| | | | | Table of ContentsOpinion Correspondence News & Views Science & Society Review Scientific Report Articles | Volume 20, Number 1 | Opinion | Funders and publishers have a lot to gain from sharing and aligning peer reviews. Michael Hill Published online 05.12.2018 | Correspondence | Comment on “Human dignity and gene editing” by Iñigo de Miguel Beriain. Daniel B Constam Published online 29.11.2018 | | The response by the author. Iñigo de Miguel Beriain Published online 13.12.2018 | News & Views | Two studies in this issue describe the G‐protein‐coupled estrogen receptor as an important regulator of PDAC‐associated stroma, modulating tissue stiffness and desmoplasia. The GPER agonist tamoxifen promotes the restoration of the PDAC microenvironment. Maren Pein and Thordur Oskarsson Published online 11.12.2018 | | The RNA‐binding protein TIAR accumulates in nuclear G2/M transition granules induced by replication stress. Upon G2/M checkpoint activation TIAR transiently sequesters CDK1 in GMGs to curb CDK1 activity and tune G2 duration and mitotic commitment. Matthias Altmeyer Published online 11.12.2018 | Science & Society | Cultured meat, produced in vitro from stem cells, could address the growing demand for meat and fish products. But the technology is not ripe enough to become a sustainable alternative to livestock. Hanna L Tuomisto Published online 14.12.2018 | | Young, independent group leaders in academia face a range of new tasks and challenges. We suggest various measures for host institutes to help them to resolve these challenges and to flourish. Ritwick Sawarkar, Ruth Scherz‐Shouval, Martin S Denzel and Juha Saarikangas Published online 23.11.2018 | | Science is helping to combat global wildlife trafficking. These efforts could be crucial to the survival of threatened animal and plant species around the world. Adam Gristwood Published online 14.12.2018 | | Remote working has long been normal for scientists in astronomy and high‐energy physics and shown to enhance productivity. Driven by technology and the growing need for data analysis, remote working is increasingly catching up in the life sciences. Philip Hunter Published online 10.12.2018 | Review | Peroxisomes have important roles in cellular metabolism, human health, redox homeostasis, intracellular metabolite transfer and signalling. This comprehensive review discusses how peroxisomes are generated, how they communicate with other organelles and how quality control mechanisms operate to maintain their homeostasis. Jean‐Claude Farré, Shanmuga S Mahalingam, Marco Proietto and Suresh Subramani Published online 10.12.2018 | Scientific Report | GPER agonist tamoxifen reprograms pancreatic stellate cells versus a non‐myofibroblastic phenotype, reducing their ability to remodel the ECM in PDAC. The resulting tumor microenvironment is less conducive to cancer cell invasion, macrophage recruitment and M2‐polarization. Ernesto Cortes, Muge Sarper, Benjamin Robinson, Dariusz Lachowski, Antonios Chronopoulos, Stephen D Thorpe, David A Lee and Armando E del Río Hernández | Articles | Tamoxifen biomechanically remodels the tumor microenvironment in pancreatic cancer independent of the nuclear estrogen receptors, but involving the GPER/HIF‐1A axis. Tamoxifen also reduces the ability of pancreatic cancer cells to survive under hypoxic conditions. Ernesto Cortes, Dariusz Lachowski, Benjamin Robinson, Muge Sarper, Jaakko S Teppo, Stephen D Thorpe, Tyler J Lieberthal, Kazunari Iwamoto, David A Lee, Mariko Okada‐Hatakeyama, Markku T Varjosalo and Armando E del Río Hernández | | The RNA‐binding protein TIAR accumulates in nuclear G2/M transition granules (GMGs) induced by replication stress. During G2/M checkpoint activation TIAR retains CDK1 in GMGs, attenuates CDK1 activity and thereby promotes genome stability. Vanesa Lafarga, Hsu‐Min Sung, Katharina Haneke, Lea Roessig, Anne‐Laure Pauleau, Marius Bruer, Sara Rodriguez‐Acebes, Andres J Lopez‐Contreras, Oliver J Gruss, Sylvia Erhardt, Juan Mendez, Oscar Fernandez‐Capetillo and Georg Stoecklin | | Elements of the bacterial cell division machinery assemble into condensates by liquid‐liquid phase separation in cell‐like crowded conditions. This suggests that phase‐separated condensation may also help to organize intracellular space in bacteria. Begoña Monterroso, Silvia Zorrilla, Marta Sobrinos‐Sanguino, Miguel A Robles‐Ramos, Marina López‐Álvarez, William Margolin, Christine D Keating and Germán Rivas Published online 06.12.2018 | | Efficient wound repair and hair follicle regeneration involve coordinated movements and cellular proliferation of skin epithelial cells. The EMT repressor Ovol2 has a major role in promoting directional migration and proliferation of adult epithelial cells. Daniel Haensel, Peng Sun, Adam L MacLean, Xianghui Ma, Yuan Zhou, Marc P Stemmler, Simone Brabletz, Geert Berx, Maksim V Plikus, Qing Nie, Thomas Brabletz and Xing Dai Published online 09.11.2018 | | The HIF‐1 and HIF‐2 transcription factors display overlapping but distinct, inherent chromatin binding preferences that are independent of cell‐type, degree or duration of hypoxia, or competition between isoforms. James A Smythies, Min Sun, Norma Masson, Rafik Salama, Peter D Simpson, Elizabeth Murray, Viviana Neumann, Matthew E Cockman, Hani Choudhry, Peter J Ratcliffe and David R Mole | | Human CDC14A negatively regulates primary cilia length in a multilayered manner by dephosphorylating actin‐associated proteins, including DBN1. Serine 142 of DBN1 is dephosphorylated by hCDC14A, thereby counteracting the cilia length promoting activity of CDK5. Borhan Uddin, Patrick Partscht, Nan‐Peng Chen, Annett Neuner, Manuel Weiß, Robert Hardt, Aliakbar Jafarpour, Bernd Heßling, Thomas Ruppert, Holger Lorenz, Gislene Pereira and Elmar Schiebel Published online 22.11.2018 | | Grp1 is a novel accessory component of endosomal mRNA transport and binds preferentially in the 3′ UTR of target mRNAs conjointly with Rrm4. Rrm4 binds distinct targets at landmark sites of translation, suggesting a link between transport and translational regulation. Lilli Olgeiser, Carl Haag, Susan Boerner, Jernej Ule, Anke Busch, Janine Koepke, Julian König, Michael Feldbrügge and Kathi Zarnack Published online 14.12.2018 | | The AT‐rich telomere‐associated sequences (TAS) in S. pombe are hyper‐recombinogenic and have metastable nucleosomes. This fragile nature of subtelomeres is counteracted by the shelterin subunit Ccq1 and its downstream partners CLRC and SHREC. Thomas S van Emden, Marta Forn, Ignasi Forné, Zsuzsa Sarkadi, Matías Capella, Lucía Martín Caballero, Sabine Fischer‐Burkart, Cornelia Brönner, Marco Simonetta, David Toczyski, Mario Halic, Axel Imhof and Sigurd Braun Published online 12.11.2018 | | | | Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation. | | | |
No comments:
Post a Comment