EMBO reports Table of Contents for February 2019; Vol. 20, No. 2

February 2019 | Volume 20, Number 2 Submit Table of Contents Opinion News & Views Science & Society Reviews Scientific Reports Articles Corrigendum Volume 20, Number 2 Opinion A case for evolutionary hermeneutics Modern science follows Bayes’ formula: reassess knowledge in light of new data to gain new knowledge. A new science of hermeneutics could systematically reevaluate old theories for new insights. Ladislav Kováč Published online 09.01.2019 News & Views Small RNA regulators of social behaviour in eutherian mammals Small non‐coding RNAs are vital in brain development to organize complex patterns of gene expression. A report in this issue demonstrates that a large cluster of microRNAs functions as a repressor of social behaviour. Murray J Cairns Published online 23.01.2019 Mimicry by a viral RHIM A report in this issue describes that the murine herpesvirus cytomegalovirus triggers necroptosis via hybrid amyloid assemblies by viral proteins similar to those used by host cells, suggesting means to selectively inhibit virus‐induced necroptosis. Miguel Mompeán, Gunes Bozkurt and Hao Wu Published online 21.01.2019 Science & Society Art and science: Intersections of art and science through time and paths forward Science and art have a long‐standing relationship as both are based on observation and interpretation. In this technology‐driven age, new interactions could lead to novel ways of looking at and interpreting complex systems. Lian Zhu and Yogesh Goyal Published online 27.12.2018 The trust game: CRISPR for human germline editing unsettles scientists and society The reaction to the alleged birth of two genome‐edited babies in China reveals deeper problems with the oversight of gene editing technologies and public trust in its applications. Matthias Braun and Darian Meacham Published online 02.01.2019 A focus on excellence: An interview with Iain Mattaj, former Director‐General of EMBL and Director of the Human Technopole An interview with Iain Mattaj about running a major research institute. Adam Gristwood and Holger Breithaupt Published online 14.01.2019 Fixing carbon: To alleviate climate change, scientists are exploring ways to harness nature's ability to capture CO2 from the atmosphere Scientists are exploring various strategies to make photosynthesis more efficient with the aim of sequestering CO2 from the atmosphere and lessening climate change. Katrin Weigmann Published online 03.01.2019 The riddle of speech: After FOXP2 dominated research on the origins of speech, other candidate genes have recently emerged The evolution of language, which is unique to humans, has been a riddle for scholars. Molecular biologists are now putting together a genetic theory of how speech and language developed. Philip Hunter Published online 11.01.2019 Reviews From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective In Gram‐negative bacteria conjugation is mediated by a large membrane‐embedded nanomachine of the type IV secretion (T4S) system. This review highlights recent research on conjugation and T4S systems, and provides a comprehensive structural and mechanistic overview. Gabriel Waksman Published online 02.01.2019 Visualizing ubiquitination in mammalian cells The covalent modification of proteins with ubiquitin serves numerous degradative and regulatory functions. This review discusses how advanced fluorescent and super‐resolution microscopy techniques can be applied to study ubiquitination to expand the current biochemical and genetic toolkits. Sjoerd JL van Wijk, Simone Fulda, Ivan Dikic and Mike Heilemann Published online 21.01.2019 Scientific Reports A placental mammal‐specific microRNA cluster acts as a natural brake for sociability in mice A placental mammal‐specific microRNA cluster regulates sociability in mice. Loss of specific miR379‐410 members leads to hypersocial behaviour in mice and enhances synaptic transmission in the hippocampus, suggesting an “anti‐autistic” function of the cluster. Martin Lackinger, A Özge Sungur, Reetu Daswani, Michael Soutschek, Silvia Bicker, Lea Stemmler, Tatjana Wüst, Roberto Fiore, Christoph Dieterich, Rainer KW Schwarting, Markus Wöhr and Gerhard Schratt Published online 14.12.2018 Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning Organoids derived from mouse primary fetal intestinal epithelial cells undergo suckling‐to‐weaning transition independent of stromal cells and can be used to model the molecular