The EMBO Journal Table of Contents for 15 January 2019; Vol. 38, No. 2

15 January 2019 | Volume 38, Number 2 Submit Table of Contents Commentary News & Views Articles Corrigendum Volume 38, Number 2 Commentary Rethinking research reproducibility One cause for the “reproducibility crisis” is that exploratory research that pushes the boundaries of knowledge is naturally different from confirmation studies to validate findings. To yield robust knowledge, both need to be equally appreciated, supported and reported. Ulrich Dirnagl Published online 05.12.2018 News & Views A magic bullet for targeting cancers with supernumerary centrosomes A new study shows the potential of small‐molecule inhibitors of centrosome clustering as specific treatment for tumors with centrosome amplification. Yi Liu and Laurence Pelletier Published online 11.12.2018 CFTR is not a gluten lover either New findings reveal the cystic fibrosis‐linked anion channel CFTR as unexpected target of dietary wheat peptides causing intestinal cell stress and coeliac disease. Laura Vachel and Shmuel Muallem Published online 20.12.2018 Fat‐fated microglial dysfunction Intriguing new data suggest a brain‐protective function of microglia that is corrupted by sphingolipid overload in lysosomal storage disorders. Aymeric Silvin and Florent Ginhoux Published online 19.12.2018 Articles Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy Autophagic clearance of damaged mitochondria and suppression of apoptotic effector proteins are coordinated functions of the Parkin ubiquitin ligase that are lost upon Parkinson's Disease‐associated mutations. Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou and Grant Dewson Published online 20.12.2018 Inhibition of CPAP–tubulin interaction prevents proliferation of centrosome‐amplified cancer cells Nucleation of microtubules from extra centrosomes can be selectively impaired by the small molecule CCB02, suppressing cell cycle progression and survival of malignant cells. Aruljothi Mariappan, Komal Soni, Kenji Schorpp, Fan Zhao, Amin Minakar, Xiangdong Zheng, Sunit Mandad, Iris Macheleidt, Anand Ramani, Tomáš Kubelka, Maciej Dawidowski, Kristina Golfmann, Arpit Wason, Chunhua Yang, Judith Simons, Hans‐Günther Schmalz, Anthony A Hyman, Ritu Aneja, Roland Ullrich, Henning Urlaub, Margarete Odenthal, Reinhardt Büttner, Haitao Li, Michael Sattler, Kamyar Hadian and Jay Gopalakrishnan Published online 10.12.2018 A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease Direct inhibition of the CFTR anion channel by dietary wheat peptides can generate the epithelial stress and innate immunity activation that lead to chronic intestinal inflammation. Valeria R Villella, Andrea Venerando, Giorgio Cozza, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Mara C Spinella, Vasilis Oikonomou, Giorgia Renga, Antonella Tosco, Federica Rossin, Stefano Guido, Marco Silano, Enrico Garaci, Yu‐Kai Chao, Christian Grimm, Alessandro Luciani, Luigina Romani, Mauro Piacentini, Valeria Raia, Guido Kroemer and Luigi Maiuri Published online 29.11.2018 Lipid‐induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders Microglia have a protective role in LSDs by clearing myelin debris in the initial stages of demyelination, but become neurotoxic upon lipid lysosomal overload and Cathepsin B exocytosis during disease progression. Enrique Gabandé‐Rodríguez, Azucena Pérez‐Cañamás, Beatriz Soto‐Huelin, Daniel N Mitroi, Sara Sánchez‐Redondo, Elena Martínez‐Sáez, César Venero, Héctor Peinado and María Dolores Ledesma Published online 07.12.2018 Miro proteins prime mitochondria for Parkin translocation and mitophagy Miro proteins function as a calcium‐dependent docking site and safety switch for Parkin on healthy mitochondria, thereby controlling initiation of damage‐induced mitophagy. Dzhamilja Safiulina, Malle Kuum, Vinay Choubey, Nana Gogichaishvili, Joanna Liiv, Miriam A Hickey, Michal Cagalinec, Merle Mandel, Akbar