Friday, December 14, 2018

The EMBO Journal Table of Contents for 14 December 2018; Vol. 37, No. 24

10X Genomics  
14 December 2018 | Volume 37, Number 24 Submit


Table of Contents

Editorial
News & Views
Articles
Resource
COVER

Volume 37, Number 24



Editorial
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Open Access mandates in Europe raise the question if the priority is to reduce publishing costs, or the overdue conversion to Open Science communication. At risk are not only high‐quality journals, but also community institutions and international research collaboration.

Bernd Pulverer
Published online 03.12.2018

News & Views
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New phosphoproteomics studies identify the first physiological substrates of the neurodevelopmental disease‐associated CDKL5 kinase, highlighting potential roles in regulation of neuronal microtubule dynamics.

Patrick A Eyers
Published online 30.10.2018 Open Access

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New work improving the properties of a fast channelrhodopsin to enable rapid light‐responsive auditory nerve activity may pave the way for optical cochlear implants.

Emiliano Ronzitti, Valeria Zampini and Valentina Emiliani
Published online 03.12.2018

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A new study finds IKKβ to control mRNA decapping, illustrating how cellular signalling shapes gene expression via both mRNA synthesis and degradation.

Neil D Perkins
Published online 03.12.2018

Articles
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The IκB kinase binds mRNA decay factors and affects the formation of P bodies, extending its function beyond the canonical role as a regulator of NFkB‐dependent transcription.

Nadine Mikuda, Marina Kolesnichenko, Patrick Beaudette, Oliver Popp, Bora Uyar, Wei Sun, Ahmet Bugra Tufan, Björn Perder, Altuna Akalin, Wei Chen, Philipp Mertins, Gunnar Dittmar, Michael Hinz and Claus Scheidereit
Published online 22.11.2018

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A new mouse model shows that the CCR4‐NOT complex ensures timely clearance of maternal mRNAs in developing oocytes, thereby preventing aberrant translation and meiotic defects.

Qian‐Qian Sha, Jia‐Li Yu, Jing‐Xin Guo, Xing‐Xing Dai, Jun‐Chao Jiang, Yin‐Li Zhang, Chao Yu, Shu‐Yan Ji, Yu Jiang, Song‐Ying Zhang, Li Shen, Xiang‐Hong Ou and Heng‐Yu Fan
Published online 26.11.2018

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The protein kinase C delta restricts primitive hematopoietic cell contribution to the blood system to set a threshold for proliferation and regeneration.

Tata Nageswara Rao, Manoj K Gupta, Samir Softic, Leo D Wang, Young C Jang, Thomas Thomou, Olivier Bezy, Rohit N Kulkarni, C Ronald Kahn and Amy J Wagers
Published online 16.11.2018 Open Access

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The finding of decreased microtubule affinity of CDKL5‐phosphorylated MAP1S provides new insights into a possible pathogenic pathway of neurodevelopmental CDKL5 deficiency disorder.

Lucas L Baltussen, Priscilla D Negraes, Margaux Silvestre, Suzanne Claxton, Max Moeskops, Evangelos Christodoulou, Helen R Flynn, Ambrosius P Snijders, Alysson R Muotri and Sila K Ultanir
Published online 28.09.2018 Open Access

Resource
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Identification of phosphorylation targets reveals a sequence preference for the neurodevelopmental disease‐linked CDKL5, and that pathogenic mutations decrease activity towards microtubule‐ and centrosome‐associated substrates.

Ivan M Muñoz, Michael E Morgan, Julien Peltier, Florian Weiland, Mateusz Gregorczyk, Fiona CM Brown, Thomas Macartney, Rachel Toth, Matthias Trost and John Rouse
Published online 28.09.2018 Open Access

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Biophysical characterization and molecular engineering of the fast channelrhodopsin Chronos results in a new optogentics tool for controlling fast neural circuitries with high temporal fidelity.

Daniel Keppeler, Ricardo Martins Merino, David Lopez de la Morena, Burak Bali, Antoine Tarquin Huet, Anna Gehrt, Christian Wrobel, Swati Subramanian, Tobias Dombrowski, Fred Wolf, Vladan Rankovic, Andreas Neef and Tobias Moser
Published online 05.11.2018

 
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