04 July 2019

Nucleoli and PML bodies act as dynamic overflow compartments recruiting quality control factors and storing DRiPs for later clearance, failure of which threatens cell survival.

Open Access
GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone
Fan Yang, Jingjing Li, Haijun Deng, Yihao Wang, Chong Lei, Qiujie Wang, Jin Xiang, Li Liang, Jie Xia, Xuanming Pan, Xiaosong Li, Quanxin Long, Lei Chang, Ping Xu, Ailong Huang, Kai Wang, Ni Tang

e101964 | First Published: 28 June 2019

The detoxification enzyme GSTZ1‐1 acts as tumor suppressor in liver cancer controlling anti‐apoptotic IGF1R signalling.

Open Access
F‐actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes
Bas van Bommel, Anja Konietzny, Oliver Kobler, Julia Bär, Marina Mikhaylova

e101183 | First Published: 27 June 2019

Dendritic organelle trafficking is controlled by opposing functions of kinesin and myosin motors, the former driving cargo along microtubules and the latter organizing actin meshes that halt organelle transport.

Open Access
Identification of a basal system for unwinding a bacterial chromosome origin
Tomas T Richardson, Daniel Stevens, Simone Pelliciari, Omar Harran, Theodor Sperlea, Heath Murray

e101649 | First Published: 27 June 2019

Systematic in vivo dissection of sequence elements essential for DnaA‐dependent strand separation in Bacillus subtilis provides a framework for understanding bacterial replication origin architecture and diversity.

Open Access
Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids
Sofiane Y Mersaoui, Zhenbao Yu, Yan Coulombe, Martin Karam, Franciele F Busatto, Jean‐Yves Masson, Stéphane Richard

e100986 | First Published: 21 June 2019

Association of DDX5 with XRN2 nuclease controlled by the methyltransferase PRMT5 is important for removing R‐loops at transcriptional termination regions.

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Dietary restriction induces posttranscriptional regulation of longevity genes

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