The EMBO Journal Table of Contents for 3 January 2019; Vol. 38, No. 1

3 January 2019 | Volume 38, Number 1 Submit Table of Contents News & Views Articles Resource Volume 38, Number 1 News & Views Alpha‐ketoglutarate: a “magic” metabolite in early germ cell development Recent implications of a Krebs cycle intermediate in stem cell pluripotency and differentiation suggest possibilities for stabilizing ephemeral embryonic cell states and enhancing desired fate transitions through specific metabolite manipulations. Vivian Lu and Michael A Teitell Published online 01.10.2018 SUMOning the base excision repair machinery for differentiation New work uncovers a surprising trans‐SUMOylation cascade between repair enzymes involved in TET‐dependent oxidative DNA demethylation. Nathaniel E Wiest and Alan E Tomkinson Published online 13.12.2018 Let it RE:IN: integrating experimental observations to predict pluripotency network behaviour New work shows how combining computational and experimental approaches can define transcription factor dynamics during pluripotency re‐acquisition. Owen JL Rackham and Jose M Polo Published online 13.12.2018 Articles Metabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate Oxidative mitochondrial metabolism and IDH2‐dependent α–ketoglutarate prolong a transient competent state for primordial germ cell specification. Julia Tischler, Wolfram H Gruhn, John Reid, Edward Allgeyer, Florian Buettner, Carsten Marr, Fabian Theis, Ben D Simons, Lorenz Wernisch and M Azim Surani Published online 26.09.2018 SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation Recruitment of base excision repair factors to TET‐induced abasic sites involves SUMO modification of XRCC1 and subsequent transfer of the modifier onto TDG glycosylase, facilitating eventual TDG dissociation and completion of oxidative demethylation. Roland Steinacher, Zeinab Barekati, Petar Botev, Anna Kuśnierczyk, Geir Slupphaug and Primo Schär Published online 06.12.2018 The kinetochore module Okp1CENP‐Q/Ame1CENP‐U is a reader for N‐terminal modifications on the centromeric histone Cse4CENP‐A Inhibition of kinetochore protein targeting by arginine 37 methylation and lysine 49 acetylation of the budding yeast H3 variant Cse4 extends the epigenetic histone code concept to centromere specification. Ekaterina A Anedchenko, Anke Samel‐Pommerencke, Tra My Tran Nguyen, Sara Shahnejat‐Bushehri, Juliane Pöpsel, Daniel Lauster, Andreas Herrmann, Juri Rappsilber, Alessandro Cuomo, Tiziana Bonaldi and Ann E Ehrenhofer‐Murray Published online 02.11.2018 Loss of VGLL4 suppresses tumor PD‐L1 expression and immune evasion VGLL4 regulates PD‐L1 expression and anti‐tumour immunity by modulating the stability of the IRF2/IRF2BP2 complex. Ailing Wu, Qingzhe Wu, Yujie Deng, Yuning Liu, Jinqiu Lu, Liansheng Liu, Xiaoling Li, Cheng Liao, Bin Zhao and Hai Song Published online 05.11.2018 Loss of T‐bet confers survival advantage to influenza–bacterial superinfection Earlier influenza virus exposure establishes a Th17 cytokine response in the lungs of mice lacking the transcription factor T‐bet, providing strong antibacterial immune defenses against subsequent Streptococcus pneumoniae infection. Jun Zhi Er, Ricky Abdi Gunawan Koean and Jeak Ling Ding Published online 15.10.2018 Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1‐integrin Murine astrocytes release innate immunity‐associated PTX3 at early postnatal stages, where it plays a key role in the functional maturation of excitatory synapses by promoting AMPAR recruitment at synapses. Giuliana Fossati, Davide Pozzi, Alice Canzi, Filippo Mirabella, Sonia Valentino, Raffaella Morini, Elsa Ghirardini, Fabia Filipello, Milena Moretti, Cecilia Gotti, Douglas S Annis, Deane F Mosher, Cecilia Garlanda, Barbara Bottazzi, Giulia Taraboletti, Alberto Mantovani, Michela Matteoli and Elisabetta Menna Published online 05.11.2018 Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone‐responsive myopathy ER stress response and altered mitochondrial functions are central to metabolic muscle injury upon loss of lipin1. Talha Rashid, Ivan Nemazanyy, Cecilia Paolini, Takashi Tatsuta, Paul Crespin, Delphine de Villeneuve, Susanne Brodesser, Paule Benit, Pierre Rustin, Martin A Baraibar, Onnik Agbulut, Anne Olivier, Feliciano Protasi, Thomas Langer, Roman Chrast, Pascale de Lonlay, Helene de Foucauld, Bert Blaauw and Mario Pende Published online 12.11.2018 EGR2 phosphatase regulates OST1 kinase activity and freezing tolerance in Arabidopsis Attenuated myristoylation of PP2C family member EGR2 upon cold stress releases its inhibitory interaction with the master plant cold response factor OST1. Yanglin Ding, Jian Lv, Yiting Shi, Junping Gao, Jian Hua, Chunpeng Song, Zhizhong Gong and Shuhua Yang Published online 14.11.2018 Resource A common molecular logic determines embryonic stem cell self‐renewal and reprogramming A single transcription factor program governs maintenance and induction of naïve pluripotency. Sara‐Jane Dunn, Meng Amy Li, Elena Carbognin, Austin Smith and Graziano Martello Published online 27.11.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.