The EMBO Journal Table of Contents for 14 September 2018; Vol. 37, No. 18

14 September 2018 | Volume 37, Number 18 Submit Table of Contents News & Views Review Articles Resource Volume 37, Number 18 News & Views Queuing up the ribosome: nutrition and the microbiome control protein synthesis A tRNA modification needed for efficient translation requires the diet‐supplied precursor queuine and its depletion activates cellular stress responses in mice. Itamar Kozlovski and Reuven Agami Published online 03.09.2018 Review Parkinson's disease: convergence on synaptic homeostasis A comprehensive overview of the interplay between synaptic dysfunction and neurodegeneration in Parkinson's disease details the roles of disease‐associated regulators of protein homeostasis, endocytosis and autophagy in synaptic homeostasis. Sandra‐Fausia Soukup, Roeland Vanhauwaert and Patrik Verstreken Published online 31.07.2018 Articles Deficiency in the nuclear long noncoding RNA Charme causes myogenic defects and heart remodeling in mice By inserting an artificial polyadenylation site in vivo, this study shows that expression of a specific lncRNA is required for local chromatin organisation and normal cardiac development. Monica Ballarino, Andrea Cipriano, Rossella Tita, Tiziana Santini, Fabio Desideri, Mariangela Morlando, Alessio Colantoni, Claudia Carrieri, Carmine Nicoletti, Antonio Musarò, Dònal O’ Carroll and Irene Bozzoni Published online 03.09.2018 Queuosine‐modified tRNAs confer nutritional control of protein translation Queuosine modification of tRNAs requires the diet‐supplied precursor queuine. Q‐bearing tRNAs control translational speed, illustrating how a nutritionally determined tRNA modification can affect polypeptide synthesis and cellular homeostasis in vivo. Francesca Tuorto, Carine Legrand, Cansu Cirzi, Giuseppina Federico, Reinhard Liebers, Martin Müller, Ann E Ehrenhofer‐Murray, Gunnar Dittmar, Hermann‐Josef Gröne and Frank Lyko Published online 09.08.2018 SHLD2/FAM35A co‐operates with REV7 to coordinate DNA double‐strand break repair pathway choice Proteomic interaction and CRISPR/Cas9 doxorubicin sensitivity screens identify the sought‐after effectors through which the 53BP1/RIF1/REV7 axis antagonizes DNA break resection and promotes non‐homologous end‐joining repair. Steven Findlay, John Heath, Vincent M Luo, Abba Malina, Théo Morin, Yan Coulombe, Billel Djerir, Zhigang Li, Arash Samiei, Estelle Simo‐Cheyou, Martin Karam, Halil Bagci, Dolev Rahat, Damien Grapton, Elise G Lavoie, Christian Dove, Husam Khaled, Hellen Kuasne, Koren K Mann, Kathleen Oros Klein, Celia M Greenwood, Yuval Tabach, Morag Park, Jean‐Francois Côté, Jean‐Yves Masson, Alexandre Maréchal and Alexandre Orthwein Published online 28.08.2018 Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis The Zika virus promotes NLRP3 inflammasome activation by stabilizing caspase‐1 to suppress cGAS‐mediated type I IFN signaling. Yanyan Zheng, Qingxiang Liu, Yaoxing Wu, Ling Ma, Zhenzhen Zhang, Tao Liu, Shouheng Jin, Yuanchu She, Yi‐Ping Li and Jun Cui Published online 31.07.2018 CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling Proteomic identification of the Cul5 ubiquitin ligase adaptor Elongin C as AMBRA1‐binding substrate of Cul4 ligase exemplifies crosstalk between cullin‐RING E3s that can modulate both cytokine signaling and HIV‐1 infectivity. Si‐Han Chen, Gwendolyn M Jang, Ruth Hüttenhain, David E Gordon, Dan Du, Billy W Newton, Jeffrey R Johnson, Joseph Hiatt, Judd F Hultquist, Tasha L Johnson, Yi‐Liang Liu, Lily A Burton, Jordan Ye, Kurt M Reichermeier, Robert M Stroud, Alexander Marson, Jayanta Debnath, John D Gross and Nevan J Krogan Published online 30.08.2018 DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development DCAF13 is a novel CRL4 ubiquitin ligase adaptor that is essential for early embryonic nuclear reprogramming. Yin‐Li Zhang, Long‐Wen Zhao, Jue Zhang, Rongrong Le, Shu‐Yan Ji, Chuan Chen, Yawei Gao, Dali Li, Shaorong Gao and Heng‐Yu Fan Published online 14.08.2018 TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy A tripartite motif‐containing ubiquitin ligase modifies the p62‐NRF2 complex for stress‐induced protein aggregation and provides an assembly scaffold for autophagy factors involved in aggregate clearance. Kautilya Kumar Jena, Srinivasa Prasad Kolapalli, Subhash Mehto, Parej Nath, Biswajit Das, Pradyumna Kumar Sahoo, Abdul Ahad, Gulam Hussain Syed, Sunil K Raghav, Shantibhusan Senapati, Swati Chauhan and Santosh Chauhan Published online 24.08.2018 MIWI2 targets RNAs transcribed from piRNA‐dependent regions to drive DNA methylation in mouse prospermatogonia The piRNA pathway represses retrotransposons during early development. Base‐pairing between nascent RNA and piRNAs bound by mouse Piwi protein MIWI2 determines the specificity of suppressive DNA methylation. Toshiaki Watanabe, Xiekui Cui, Zhongyu Yuan, Hongying Qi and Haifan Lin Published online 14.08.2018 Error‐free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin A yeast Snf2‐family DNA translocase promotes cohesin loading near stalled forks to facilitate sister chromatid template use for the bypass of replication‐blocking DNA damage. Ireneusz Litwin, Tomasz Bakowski, Barnabas Szakal, Ewa Pilarczyk, Ewa Maciaszczyk‐Dziubinska, Dana Branzei and Robert Wysocki Published online 14.08.2018 Resource One‐step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock‐in mice Direct recombination of pre‐arranged human B‐cell receptor into the native immunoglobulin locus in fertilized mouse oocytes provides a facile strategy for obtaining vaccination models for infectious disease. Ying‐Cing Lin, Simone Pecetta, Jon M Steichen, Sven Kratochvil, Eleonora Melzi, Johan Arnold, Stephanie K Dougan, Lin Wu, Kathrin H Kirsch, Usha Nair, William R Schief and Facundo D Batista Published online 07.08.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.