mechanisms of postnatal epithelial development. Marit Navis, Tânia Martins Garcia, Ingrid B Renes, Jacqueline LM Vermeulen, Sander Meisner, Manon E Wildenberg, Gijs R van den Brink, Ruurd M van Elburg and Vanesa Muncan Published online 10.12.2018 The long non‐coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis lncRNA LINC00941 inhibits premature differentiation in weakly differentiated strata of the human epidermis through repression of previously uncharacterized SPRR5, shown here to promote keratinocyte differentiation. Christian Ziegler, Johannes Graf, Stefan Faderl, Jessica Schedlbauer, Nicholas Strieder, Bianca Förstl, Rainer Spang, Astrid Bruckmann, Rainer Merkl, Sonja Hombach and Markus Kretz Published online 08.01.2019 Gustatory receptor 28b is necessary for avoiding saponin in Drosophila melanogaster This study reveals that the Gr28b.c isoform expressed in the Drosophila labellum is necessary to detect a saponin extracted from Quillaja saponaria. Jiun Sang, Suman Rimal and Youngseok Lee Published online 08.01.2019 Articles Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies The murine cytomegalovirus protein M45 forms heteromeric amyloid fibrils with RIPK1, ZBP1 and RIPK3 through its RIP homotypic interaction motif. The sequestration of RHIM proteins in M45‐contaning fibrils might explain its ability to inhibit necroptosis. Chi LL Pham, Nirukshan Shanmugam, Merryn Strange, Ailis O'Carroll, James WP Brown, Emma Sierecki, Yann Gambin, Megan Steain and Margaret Sunde Published online 29.11.2018 AGO2 promotes telomerase activity and interaction between the telomerase components TERT and TERC AGO2 promotes telomerase activity and the interaction between TERT and TERC. AGO2 further binds TERC and a small RNA derived from TERC, terc‐sRNA, that also stimulates telomerase activity. Ilaria Laudadio, Francesca Orso, Gianluca Azzalin, Carlo Calabrò, Francesco Berardinelli, Elisa Coluzzi, Silvia Gioiosa, Daniela Taverna, Antonella Sgura, Claudia Carissimi and Valerio Fulci Published online 27.12.2018 Splicing factor ESRP1 controls ER‐positive breast cancer by altering metabolic pathways RNA binding protein ESRP1 is known to regulate EMT by modifying alternative splicing events. In ER‐positive breast cancer ESRP1 modulates growth without triggering EMT, and acts as a novel regulator of metabolic pathways. Yesim Gökmen‐Polar, Yaseswini Neelamraju, Chirayu P Goswami, Yuan Gu, Xiaoping Gu, Gouthami Nallamothu, Edyta Vieth, Sarath C Janga, Michael Ryan and Sunil S Badve Published online 21.01.2019 A microRNA cluster in the Fragile‐X region expressed during spermatogenesis targets FMR1 The rapidly evolving X‐linked microRNA cluster Fx‐mir is strongly induced during Sertoli cell development. Fx‐mir miRNAs target components of a translational regulatory complex, including the Fragile‐X protein FMRP, the initiation factor eIF4E and the repressor CYFIP1. Madhuvanthi Ramaiah, Kun Tan, Terra‐Dawn M Plank, Hye‐Won Song, Jennifer N Dumdie, Samantha Jones, Eleen Y Shum, Steven D Sheridan, Kevin J Peterson, Jörg Gromoll, Stephen J Haggarty, Heidi Cook‐Andersen and Miles F Wilkinson Published online 20.12.2018 APEX2‐mediated RAB proximity labeling identifies a role for RAB21 in clathrin‐independent cargo sorting Quantitative proteomics and APEX2‐mediated proximity labeling of early endosomal RAB GTPases identify a novel interaction between RAB21 and the WASH/retromer complexes and defines a role for RAB21 in endosomal sorting of a subset of clathrin‐independent cargos. Tomas Del Olmo, Annie Lauzier, Caroline Normandin, Raphaëlle Larcher, Mia Lecours, Dominique Jean, Louis Lessard, Florian Steinberg, François‐Michel Boisvert and Steve Jean Published online 03.01.2019 Serendipita indica E5′NT modulates extracellular nucleotide levels in the plant apoplast and affects fungal colonization The beneficial fungal root endophyte Serendipita indica alters extracellular nucleotide levels and plant responses to biotic stresses. Shadab Nizam, Xiaoyu Qiang, Stephan Wawra, Robin Nostadt, Felix Getzke, Florian Schwanke, Ingo Dreyer, Gregor Langen and Alga Zuccaro Published online 14.01.2019 Corrigendum RKIP mediates autoimmune inflammation by positively regulating IL‐17R signaling Wenlong Lin, Ning Wang, Kangxing Zhou, Fasheng Su, Yu Jiang, Jianan Shou, Huan Liu, Chunmei Ma, Youchun Qian, Kai Wang and Xiaojian Wang Published online 05.02.2019   Unsubscribe from or edit your subscription for this service. 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