Table of Contents Alert: The EMBO Journal, Vol. 38, No. 14, 15 July 2019

The EMBO Journal Volume 38, Issue 14 15 July 2019

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Reviews

Open Access

Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer

Davide Pellacani, Susanna Tan, Sylvain Lefort, Connie J Eaves

e100330 | First Published: 11 January 2019

This review summarises our current view of how plasticity of human mammary cells is transcriptionally controlled under homeostastis and perturbed at malignant conditions.

Open Access

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention

Pirashaanthy Tharmapalan, Mathepan Mahendralingam, Hal K Berman, Rama Khokha

e100852 | First Published: 21 June 2019

In our mini‐series on breast cancer, Khokha and colleagues review the revised perspectives on chemoprevention for high‐risk patients based on the current state of mammary gland molecular biology, and discuss its promises and challenges.

Articles

In situ imaging of the bacterial flagellar motor disassembly and assembly processes

Mohammed Kaplan, Poorna Subramanian, Debnath Ghosal, Catherine M Oikonomou, Sahand Pirbadian, Ruth Starwalt‐Lee, Shrawan Kumar Mageswaran, Davi R Ortega, Jeffrey A Gralnick, Mohamed Y El‐Naggar, Grant J Jensen

e100957 | First Published: 20 May 2019

Electron cryo‐tomography reveals that Gammaproteobacteria disassemble their flagella in response to limited nutrient sources in the environment, whereas flagellar assembly is regulated via an "inside‐out" pathway.

PTPN3 acts as a tumor suppressor and boosts TGF‐β signaling independent of its phosphatase activity

Bo Yuan, Jinquan Liu, Jin Cao, Yi Yu, Hanchenxi Zhang, Fei Wang, Yezhang Zhu, Mu Xiao, Sisi Liu, Youqiong Ye, Le Ma, Dewei Xu, Ningyi Xu, Yi Li, Bin Zhao, Pinglong Xu, Jianping Jin, Jianming Xu, Xi Chen, Li Shen, Xia Lin, Xin‐Hua Feng

e99945 | First Published: 14 June 2019

A new PTPN3 function as regulator of Smurf2 binding to TβRI is abolished by mutations associated with intrahepatic cholangiocarcinoma.

ROCK2 inhibition triggers the collective invasion of colorectal adenocarcinomas

Fotine Libanje, Joel Raingeaud, Rui Luan, ZoéAp Thomas, Olivier Zajac, Joel Veiga, Laetitia Marisa, Julien Adam, Valerie Boige, David Malka, Diane Goéré, Alan Hall, Jean‐Yves Soazec, Friedrich Prall, Maximiliano Gelli, Peggy Dartigues, Fanny Jaulin

e99299 | First Published: 18 June 2019

Colorectal cancer specimens show coordinated gland‐like dissemination controlled by Rho‐GTPase signalling.

Open Access

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma

Hanneke Vlaming, Chelsea M McLean, Tessy Korthout, Mir Farshid Alemdehy, Sjoerd Hendriks, Cesare Lancini, Sander Palit, Sjoerd Klarenbeek, Eliza Mari Kwesi‐Maliepaard, Thom M Molenaar, Liesbeth Hoekman, Thierry T Schmidlin, AF Maarten Altelaar, Tibor van Welsem, Jan‐Hermen Dannenberg, Heinz Jacobs, Fred van Leeuwen

e101564 | First Published: 17 June 2019

Rpd3/HDAC1 histone deacetylases restrict Dot1‐mediated H3K79 methylation in yeast and mammals, with consequences for murine lymphomagenesis.

A specialised SKI complex assists the cytoplasmic RNA exosome in the absence of direct association with ribosomes

Elodie Zhang, Varun Khanna, Estelle Dacheux, Abdelkader Namane, Antonia Doyen, Maïté Gomard, Bernard Turcotte, Alain Jacquier, Micheline Fromont‐Racine

e100640 | First Published: 07 June 2019

Association with the novel factor Ska1 defines a specialized Ski2‐Ski3‐Ski8 complex in the budding yeast that targets ribosome‐free RNA regions for 3′‐5′ degradation via the exosome.

Highlight

DSCR1‐mediated TET1 splicing regulates miR‐124 expression to control adult hippocampal neurogenesis

Chiyeol Choi, Taehoon Kim, Karen T Chang, Kyung‐Tai Min

e101293 | First Published: 11 June 2019

The Down syndrome critical region1 (DSCR1) protein acts upstream of DNA methylation and miRNA pathways to regulate learning and memory.

Open Access

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

Xiang He, Yongjie Zhu, Yanhong Zhang, Yunqi Geng, Jing Gong, Jin Geng, Pingping Zhang, Xiaotong Zhang, Ning Liu, Yumeng Peng, Chenbin Wang, Yujie Wang, Xin Liu, Luming Wan, Feng Gong, Congwen Wei, Hui Zhong

e100978 | First Published: 17 June 2019

Ubiquitin‐dependent targeting of MAVS aggregates to autophagy receptor NDP52 controls antiviral interferon signaling upon RIG‐I stimulation.

Open Access

Transnuclear mice reveal Peyer's patch iNKT cells that regulate B‐cell class switching to IgG1

Eleanor Clancy‐Thompson, Gui Zhen Chen, Nelson M LaMarche, Lestat R Ali, Hee‐Jin Jeong, Stephanie J Crowley, Kelly Boelaars, Michael B Brenner, Lydia Lynch, Stephanie K Dougan

e101260 | First Published: 31 May 2019

A novel population of iNKT cells with a unique function in supporting IgG1 class switching in the gut mucosa may be important for surveillance for mucosal pathogens.

Resources

Open Access

Centriolar satellites are acentriolar assemblies of centrosomal proteins

Valentina Quarantotti, Jia‐Xuan Chen, Julia Tischer, Carmen Gonzalez Tejedo, Evaggelia K Papachristou, Clive S D'Santos, John V Kilmartin, Martin L Miller, Fanni Gergely

e101082 | First Published: 03 June 2019

Proteomic profiling of the cytoplasmic granules implicated in centrosome and primary cilia function reveals considerable overlap with the centrosome proteome, both in normal and acentriolar cells.

Open Access

Spatial and proteomic profiling reveals centrosome‐independent features of centriolar satellites

Ladan Gheiratmand, Etienne Coyaud, Gagan D Gupta, Estelle MN Laurent, Monica Hasegan, Suzanna L Prosser, João Gonçalves, Brian Raught, Laurence Pelletier

e101109 | First Published: 03 June 2019

Bio‐ID of 22 centriolar satellite proteins defines a proximity interaction landscape amongst more than 600 proteins, which is greatly affected by depletion of the key satellite constituent PCM1.

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