Zeb, Mailis Liiv and Allen Kaasik Published online 30.11.2018 Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth Active Akt in mitochondria phosphorylates MICU1 to functionally inhibit the MCU complex, thereby increasing basal mitochondrial calcium levels and promoting tumour progression. Saverio Marchi, Mariangela Corricelli, Alessio Branchini, Veronica Angela Maria Vitto, Sonia Missiroli, Giampaolo Morciano, Mariasole Perrone, Mattia Ferrarese, Carlotta Giorgi, Mirko Pinotti, Lorenzo Galluzzi, Guido Kroemer and Paolo Pinton Published online 30.11.2018 A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex Calnexin and the ER‐phagy receptor FAM134B recognize misfolded procollagen in the ER and mediate its LC3‐dependent delivery to the lysosome for autophagic degradation. Alison Forrester, Chiara De Leonibus, Paolo Grumati, Elisa Fasana, Marilina Piemontese, Leopoldo Staiano, Ilaria Fregno, Andrea Raimondi, Alessandro Marazza, Gemma Bruno, Maria Iavazzo, Daniela Intartaglia, Marta Seczynska, Eelco van Anken, Ivan Conte, Maria Antonietta De Matteis, Ivan Dikic, Maurizio Molinari and Carmine Settembre Published online 17.12.2018 Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics The glycoprotein Prom1 has functional roles in stem cell activation and self‐renewal by regulating primary cilia biogenesis and cilia‐associated signaling. Donald Singer, Kristina Thamm, Heng Zhuang, Jana Karbanová, Yan Gao, Jemma Victoria Walker, Heng Jin, Xiangnan Wu, Clarissa R Coveney, Pauline Marangoni, Dongmei Lu, Portia Rebecca Clare Grayson, Tulay Gulsen, Karen J Liu, Stefano Ardu, Angus KT Wann, Shouqing Luo, Alexander C Zambon, Anton M Jetten, Christopher Tredwin, Ophir D Klein, Massimo Attanasio, Peter Carmeliet, Wieland B Huttner, Denis Corbeil and Bing Hu Published online 06.12.2018 Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth Lymphatic endothelial cell‐specific depletion of integrin‐linked kinase (ILK) in mice identifies it as mechanosensitive regulator of physiological lymph vessel expansion. Sofia Urner, Lara Planas‐Paz, Laura Sophie Hilger, Carina Henning, Anna Branopolski, Molly Kelly‐Goss, Lukas Stanczuk, Bettina Pitter, Eloi Montanez, Shayn M Peirce, Taija Mäkinen and Eckhard Lammert Published online 05.12.2018 Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self‐reactive plasma cells Premature expression of the Blimp1 transcription factor alters early B cell development and favours the development of autoantibody‐producing plasma cells, outlining a novel mechanism for how Blimp1 acts as a risk factor in the development of autoimmune disease. Peter Bönelt, Miriam Wöhner, Martina Minnich, Hiromi Tagoh, Maria Fischer, Markus Jaritz, Anoop Kavirayani, Manasa Garimella, Mikael CI Karlsson and Meinrad Busslinger Published online 29.11.2018 TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes Genome‐wide gene expression and β‐catenin DNA binding analyses in TCF/LEF knockout cells reveal a subset of Wnt/β‐catenin target genes that do not depend on these transcription factors. Nikolaos Doumpas, Franziska Lampart, Mark D Robinson, Antonio Lentini, Colm E Nestor, Claudio Cantù and Konrad Basler Published online 13.11.2018 An inter‐dimer allosteric switch controls NMDA receptor activity Modelling and functional data show how the NMDA receptor domains move in a concerted manner to transduce long‐range conformational changes between membrane‐distal domains and downstream gating machinery. Jean‐Baptiste Esmenjaud, David Stroebel, Kelvin Chan, Teddy Grand, Mélissa David, Lonnie P Wollmuth, Antoine Taly and Pierre Paoletti Published online 05.11.2018 Corrigendum Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase Elena Purlyte, Herschel S Dhekne, Adil R Sarhan, Rachel Gomez, Pawel Lis, Melanie Wightman, Terina N Martinez, Francesca Tonelli, Suzanne R Pfeffer and Dario R Alessi Published online 15.01.2019   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.